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RISS 인기검색어
- 검색키워드
- 저자 : Tinglin Zhang (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Zhang, Penghui,Dong, Sheying,Gu, Guangzhe,Huang, Tinglin Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.10
Ionic liquid-functionalized ordered mesoporous silica SBA-15 modified carbon paste electrode (CISPE) was fabricated and its electrochemical performance was investigated by cyclic voltammetry, electrochemical impedance spectra. The electrochemical behavior of $Cd^{2+}$, $Pb^{2+}$, $Cu^{2+}$ and $Hg^{2+}$ at CISPE was studied by differential pulse anodic stripping voltammetry (DPASV). Compared with carbon paste electrode, the stripping peak currents had a significant increase at CISPE. Under the optimized conditions, the detection limits were $8.0{\times}10^{-8}\;M$ ($Cd^{2+}$), $4.0{\times}10^{-8}\;M$ ($Pb^{2+}$), $6.0{\times}10^{-8}\;M$ ($Cu^{2+}$), $1.0{\times}10^{-8}\;M$ ($Hg^{2+}$), respectively. Furthermore, the present method was applied to the determination of $Cd^{2+}$, $Pb^{2+}$, $Cu^{2+}$ and $Hg^{2+}$ in water samples and people hair sample.
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Tinglin Pu,Wenyan Zou,Weixi Feng,Yanli Zhang,Linmei Wang,Hongxing Wang,Ming Xiao 한국뇌신경과학회 2019 Experimental Neurobiology Vol.28 No.1
Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular event that often is followed by permanent brain impairments. It is necessary to explore the pathogenesis of secondary pathological damages in order to find effective interventions for improving the prognosis of SAH. Blockage of brain lymphatic drainage has been shown to worsen cerebral ischemia and edema after acute SAH. However, whether or not there is persistent dysfunction of cerebral lymphatic drainage following SAH remains unclear. In this study, autologous blood was injected into the cisterna magna of mice to establish SAH model. One week after surgery, SAH mice showed decreases in fluorescent tracer drainage to the deep cervical lymph nodes (dcLNs) and influx into the brain parenchyma after injection into the cisterna magna. Moreover, SAH impaired polarization of astrocyte aquaporin-4 (AQP4) that is a functional marker of glymphatic clearance and resulted in accumulations of Tau proteins as well as CD3+ , CD4+ , and CD8+ cells in the brain. In addition, pathological changes, including microvascular spasm, activation of glial cells, neuroinflammation, and neuronal apoptosis were observed in the hippocampus of SAH mice. Present results demonstrate persistent malfunction of glymphatic and meningeal lymphatic drainage and related neuropathological damages after SAH. Targeting improvement of brain lymphatic clearance potentially serves as a new strategy for the treatment of SAH.
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Penghui Zhang,Sheying Dong,Guangzhe Gu,Tinglin Huang 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.10
Ionic liquid-functionalized ordered mesoporous silica SBA-15 modified carbon paste electrode (CISPE) was fabricated and its electrochemical performance was investigated by cyclic voltammetry, electrochemical impedance spectra. The electrochemical behavior of Cd2+, Pb2+, Cu2+ and Hg2+ at CISPE was studied by differential pulse anodic stripping voltammetry (DPASV). Compared with carbon paste electrode, the stripping peak currents had a significant increase at CISPE. Under the optimized conditions, the detection limits were 8.0 × 10‒8 M (Cd2+), 4.0 × 10‒8 M (Pb2+), 6.0 ×10‒8 M (Cu2+), 1.0 × 10‒8 M (Hg2+), respectively. Furthermore, the present method was applied to the determination of Cd2+, Pb2+, Cu2+ and Hg2+ in water samples and people hair sample.
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Wenjing Li,Ying Bei,Xiangqiang Pan,Jian Zhu,Zhengbiao Zhang,Tinglin Zhang,Jieting Liu,Dan Wu,Meng Li,Yan Wu,Jie Gao 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Multifunctional hydrogels with controllable degradation and drug release have attracted extensive attention in diabetic wound healing. This study focused on the acceleration of diabetic wound healing with selenidelinked polydopamine-reinforced hybrid hydrogels with on-demand degradation and light-triggered nanozyme release. Methods Herein, selenium-containing hybrid hydrogels, defined as DSeP@PB, were fabricated via the reinforcement of selenol-end capping polyethylene glycol (PEG) hydrogels by polydopamine nanoparticles (PDANPs) and Prussian blue nanozymes in a one-pot approach in the absence of any other chemical additive or organic solvent based on diselenide and selenide bonding-guided crosslinking, making them accessible for large-scale mass production. Results Reinforcement by PDANPs greatly increases the mechanical properties of the hydrogels, realizing excellent injectability and flexible mechanical properties for DSeP@PB. Dynamic diselenide introduction endowed the hydrogels with on-demand degradation under reducing or oxidizing conditions and light-triggered nanozyme release. The bioactivity of Prussian blue nanozymes afforded the hydrogels with efficient antibacterial, ROS-scavenging and immunomodulatory effects, which protected cells from oxidative damage and reduced inflammation. Further animal studies indicated that DSeP@PB under red light irradiation showed the most efficient wound healing activity by stimulating angiogenesis and collagen deposition and inhibiting inflammation. Conclusion The combined merits of DSeP@PB (on-demand degradation, light-triggered release, flexible mechanical robustness, antibacterial, ROS-scavenging and immunomodulatory capacities) enable its high potential as a new hydrogel dressing that can be harnessed for safe and efficient therapeutics for diabetic wound healing.
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