Secreted Phosphoprotein 1 Promoter Genetic Variants Are Associated with the Response to Pegylated Interferon α Plus Ribavirin Combination Therapy in Egyptian Patients with Chronic Hepatitis C Virus Infection

( Fahmy T Ali ),( Mohamed A M Ali ),( Mayada M A Elgizawy ),( Ahmed M Elsawy ) 대한소화기학회 2015 Gut and Liver Vol.9 No.4

Background/Aims: The T-helper 1 (TH1) immune reaction is essential for the eradication of hepatitis C virus (HCV) during pegylated interferon α (PEG-IFN-α)- and ribavirin (RBV)-based therapy in chronic HCV patients. Secreted phosphoprotein 1 (SPP1) was shown to be a crucial cytokine for the initiation of a TH1 immune response. We aimed to investigate whether SPP1 single nucleotide polymorphisms (SNPs) may influence sustained virological response (SVR) rates. Methods: Two SNPs in the promoter region of SPP1 at the .443 C>T and .1748 G>A loci were genotyped in 100 patients with chronic HCV genotype 4 infection using a TaqMan SNP genotyping assay. Results: Sixty-seven patients achieved a SVR, and 33 patients showed no SVR. Patients carrying the T/T genotype at the .443 locus showed a significantly higher SVR rate than those carrying the C/T or C/C genotype (83.67% vs 50.98%, p<0.001). At the .1748 locus, the SVR rate was significantly higher in patients with the G/G genotype than in those with the A/A genotype (88.89% vs 52.63%, p=0.028) and in patients with the G/A genotype than in those with the A/A genotype (85.29% vs 52.63%, p=0.001). Conclusions: SPP1 SNPs at .443 C>T and .1748 G>A loci may be useful markers for predicting the response to PEG-IFN-α-2b plus RBV therapy in Egyptian patients with chronic HCV genotype 4 infection. (Gut Liver 2015;9:516-524)

Sub-switching domain effect for analysis the non-linear dielectric behavior of (K0.49 Na0.49Li0.02) (Nb0.98Sb0.02)O3 ceramic based on Rayleigh model

Atito Ibrahim A.,Shaban H. T.,Salem A.,Ezzeldien Mohammed,Mahmoud Abd El-razek 한국세라믹학회 2022 한국세라믹학회지 Vol.59 No.5

The solid-state sintering technique has been implemented to synthesize (K 0.5 Na 0.5 NbO 3 )-0.02(LiSbO 3 ) (KNN-LS) Pb- free ceramic. The crystal structure, dielectric and ferroelectric properties of the prepared material were investigated. Pure orthorhombic perovskite phase [ I (220) / I (002) = 1.68] with Amm2 space group has been detected at room temperature for sintered ceramic. Two anomalous permittivity peaks corresponding to orthorhombic–tetragonal (O–T) phase transition at T = 175 °C and tetragonal–cubic (T–C) phase transition at T = 355 °C have been observed. At polymorphic phase transition, the Ray- leigh model shown the extrinsic contributions caused by domain wall motion is about 80%, while the intrinsic contribution attributed to the lattice distortion is about 20%. Ferroelectric properties were investigated in a wide range of temperatures (RT-225)°C. The results shown a conductive material at high temperature due to the higher cation disorder and leakage cur- rent above PPT. The present results are interested for understanding the mechanism of t permittivity–temperature behavior of KNN-doped LS ions based on Rayleigh model. The large remnant polarization and low coercive fi eld below PPT make the material a suitable candidate for energy storage application.

Electricity generation from real industrial wastewater using a single-chamber air cathode microbial fuel cell with an activated carbon anode

Mohamed, H. O.,Obaid, M.,Sayed, E. T.,Liu, Y.,Lee, J.,Park, M.,Barakat, N. A.,Kim, H. Y. Springer Science + Business Media 2017 BIOPROCESS AND BIOSYSTEMS ENGINEERING Vol.40 No.8

<P>This study introduces activated carbon (AC) as an effective anode for microbial fuel cells (MFCs) using real industrial wastewater without treatment or addition of external microorganism mediators. Inexpensive activated carbon is introduced as a proper electrode alternative to carbon cloth and carbon paper materials, which are considered too expensive for the large-scale application of MFCs. AC has a porous interconnected structure with a high bio-available surface area. The large surface area, in addition to the high macro porosity, facilitates the high performance by reducing electron transfer resistance. Extensive characterization, including surface morphology, material chemistry, surface area, mechanical strength and biofilm adhesion, was conducted to confirm the effectiveness of the AC material as an anode in MFCs. The electrochemical performance of AC was also compared to other anodes, i.e., Teflon-treated carbon cloth (CCT), Teflon-treated carbon paper (CPT), untreated carbon cloth (CC) and untreated carbon paper (CP). Initial tests of a single air-cathode MFC display a current density of 1792 mAm(-2), which is approximately four times greater than the maximum value of the other anode materials. COD analyses and Coulombic efficiency (CE) measurements for AC-MFC show the greatest removal of organic compounds and the highest CE efficiency (60 and 71%, respectively). Overall, this study shows a new economical technique for power generation from real industrial wastewater with no treatment and using inexpensive electrode materials.</P>

Planning and decommissioning of a disused Theratron- 780 teletherapy machine and the dose assessment methodology for normal and radiological emergency conditions

Mohamed M.Elsayed Breky,Muhammad S. Mansy,A.A. El-Sadek,Yousif M. Mousa,Yasser T. Mohamed 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.1

The present work represents a technical guideline for decommissioning a disused teletherapy machine model Theratron-780 and contains category one 60Co radioactive source. The first section predicts the dose rate from the source in case of normal and radiological emergency situations via FLUKA-MC simulation code. Moreover, the dose assessment for the occupational during the whole process is calculated and compared to the measured values. A suggested cordoned area for safety and security in a radiological emergency is simulated. The second section lists the whole process's technical procedures, including (preview, dismantle, securing, transport and storage) of the disused teletherapy machine. Results show that the maximum obtained accumulated dose for occupational were found to be 24.5 ± 4.9 mSv in the dismantle and securing process in addition to 3.5 ± 1.8 mSv during loading on the transport vehicle and unloading at the storage facility. It was found that the measured accumulated dose for workers is in good agreement with the estimated one by uncertainty not exceeding 5% in normal operating conditions

Modeling of combined thermal and mechanical action in roller compacted concrete dam by three-dimensional finite element method

Abdulrazeg, A.A.,Noorzaei, J.,Mohammed, T.A.,Jaafar, M.S. Techno-Press 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.47 No.1

A combined thermal and mechanical action in roller compacted concrete (RCC) dam analysis is carried out using a three-dimensional finite element method. In this work a numerical procedure for the simulation of construction process and service life of RCC dams is presented. It takes into account the more relevant features of the behavior of concrete such as hydration, ageing and creep. A viscoelastic model, including ageing effects and thermal dependent properties is adopted for the concrete. The different isothermal temperature influence on creep and elastic modulus is taken into account by the maturity concept, and the influence of the change of temperature on creep is considered by introducing a transient thermal creep term. Crack index is used to assess the risk of occurrence of crack either at short or long term. This study demonstrates that, the increase of the elastic modulus has been accelerated due to the high temperature of hydration at the initial stage, and consequently stresses are increased.

Modeling of combined thermal and mechanical action in roller compacted concrete dam by three-dimensional finite element method

A.A. Abdulrazeg,J. Noorzaei,T.A. Mohammed,M.S. Jaafar 국제구조공학회 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.47 No.1

A combined thermal and mechanical action in roller compacted concrete (RCC) dam analysis is carried out using a three-dimensional finite element method. In this work a numerical procedure for the simulation of construction process and service life of RCC dams is presented. It takes into account the more relevant features of the behavior of concrete such as hydration, ageing and creep. A viscoelastic model, including ageing effects and thermal dependent properties is adopted for the concrete. The different isothermal temperature influence on creep and elastic modulus is taken into account by the maturity concept, and the influence of the change of temperature on creep is considered by introducing a transient thermal creep term. Crack index is used to assess the risk of occurrence of crack either at short or long term. This study demonstrates that, the increase of the elastic modulus has been accelerated due to the high temperature of hydration at the initial stage, and consequently stresses are increased.

Promising Fe3O4/CdSe Nanocomposites for Rug Delivery in Liver Cancer Treatment

( Shaimaa A. Habib ),( M. B. Mohamed ),( S. A. Saafan ),( T. M. Meaz ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Nowadays, magnetic semiconductors nanocomposites have become a new class of materials of great importance promising with new properties and exploiting unique incorporation between materials. For example, one can make use of a variety of spin-related phenomena, not readily available in other materials. this work concentrates on synthesis of magnetic iron oxide nanoparticles (MNs) and Cadmium Selenide (CdSe) quantum dots (QDs). CdSe QDs have attractive optical properties such as bright fluorescence emission and wide absorption band in the visible region and they possess the ability to act as energy donors through Förster resonance energy transfer (FRET). MNs also are known to have interesting applications in biomedical field and drug delievery system. Methods: In the present work, bi-functional magnetic-luminescent nanocomposites with Fe₃O₄ nanoparticles as the cores and CdSe as the shells have been synthesized by a facile direct precipitation method. Transmission electron microscopy (TEM) images revealed that the obtained bi-functional nanocomposites had a core-shell structure. The flower shape has been ascribed to the inhomogeneous growth of CdSe due to the presence of many active sites which turn to be nucleation centers for the CdSe on the surface of the nano-magnetite. The X-ray diffraction (XRD) patterns ensured the cubic spinel structure of the Fe₃O₄ core. Results: Magnetic measurements indicated that the presence of CdSe in the composite has reduced its magnetic properties. Optical measurements of the Fe₃O₄/CdSe nanocomposites showed that the prepared samples have dual functions, optical tunable band gap similar to the semiconductor quantum dots and magnetic properties due to Fe₃O₄ nanoparticles. According to the values of Stokes shift of the new hybrid composites, one can suggest that they may be promising in drug delivery (liver cancer treatment). All of the first line of result idicate that all of fabricated samples are so promising in drug delivery system. Conclusions: Fe₃O₄ nanoparticles has been successfully prepared by the co-precipetation method. The have been investigated via XRD, TEM and VSM. The XRD confirms the formation of the required cubic ferrite without other unwanted phases. The Fe₃O₄has been used as a seed or as a core to grow CdSe nanoshell around. The obtained hybrid Fe₃O₄ nanostructure has flower shape particles. The Fe₃O₄/CdSe nanocomposites has larger quantum yield values thanthose of pure CdSe QDs may be due to the fact that magnetic nanoparticles facilitate the electron holerecombination and enhance the emission from the quantum dots. In other words, the presence of Fe₃O₄ enhances the optical properties of CdSe quantum dots. The prepared nanocomposites have dual functions, optical tunable band gap similar to the semiconductor quantum dots and magnetic properties due to Fe₃O₄nanoparticles. This composite would be considered as dilute magnetic-semiconductor and could be used in spintronics, biosensors, solarcells and biomedical lables which could confirm that these nanoparticles could be a suitable drug delievery tool for many anticancer agent in the future.

Design of A new Algorithm by Using Standard Deviation Techniques in Multi Edge Computing with IoT Application

HASNAIN A. ALMASHHADANI,XIAOHENG DENG,OSAMAH R. AL-HWAIDI,SARMAD T. ABDUL-SAMAD,MOHAMMED M. IBRAHM,SUHAIB N. ABDUL LATIF 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.4

The Internet of Things (IoT) requires a new processing model that will allow scalability in cloud computing while reducing time delay caused by data transmission within a network. Such a model can be achieved by using resources that are closer to the user, i.e., by relying on edge computing (EC). The amount of IoT data also grows with an increase in the number of IoT devices. However, building such a flexible model within a heterogeneous environment is difficult in terms of resources. Moreover, the increasing demand for IoT services necessitates shortening time delay and response time by achieving effective load balancing. IoT devices are expected to generate huge amounts of data within a short amount of time. They will be dynamically deployed, and IoT services will be provided to EC devices or cloud servers to minimize resource costs while meeting the latency and quality of service (QoS) constraints of IoT applications when IoT devices are at the endpoint. EC is an emerging solution to the data processing problem in IoT. In this study, we improve the load balancing process and distribute resources fairly to tasks, which, in turn, will improve QoS in cloud and reduce processing time, and consequently, response time.

Anti-proliferative Activities of Metallic Nanoparticles in an in Vitro Breast Cancer Model

Loutfy, Samah A,Al-Ansary, Nadia A,Abdel-Ghani, Nour T,Hamed, Ahmed R,Mohamed, Mona B,Craik, James D,Eldin, Taher A. Salah,Abdellah, Ahmed M,Hussein, Yassmein,Hasanin, MTM,Elbehairi, Serag Eldin I Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

Aims: To investigate effect of metallic nanoparticles, silver (AgNPs) and gold nanoparticles (AuNPs) as antitumor treatment in vitro against human breast cancer cells (MCF-7) and their associated mechanisms. This could provide new class of engineered nanoparticles with desired physicochemical properties and may present newer approaches for therapeutic modalities to breast cancer in women. Materials and Methods: A human breast cancer cell line (MCF-7) was used as a model of cells. Metallic nanoparticles were characterized using UV-visible spectra and transmission electron microscopy (TEM). Cytotoxic effects of metallic nanoparticles on MCF-7 cells were followed by colorimetric SRB cell viability assays, microscopy, and cellular uptake. Nature of cell death was further investigated by DNA analysis and flow cytometry. Results: Treatment of MCF-7 with different concentrations of 5-10nm diameter of AgNPs inhibited cell viability in a dose-dependent manner, with IC50 value of $6.28{\mu}M$, whereas treatment of MCF-7 with different concentrations of 13-15nm diameter of AuNPs inhibited cell viability in a dose-dependent manner, with IC50 value of $14.48{\mu}M$. Treatment of cells with a IC50 concentration of AgNPs generated progressive accumulation of cells in the S phase of the cell cycle and prevented entry into the M phase. The treatment of cells with IC50 concentrations of AuNPs similarly generated progressive accumulation of cells in sub-G1 and S phase, and inhibited the entrance of cells into the M phase of the cell cycle. DNA fragmentation, as demonstrated by electrophoresis, indicated induction of apoptosis. Conclusions: Our engineered silver nanoparticles effectively inhibit the proliferation of human breast carcinoma cell line MCF-7 in vitro at high concentration ($1000{\mu}M$) through apoptotic mechanisms, and may be a beneficial agent against human carcinoma but further detailed study is still needed.

The Top-100 most cited articles on dural arteriovenous fistula: A bibliometric analysis

Alkhaibary Ali,Almutairi Othman T.,Elarjani Turki,Okal Fahad M.,Alhussinan Modhi A.,Bafaquh Mohammed,Alturki Abdulrahman Y. 대한뇌혈관외과학회 2021 Journal of Cerebrovascular and Endovascular Neuros Vol.23 No.1

Objective Dural arteriovenous fistula (DAVF) is a rare pathological vascular lesion with variable clinical manifestations. Since 1968, several articles have been published to address spinal and cranial DAVFs. The aim of this study is to identify, analyse, and review the pertinent literature of the top-100 most cited articles on DAVFs published to date. Methods A title-specific, keyword-based search with no time restriction was performed in June 2020. The Scopus database was used to identify the top-100 most cited articles on DAVFs. The term “dural arteriovenous fistula” was used as a search keyword. The search results were arranged in descending order based on the total citation count. The top-100 articles were categorized into ten categories. Results Between 1968 and 2020, a total of 2298 articles were published on DAVFs. The top-100 most cited articles were published between 1983 and 2012. The total number of citations for the top-100 articles was 12393 (123 citations/article). Most articles (34%) were investigating the clinical aspect of DAVFs. The country contributing to the most impactful and highest volume of publications (46%) was the United States. The Mayo Clinic was the most active institute in contribution. Most articles (29%) were published by the Journal of Neurosurgery. Conclusions In the top-100 most cited articles on DAVF, most studies were published in neurosurgery/neuroradiology-dedicated journals. This bibliometric analysis identifies the publication trends and provides a comprehensive overview of the most influential articles addressing DAVFs. Objective Dural arteriovenous fistula (DAVF) is a rare pathological vascular lesion with variable clinical manifestations. Since 1968, several articles have been published to address spinal and cranial DAVFs. The aim of this study is to identify, analyse, and review the pertinent literature of the top-100 most cited articles on DAVFs published to date. Methods A title-specific, keyword-based search with no time restriction was performed in June 2020. The Scopus database was used to identify the top-100 most cited articles on DAVFs. The term “dural arteriovenous fistula” was used as a search keyword. The search results were arranged in descending order based on the total citation count. The top-100 articles were categorized into ten categories. Results Between 1968 and 2020, a total of 2298 articles were published on DAVFs. The top-100 most cited articles were published between 1983 and 2012. The total number of citations for the top-100 articles was 12393 (123 citations/article). Most articles (34%) were investigating the clinical aspect of DAVFs. The country contributing to the most impactful and highest volume of publications (46%) was the United States. The Mayo Clinic was the most active institute in contribution. Most articles (29%) were published by the Journal of Neurosurgery. Conclusions In the top-100 most cited articles on DAVF, most studies were published in neurosurgery/neuroradiology-dedicated journals. This bibliometric analysis identifies the publication trends and provides a comprehensive overview of the most influential articles addressing DAVFs.