Tuberculosis risk is associated with genetic polymorphisms in the LRP2, CUBN, and VDR genes

Sung‑Soo Kim,Sang In Lee,Hyun‑Seok Jin,Sangjung Park 한국유전학회 2020 Genes & Genomics Vol.42 No.10

Background Vitamin D (Vit. D) is used extensively during tuberculosis treatment. Low levels of serum Vit. D increase the risk of active tuberculosis development. Altered expression of the proteins involved in Vit. D metabolism impairs cathelicidin production, thereby increasing the host susceptibility to tuberculosis. Objective We are trying to investigate whether single nucleotide polymorphisms (SNPs) in LRP2, CUBN, and VDR genes could afect tuberculosis development. Methods We included participants of the Korean Association Resource (KARE), part of the Korean Genome and Epidemiology Study (KoGES), and used their recorded data. A total of 8840 people (4182 men and 4658 women) were eligible subjects. The 5-kb regions from the ends of transcripts of GC, LRP2, CUBN, and VDR genes were amplifed to select 13, 47, 70, and 15 SNPs, respectively. For association analysis and statistical analysis, PLINK version 1.07 and PASW Statistics version 18.0 were used. Results Signifcant correlation was observed in 11, 2, and 1 SNPs in LRP2, CUBN, and VDR genes. The efect of rs6747692 of LRP2 on transcription factor binding was confrmed using RegulomeDB. We confrmed that rs2239182 of VDR is located in the genomic eQTL region and can afect transcription factor binding and gene expression. Conclusions Genetic polymorphisms in genes encoding proteins involved in Vit. D metabolism infuence immune system components. Therefore, such polymorphisms may infuence the susceptibility to Mycobacterium tuberculosis invasion and alter the defense mechanisms against Mycobacterium tuberculosis infection. The correlation between genetic variation and tuberculosis development can provide new guidelines for the management of tuberculosis.

Robust Control of Robot Manipulators Using Inclusive and Enhanced Time Delay Control

Jin, Maolin,Kang, Sang Hoon,Chang, Pyung Hun,Lee, Jinoh Institute of Electrical and Electronics Engineers 2017 IEEE/ASME Transactions on Mechatronics Vol. No.

<P>Thanks to its simplicity and robustness, time delay control (TDC) has been recognized as a simple and yet effective alternative to robot model-based controls and/or intelligent controls. An inclusive and enhanced formulation of TDC for robust control of robot manipulators is presented in this paper. The proposed formulation consists of three intuitive terms: 1) time delay estimation (TDE), inherited from the original TDC, for cancellation of mostly continuous nonlinearities; 2) nonlinear desired error dynamics (DED) (i.e., a 'mass'-'nonlinear damper'-'nonlinear spring' system) injection term; and 3) a TDE error correction term based on a nonlinear sliding surface. The proposed TDC formulation has an inclusive structure. Depending on the gain/parameter set chosen, the proposed formulation can become Hsia's formulation, Jin's formulations including a type of terminal sliding mode control (SMC), an SMC with a switching signum function, or a novel enhanced formulation. Experimental comparisons were made using a programmable universal manipulator for assembly-type robot manipulator with various parameter sets for the proposed control. Among them, the highest position tracking accuracy was obtained by using a terminal sliding DED with a terminal sliding correction term.</P>

Analysis of eco-corridor usage status of mammals in Odaesan National Park

Sang Jin Lim,Ki Yoon Kim,TaeJun Lee,Woo Chan Lim,Ji Hong Min,Hyeong Woo Ji,Baek Soon Choi,Tae Il Kim,Hyo Nam Kim,Hee Bok Park,Yung Chul Park 강원대학교 산림과학연구소 2017 강원대학교 산림과학연구소 학술대회 Vol.2017 No.11

We investigated species, ecological pathway type, and mammal size using two eco-tunnels from trail-camera data. The analyses of the camera data showed that 12 mammalian species from 8 families of 5 orders used Jin-gogae eco-corridor (bridge type) and 14 mammalian species from 9 family 5 orders were found at Odaesan eco-corridor (tunnel type). At both eco-corridors, water deer used eco-corridor most frequently, and then secondly racoon dog did. The analyses by mammal size (small, medium, and large) showed that large-sized mammals were found in high ratio at the bridge type of the eco-corridors. In case of medium-sized mammals, utilization ratio of the tunnel-typed corridor was 42%, whereas that of the bridge-typed corridor was 24%, showing 1.8 times higher usage.

Differential Manifestation of Ocular Phenotypes in TALEN-mediated p19arf Knockout FVB/N and C57BL/6J mouse lines

Jin‑Sung Park,Joo‑Il Kim,Hyun‑Jin Lim,Soo‑Kyung Ryu,Euna Kwon,Kang‑Min Han,Ki‑Taek Nam,Han‑Woong Lee,Byeong‑Cheol Kang 한국유전학회 2020 Genes & Genomics Vol.42 No.9

Background p19arf, primarily known as a tumor suppressor, has also been reported to play an essential role in normal development of mouse eyes. Consistently, lack of p19arf has been associated with ocular defects, but the mixed background of the knockout (KO) mouse strain used raised a concern on the accuracy of the phenotypes observed in association with the targeted gene due to genetic heterogeneity. Object We carried out a study to investigate into the efect of genetic background on the manifestation of p19arf KO associated phenotypes. Methods We characterized the phenotypes of novel p19arf KO mouse lines generated in FVB/N and C57BL/6J using a transcription activator-like efector nuclease (TALEN) system in comparison to the reported phenotypes of three other p19arf-defcient mouse lines generated using homologous recombination. Results Ninety-fve percent of FVB/N-p19arf KO mice showed ocular opacity from week 4 after birth which worsened rapidly until week 6, while such abnormality was absent in C57BL/6J-p19arf KO mice up to the age of 26 weeks. Histopathological analysis revealed retrolental masses and dysplasia in the retinal layer in FVB/N-p19arf KO mice from week 4. Besides these, both strains developed normally from birth to week 26 without increased tumorigenesis except for a subcutaneous tumor found in a C57BL/6J-p19arf KO mouse. Conclusion Our fndings demonstrated surprisingly variable manifestation of p19arf-linked phenotypes between FVB/N and C57BL/6J mice, and furthermore between our mouse lines and the established lines, indicating a critical impact of genetic background on functional study of genes using gene targeting strategies in mice.

A Study of English Neologisms with Some Comparing Notes on Korean Neologisms

Lee Jin-sung 한국사회언어학회 2012 사회언어학 Vol.20 No.2

Lee Jin-sung. 2012. A Study of English Neologisms with Some Comparing Notes on Korean Neologisms. The Sociolinguistic Journal of Korea 20(2). pp. 367-400. This study examines how English is reflecting the changing society on neologisms, and how the language and the society is interwoven in neologisms of English. It also investigates English neologisms from the perspective of morphological formation and semantic change. In doing this Korean neologisms are partly dealt with comparatively to bring out the contrastive characters of the two languages. From the sociolinguistic point of view, the data were classified into three categories: society, life style, and people. These were further subdivided into several areas: general affairs, economics, IT new jobs, new technology under the category of society; language, daily lives, leisure, health, food, and apparel under the life style; men and women, men, women, youngsters and the olds under the people. It was found that the categorial classifications of neologisms reveals how social change is reflected on neologisms of each language, and also discloses the way the two languages enrich their expressive power. From the perspective of morphological formation and semantic change, the English data were classified into compounds, new words, verbal phrases, and independent expressions. The compounds were subdivided into simple compounds and compounds within compounds to diagnose the degree of recursive character in English. In the category of new words, the followings were investigated: affixations, blendings, abbreviations, acronyms, euphemisms, semantic shifts, foreign languages, functional shifts, coinages and clippings. The distribution of neologisms in regard to their parts of speech was also examined. In comparing notes of the two languages, the followings are provided: first, sociocultural character reflected on neologisms; second, the frequencies and characterizations of neologisms from morphological perspectives; third, the distribution of parts of speech.

Session 3 Distribution Science II

Lee,Sang-Yoon,Kim,Kyeung-Cho,Kim,Pan-Jin,Sun,Il-suck 한국유통과학회 2008 한국유통과학회 학술대회 논문집 Vol.2008 No.-

Resistive switching characteristic of Ce0.9Y0.1O2/ TiO2 bi‑layer structure by photochemical metal‑organic deposition

Sung‑Eun Kim,Jin-Gyu Lee,In-Young Choi,Ha-Eun Kim,Hong-Sub Lee 한국세라믹학회 2020 한국세라믹학회지 Vol.57 No.1

Sneak current is one of the main bottlenecks for dense crossbar array resistive random access memory. This study reports highly non-linear resistive switching characteristic from Ce0.9Y0.1O2/ TiO2 bi-layer (1S/1R device) structure, fabricated by photochemical metal-organic deposition, as a solution for sneak current issue. Ce0.9Y0.1O2 material, possessing oxygen vacancies, was used as a potential barrier as well as oxygen reservoir which rectified the current of low resistance state without an electrical breakdown in 1S/1R device. TiO2 was adopted for resistive switching property, and TiO2 layer having mixed phase (anatase and brookite) showed typical diode switching behavior. The photochemical reaction of photochemical metal-organic deposition process and phase formation were monitored and established using by Fourier-transform infrared spectroscopy and X-ray diffraction, respectively. The 1S/1R device showed highly non-linear resistive switching characteristic, large on/ off ratio of above three orders of magnitude with low operating current.

Magnetization Analysis for Outer Rotor Brushless DC Motors Using Polar Anisotropic Ferrite Ring Magnets

Sung‑Il Kim,Su‑Jin Lee,Jeong‑Jong Lee,Chang‑Eob Kim 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.3

Ferrite-bonded magnets have been extensively used in small brushless DC (BLDC) motors for low torque applications such as fans and pumps. In particular, some motors of them with ferrite-bonded magnets, frequently called as plastic magnets, do not have a rotor core in order to reduce manufacturing costs and inertia of the rotating part. Accordingly, the magnetization distribution of the bonded magnets has a polar anisotropic direction to secure more magnetic fux. As a result, the magnetization orientation of the magnets is highly signifcant to accurately predict the performances of the BLDC motors. This paper deals with the magnetization analysis of the polar anisotropic ferrite ring magnet applied to an outer rotor type BLDC motor. The motor is employed for an electric water pump, and its rotor including the impeller consists of only the ferrite-bonded magnet material and made by injection molding. Consequently, a magnetizing fxture and an impulse magnetizer are not used for the magnetization of the outer rotor type motor. Instead, samarium–cobalt (SmCo) magnets having a relatively high curie temperature are applied for generating magnetic feld. Finally, this paper presents a process to determine the anisotropic orientations of a ferrite ring magnet by fnite element method. In addition, the validity of the analysis method is verifed by test results

論文(론문) : 大腸正格證(대장정격증)과 장누수증후군(Leaky Gut Syndrome)과의 관계 考察(고찰)

이진철 ( Jin Cheoul Lee ),박상균 ( Sang Kyun Park ),방정균 ( Jung Kyun Bang ) 대한한의학원전학회(구 대한원전의사학회) 2013 대한한의학원전학회지 Vol.26 No.4

A Study on the Relationship between Dae-Jang-Jung-Gyeok(大腸正格) and Leaky Gut Syndrome Lee Jin-Cheoul1·Park Sang-Kyun2·Bang Jung-kyun3 *1Dept. of Medical History, College of Korean Medicine, Kyunghee University 2Dept. of Meridian, College of Korean Medicine, Sangji University 3Dept. of Korean Medical Classics and History, College of Korean Medicine, Sangji University Objective: If the penetration ratio of the intestinal mucosa is increased, the toxic or unhealthy materials - which should not be absorbed into our bodies - will be come into our bodies. They cause a sort of anti-toxic response or confusion of the immune system, and ultimately bring various types of diseases. This syndrome is related "Poison in Excrement" or "Internal Damage(內傷發□)" and Leaky Gut Syndrome, so I will study on the relationship between them. Method: Study on the relationship between Dae-Jang-Jung-gyeok and Leaky Gut Syndrome. Result: Korean doctors in ancient times called this syndrome "Poison in Excrement" or "Internal Damage(內傷發□)" and treated it with "Dae-Jang-Jung-Gyeok(大腸正格)". Leaky Gut Syndrome is a sort of clinical lesion, which allows foreign and harmful toxins in and results in a disorder of the immune system due to the leaking intestinal mucosa. Conclusion: Based upon the analyses, Dae-Jang-Jung-Gyeok and Leaky Gut Syndrome are closely related. Therefore diseases caused by the Leaky Gut Syndrome might be expected to be cured by Dae-Jang-Jung-Gyeok. Particularly the use of treatments for self-immune diseases and allergic diseases such as atopyic dermatitis and articular rheumatism should be expected to reveal a new path of treatment for other disorders such as Leaky Gut Syndrome. Key Words: Poison in Excrement, Internal Damage(內傷發□), Dae-Jang-Jung-Gyeok(大腸正格), Leaky Gut Syndrome

Piezoelectric Materials: All‐Solution‐Processed Flexible Thin Film Piezoelectric Nanogenerator (Adv. Mater. 45/2012)

Chung, Sung Yun,Kim, Sunyoung,Lee, Ju‐,Hyuck,Kim, Kyongjun,Kim, Sang‐,Woo,Kang, Chong‐,Yun,Yoon, Seok‐,Jin,Kim, Youn Sang WILEY‐VCH Verlag 2012 ADVANCED MATERIALS Vol.24 No.45

<P>An all‐solution‐processed flexible piezoelectric nanogenerator, composed of polycrystalline ZnO thin film and functional polymer layers such as P3HT/PCBM and PEDOT:PSS, generates energy through a mechanical rolling and muscle stretching system. On page 6022, Youn Sang Kim, Sang‐Woo Kim, and co‐workers show that this all‐solution‐processed nanogenerator is feasible as a piezoelectric patchable device and is promising for use in future energy harvesters such as wearable human patches and mobile electronics. </P>