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Choi-Kwon, Smi,Ko, Mihye,Jun, Sang-Eun,Kim, Juhan,Cho, Kyung-Hee,Nah, Hyun-Wook,Song, Hasup,Kim, Jong S. S KARGER AG 2017 Cerebrovascular Diseases Vol.43 No.1
<P><B><I>Background:</I></B> Post-stroke fatigue (PSF) is a common sequela of stroke. Despite reports of serotonergic involvement in the etiology of PSF, the potential contribution of serotonergic genes in the development of PSF needs to be investigated. <B><I>Methods:</I></B> A total of 373 patients, who experienced ischemic stroke for PSF, were evaluated 3 months after the stroke. PSF was assessed using the Fatigue Severity Scale. The genomic DNA collected and stored in a -70°C freezer was genotyped for 6 polymorphisms in genes associated with serotonin synthesis (tryptophan hydroxylase 1 (TPH1) A218C, TPH2 rs10879355, and TPH2 rs4641528), transport (the promoter region of the serotonin transporter protein), and catabolism (the 30-bp functional variable number tandem repeat) polymorphism in the promoter region of <I>monoamine oxidase A (MAO-A)</I>. <B><I>Results:</I></B> Among the 373 patients, 164 (44%) had PSF. All patients were ethnic Koreans. Of the 6 polymorphisms examined, only one marker, that is, low-activity <I>MAO-A</I> was associated with PSF (p < 0.05) in female patients. Multiple logistic regression analyses showed that post-stroke depression (PSD; 95% CI 1.561-14.323, p = 0.006) and low <I>MAO-A</I> activity (95% CI 0.166-0.722, p = 0.005) were factors associated with PSF in female patients, whereas only PSD (95% CI 5.511-65.269, p = 0.000) was associated with PSF in male patients. <B><I>Conclusions:</I></B> Our findings suggest that PSF may be associated with a genetic polymorphism involving <I>MAO-A</I>, at least in female stroke patients.</P>
Simultaneous flow enhancement of high-filled polyamide 66/glass fiber composites
Choi, Hwan Seok,Lim, Dohyun,Kim, Dong-Gyun,Kim, Byoung Gak,Kim, Yong Seok,Lee, Sung-Goo,Kim, Sang Gu,Park, Byung Wook,Seo, Kwan Ho,Yoon, Ho Gyu,Yoo, Youngjae Elsevier 2017 JOURNAL OF ALLOYS AND COMPOUNDS Vol.722 No.-
<P><B>Abstract</B></P> <P>In this work, we investigated the effects of the flow modifier addition on the rheological behavior and mechanical properties of high-filled polyamide 66 composites prepared from melt compounding. The flow modifiers were prepared from various amine monomers and fatty acids, and their structures were analyzed by Fourier transform infrared spectroscopy. The synthesized flow modifiers were added simultaneously during melt compounding. The presence of flow modifiers significantly reduced torque in neat polyamide 66 polymer and glass fiber-reinforced polyamide 66 composites, respectively, while the torque during compounding in composites with glass fiber contents of 50 wt% has decreased by approximately 12% after the addition of 1 phr of hexamethylene <I>bis</I>-stearamide indicating the simultaneous enhancement in flowability. The presence of the synthesized flow modifiers in matrix polymers improves flowability of the composites during injection molding without compromising the mechanical properties.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Amide-based flow modifiers were successfully prepared. </LI> <LI> Image analysis of glass fiber in the composites was directly correlated with the properties of the composites. </LI> <LI> Analytical model analysis shows good agreement with the properties of the composites. </LI> </UL> </P>
Choi, Han Ah,Park, Ha Neul,Won, Sung Wook Academic Press 2017 Journal of Environmental Management Vol. No.
<P>In this study, a mixture of polyethylenimine (PEI) and polyvinyl chloride (PVC) was reacted at 80 degrees C for 6 h to synthesize crosslinked PEI/PVC polymer solution, which was injected to produce the PEI/PVC-crosslinked fiber (PEI/PVC-CF). PEI/PVC-CF was investigated as an adsorbent to remove and recover Pd(II) from acidic solutions. In order to examine the adsorption characteristics and usability of PEI/PVC-CF for Pd(II) recycling, several experiments such as isotherm, kinetics, desorption and reuse were conducted. The adsorption isotherms were fitted using the Langmuir and Freundlich models, respectively. The maximum adsorption capacity was estimated as 146.03 mg/g according to the Langmuir model. The kinetic experiments demonstrated that adsorbent reaches adsorption equilibrium within 60 min for initial Pd(II) concentrations of 25-100 mg/L. After adsorption, Pd(II) on PEI/PVC-CF was easily desorbed using acidified thiourea solution, and the desorption efficiency increased with the thiourea concentration. It was also demonstrated that PEI/PVC-CF can be used repeatedly for at least five cycles without reduction in adsorption capacity. (C) 2017 Elsevier Ltd. All rights reserved.</P>
Choi, Won-Joon,Cho, Ki-Chul,Lee, Sang-Sup,Shim, Jae-Goo,Hwang, Hye-Ryun,Park, Sang-Wook,Oh, Kwang-Joong Royal Society of Chemistry 2007 GREEN CHEMISTRY Vol.9 No.6
<P>The emissions of anthropogenic carbon dioxide (CO<SUB>2</SUB>) are believed make a significant impact on global climate change. Hence, amine chemical absorption technology has been suggested to separate and recover CO<SUB>2</SUB>. In this study, reaction rate constants between CO<SUB>2</SUB> and blended amines were determined by measuring their absorption rate for CO<SUB>2</SUB>. The experiments were carried out to investigate the characteristics of CO<SUB>2</SUB> absorption by using additional absorbents such as hexamethylenediamine (HMDA), <I>N</I>-methyldiethanolamine (MDEA) or piperazine blended into 2-amino-2-methyl-1-propanol (AMP) in an agitated vessel. The absorption rates of CO<SUB>2</SUB> into aqueous blended amine solutions were measured. Additive concentrations of 1, 3, and 5 wt% were added for each 30 wt% AMP solution. The results showed that the addition of HMDA, MDEA or piperazine into AMP increased the absorption rate as compared to AMP alone. Of these additives, HMDA showed the most enhancement in the reaction rate of AMP. The reaction rate constants of HMDA, MDEA and piperazine blended into AMP at 303–343 K were given by <I>k</I><SUB>H</SUB> = 3.84 × 10<SUP>10</SUP>exp(−5361/<I>T</I>), <I>k</I><SUB>M</SUB> = 6.60 × 10<SUP>9</SUP>exp(−4959/<I>T</I>), and <I>k</I><SUB>P</SUB> = 9.09 × 10<SUP>9</SUP>exp(−5058/<I>T</I>), respectively.</P> <P>Graphic Abstract</P><P>The addition of 1, 3, and 5 wt% HMDA, MDEA or piperazine into 30 wt% AMP increased the absorption rate as compared to AMP alone. The reaction rate constants of HMDA, MDEA and piperazine blended into AMP at 303–343 K were given by <I>k</I><SUB>H</SUB> = 3.84 × 10<SUP>10</SUP> exp(−5361/<I>T</I>), <I>k</I><SUB>M</SUB> = 6.60 × 10<SUP>9</SUP> exp(−4959/<I>T</I>), and <I>k</I><SUB>P</SUB> = 9.09 × 10<SUP>9</SUP> exp(−5058/<I>T</I>), respectively. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b614101c'> </P>
Choi Ui Yoon,Kim Ki Hwan,Lee Jin,Eun Byung Wook,Kim Hwang Min,Lee Kyung-Yil,Kim Dong Ho,Ma Sang Hyuk,Lee Jina,Kim Jong-Hyun 대한의학회 2021 Journal of Korean medical science Vol.36 No.49
Background: Although the combination tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) is recommended at adolescence in developed countries, the tetanus and diphtheria toxoid vaccine (Td), which is less costly, is recommended instead in some parts of the world. A new Td, BR-TD-1001, was developed by a Korean manufacturer for distribution to endemic regions and for use in the initial step of novel Tdap development. Methods: This phase 3, randomized, double-blind, multi-center trial, conducted in Korea, aimed to evaluate the immunogenicity and safety of BR-TD-1001. Healthy children aged 10 to 12 years were randomized 1:1 to receive either BR-TD-1001 or the control Td (Td-pur, GlaxoSmithKline). Antibodies were measured using enzyme-linked immunosorbent assay. Results: A total of 218 subjects (BR-TD-1001, n = 108; control, n = 110) were enrolled and included in the safety analysis. Vaccine-mediated antibody responses were similar in both groups. We confirmed the non-inferiority of BR-TD-1001 against the control, Td; 100% of both groups achieved seroprotection against diphtheria and tetanus. Furthermore, there was no significant difference between groups in the proportion of participants who demonstrated boost responses against diphtheria and tetanus toxoids. The incidence of solicited local and systemic adverse events (AEs), unsolicited AEs, and serious AEs did not differ significantly between groups. Conclusion: The BR-TD-1001 satisfied the immunological non-inferiority criterion against diphtheria and tetanus, with a clinically acceptable safety profile.
Wook Chang,Won Chul Bang,Eun Seok Choi,Jing Yang,Sung Jung Cho,Joon Kee Cho,Jong Koo Oh,Dong Yoon Kim 한국지능시스템학회 2005 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.5 No.3
In this paper, we develop a gesture-based input device equipped with accelerometers and gyroscopes. The sensors measure the inertial measurements, i.e., accelerations and angular velocities produced by the movement of the system when a user is inputting gestures on a plane surface or in a 3D space. The gyroscope measurements are integrated to give orientation of the device and consequently used to compensate the accelerations. The compensated accelerations are doubly integrated to yield the position of the device. With this approach, a user's gesture input trajectories can be recovered without any external sensors. Three versions of motion tracking algorithms are provided to cope with wide spectrum of applications. Then, a Bayesian network based recognition system processes the recovered trajectories to identify the gesture class. Experimental results convincingly show the feasibility and effectiveness of the proposed gesture input device. In order to show practical use of the proposed input method, we implemented a prototype system, which is a gesture-based remote controller (Magic Wand).