http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Takei, Hiroki,Yamamoto, Kiyofumi,Bae, Yong-Chul,Shirakawa, Tetsuo,Kobayashi, Masayuki Frontiers Media S.A. 2017 Frontiers in neural circuits Vol.11 No.-
<P>Histamine H<SUB>3</SUB> receptors are autoreceptors that regulate histamine release from histaminergic neuronal terminals. The cerebral cortex, including the insular cortex (IC), expresses abundant H<SUB>3</SUB> receptors; however, the functions and mechanisms of H<SUB>3</SUB> receptors remain unknown. The aim of this study was to elucidate the functional roles of H<SUB>3</SUB> in synaptic transmission in layer V of the rat IC. Unitary excitatory and inhibitory postsynaptic currents (uEPSCs and uIPSCs) were obtained through paired whole-cell patch-clamp recording in cerebrocortical slice preparations. The H<SUB>3</SUB> receptor agonist, R-α-methylhistamine (RAMH), reduced the uEPSC amplitude obtained from pyramidal cell to pyramidal cell or GABAergic interneuron connections. Similarly, RAMH reduced the uIPSC amplitude in GABAergic interneuron to pyramidal cell connections. RAMH-induced decreases in both the uEPSC and uIPSC amplitudes were accompanied by increases in the failure rate and paired-pulse ratio. JNJ 5207852 dihydrochloride or thioperamide, H<SUB>3</SUB> receptor antagonists, inhibited RAMH-induced suppression of uEPSCs and uIPSCs. Unexpectedly, thioperamide alone increased the uIPSC amplitude, suggesting that thioperamide was likely to act as an inverse agonist. Miniature EPSC or IPSC recordings support the hypothesis that the activation of H<SUB>3</SUB> receptors suppresses the release of glutamate and GABA from presynaptic terminals. The colocalization of H<SUB>3</SUB> receptors and glutamate decarboxylase or vesicular glutamate transport protein 1 in presynaptic axon terminals was confirmed through double pre-embedding microscopy, using a combination of pre-embedding immunogold and immunoperoxidase techniques. The suppressive regulation of H<SUB>3</SUB> heteroreceptors on synaptic transmission might mediate the regulation of sensory information processes, such as gustation and visceral sensation, in the IC.</P>
Takei Mari,Nin Charles,Iizuka Tomona,Pawlikowski Marine,Selva Marie-Ange,Chantran Yannick,Nakajima Yurie,Zheng Jingkang,Aizawa Tomoyasu,Ebisawa Motohiro,Sénéchal Hélène,Poncet Pascal 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.3
The Capsicum genus belongs to the Solanaceae family. Bell or chili peppers are consumed worldwide, but allergy to Capsicum is rare. It is involved in the celery-birch-mugwort-spice syndrome and cross-reactivities were reported with latex. Several allergens have been described, but only 2 are referenced in the World Health Organization/International Union of Immunological Societies allergen data bank, a thaumatin-like protein and a profilin. A patient allergic to bell/chili pepper, peach, orange and Japanese cedar pollen was clinically and biologically analyzed including direct and competitive immunoblots and basophil activation tests (BATs) with allergenic source extracts and recombinant gibberellin-regulated proteins (GRPs). The patient was shown to be sensitized to Cap a 7, the GRP of Capsicum annuum newly described herein. Cross-reactivities were demonstrated between various GRPs from bell/chili pepper, peach, orange and Japanese cedar pollen either in native form in the different extracts or as recombinant allergens. A similar immunoglobulin E reactivity was found also in Capsicum chinense and against snakin-1, the GRP from potato. The patient showed a positive BAT with recombinant Cry j 7, Pru p 7 and Cap a 7, but not with recombinant snakin-1. Despite the ubiquitous nature of GRPs in plants and the immunochemical cross-reactivity observed between different GRPs, clinically relevant sensitization to this protein family seems restricted to some allergenic sources, often associated with Cupressaceae pollen allergy, and to some patients, therefore reflecting very specific and peculiar mechanisms of conditional sensitization.
Nanowire active-matrix circuitry for low-voltage macroscale artificial skin
Takei, Kuniharu,Takahashi, Toshitake,Ho, Johnny C.,Ko, Hyunhyub,Gillies, Andrew G.,Leu, Paul W.,Fearing, Ronald S.,Javey, Ali Nature Publishing Group, a division of Macmillan P 2010 NATURE MATERIALS Vol.9 No.10
Large-scale integration of high-performance electronic components on mechanically flexible substrates may enable new applications in electronics, sensing and energy. Over the past several years, tremendous progress in the printing and transfer of single-crystalline, inorganic micro- and nanostructures on plastic substrates has been achieved through various process schemes. For instance, contact printing of parallel arrays of semiconductor nanowires (NWs) has been explored as a versatile route to enable fabrication of high-performance, bendable transistors and sensors. However, truly macroscale integration of ordered NW circuitry has not yet been demonstrated, with the largest-scale active systems being of the order of 1??cm<SUP>2</SUP> (refs?11,15). This limitation is in part due to assembly- and processing-related obstacles, although larger-scale integration has been demonstrated for randomly oriented NWs (ref.?16). Driven by this challenge, here we demonstrate macroscale (7?7??cm<SUP>2</SUP>) integration of parallel NW arrays as the active-matrix backplane of a flexible pressure-sensor array (18?19?pixels). The integrated sensor array effectively functions as an artificial electronic skin, capable of monitoring applied pressure profiles with high spatial resolution. The active-matrix circuitry operates at a low operating voltage of less than 5??V and exhibits superb mechanical robustness and reliability, without performance degradation on bending to small radii of curvature (2.5??mm) for over 2,000 bending cycles. This work presents the largest integration of ordered NW-array active components, and demonstrates a model platform for future integration of nanomaterials for practical applications.
Quantum Confinement Effects in Nanoscale-Thickness InAs Membranes
Takei, Kuniharu,Fang, Hui,Kumar, S. Bala,Kapadia, Rehan,Gao, Qun,Madsen, Morten,Kim, Ha Sul,Liu, Chin-Hung,Chueh, Yu-Lun,Plis, Elena,Krishna, Sanjay,Bechtel, Hans A.,Guo, Jing,Javey, Ali American Chemical Society 2011 NANO LETTERS Vol.11 No.11
<P>Nanoscale size effects drastically alter the fundamental properties of semiconductors. Here, we investigate the dominant role of quantum confinement in the field-effect device properties of free-standing InAs nanomembranes with varied thicknesses of 5–50 nm. First, optical absorption studies are performed by transferring InAs “quantum membranes” (QMs) onto transparent substrates, from which the quantized sub-bands are directly visualized. These sub-bands determine the contact resistance of the system with the experimental values consistent with the expected number of quantum transport modes available for a given thickness. Finally, the effective electron mobility of InAs QMs is shown to exhibit anomalous field and thickness dependences that are in distinct contrast to the conventional MOSFET models, arising from the strong quantum confinement of carriers. The results provide an important advance toward establishing the fundamental device physics of two-dimensional semiconductors.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2011/nalefd.2011.11.issue-11/nl2030322/production/images/medium/nl-2011-030322_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl2030322'>ACS Electronic Supporting Info</A></P>