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( Suyeon Jin ),( Chan Joo Lee ),( Gibbeum Lim ),( Sungha Park ),( Sang-hak Lee ),( Ji Hyung Chung ),( Jaewon Oh ),( Seok-min Kang ) 생화학분자생물학회 2023 BMB Reports Vol.56 No.12
C-reactive protein (CRP) is an inflammatory marker and risk factor for atherosclerosis and cardiovascular diseases. However, the mechanism through which CRP induces myocardial damage remains unclear. This study aimed to determine how CRP damages cardiomyocytes via the change of mitochondrial dynamics and whether survivin, an anti-apoptotic protein, exerts a cardioprotective effect in this process. We treated H9c2 cardiomyocytes with CRP and found increased intracellular ROS production and shortened mitochondrial length. CRP treatment phosphorylated ERK1/2 and promoted increased expression, phosphorylation, and translocation of DRP1, a mitochondrial fission-related protein, from the cytoplasm to the mitochondria. The expression of mitophagy proteins PINK1 and PARK2 was also increased by CRP. YAP, a transcriptional regulator of PINK1 and PARK2, was also increased by CRP. Knockdown of YAP prevented CRP-induced increases in DRP1, PINK1, and PARK2. Furthermore, CRP-induced changes in the expression of DRP1 and increases in YAP, PINK1, and PARK2 were inhibited by ERK1/2 inhibition, suggesting that ERK1/2 signaling is involved in CRP-induced mitochondrial fission. We treated H9c2 cardiomyocytes with a recombinant TAT-survivin protein before CRP treatment, which reduced CRP-induced ROS accumulation and reduced mitochondrial fission. CRP-induced activation of ERK1/2 and increases in the expression and activity of YAP and its downstream mitochondrial proteins were inhibited by TAT-survivin. This study shows that mitochondrial fission occurs during CRPinduced cardiomyocyte damage and that the ERK1/2-YAP axis is involved in this process, and identifies that survivin alters these mechanisms to prevent CRP-induced mitochondrial damage. [BMB Reports 2023; 56(12): 663-668]
Park Yeong-Ju,Hwang Unsik,Park Suyeon,Sim Sol,Jeong Soyeon,Park Misun,Kang Minji,Lee Youngsoo,Song Youngju,Park Hoon,Suh Hee-Jae 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.1
Compound K (CK; 20-O-β-(d-glucopyranosyl)-20(S)-protopanaxadiol) is one of the metabolites of ginsenosides contained in red ginseng (RG) and is known to have high bioavailability. This study aimed to establish the optimal conditions for enzyme treatment to convert ginsenosides from RG extract to CK, and to prove the characteristics of bioconverted red ginseng (BRG) extract. CK was not detected in unenzyme-treated RG extract, and in the single-step enzyme treatment, it was produced at less than 4.58 mg/g only in treatment group with Pyr-flo or Sumizyme AC (at 50 °C for 48 h). The highest yield of CK (14.32 mg/g) was obtained by Ultimase MFC treatment at 50 °C for 48 h after treatment with a mixture of Pyr-flo and Rapidase at 50 °C for 24 h. Total polyphenol, 2,2-diphenyl-1-picrylhydrazyl (DPPH), and 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) (ABTS) radical scavenging activity were higher in BRG than in RG (p < 0.5). High-fat diet (HD) rat fed 1% BRG had significantly lower body weight, heart weight, fat pads (periosteal fat, epididymal fat), serum glucose levels, and hepatic triglyceride levels than those HD rat fed 1% RG (p < 0.05). In conclusion, the sequential enzymatic bioconversion was produces higher CK in RG root extract than single-step enzyme treatment.
( Suyeon Park ),( Young-eun Lee ),( Seong-sik Cho ),( Sung-ho Park ),( Sung Taek Park ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.6
Objective This study aimed to evaluate patient-reported satisfaction following robot-assisted hysterectomy due to benign uterine disease, and to identify the factors associated. Methods We used a questionnaire to evaluate patients' satisfaction with robot-assisted hysterectomy. The questions concerned overall patient-reported satisfaction and specific factors affecting satisfaction, including postoperative pain, return to daily life, the hospital experience, wounds, cost, the doctor-patient relationship, whether expectations were met, and whether detailed information was provided. We also collected data from patient records, such as uterine weight, rate of pelvic adhesion, operation time, rate of transfusion, delayed discharge, and readmission. One hundred patients who underwent robot-assisted hysterectomy participated in the study. Seventy-three fully completed questionnaires were returned. Results The majority of patients (95.9%) were satisfied with robot-assisted hysterectomy. The doctor-patient relationship, whether expectations were met, the hospital experience, wounds, and whether detailed information was provided were statistically significant factors influencing patients' overall satisfaction. Payment of fees and clinical and surgical outcomes did not significantly influence patients' overall satisfaction. Conclusion Our findings show that most patients reported high levels of satisfaction following robot-assisted hysterectomy, regardless of cost or clinical and surgical outcomes. Therefore, if gynecologists consider robot-assisted hysterectomy suitable for patients they need not hesitate based on potential costs; they should feel confident in recommending the procedure to patients.
Park Hye Ran,Jeong Sang Soon,Kim Jung Hoon,Myeong Ho Sung,Park Hyun Joo,Park Kwang Hyon,Park Kawngwoo,Yoon Byung Woo,Park Suyeon,Kim Jin Wook,Chung Hyun-Tai,Kim Dong Gyu,Paek Sun Ha 대한의학회 2023 Journal of Korean medical science Vol.38 No.40
Background: Since the long-term outcomes of 162 patients who underwent gamma knife radiosurgery (GKS) as an initial or adjuvant treatment for acoustic neuromas (ANs) with unilateral hearing loss were first reported in 1998, there has been no report of a comprehensive analysis of what has changed in GKS practice. Methods: We performed a retrospective study of the long-term outcomes of 106 patients with unilateral sporadic ANs who underwent GKS as an initial treatment. The mean patient age was 50 years, and the mean initial tumor volume was 3.68 cm3 (range, 0.10–23.30 cm3 ). The median marginal tumor dose was 12.5 Gy (range, 8.0–15.0 Gy) and the median follow-up duration was 153 months (range, 120–216 months). Results: The tumor volume increased in 11 patients (10.4%), remained stationary in 27 (25.5%), and decreased in 68 patients (64.2%). The actuarial 3, 5, 10, and 15-year tumor control rates were 95.3 ± 2.1%, 94.3 ± 2.2%, 87.7 ± 3.2%, and 86.6 ± 3.3%, respectively. The 10-year actuarial tumor control rate was significantly lower in the patients with tumor volumes of ≥ 8 cm3 (P = 0.010). The rate of maintaining the same Gardner-Robertson scale grade was 28.6%, and that of serviceable hearing was 46.4%. The rates of newly developed facial and trigeminal neuropathy were 2.8% and 4.7%, respectively. The patients who received marginal doses of less than 12 Gy revealed higher tumor control failure rates (P = 0.129) and newly occurred facial or trigeminal neuropathy rates (P = 0.040 and 0.313, respectively). Conclusion: GKS as an initial treatment for ANs could be helpful in terms of tumor control, the preservation of serviceable hearing, and the prevention of cranial neuropathy. It is recommended to perform GKS as soon as possible not only for tumor control in unilateral ANs with hearing loss but also for hearing preservation in those without hearing loss.
Suyeon Sun,Jenny Park,Baek Sujin,Haejin Chung,Jung Bokmoon,Park Sohyun,Seunghun Baek,Eung-Kyo Suh 한국차세대컴퓨팅학회 2021 한국차세대컴퓨팅학회 학술대회 Vol.2021 No.11
The main research topic of this study is how much ‘opinion mining’ of online comments on specific keywords reflects actual public opinion. In detail, we compared and analyzed how much the results of sentiment analysis for comments by platform reflect the actual opinion poll results. We analyzed the most mentioned keywords by platform and by parking in the comments classified as positive, and the most mentioned keywords by platform and by parking in the comments classified as negative. As a result of the study, it was found that the results of the polls were similarly reflected in the order of the Naver News model, Naver News + YouTube model, and YouTube model. In addition, it was possible to find out keywords with high interest by positive/negative public opinion through positive/negative word cloud analysis by parking and platform.
( Suyeon Park ),( Ga-hyun Son ),( Keun-young Lee ),( Ji Eun Song ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: To assess the outcome of physical exam indicated cerclage (PEIC) in twin pregnancy with bulging fetal membranes. Methods: This was a retrospective cohort study of 39 twin gestations at Hallym University Kangnam Sacred Heart Hospital from 2007 to 2018. The following variables were collected by chart review ; parity, gestational age at the time of cerclage, preoperative membranes bulging size, postoperative cervical length, GA at delivery, neonatal outcomes such as birth weight, neonatal survival. The overall results of PEIC in twin pregnancy were analyzed. Then subgroup analysis was performed according to the size of bulging fetal membranes (30 mm) to compare the outcomes between two groups. Results: Total 39 patients were identified, but 7 patients were excluded because of follow-up loss. Overall, 32 patients were analyzed. The mean size of bulging fetal membranes was 31.72mm and postoperative CL was 13.55mm. The average gestational age at PEIC was 22.01 weeks and the average GA at delivery was 27.76 weeks. The mean length of hospital stay was 24.72 days and the mean cerclage-to-delivery interval day was 40.28days. The perinatal survival rate was 81.25%(26/32). We analyzed subgroups according to the size of bulging fetal membrane (30mm) : 19 patients had bulging membrane 30mm (A group) and 13 patients had bulging membrane >30mm (B group). There were no statistically differences in postoperative cervical length, GA at PEIC GA at delivery, and cerclage-to-delivery interval between two group. There was no difference in birth weight, and fetal survival rate between two groups. Conclusion: PEIC in twin pregnancy showed favorable obstetric outcomes. It might be beneficial to perform PEIC in twin pregnancy with bulging fetal membranes to prolong gestational weeks. However, the size of bulging fetal membranes did not affect the pregnancy outcome of PEIC in twin gestation. Further study is needed to find appropriate prognostic factors of PEIC in twin pregnancy.