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Kaori Matsumoto,Tetsuya Hasegawa,Kosuke Ohara,Chihiro Takei,Masayuki Akimoto 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.1
Nabumetone is a prodrug, used as an anti-inflammation agent and having the active metabolite 6-methoxy-2-naphthylacetic acid (6-MNA). The role of the polymorphic enzyme responsible for the 6-O-demethylation of 6-MNA to 6-hydroxy- 2-naphtylacetic acid (6-HNA) was studied using recombinant cytochrome CYP2C9 microsomes (CYP2C9.1, CYP2C9.2 and CYP2C9.3) and human liver microsomes of known genotypes of CYP2C9. Utilizing recombinant CYP2C9.1, Vmax and Vmax/Km values of 6.3 ± 3.3 pmol/min/pmol P450 and 12.4 ± 4.7 nL/min/pmol P450, respectively, were obtained for the 6-MNA metabolism, and were almost similar to those in CYP2C9.2. In contrast, the Vmax/Km value in recombinant CYP2C9.3 was about one-third that of CYP2C9.1. In kinetic studies using liver microsomes of humans genotyped for the CYP2C9 genes, a sample genotyped as *3/*3 revealed about 4- to sixfold lower intrinsic clearance for 6-HNA formation than did samples genotyped as *1/*1. No appreciable differences were observed in kinetic parameters for 6-HNA formation in *1/*2 and *1/*3, while *2/*2 microsomes was comparable to wild type microsomes. In addition, S-warfarin 7-hydroxylation by recombinant CYP2C9.1 and CYP2C9.3 was inhibited by 6-MNA in a mixed manner. The apparent Ki value of 6-MNA on S-warfarin 7-hydroxylation by CYP2C9.3 was higher than that by CYP2C9.1. These results may provide valuable information for optimizing the anticoagulant activity of warfarin when nabumetone is co-administrated to patients.
Analysis of Relaying Probability in Wireless Multi-hop Networks with QoS Routing
Kazuyuki Miyakita,Keisuke Nakano,Tetsuya Hasegawa,Masakazu Sengoku,Shoji Shinoda 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
In wireless multi-hop networks, source and destination nodes usually have some candidate paths between them, and communication quality depends on selection of a multi-hop path from these candidates. We theoretically analyzed ETX which is a measure of communication quality, for three routing algorithms in one-dimensional multi-hop networks. In this paper, we theoretically analyze relaying probability of each relay node in a one-dimensional multi-hop network with QoS routing, which minimizes ETX and propose an algorithm that makes relaying probability of each node as uniform as possible.