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Takeshi Kobayashi,Toshiaki Imanishi,Taizo Hanai,Ichiro Aoyagi,Jun Uemura,Katsuhiro Araki,Hiroshi Yoshimoto,Takeshi Harima,Hiroyuki Honda 한국생물공학회 2002 Biotechnology and Bioprocess Engineering Vol.7 No.5
In order to control glucose concentration during fed-batch culture for antibiotic production, we applied so called “software sensor” which estimates unmeasured variable of interest from measured process variables using software. All data for analysis were collected from industrial scale cultures in a pharmaceutical company. First, we constructed an estimation model for glucose feed rate to keep glucose concentration at target value. In actual fed-batch culture, glucose concentration was kept at relatively high and measured once a day, and the glucose feed rate until the next measurement time was determined by an expert worker based on the actual consumption rate. Fuzzy neural network (FNN) was applied to construct the estimation model. From the simulation results using this model, the average error for glucose concentration was 0.88 g/L. The FNN model was also applied for a special culture to keep glucose concentration at low level. Selecting the optimal input variables, it was possible to simulate the culture with a low glucose concentration from the data sets of relatively high glucose concentration. Next, a simulation model to estimate time course of glucose concentration during one day was constructed using the on-line measurable process variables, since glucose concentration was only measured off-line once a day. Here, the recursive fuzzy neural network (RFNN) was applied for the simulation model. As the result of the simulation, average error of RFNN model was 0.91 g/L and this model was found to be useful to supervise the fed-batch culture.
Takeshi Sasagawa,Hideki Murakami,Yoshinobu Maruhashi,Takeshi Segawa,Daiki Yamamoto,Shusuke Shimizu,Yasuhiko Morita,Takuya Nakamura 대한척추외과학회 2015 Asian Spine Journal Vol.9 No.5
Vertebral fractures occur with only slight trauma in patients with diffuse idiopathic skeletal hyperostosis (DISH). However, a lumbar vertebra fracture, due to an intraoperative body position has not been previously reported. An 87-year-old woman with kyphosis sustained a left trochanteric fracture of her femur. The patient was placed in a supine position during the operation. Postoperatively, the patient experienced severe right thigh pain. Magnetic resonance imaging revealed an L4 vertebral fracture. Computed tomography revealed ankylosis from the upper thoracic spine to the sacrum. While in a supine position under general anesthesia, the contact of the patient’s lower back with operating table likely created a fulcrum at her lumbosacral spine acting as a long lever arm, bearing the mass of her upper body. We performed L1–S2 posterior stabilization. DISH patients with kyphosis placed in a supine position have an increased risk for lumbar vertebral fracture.
Performance Enhancement of TFI-OFDM with Path Selection based Channel Identification
Takeshi Yoshimura,Chang-Jun Ann,Takeshi Kamio,Hisato Fujisaka,Kazuhisa Haeiwa 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
Recently time-frequency interferometry (TFI)-OFDM has been proposed as a channel identification scheme. TFI-OFDM system can multiplex the same impulse response in twice on the time domain without overlapping to each other. In this case, the required pilot signal is only one. Moreover, by averaging of these impulse responses, the accurated channel impulse responses are obtained. However, if the total channel paths are reduced, the performance might be degraded. This is because the channel identification of TFI-OFDM is operated with averaging the selected spectrum signals from the time windows. For the case with reduced channel paths, the selected time spectrum signals include the noise terms. By applying the FFT operation, these noise terms are spread in the frequency domain. In this case, the channel identification is poorly operated due to the noise. To reduce this problem, in the paper, we propose the channel identification method with path selection for performance enhancement of TFI-OFDM.
Study on intelligent baby carriage with power assist system and comfortable basket
Takeshi Kawashima 대한기계학회 2009 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.23 No.4
In Japan, lightweight and easy-to-fold baby carriages are commonly used because a parent has to hold both the baby and its carriage while ascending or descending a flight of stairs. Since families commuting by private automobiles are increasing, there is a demand for carriages with high functionality. In this study, an intelligent baby carriage equipped with an advanced electro-hybrid power assist system that uses in-wheel-type motors is experimentally developed. This system assists the parent in lifting the carriage onto a sidewalk by detecting the edge of the sidewalk using an ultrasonic distance sensor. The carriage also has the following features: a tilt control system that keeps the basket in a horizontal position even on a slope, and a heartbeat simulator that provides comfort to the baby in the basket by simulating the heartbeat of the parent. The effectiveness of the proposed carriage is confirmed by performing experiments.
Technical Review of Developments in Endoscopic Ultrasound- Guided Hepaticogastrostomy
Takeshi Ogura,Kazuhide Higuchi 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.5
Endoscopic ultrasound-guided biliary drainage has been developed as an alternative method for biliary drainage. EUS-guidedhepaticogastrostomy (EUS-HGS) can be attempted via the trans-gastric route. These procedures are technically complex for tworeasons. First, puncture of the intrahepatic bile duct via the trans-gastric route can be more difficult than that by other approachesbecause of the small diameter of the target site, and guidewire insertion or manipulation is challenging during EUS-HGS. Second,critical adverse events, such as stent migration into the abdominal cavity, could occur because of the greater mobility of the stomachcompared to the duodenum. Therefore, endoscopists should be cautious when performing EUS-HGS. An advantage of EUS-HGSis that it can be performed in patients with complications such as duodenal bulb obstruction or surgically altered anatomy. Recentadvances in technique and improvements in devices and stents for EUS-HGS have shown promise for improving the technicalsuccess rate of EUS-HGS and reducing the rate of adverse events. However, endoscopists should remain aware of the possibility ofcritical adverse events such as stent migration.