담즙정체성 간염의 임상적 양상

최선택,은종렬,임상우,김봉준,이헌주,구미진,최준혁 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1

Background: Cholestatic hepatitis is failure of bile to reach the duodenum with hepatocellular damage and no demonstrable obstruction of the major bile ducts. The prognosis is usually good with recovery in less than 4 weeks after withdrawal of the offending drug. However, a prolonged course lasting over 3 months is possible and, in rare cases, progression to ductopenia with development of a vanishing bile duct syndrome occurs. A differential diagnosis with other causes of Chronic liver disease is needed. Materials and Methods: From January 1991 through Jaunary 2000, 14 patients diagnosed as cholestatic hepatitis by liver biopsy were inclouded. The possible causative drug, clinical features, laboatory findings, and progression of cholestatic hepatitis were evaluated. The semiquantitative study of liver lesions was performed by two independent observers. Results: Causes of cholestatic hepatitis are 5 cases of oriental medicine, 3 cases of anti-tuberculosis medication, 1 case of ticlopidine and antibiotics and 4 cases of unknown causes. The clinical features of cholestatic hepatitis were jaundice, itching, urine color change, and general weakness. During 6 to 30 months, LFT of 5 patients showed prolonged elevation. Elevated total cholesterol ≥250 mg/dL in 6 patients, pheripheral blood eosinophilia in 5 patients, auto-antibody positive in 6 patients were observed respectively. The biopsies showed intralobular bilirubinostasis with a mixed portal inflammatory infiltration. Conclusion: In cholestatic hepatitis. durations of abnormal LFT are variable regardless of causative drugs. If cholestatic hepatitis progresses toward chronic course, viral hepatitis, primary biliary cirrhosis, and autoimmune hepatitis should be differentially diagnosed and sequential liver biopsies are needed.

소아 대퇴 근위부 골절의 치료결과

정성택,이근배,윤택림,문은선,송은규 全南大醫大 2001 전남의대학술지 Vol.37 No.1

정형외과 영역에서의 골 이식술의 유용성

윤택림,정재윤,문은선,송은규,서형연 全南大醫大 2000 전남의대학술지 Vol.36 No.2

제지폐수처리용 생물고분자응집제를 생산하는 Bacillus sp. K-111의 배양특성조사

권기석,손용호,최선택,정석관,송숙희,김동걸 7개 국립대학교 환경연구 논문집 공동발행 위원회 2002 환경연구논문집 Vol.2 No.1

Flocculant-producing microorganisms were screened from obtained strains in the laboratory using a pulp-wastewater treatment as the flocculating agent. K-111 strain that had high flocculating activity among them was selected and identified as Bacillus sp. K-111 16s rDNA sequencing. The favorable medium for the production of flocculant was glucose 1.5%, NH_4NO_3 0.2%, tryptone 0.01%, K_2HPO_4 0.08%, KH_2PO_4 0.06%, CaCO_3 0.03%, MgSO_4·7H_2O 0.005%, MnSO_4 0.005% in 1 liter of D.W. at initial pH 7.0. The optimum culture temperature and pH were 30℃ and pH 7.0, respectively. the flocculating activity was observed most highly after 36 to 48 hr of cultivation at the optimum conditions. the flocculating activity of produced biopolymer on optimum conditions was about 2.5-fold higher than that of screening medium.

Compensatory Mutations in the Development of Rifampicin Resistance in M. tuberculosis (초)

Taek Sun Song,Yu Mi Park,Jong Seok Lee,John Walker,Whitney Barnes,Serge Batalov,Richard Glynne,Isdore Chola Shamputa,Laura E. Via,Clifton E. Barry 대한결핵 및 호흡기학회 2010 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.110 No.-

Session C : Cell Biology : Transport , Growth , and Differentiation : Introduction of negative charges in the begining of mature portion can suppress the export - defective signal sequence mutation

Taek Sun Song,Chan Kyu Park 생화학분자생물학회(구 한국생화학분자생물학회) 1993 추계학술대회집 Vol.- No.-

Halothane 저혈압 마취가 신장기능에 미치는 영향

송선옥,박양생,정상섭,박광원,이희전,남용택,도종웅 대한마취과학회 1978 Korean Journal of Anesthesiology Vol.11 No.1

Hypotensive anesthesia is widely used in an operation since 1) it minimizes bleeding and provides a good operarion field, 2) it prevents massive hemorrhage in an operation which otherwise involes a large amount of b1ood loss and 3) it is useful in an operation for hypertensive patients. This procedure also involves a number of risks such as delayed awakening, reactionary bleeding, decrease in urine output and tissue hypoxia. The most dangerous complication can be hypoxia especialIy in the vital organs. 1t is therefore necessary to treat dehydration or blood loss before hypotensive anesthesia is induced. Since hypotensive anesthesia was introduced by Gardner (1947) for an operation of olfactory groove meningioma, various methods of deliberate hypotension have been developed. The most common method of hypotensive anesthesia in the present day is to use drugs, such as trmetaphan, nitroprusside and halothane. The effect of hypotensive anesthesia an various physiological functions of animals have been inveatigated ia the past. Giffiths and Gillies (1948) reported that, in the hypotension induced by sympathectomy, an arterial systolic pressure of 32 mmHg is the minimum to overcome peripheral resistance. Chung (19743 observed in the halothane-induced hypotensive dogs that a systolic pressure of 30mmHg was required to assure adequate cerebral oxygenation. In the present study, we have investigated the effect of halothanie-induced hypotension on the renal function of dogs. The arterial systolic pressure was successively reduced to 60 and 30mmHg for 30min. eech, and chaages ia various renal functians were studied during 100min. of the recovety period. The results are summarixed as follows: 1. The systolic blccd pressure was ccmpletely reeovered 80min. after the cessation of halothane inhalation. 2. Average renal blccd flow Cestimated by Cppe) and glomerular filtration rate (estimated by Cg) during the first 20min. of the recovery phase were 26% ind 45% of the control level. However after 100min. of thy reeovery period, repal blqcd flow wasrecovered to 63% and glomerular filtration rate to 74%of the control leveL 3. Average urine flow during the first 20min. of tht rtcovery phase was approximately 40% of the control. 4. U/P osm. ratio was reduced to 90% the control level during the first 20min. of recovery, but it exceeded the control value after 20min. of recovery. 5. Thero was only 24% of the-tml value in the first 20min. of reeavery phese, but there- after it gradually returned to the control level. 6. FEH2O (fractional excretion of N2) was ned eignificantly changed- by halothane inhalation although there was a tendency to slight reduction at the beginnjng of the recovery phase. 7. FEK was 47% of the control value dqring ghe initial phase of recovery, but it returned to the control level after 40min. of the recovery period. 8. FE, and FEH2O were reduced to 56% and 50% of the control level after the hypotensive pericd, but returned to 70% and 82% of the control level after 40min. of the recovery period. These resutts indicate that although tbe systemic blood pressure completely recovered after halothane-induced hypotension, renal hemodynamics are not completely recovered with 100min. of the recovery period. However renal functions are mostly reversible, suggesting that halathane -induced hypotension did not induce irreversible damage of renal tissue.

건강한 성인의 연령 증가에 따른 폐기능 변화에 관한 고찰

송선희,김현욱,주진철,유승택 대한마취과학회 1990 Korean Journal of Anesthesiology Vol.23 No.6

Pulmonary function tests were conducted in 60 male adults and 60 female adults at 20~79 years of age. They showed noevidenee of pulmonary disease on clinical symptoms, X-ray finidngs and past history. We wanted to evaluate the deterioration of pulmonary functional reserve in the aged. The results were as follows: 1) In males, FVC decreased significantly (p $lt;0.01) from 4440±271.38 ml in 20~29 year-old subjects to 3090±445.75 ml 70~79 year-old subjects. The correlation coefficient with age was-0.6846. 2) In females, FVC decreased significantly (p$lt;0.01) from 2097±479.42ml in 20~29 year-old subjects to 2142±233.13ml in 70~79 year-old subjects The correlation coefficient woth age was 0.6454. 3) In males, FEV, decreased significantly (p$lt;0.01) from 4005±268.26 ml in 20~29 year-old subjects to 2373±326.36ml in 10~79 year-old subjects. The correlation coefficient with age was-0.8229. 4) In females, FEV1 decreased significantly (p$lt;0.01) from 2586±519.00 ml in 20~29 yrar-old subjects to 1645±330.36ml in 70~79 yeubjects The correlation coefficient with age was 0.7013. 5) In males, FEV1/FVC decreased significantly (p$lt;0.01) from 90.17±4.90% in 20~29 year-old subjects to 76.72±8.13% in 70~79 year-old subjects. The correlation coefficient with age was-0.5595. 6) In females, FEV1/FVC decreased significantly (p$lt;0.01) from 88.66±6.58% in 20-29 year-old subjects to 76.80±9.32% in 70~79 year-old subjects. The correlation coefficient with age wae-0.4489.

MOCVD of GaN Films on Si Substrates Using a New Single Precursor

Song, Seon-Mi,Lee, Sun-Sook,Yu, Seung-Ho,Chung, Taek-Mo,Kim, Chang-Gyoun,Lee, Soon-Bo,Kim, Yun-Soo Korean Chemical Society 2003 Bulletin of the Korean Chemical Society Vol.24 No.7

Hexagonal GaN (h-GaN) films have been grown on Si(111) substrates by metal organic chemical vapor deposition using the azidodiethylgallium methylamine adduct, Et₂Ga(N₃)·NH₂Me, as a new single precursor. Deposition was carried out in the substrate temperature range 385-650 °C. The GaN films obtained were stoichiometric and did not contain any appreciable amounts of carbon impurities. It was also found that the GaN films deposited on Si(111) had the [0001] preferred orientation. The photoluminescence spectrum of a GaN film showed a band edge emission peak characteristic of h-GaN at 378 nm.

40세 이상의 연령에서 시행한 전방 십자 인대 재건술의 결과

송은규,문은선,윤택림,김종석,--,손일진 대한슬관절학회 2003 대한슬관절학회지 Vol.15 No.1

목적 : 40세 이상의 연령에서 전방 십자 인대 재건술을 시행받은 환자의 결과를 얻고, 결과에 영향을 미치는 인자에 대해 알아보고자 하였다. 대상 및 방법 : 1988년 8월부터 2002년 1월까지 관절경적 전방 십자 인대 재건술을 시행받은 수술 당시 연령이 40세 이상이었던 60명 60예와 40세 이하에서 표본 추출한 58명 58예의 임상적 결과와 스포츠 복귀, Telos기기를 이용한 스트레스 방사선 촬영을 이용하여 비교 연구하였다. 결과 : Lysholm Knee Score는 40세 이상군에서 54.0점에서 92.9점으로 호전되었으며, 40세 이하군에서는 56.2점에서 92.2점으로 호전되었다. 40세 이상군에서 임상적 결과가 우수 51예(85%), 양호 9예(15%)로 모두 만족스러운 결과를 얻었으며, 40세 이하군에서 우수 47예(81.0%), 양호 11예(19.0%)로 모두 만족스러운 결과를 얻었다. 스포츠로의 복귀는 40세 이상의 군에서 36예(60%), 40세 이하의 군에서 48%(82.8%)의 복귀율을 보였다. 40세 이하에서는 술 전 10.7 ㎜에서 술 후 2.9 ㎜의 차이를 보였다. 연령, 성별, 수술 방법, 동반 질환 유무, 수상 전 스포츠 활동으로 복귀 정도와 임상적 결과와의 인과 관계는 통계학적으로 의의가 없었다(p>0.05). 결론 : 전방 십자 인대 손상의 치료에 있어서 연령이 수술적 치료를 방해하는 요인으로 되지 않으며, 40세 이상의 연령에서도 전방 십자 인대 재건술을 시행하여 만족할 만한 결과를 얻을 수 있을 것으로 사료된다. Purpose: The purpose of the current study was to examine treatment outcome after anterior cruciate ligament (ACL) reconstruction in patients older than 40 years of age and determine the factors affecting the outcome. Subjects & Materials : Clinical results obtained from 60 cases from 60 patients older than 40 years of age at the time of surgery and 58 cases from 58 patients younger than 40 years of age who underwent ACL reconstruction between August 1988 to January 2002, return to sports activity, and stress radiographs using Telos instrument were compared. Result : The Lysholm knee score was improved from the preoperative score of 54.0 points the postoperative score of 92.9 in patients older than 40 years of age. Clinical outcome was excellent in 51 cases (85%) and good in 9 cases (15%) in patients older than years 40 years of age and was excellent in 47 cases (81.0%) and good in 11 cases (19.0%) in patients younger than 40 years of age. The rate of returning to preperative sports activity was high in 36 cases (60%) in patients older than 40 years of age and 48 cases (82.8%) in patients younger than 40 years of age. According to Telos stress rsdiography, the preoperative difference of 11.2 ㎜ was decrease to the postoperative difference of 3.1 ㎜ in patients older than 40 years of age and the preoperative difference of 10.7 ㎜ was decreased to the postoperative dufference of 2.9 ㎜ in patients younger than 40 years of age. Clinical outcome did not show significant correlation with age, gender, surgery method, the presence of additional injury, and the rate of return to sports activity before receiving injury(p>0.05). Conclusion : Age was not a factor interesting with the outcome of surgery for ACL injury, and satisfactory outcome could be obtained with ACL reconstruction even in patients older than 40 years of age.