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Thimmegowda MN.,Suresh Suroshe Sachin,Sagar D. 한국응용곤충학회 2024 Journal of Asia-Pacific Entomology Vol.27 No.1
The sustainability and fitness of biocontrol agents depends on the abiotic factors of which temperature is the most critical factor. Thermal stress affects parasitoid behavior owing to change in physiological activities. So, an experiment was conducted to know the effect of thermal stress on the antioxidant enzymes in Aenasius arizonensis (Girault), a specific parasitoid of cotton mealybug, Phenacoccus solenopsis (Tinsley). Enzyme activity in P. solenopsis and A. arizonensis at each thermal stress treatment was noticed. At 3 h of thermal stress, the tem perature dependent increase in the SOD activity was observed. The maximum activity was noticed at 41 ◦ C in both P. solenopsis and A. arizonensis compared to the 27 ◦ C. The SOD activity was found more in four hours exposure compared to the three hours exposure at all the temperature treatments. Catalase activity was also found to increase with the increase in temperature, the effect of thermal stress was found to be significant in A. arizonensis and P. solenopsis for the activity of catalase. The maximum GST activity was found at 41 ◦ C for both P. solenopsis nymphs and A. arizonensis adults exposed to different temperature treatments for 3 h of duration. However, all the temperature treatments for P. solenopsis nymphs were non-significant, whereas, for A. arizonensis, it was found significant for the GST activity. We observed that thermal stress had no effect on the concentration of MDA in both P. solenopsis and A. arizonensis subjected to different durations of temperature regimes. Elevated levels of SOD, CAT and GST might be providing possible protection against reactive oxygen species generated under elevated thermal stress.
Certain study of generalized $B$ curvature tensor within the framework of Kenmotsu manifold
Rahuthanahalli Thimmegowda Naveen Kumar,Basavaraju Phalaksha Murthy,Puttasiddappa Somashekhara,Venkatesha Venkatesha 대한수학회 2023 대한수학회논문집 Vol.38 No.3
In the present study, we consider some curvature properties of generalized $B$-curvature tensor on Kenmotsu manifold. Here first we describe certain vanishing properties of generalized $B$ curvature tensor on Kenmostu manifold. Later we formulate generalized $B$ pseudo-symmetric condition on Kenmotsu manifold. Moreover, we also characterize generalized $B$ $\phi$-recurrent Kenmotsu manifold.
Some Symmetric Properties on (LCS)<sub>n</sub>-manifolds
Venkatesha, Venkatesha,Naveen Kumar, Rahuthanahalli Thimmegowda Department of Mathematics 2015 Kyungpook mathematical journal Vol.55 No.1
We analyze the $(LCS)_n$-manifolds endowed with some symmetric properties, focusing on Ricci tensor and the 1-form ${\gamma}$. We study some properties of special Weakly Ricci-Symmetric $(LCS)_n$-manifolds and also shown that Weakly ${\phi}$-Ricci Symmetric $(LCS)_n$-manifold is an ${\eta}$-Einstein manifold.
Liu, Haidan,Hwang, Joonsung,Li, Wei,Choi, Tae Woong,Liu, Kangdong,Huang, Zunnan,Jang, Jae-Hyuk,Thimmegowda, N.R.,Lee, Ki Won,Ryoo, In-Ja,Ahn, Jong-Seog,Bode, Ann M.,Zhou, Xinmin,Yang, Yifeng,Erikson, American Association for Cancer Research 2014 CANCER PREVENTION RESEARCH Vol.7 No.1
<P>Mitogen- and stress-activated kinase 1 (MSK1) is a nuclear serine/threonine protein kinase that acts downstream of both extracellular signal-regulated kinases and p38 mitogen-activated protein kinase in response to stress or mitogenic extracellular stimuli. Increasing evidence has shown that MSK1 is closely associated with malignant transformation and cancer development. MSK1 should be an effective target for cancer chemoprevention and chemotherapy. However, very few MSK1 inhibitors, especially natural compounds, have been reported. We used virtual screening of a natural products database and the active conformation of the C-terminal kinase domain of MSK1 (PDB id 3KN) as the receptor structure to identify chrysin and its derivative, compound 69407, as inhibitors of MSK1. Compared with chrysin, compound 69407 more strongly inhibited proliferation and 12-<I>O</I>-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic transformation of JB6 P+ cells with lower cytotoxicity. Western blot data demonstrated that compound 69407 suppressed phosphorylation of the MSK1 downstream effector histone H3 in intact cells. Knocking down the expression of MSK1 effectively reduced the sensitivity of JB6 P+ cells to compound 69407. Moreover, topical treatment with compound 69407 before TPA application significantly reduced papilloma development in terms of number and size in a two-stage mouse skin carcinogenesis model. The reduction in papilloma development was accompanied by the inhibition of histone H3 phosphorylation at Ser10 in tumors extracted from mouse skin. The results indicated that compound 69407 exerts inhibitory effects on skin tumorigenesis by directly binding with MSK1 and attenuates the MSK1/histone H3 signaling pathway, which makes it an ideal chemopreventive agent against skin cancer. <I>Cancer Prev Res; 7(1); 74–85. ©2013 AACR</I>.</P>
Byun, Sanguine,Lim, Semi,Mun, Ji Young,Kim, Ki Hyun,Ramadhar, Timothy R.,Farrand, Lee,Shin, Seung Ho,Thimmegowda, N. R.,Lee, Hyong Joo,Frank, David A.,Clardy, Jon,Lee, Sam W.,Lee, Ki Won American Society for Biochemistry and Molecular Bi 2015 The Journal of biological chemistry Vol.290 No.39
<P>Bioactive phytochemicals can suppress the growth of malignant cells, and investigation of the mechanisms responsible can assist in the identification of novel therapeutic strategies for cancer therapy. Ginger has been reported to exhibit potent anti-cancer effects, although previous reports have often focused on a narrow range of specific compounds. Through a direct comparison of various ginger compounds, we determined that gingerenone A selectively kills cancer cells while exhibiting minimal toxicity toward normal cells. Kinase array screening revealed JAK2 and S6K1 as the molecular targets primarily responsible for gingerenone A-induced cancer cell death. The effect of gingerenone A was strongly associated with relative phosphorylation levels of JAK2 and S6K1, and administration of gingerenone A significantly suppressed tumor growth <I>in vivo</I>. More importantly, the combined inhibition of JAK2 and S6K1 by commercial inhibitors selectively induced apoptosis in cancer cells, whereas treatment with either agent alone did not. These findings provide rationale for dual targeting of JAK2 and S6K1 in cancer for a combinatorial therapeutic approach.</P>