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Stratum corneum lipids and circulating lipids in atopic dermatitis
( Takashi Sakai ) 한국피부장벽학회 2022 한국피부장벽학회지 Vol.24 No.2
Atopic dermatitis (AD) is the most common inflammatory skin disease, characterized by abnormal skin barrier function and type 2 inflammation. It is well known that stratum corneum (SC) lipids, including ceramides, play pivotal roles in the basis of the skin barrier. On the other hand, little is known about the circulating lipids in patients with AD, although circulating lipids work as biomarkers in several other disorders. In this lecture, I talk about (i) the possibility that SC ceramides could be biomarkers, indicating complete remission or potential flares in patients with AD, and (ii) the multiple circulating lipids in patients with AD are altered, and some of them are associated with the clinical status of AD. Until now, only SC lipids have been focused on AD. Evaluating SC lipids and circulating lipids in AD provides new insight into AD's pathogenesis and therapeutic strategies.
( Takashi Nonaka ),( Yusuke Sekino ),( Hiroshi Iida ),( Eiji Yamada ),( Hidenori Ohkubo ),( Eiji Sakai ),( Takuma Higurashi ),( Kunihiro Hosono ),( Hiroki Endo ),( Tomoko Koide ),( Hirokazu Takahashi 대한소화기기능성질환·운동학회 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.2
The gastrointestinal motility effects of endogenous incretin hormones enhanced by dipeptidyl peptidase-IV (DPP-IV) inhibitors have not yet been sufficiently investigated. The aim of this study was to determine whether single pre-prandial sitagliptin, the DPP-IV inhibitor, administration might have an effect on the rate of liquid gastric emptying using the 13C-acetic acid breath test. Methods Ten healthy male volunteers participated in this randomized, two-way crossover study. The subjects fasted for overnight and were randomly assigned to receive 50 mg sitagliptin 2 hours before ingestion of the liquid test meal (200 kcal per 200 mL, containing 100 mg 13C-acetate) or the test meal alone. Under both conditions, breath samples were collected for 150 minutes following the meal. Liquid gastric emptying was estimated by the values of the following parameters: the time required for 50% emptying of the labeled meal (T1/2), the analog to the scintigraphy lag time for 10% emptying of the labeled meal (Tlag), the gastric emptying coefficient and the regression-estimated constants (β and k), calculated by using the 13CO2 breath excretion curve using the conventional formulae. The parameters between the 2 test conditions were compared statistically. Results No significant differences in the calculated parameters, including T1/2, Tlag, gastric emptying coefficient or β and k, were observed between the 2 test conditions. Conclusions The present study revealed that single-dose sitagliptin intake had no significant influence on the rate of liquid gastric emptying in asymptomatic volunteers.
Iwahashi, Takashi,Miwa, Yujiro,Zhou, Wei,Sakai, Yasunari,Yamagata, Masaki,Ishikawa, Masashi,Kim, Doseok,Ouchi, Yukio Elsevier 2016 Electrochemistry Communications Vol.72 No.-
<P><B>Abstract</B></P> <P>The effect of Li<SUP>+</SUP> addition at the interface of a 1-ethyl-3-methylimidazolium bis(fluorosulfonyl)amide ([C<SUB>2</SUB>mim][FSA]) room-temperature ionic liquid (RTIL) and a Pt electrode is investigated by infrared-visible sum-frequency generation (IV-SFG) vibrational spectroscopy. Addition of Li<SUP>+</SUP> to the Pt|[C<SUB>2</SUB>mim][FSA] system results in the extension of the electrochemical window (EW) by >1.0V at its negative edge. The potential dependence of the SF signal reveals that the [FSA]<SUP>−</SUP> anion of neat [C<SUB>2</SUB>mim][FSA] is desorbed at −1.5V while it remains in place even at −2.0V when Li<SUP>+</SUP> is added. The SFG spectra indicate that the [FSA]<SUP>−</SUP> anion at the Pt|[C<SUB>2</SUB>mim][FSA] interface interacts with Li<SUP>+</SUP> at the interface with the negatively-charged Pt electrode. This [FSA]<SUP>−</SUP> anion layer anchored through Li<SUP>+</SUP> suppresses [C<SUB>2</SUB>mim]<SUP>+</SUP> cation adsorption on the negatively-charged Pt electrode, resulting in a wider electrochemical window.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Li<SUP>+</SUP> addition to Pt|[C<SUB>2</SUB>mim][FSA] extends EW by >1V at the negative edge. </LI> <LI> IV-SFG directly probes the presence of [FSA]<SUP>−</SUP> on Pt. </LI> <LI> Without Li<SUP>+</SUP>, [FSA]<SUP>−</SUP> desorbs from Pt at −1.0V. </LI> <LI> Li<SUP>+</SUP> is adsorbed on Pt to anchor [FSA]<SUP>−</SUP> to suppress [C2mim]<SUP>+</SUP> adsorption at −2.0V. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>