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RISS 인기검색어
- 검색키워드
- 저자 : Sungwook Chun (검색결과 55 건)
- 무료
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Chun, Sungwook The Korean Society for Reproductive Medicine 2019 Clinical and Experimental Reproductive Medicine Vol.46 No.4
Objective: The aim of this study was to establish whether differences in ovarian size exist between the right and the left ovary of the same individual in women with polycystic ovary syndrome. Methods: In total, 206 Korean women with polycystic ovary syndrome were included in this study. In all participants, a transvaginal or transrectal ultrasound examination was conducted in the early follicular phase of the menstrual cycle. Results: A significant linear correlation was found between the two ovaries with regard to antral follicle count and ovarian volume. The mean antral follicle count in the right ovary (26.75 ± 11.72) was significantly higher than that in the left ovary (23.98 ± 10.85), and the mean volume of the right ovary (11.06 ± 5.17 cm<sup>3</sup>) was significantly different from that of the left ovary (9.12 ± 4.89 cm<sup>3</sup>). Conclusion: Ovarian size is different between the right and the left ovary in women with polycystic ovary syndrome.
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( Sungwook Chun ),( Gyun Ho Jeon ),( Hyun Jin Cho ),( Yong Il Ji ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: The aim of this study was to evaluate the difference of the change of ovarian reserve after unilateral laparoscopic ovarian cystectomy (LOC) in early postoperative period between patients with endometrioma and those with mature cystic teratoma. 방법: Sixty-five patients who received scheduled unilateral LOC for benign ovarian disease were participated in this study. All participants were divided into three groups according to pathologic diagnosis after LOC: 26 patients diagnosed as ovarian endometrioma were included in group 1, 24 patients with mature cystic teratoma in group 2, and 15 patients with other benign cyst in group 3. Preoperative and postoperative day 3 serum samples were collected and assayed for anti-Mullerian hormone (AMH) levels, and the changes between the two samples were analyzed. The rate of decline of AMH levels was calculated by [(preoperative AMH level ? postoperative day 3 AMH level)/ (preoperative AMH level)] × 100 (%). 결과: Mean age in patients with endometrioma was significantly higher than those in the other two groups. Preoperative AMH levels were not significantly different between three groups. Postoperative day 3 AMH levels were significantly reduced compared to preoperative ones in all three groups. The rate of decline of AMH levels after LOC in patients with teratoma (28.25 ± 22.16%) was similar to that in those with endometrioma (26.37 ± 20.70%). The mean AMH decline in patients with other benign cyst (12.03 ± 18.56%) is lower compared to other two groups. AMH decline after LOC was not significantly correlated with age, body mass index, the size of ovarian cyst, or preoperative AMH levels. 결론: Our results suggest that the postoperative decline of AMH levels after LOC in early postoperative period is similar between patients with endometrioma and those with mature cystic teratoma.
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Chun, Sungwook The Korean Society for Reproductive Medicine 2014 Clinical and Experimental Reproductive Medicine Vol.41 No.2
Objective: The aim of the present study was to investigate the relationship between ovarian follicle count and volume on ultrasonography and serum hormone levels including the levels of the anti-$M\ddot{u}llerian$ hormone (AMH) and gonadotropin in women with the polycystic ovary syndrome (PCOS). Methods: A total of 118 Korean women aged 18-35 years who were newly diagnosed with PCOS at a university hospital were included in this study. Serum LH, FSH, and AMH levels were measured in the early follicular phase, and the total antral follicle count (TFC) and the total ovarian volume (TOV) were assessed by ultrasonography. The correlations between serum hormonal parameters and ultrasonography characteristics in women with PCOS were evaluated using Pearson's correlation coefficients and a linear regression analysis. Results: Serum AMH levels were significantly correlated with serum LH levels and LH/FSH ratios, and TFC and TOV were significantly correlated with each other on ultrasonography. Serum AMH and LH levels and the LH/FSH ratio were significantly correlated with TFC. Statistically significant correlations between TOV and the LH level (r=0.208, p=0.024) and the LH/FSH ratio (r=0.237, p=0.010) were observed. However, the serum AMH level was not significantly correlated with the ovarian volume, and this result did not change after adjusting for age and body mass index. Conclusion: Serum AMH is not related to the ovarian volume in women with PCOS. My results suggest that serum LH level and the LH/FSH ratio may be more useful than the serum AMH level for representing the status of the ovarian volume in women with PCOS.
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( Sungwook Chun ),( Yong Il Ji ) 대한폐경학회 2020 대한폐경학회지 Vol.26 No.3
Objectives: This study aimed to evaluate the influence of simple hysterectomy on the ovarian reserve based on the type of surgery. Methods: Eighty-six premenopausal women between 31 and 48 years who underwent hysterectomy for benign gynecologic disease without additional adnexal surgery at a university hospital participated in this study. Seventy-one patients underwent laparoscopy-assisted vaginal hysterectomy (LAVH), and 15 patients underwent abdominal hysterectomy (AH). Blood samples were obtained from all study participants on preoperative day and 3 days after the operation to determine the anti-Müllerian hormone (AMH) levels. Results: The postoperative reduction of the mean serum AMH level in the LAVH group (0.42 ± 0.76 ng/mL) was greater than that in the AH group, although the difference was not statistically significant (0.01 ± 0.60 ng/mL) (P = 0.053). The mean baseline AMH level (2.59 ± 2.33 ng/mL) was significantly reduced to 2.24 ± 2.08 ng/mL at 3 days after hysterectomy, and the mean rate of decline of AMH levels after surgery was 13.61% ± 30.81%. In subgroup analysis based on the type of surgery, the mean serum AMH level decreased significantly after surgery in the LAVH group, but no significant changes were found in serum AMH levels before and after the surgery in the AH group. Conclusions: These preliminary results suggest that simple hysterectomy affects the early postoperative decline of ovarian reserve, and these results might vary depending on the type of surgery.
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Sungwook Chun 대한생식의학회 2021 Clinical and Experimental Reproductive Medicine Vol.48 No.2
Objective: The aim of the present study was to evaluate the predictive capability of fasting-state measurements of glucose and insulin levels alone for abnormal glucose tolerance in women with polycystic ovary syndrome (PCOS).Methods: In total, 153 Korean women with PCOS were included in this study. The correlations between the 2-hour postload glucose (2-hr PG) level during the 75-g oral glucose tolerance test (OGTT) and other parameters were evaluated using Pearson correlation coefficients and linear regression analysis. The predictive accuracy of fasting glucose and insulin levels and other fasting-state indices for assessing insulin sensitivity derived from glucose and insulin levels for abnormal glucose tolerance was evaluated using receiver operating characteristic (ROC) curve analysis.Results: Significant correlations were observed between the 2-hr PG level and most fasting-state parameters in women with PCOS. However, the area under the ROC curve values for each fasting-state parameter for predicting abnormal glucose tolerance were all between 0.5 and 0.7 in the study participants, which falls into the “less accurate” category for prediction.Conclusion: Fasting-state measurements of glucose and insulin alone are not enough to predict abnormal glucose tolerance in women with PCOS. A standard OGTT is needed to screen for impaired glucose tolerance and type 2 diabetes mellitus in women with PCOS.
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Sungwook Chun,Yun Hee Koo,나용진 대한폐경학회 2020 대한폐경학회지 Vol.26 No.2
Primary ovarian insufficiency (POI) is defined as the presence of amenorrhea for ≥ 4 months accompanied by evidence of two serum follicle-stimulating hormone levels in the menopausal range in women aged < 40 years. Anti-Müllerian hormone (AMH) has been recognized as the most reliable marker of ovarian reserve status, and its serum level is very low or undetectable in women with POI. Here we report two cases of patients who were diagnosed with POI despite high serum AMH levels and preservation of ovarian follicles, as revealed by ultrasound. In addition, we have presented a review of the current literature regarding this condition.
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( Sungwook Chun ),( Eunhyun Lee ),( Yong Il Ji ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: The aim of this prospective study was to assess the impact of simple hysterectomy with ovarian preservation on ovarian reserve in early postoperative period. Methods: A total of eighty-six premenopausal women aged 31-45 years with regular menstruation who underwent scheduled hysterectomy for benign gynecologic disease without additional adnexal surgery were included in this study. Serum samples were collected preoperatively and 3-days postoperatively in all study participants for the determination of serum anti-Mllerian hormone (AMH) levels, and the changes between the two samples were analyzed. The rate of decline of AMH levels after hysterectomy was calculated using the following formula: [(preoperative AMH level postoperative day 3 AMH level)]/(preoperative AMH level)]) 100 (%). Results: Seventy-one patients underwent laparoscopy-assisted vaginal hysterectomy (LAVH), and fifteen patients underwent abdominal hysterectomy (AH). Postoperative day 3 serum AMH levels after hysterectomy with ovarian preservation (2.24 2.08 ng/ml) significantly reduced compared with preoperative AMH levels (2.59 2.33 ng/ml) (P < 0.001). The mean value of the rate of decline of AMH levels after hysterectomy was 13.61 30.81%. In subgroup analysis according to the type of surgery, postoperative day 3 serum AMH levels in LAVH group (2.26 2.20 ng/mL) were significantly different compared with preoperative AMH levels (2.69 2.46 ng/mL), on the contrary, there were no significant differences between pre- and postoperative AMH levels in AH group (2.12 1.56 ng/mL preoperatively, and 2.11 2.09 ng/mL postoperatively). Conclusion: Our results suggest that hysterectomy have an influence on ovarian reserve in early postoperative period, and this result may be influenced by the type of surgery.
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전성욱 ( Sungwook Chun ),( Jung Eun Seo ),( Yun Jeung Rim ),( Jae Hong Joo ),( Yong Chan Lee ),( Yun Hee Koo ) 대한산부인과학회 2017 대한산부인과학회 학술대회 Vol.103 No.-
Objective: To evaluate the effect of hyaluronan-rich transfer medium on pregnancy and implantation rates in fresh and frozen-thawed embryo transfers in Korean women with previous implantation failure. Methods: This retrospective study included 283 blastocyst transfers in patients with previous embryo transfer failure at a private fertility clinic. In the study group (n=88), blastocyst transfers were performed using an hyaluronan-rich transfer medium prior to transfer, whereas blastocyst transfers without any treatment served as controls (n=195). According to the type of transfer (fresh elective or frozen-thawed), all the blastocyst transfers were divided into two study and two control groups. Results: The patient’s mean age, serum anti-Mullerian hormone level, causes of infertility, embryo quality, and the number of transferred embryos were comparable between the study and control groups. There were no significant differences in clinical pregnancy rate (45.5% vs. 43.1%), implantation rate (28.9% vs. 28.8%), and clinical abortion rate (10.0% vs. 8.3%) between the two groups, and these findings were not changed after subgroup analysis according to the type of transfer. Conclusion: The use of hyaluronan-rich transfer medium in the blastocyst transfer does not appear to have any significant effect on the implantation and pregnancy rates in patients with previous implantation failure.
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전성욱 ( Sungwook Chun ),전균호 ( Gyun Ho Jeon ),조현진 ( Hyun Jin Cho ),지용일 ( Yong Il Ji ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.1
목적 자궁절제술을 시행받은 한국여성에서 수술 초기 난소예비력의 변화에 대해 알아보고자 하였다. 연구방법 후향적으로 자궁절제술 수술 전 규칙적인 월경을 보이던 30-50세 사이의 여성에 대한 의무기록과 검사 결과를 확인하였으며, 총 31명의 환자가 연구에 포함되었다. 모든 대상 환자는 양쪽 난소수술 없이 예정된 자궁절제술을 시행받았으며 이 중 복강경하 질식자궁절제술을 시행받은 환자는 21명, 복식전자궁절제술을 시행받은 환자는 10명이었다. 모든 대상 환자는 수술 전과 수술 후 3일째 Anti-Mullerian hormone (AMH) 검사를 시행받았다. 모든 개별 환자들의 수술 전 후 AMH 농도의 변화율을 계산하였다. 결과 수술 전과 수술 후 AMH의 평균 농도는 유의한 차이가 없었다(2.46±0.49 ng/mL and 2.29±0.43 ng/mL; P=0.200). 수술 전후 유의한 AMH 변화는 없었다(1.17±6.63%; P=0.861). 결론 자궁절제술은 수술 초기 난소예비력에 영향을 미치지 않았다. Objective The aim of this study was to evaluate the changes of the ovarian reserve in early postoperative period after hysterectomy in Korean women. Methods We retrospectively reviewed the medical records and laboratory data of patients aged 30-50 years with regular menstruation before hysterectomy, and 31 patients were included in this study. All patients enrolled underwent scheduled hysterectomy with conservation of both ovaries (laparoscopy-assisted vaginal hysterectomy, n=21; and total abdominal hysterectomy, n=10), and received serum anti-Mullerian hormone (AMH) tests preoperatively and 3 days after operation. Changes between preoperative and postoperative AMH levels of each patient were calculated. Results There were no signifi cant differences between pre-and postoperative AMH concentration (2.46±0.49 ng/mL and 2.29±0.43 ng/ mL; P=0.200). No signifi cant percentage reduction of AMH level existed (1.17±6.63%, P=0.861). Conclusion Our results suggest that hysterectomy does not infl uence the ovarian reserve in early postoperative period.
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