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Manwong, Mereerat,Songserm, Nopparat,Promthet, Supannee,Matsuo4, Keitaro Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Background: Cholangiocarcinoma (CCA) is the most common cancer in Northeast Thailand. It is also a crucial health problem for Thai people. Various risk factors for CCA have been identified in the upper part of Northeast Thailand, but no similar studies of risk factors have been conducted in the lower parts of the region. This study aimed to investigate factors associated with CCA in the resident population. Materials and Methods: A hospital-based case-control study was conducted during 2009-2012 with the recruitment of 123 CCA cases and 123 non-CCA patient controls, matched for sex, age and residential area. Information was collected by interview with a structured questionnaire. Blood samples were collected for assays of anti-OV antibodies. Associations between various personal factors, dietary habits, family history, the presence of anti-OV antibodies and CCA were analyzed using multiple conditional logistic regression. Results: Patients who consumed raw meat (beef, pork) and alcoholic beverages ${\geq}3$ times per week had a higher risk of CCA than non-consumers ($OR_{adj}$=4.33; 95%CI=1.14-16.35 and $OR_{adj}$=2.13; 95%CI=1.00-4.55, respectively). Patients who had a family history of cancer had a higher risk than those who did not ($OR_{adj}$=4.34; 95%CI=1.80-10.43). Also, patients who had anti-OV antibodies (AU>23.337) had a higher risk than those whose anti-OV antibodies were below the cut-off ($AU{\leq}23.34$) ($OR_{adj}$=3.09; 95%CI=1.04-9.16). Conclusions: As is the case in the upper part of Northeast Thailand, OV infection is a crucial risk factor for CCA in people who live in lower part of the region. Similarly, a family history of cancer and the consumption of alcohol are risk factors for CCA.
Matsuo Yumiko(Matsuo Yumiko) 새한영어영문학회 2004 새한영어영문학 Vol.46 No.3
『벨레프로가문사』는 조이스 케롤 오츠의 대표적인 고딕소설로서 벨레프로 7대가문사를 다룬 대표작이다. 시대적, 세대적, 기교적 관점에서 미국의 대표적인 고딕소설로 평가되는 이 작품은 현대적 페미니즘적 고딕소설로 간주되는 만큼 여성적 주제성과 고딕 기법과 연관 지워 해독하는 것은 매우 의미 있는 연구방향에 해당한다.<br/> 벨레프로 이야기에는 작가의 시대적 인식이 바탕이 되어있다. 조이스 케롤 오츠의 소설적 공통점은 폭력이 빚어내는 정서적 심리적 마비 상태가 여성 등장인물에 미치는 삶과 부조리성을 고딕 기법으로 펼쳐내는 데 있다. 그녀가 지닌 사회적 인식이라면 초창기의 개척시대를 벗어나 물질화 상업화되면서 사회와 인간 심성에 깔린 폭력성은 더욱 노출된다는 것이다. 이것을 페미니즘 관점의 분석한 대표작이 상기 작품이라고 하겠다. 더욱이 『벨레프로가문사』는 고딕소설 정통적 기법에 해당하는 구세대의 번영과 몰락을 다룸으로써 미국의 묵시론적 미래를 제시한 점은 미국소설에 대한 작가의 공적이라고 볼 수 있다. 이러한 시대상과 여성관을 구현하기 위하여 교통 통신의 메커니즘을 배경적 측면에서 분석하고 농촌의 도시화를 통하여 가정과 가계의 붕괴상을 살핀 사회적 해석도 작품분석에서 빠뜨릴 수 없다. 따라서 빛과 어둠의 이미지, 의식적 무의식적 서술 기법, 과거와 현재의 시간 경계, 삶과 죽음, 빈부라는 이원적 구도는 조이스 케롤 오츠의 폭력적 주제를 강조하는 기법으로써 현대 고딕 소설의 기교적 전범으로 평가되고 있다.<br/> 『벨레프로가문사』는 흥미와 센티멘털리즘을 자극하는 통속성을 초월하여 미국사의 근저에 깔린 문제점을 제시한 점에서 현대고딕소설의 새로 읽기의 정전에 속하다고 볼 수 있다.
Matsuo, Hidenori,Yoshimoto, Nobuo,Iijima, Masumi,Niimi, Tomoaki,Jung, Joohee,Jeong, Seong-Yun,Choi, Eun Kyung,Sewaki, Tomomitsu,Arakawa, Takeshi,Kuroda, Shun’ichi Dove Medical Press 2012 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.7 No.-
<P>Dendritic cells (DCs) are key regulators of adaptive T-cell responses. By capturing exogenous antigens and presenting antigen-derived peptides via major histocompatibility complex molecules to naïve T cells, DCs induce antigen-specific immune responses in vivo. In order to induce effective host immune responses, active delivery of exogenous antigens to DCs is considered important for future vaccine development. We recently generated bionanocapsules (BNCs) consisting of hepatitis B virus surface antigens that mediate stringent in vivo cell targeting and efficient endosomal escape, and after the fusion with liposomes (LP) containing therapeutic materials, the BNC-LP complexes deliver them to human liver-derived tissues in vivo. BNCs were further modified to present the immunoglobulin G (IgG) Fc-interacting domain (Z domain) derived from <I>Staphylococcus aureus</I> protein A in tandem. When mixed with IgGs, modified BNCs (ZZ-BNCs) displayed the IgG Fv regions outwardly for efficient binding to antigens in an oriented-immobilization manner. Due to the affinity of the displayed IgGs, the IgG-ZZ-BNC complexes accumulated in specific cells and tissues in vitro and in vivo. After mixing ZZ-BNCs with antibodies against DCs, we used immunocytochemistry to examine which antibodies delivered ZZ-BNCs to mouse splenic DCs following intravenous injection of the ZZ-BNCs. ZZ-BNCs displaying anti-CD11c monoclonal antibodies (α-CD11c-ZZ-BNCs) were found to accumulate with approximately 62% of splenic DCs, and reside within some of them. After the fusion with liposomes containing antigens, the α-CD11c-ZZ-BNCs could elicit the respective antibodies more efficiently than other nontargeting control vaccines, suggesting that this DC-specific nanocarrier is promising for future vaccines.</P>
Shuttle Vectors Derived from pN315 for Study of Essential Genes in <i>Staphylococcus aureus</i>
Matsuo, Miki,Kurokawa, Kenji,Lee, Bok-Luel,Sekimizu, Kazuhisa Pharmaceutical Society of Japan 2010 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.33 No.2
<P>Using the <I>par</I> to <I>rep</I> region of the 24653 bp plasmid pN315, which is present in <I>Staphylococcus aureus</I> strain N315, we constructed three vectors that can be shuttled between <I>Escherichia coli</I> and <I>S. aureus</I> and maintained stably in <I>S. aureus</I>. Due to plasmid incompatibility, the resident plasmid in <I>S. aureus</I> cells can be replaced <I>via</I> transformation with an entering plasmid, which carries a different drug resistance gene. To evaluate the applicability of this plasmid-based approach for identifying genes essential for <I>S. aureus</I> cell growth, the chromosomal <I>mraY</I> gene, which is involved in peptidoglycan biosynthesis, was deleted in cells harboring a resident plasmid with an intact <I>mraY</I> gene. The resultant disruptant was then transformed with an empty vector. Cells with a chromosomal <I>mraY</I> deletion but lacking the plasmid supplying <I>mraY</I> could not be recovered, suggesting that <I>mraY</I> is indispensable for staphylococcal cell growth or viability. In contrast, other two genes were shown to be dispensable by this system. Thus, the pN315-based plasmids appear to be useful for studying genes essential for <I>S. aureus</I> cell growth.</P>