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      • Effect of Azadirachta indica flower extract on basal and experimentally elevated blood glucose in rats

        Waliullah, S,Javed, Kalim,Jafri, MA,Singh, S Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.3

        Azadirachta indica A. Juss (N.O. Meliaceae), popularly known, as 'Neem' is an indigenous tree widely available in India. Almost every part of the tree has long been used in Unani system of medicine for the treatment of a variety of human ailments. The flowers have been mentioned as a remedy useful in controlling diabetes mellitus. The present study had been designed to investigate the hypoglycemic/anti-hyperglycemic effects of the methanolic extract of the flowers of A. indica (Gule-Neem) and its different fractions on normal, glucose fed hyperglycemic, adrenaline induced hyperglycemic and alloxan induced diabetic rats. The methanolic extract was resolved into water soluble and water insoluble fractions. Water soluble portion of the methanolic extract was found to possess significant blood sugar lowering effect in glucose-fed and adrenaline-induced hyperglycemic rats but it did not show such effect in normal and alloxan induced mild and severe diabetic rats. Water-soluble portion was fractionated by employing the polarity criterion with ethyl acetate and butanol. The ethyl acetate fraction was further fractionated into phenolic and non-phenolic fractions. Hypoglycemic effect of these fractions was also evaluated. The results suggest that the flowers of A. indica contain at least two different constituents, responsible for the said activity. These investigations validate the use of flowers of A. indica in diabetes by Unani physicians.

      • Synthesis and micellization of a novel diblock copolymer of poly(<i>N</i>-isopropylacrylamide)-<i>b</i>-SGLCP and its application in stability of 5CB droplets in aqueous medium

        Khan, Waliullah,Seo, Jung-Min,Park, Soo-Young The Royal Society of Chemistry 2011 Soft matter Vol.7 No.2

        <P>A novel diblock copolymer of poly(<I>N</I>-isopropylacrylamide)-<I>b</I>-poly(4-cyanobiphenyl-4-oxyundecylacrylate) (PNIPAM-<I>b</I>-LCP) was synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization. PNIPAM-<I>b</I>-LCP was formed into the core–shell micelle in an aqueous solution, which consisted of the hydrophobic LCP block in the core and the hydrophilic PNIPAM block in the shell with a critical micelle concentration of 0.043 mg mL<SUP>−1</SUP>. The hydrophobic 4-cyano-4′-pentylbiphenyl (5CB, nematic liquid crystal (LC)) was added into the PNIPAM-<I>b</I>-LCP aqueous solution to incorporate hydrophobic LC monomers in the micelle core. The size of the micelles increased as the concentration of the 5CB increased, indicating that the 5CB was successfully loaded in the core. The size of the PNIPAM-<I>b</I>-LCP micelle in water also showed a step-wise decrease at ∼33 °C as temperature increased (or <I>vice versa</I>) due to the lower critical solution temperature (LCST) behavior of the PNIPAM. The combination of the LC properties in the core and the thermo-responsive behaviors in the shell might open new applications in the fields of smart windows, nanoactuation, controlled release, photonics, <I>etc.</I></P> <P>Graphic Abstract</P><P>The novel PNIPAM-<I>b</I>-LCP might work as a block copolymer surfactant of LC which makes the 5CB droplets stable and thermo-responsive. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0sm00758g'> </P>

      • KCI등재후보

        Effect of Azadirachta indica flower extract on basal and experimentally elevated blood glucose in rats

        S Waliullah,Kalim Javed,MA Jafri,S Singh 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.3

        Azadirachta indica A. Juss (N.O. Meliaceae), popularly known, as ‘Neem’ is an indigenous tree widely available in India. Almost every part of the tree has long been used in Unani system of medicine for the treatment of a variety of human ailments. The flowers have been mentioned as a remedy useful in controlling diabetes mellitus. The present study had been designed to investigate the hypoglycemic/anti-hyperglycemic effects of the methanolic extract of the flowers of A. indica (Gule-Neem) and its different fractions on normal, glucose fed hyperglycemic, adrenaline induced hyperglycemic and alloxan induced diabetic rats. The methanolic extract was resolved into water soluble and water insoluble fractions. Water soluble portion of the methanolic extract was found to possess significant blood sugar lowering effect in glucose-fed and adrenaline-induced hyperglycemic rats but it did not show such effect in normal and alloxan induced mild and severe diabetic rats. Water-soluble portion was fractionated by employing the polarity criterion with ethyl acetate and butanol. The ethyl acetate fraction was further fractionated into phenolic and non-phenolic fractions. Hypoglycemic effect of these fractions was also evaluated. The results suggest that the flowers of A. indica contain at least two different constituents, responsible for the said activity. These investigations validate the use of flowers of A. indica in diabetes by Unani physicians. Azadirachta indica A. Juss (N.O. Meliaceae), popularly known, as ‘Neem’ is an indigenous tree widely available in India. Almost every part of the tree has long been used in Unani system of medicine for the treatment of a variety of human ailments. The flowers have been mentioned as a remedy useful in controlling diabetes mellitus. The present study had been designed to investigate the hypoglycemic/anti-hyperglycemic effects of the methanolic extract of the flowers of A. indica (Gule-Neem) and its different fractions on normal, glucose fed hyperglycemic, adrenaline induced hyperglycemic and alloxan induced diabetic rats. The methanolic extract was resolved into water soluble and water insoluble fractions. Water soluble portion of the methanolic extract was found to possess significant blood sugar lowering effect in glucose-fed and adrenaline-induced hyperglycemic rats but it did not show such effect in normal and alloxan induced mild and severe diabetic rats. Water-soluble portion was fractionated by employing the polarity criterion with ethyl acetate and butanol. The ethyl acetate fraction was further fractionated into phenolic and non-phenolic fractions. Hypoglycemic effect of these fractions was also evaluated. The results suggest that the flowers of A. indica contain at least two different constituents, responsible for the said activity. These investigations validate the use of flowers of A. indica in diabetes by Unani physicians.

      • Microfluidic formation of pH responsive 5CB droplets decorated with PAA-<i>b</i>-LCP

        Khan, Waliullah,Choi, Jin Ho,Kim, Gyu Man,Park, Soo-Young Royal Society of Chemistry 2011 Lab on a chip Vol.11 No.20

        <P>We are reporting for the first time the pH responsiveness of liquid crystal (LC) microdroplets decorated with an amphiphilic block copolymer of PAA-<I>b</I>-LCP. We successfully demonstrated the adsorption of block copolymer on LC droplets by fluorescence microscopy and pH response to the radial-to-bipolar orientational change of the LC droplets by changing pH from 12 to 2 through the polarized optical microscope (POM). We believe that our results may pave the way for the generation of monodisperse droplets decorated by various amphiphilic block copolymers which respond to several kinds of the external stimuli. These developments may be important for potential applications of the LC droplets in sensing and encapsulation fields.</P> <P>Graphic Abstract</P><P>pH-responsive 5CB droplets coated with PAA-<I>b</I>-LCP are reported which have many potential applications based on LC droplets. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1lc20402e'> </P>

      • An Experimental Study Analysis of Security Attacks at IEEE 802.11 Wireless Local Area Network

        Md Waliullah,A B M Moniruzzaman,Md. Sadekur Rahman,Member, IEEE 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.1

        IEEE802.11 wireless networks have become one of the most widely used networks. Due to open nature of wireless medium, hackers and intruders can make utilization of the loopholes of the wireless communication; as a result, there are many security threats associated with Wireless Local Area Network (WLAN). In this paper, we have worked an experimental analysis to study some of the well known attacks pertaining to IEEE 802.11 WLAN. At first, some of the open issues related to this fragile technology have been discussed. Based on this vulnerabilities and threats categories some of the major attack has been performed in a live environment by using open source software tools i.e Aircrak-nj, kismet. etc. The analysis and finding from this paper’s proved that the complexity of attacks had increased by time and the Wifi technology are becoming more dangerous to the end users and business environment.

      • Configuration change of liquid crystal microdroplets coated with a novel polyacrylic acid block liquid crystalline polymer by protein adsorption.

        Khan, Waliullah,Park, Soo-Young Royal Society of Chemistry 2012 Lab on a chip Vol.12 No.21

        <P>4-cyano-4'-pentylbiphenyl (5CB) microdroplets coated with PAA-b-LCP were successfully made via microfluidics. Their functionalized interfaces were examined for lysozyme and bovine serum albumin detection, which could be easily visualized with an optical microscope under crossed polarizers by the radial-to-bipolar configurational change of the 5CB. This transition was strongly dependent on the electrostatic states of the proteins and PAA chains, which were controlled by the pH of the water. This study demonstrated a simple approach for the development of a liquid crystal-based sensor for label-free detection of proteins, which may have diverse applications in various biomedical fields.</P>

      • A High Availability Clusters Model Combined with Load Balancing and Shared Storage Technologies for Web Servers

        A. B. M. Moniruzzaman,Md. Waliullah,Md. Sadekur Rahman 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.1

        This paper designs and implements a high availability clusters and incorporated with load balance infrastructure of web servers. The paper described system can provide full facilities to the website hosting provider and large business organizations. This system can provide continuous service though any system components fail uncertainly with the help of Linux Virtual Server (LVS) load-balancing cluster technology and combined with virtualization as well as shared storage technology to achieve the three-tier architecture of Web server clusters. This technology not only improves availability, but also affects the security and performance of the application services being requested. Benefits of the system include node failover overcome; network failover overcome; storage limitation overcome and load distribution.

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