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Tsutsumi, Takashi,Iwashita, Hiroshi,Miyahara, Kagenobu Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.38 No.3
This paper shows the solution for an orthotropic disk under the plane strain condition obtained with complex stress functions. These stress functions were induced by Lekhnitskii and expanded by one of the authors. Regarding diametrical compression test, the finite element method poses difficulties in representing the concentrated force because the specimens must be divided into finite elements during calculation. On the other hand, the method shown in this study can exactly represent this force. Some numerical results are shown and compared with those obtained under the plane stress condition for both stress and displacement. This comparison shows that the differences between the tensile stresses occurred under the plane strain condition and also that the differences under a plane stress condition increase as the orthotropy ratio increases for some cases.
Hepcidin Levels and Pathological Characteristics in Children with Fatty Liver Disease
Tsutsumi, Norito,Nishimata, Shigeo,Shimura, Masaru,Kashiwagi, Yasuyo,Kawashima, Hisashi The Korean Society of Pediatric Gastroenterology 2021 Pediatric gastroenterology, hepatology & nutrition Vol.24 No.3
Purpose: Hepcidin levels have previously been reported to be correlated with liver damage. However, the association between hepcidin levels and liver fibrosis in children with fatty liver disease remains unclear. This study therefore aimed to investigate the pathophysiology of fibrosis in children with fatty liver disease and its association with hepcidin levels. Methods: This retrospective case series included 12 boys aged 6-17 years who were diagnosed with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH) at the Tokyo Medical University Hospital. Sixteen liver biopsy samples from 12 subjects were analyzed. Serum hepcidin levels were assayed using enzyme-linked immunosorbent assay. Immunostaining for hepcidin was performed, and the samples were stratified by staining intensity. Results: Serum hepcidin levels were higher in pediatric NAFLD/NASH patients than in controls. Conversely, a significant inverse correlation was observed between hepcidin immunostaining and Brunt grade scores and between hepcidin scores and gamma-glutamyltranspeptidase, hyaluronic acid, and leukocyte levels. We observed inverse correlations with a high correlation coefficient of >0.4 between hepcidin immunostaining and aspartate aminotransferase, alanine aminotransferase, total bile acid, and platelet count. Conclusion: There was a significant inverse correlation between hepcidin immunoreactivity and fibrosis in pediatric NAFLD patients; however, serum hepcidin levels were significantly higher, suggesting that these patients experienced a reduction in the hepcidin-producing ability of the liver in response to iron levels, leading to subsequent fibrosis. Therefore, hepcidin levels can be used as markers to identify the progression of fibrosis in patients with NAFLD.
Analysis of orthotropic circular disks and rings under diametrical loadings
Tsutsumi, Takashi,Hirashima, Ken-Ichi Techno-Press 2000 Structural Engineering and Mechanics, An Int'l Jou Vol.9 No.1
Very few studies on orthotropic circular disks or rings under diametrical loadings are conducted because of difficulties in treatment. This paper shows analytical solutions and gives the distributions of stresses and displacements by using Lekhnitskii's complex variable method. Several numerical results are shown by graphical representation.
Tsutsumi, Atsushi,Chen, Wei,Kim, Yong Han 한국화학공학회 1999 Korean Journal of Chemical Engineering Vol.16 No.6
According to axial profile of solid concentration, the cocurrent upward three-phase reactors with liquid as continuous phase can be classified into three types: (a) gas-sparged slurry reactors, (b) three-phase bubble columns, and (c) three-phase fluidized beds. Comparative study shows that the gas hold up, bubble characteristics and mass transfer are significantly dependent on the type of three-phase reactors. Three types of reactors exhibit the different hydrodynamic and transport behaviors with particle size, solid concentration and gas holdup. The structural analysis of the axial solid distribution indicates the bubble and bubble wake dynamics are the key factors to the hydrodynamic and transport behaviors of three-phase reactors.
Design of launch pad for mitigating acoustic loads on launch vehicle at liftoff
Tsutsumi, Seiji The Acoustical Society of Korea 2020 韓國音響學會誌 Vol.39 No.4
우주발사체는 발사 시 추진장치에서 발생하는 고강도 소음에 의한 음향하중의 영향을 받는다. 로켓소음은 발사체와 페이로드 내 전자 및 기계 부품의 손상 및 오작동을 유발할 수 있기 때문에 음향하중의 예측 및 저감은 설계에 있어 중요한 고려사항이다. 본 논문에서는 로켓 소음의 생성 및 발사대의 음향설계 기법에 대한 최신 연구동향을 논하였다. 특히, 새로운 발사대 설계 방법론의 예로서 일본 Epsilon 로켓 발사대의 개발과정을 기술하였다. 전산유체역학 모사 및 1/42 축소모형 실험을 통하여 설계된 발사대의 음향하중 저감 효과를 Epsilon 로켓의 실제 비행 데이터 분석을 통하여 검증하였다.
Preliminary Analysis of Interconnect Full Open Faults using TEG chips
Toshiyuki Tsutsumi,Yasuyuki Kariya,Masaki Hashizume,Hiroyuki Yotsuyanagi,Koji Yamazaki,Yoshinobu Higami,Hiroshi Takahashi,Yuzo Takamatsu 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
As LSIs are scale-down, there is an increasing need to take measures against open faults. However, no practical model for open faults exists at present. Therefore, we fabricated Test Element Group (TEG) chips that intentionally incorporated full (complete) open defects and electrically measured the output signals relevant to its defective lines in order to create a new model for open fault behavior. This study reveals the effect boundary of adjacent signal lines on the line containing the full open defect for the first time using the TEG chips.
HCCI COMBUSTION CHARACTERISTICS DURING OPERATION ON DME AND METHANE FUELS
Y. TSUTSUMI,A. IIJIMA,K. YOSHIDA,H. SHOJI,J. T. LEE 한국자동차공학회 2009 International journal of automotive technology Vol.10 No.6
The Homogeneous Charge Compression Ignition (HCCI) engine has attracted much interest because it can simultaneously achieve high efficiency and low emissions. However, the ignition timing is difficult to control because this engine has no physical ignition mechanism. In addition, combustion proceeds very rapidly because the premixed mixture ignites simultaneously at multiple locations in the cylinder, making it difficult to increase the operating load. In this study, an HCCI engine was operated using blended test fuels comprised of dimethyl ether (DME) and methane, each of which have different ignition characteristics. The effects of mixing ratios and absolute quantities of the two types of fuel on the ignition timing and rapidity of combustion were investigated. Cool flame reaction behavior, which significantly influences the ignition, was also analyzed in detail on the basis of in-cylinder spectroscopic measurements. The experimental results revealed that within the range of the experimental conditions used in this study, the quantity of DME supplied substantially influenced the ignition timing, whereas there was little observed effect from the quantity of methane supplied. Spectroscopic measurements of the behavior of a substance corresponding to HCHO also indicated that the quantity of DME supplied significantly influenced the cool flame behavior. However, the rapidity of combustion could not be controlled even by varying the mixing ratios of DME and methane. It was made clear that changes in the ignition timing substantially influence the rapidity of combustion.