Aquilanols A and B, Macrocyclic Humulene-Type Sesquiterpenoids from the Agarwood of <i>Aquilaria malaccensis</i>

Ma, Chi Thanh,Eom, Taeyong,Cho, Eunji,Wu, Bo,Kim, Tae Ryong,Oh, Ki Bong,Han, Sang Beom,Kwon, Sung Won,Park, Jeong Hill American Chemical Society and American Society of 2017 Journal of natural products Vol.80 No.11

<P>Four new and five known sesquiterpenoids were isolated from the agarwood of <I>Aquilaria malaccensis</I>. Aquilanols A and B (<B>1</B> and <B>2</B>) have an unprecedented macrocyclic humulene structure with a bicyclic 7/10 ring system. Compound <B>2</B> was obtained as a scalemic mixture that was resolved by HPLC analysis using a chiral column. Their structures were deduced based on spectroscopic data analysis, and the absolute configurations were unambiguously determined by X-ray crystallographic data and ECD spectroscopic analysis. A putative biosynthetic pathway of these sesquiterpenoids is proposed.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2017/jnprdf.2017.80.issue-11/acs.jnatprod.7b00462/production/images/medium/np-2017-00462d_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np7b00462'>ACS Electronic Supporting Info</A></P>

Effects of Hand Individual Finger Exercise after 1 ㎐ Low-Frequency rTMS on Cerebral Motor Evoked Potential and Latency in Patients with Stroke

Sung-Ryong Ma,Jong-Bae Choi 한국자기학회 2023 Journal of Magnetics Vol.28 No.4

This study aimed to investigate the effects of individual finger exercise under the residual effect after low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) on cerebral motor-evoked potential amplitude (MEP amplitude) and cerebral MEP latency (MEP latency) in patients with stroke. This study conducted an intervention program in two groups of patients with chronic stroke (experimental group, individual finger exercise including residual effect after LF-rTMS group; IFE-rTMS group, individual finger exercise; IFE group, each comprising 10 patients). The program, which was conducted five times a week for 1 week, evaluated the MEP amplitude and MEP latency before and after the experiment. In an inter-group test of MEP amplitude and latency, all groups demonstrated an increase between the pre- and post-test evaluations. In an inter-group examination of MEP amplitude and latency, a significant difference was observed between the IFE-rTMS and IFE groups.

A 16-Year Single Center Experience of Resected 2029 Pancreatic Ductal Adenocarcinoma

Sang Hyun Shin,Song Cheol Kim,Dae Wook Hwang,Ki Byung Song,Jae Hoon Lee,Bong Jun Kwak,Seong-Ryong Kim,Jaewoo Kwon,Chung Hyeun Ma,Seunghyun Hwang,Kwang-Min Park,Young-Joo Lee 대한외과학회 2016 대한외과학회 학술대회 초록집 Vol.2016 No.11

Effects of Hand Intrinsic Muscle Treatment after Low Frequency rTMS on Cerebral Motor Evoked Potential and Latency in Patients with Stroke

Sung-Ryong Ma,Byung-Il Yang,Bo-Kyoung Song 한국자기학회 2023 한국자기학회 학술연구발표회 논문개요집 Vol.33 No.1

Effects of Stimulation Method and Frequency of rTMS on Motor Cortex Activation in Stroke Patients

Sung-Ryong Ma,Byung-Il Yang,Bo-Kyoung Song 한국자기학회 2022 한국자기학회 학술연구발표회 논문개요집 Vol.32 No.1

황금작약탕(黃芩芍藥湯)의 RAW 264.7 대식 세포에서의 항염증 효과에 관한 연구

김마룡 ( Ma Ryong Kim ),강옥화 ( Ok Hwa Kang ),김성배 ( Sung Bae Kim ),강희정 ( Hee Jung Kang ),김지은 ( Ji Eun Kim ),황형칠 ( Hyeong Chil Hwang ),김인원 ( In Won Kim ),권동렬 ( Dong Yeul Kwon ) 대한본초학회 2013 大韓本草學會誌 Vol.28 No.1

Objectives : Hwanggeumjakyak-tang (huangqin shaoyao tang, HJT) has been used to treat acute enteritis in traditional oriental medicine. However, there has been a lack of studies regarding the effects of HJT on the inflammatory activities and effector inflammatory disease mechanism about macrophage before is not known. So we examined the effect of HJT water extract on pro-inflammatory mediators in lipopolysaccharide (LPS) - stimulated mouse macrophage, RAW 264.7 cells, Methods : Cells were treated with 2 ug/mL of LPS 1 h prior to the addition of HJT. Cell viability was measured by MTS assay. The production of nitric oxide (NO) was determined by reacting cultured medium with Griess reagent. The expression of cyclooxygenase-2 (COX-2), inducible NO synthase (iNOS) and mitogen-activated protein kinases (MAPKs) was investigated by Western blot, RT-PCR. The content of level of cytokines (prostaglandin (PG) E₂, interleukin (IL)-6, IL-12, Tumor necrosis factor-alpha (TNF-α) and monocyte chemoattractant protein-1 (MCP-1) in media from LPS-stimulated Raw 264.7 cells was analyed by ELISA kit, Results : HJT inhibited the production of NO, PGE₂, IL-6 as well as the expressions of iNOS, COX-2 but did not inhibit the production of IL-12, TNF-α, MCP-1 in the murine macrophage, RAW 264.7 cells. HJT also had suppression effects of LPS- induced MAPKs activation, Conclusion : These results suggest that HJT has an anti-inflammatory therapeutic potential, which may result from inhibition of MAPK phosphorylation, thereby decreasing the expression of pro-inflammatory genes.

뇌졸중 환자의 돌림근띠 근력강화 운동이 어깨 관절가동범위와 어깨 대동작에 미치는 영향

마성룡 ( Sung-ryong Ma ),양종은 ( Jong-eun Yang ),이선일 ( Sun-il Lee ) 대한신경치료학회 2021 신경치료 Vol.25 No.2

Purpose The purpose of this study was to investigate the effect of rotator cuff strengthening exercises on the shoulder joint range of motion and gross motor in patients with weakened rotator cuff muscle strength of the paralyzed shoulder due to stroke. Methods A total of 25 stroke patients were conducted, including 12 in the experimental group and 13 in the control group. The experimental group provided rotator cuff strengthening exercises, and the control group provided treatment to increase shoulder flexibility and mobility. Both groups were treated 3 times a week for 4 weeks after the common rehabilitation treatment routine. A ROM test using a goniometer was used to measure the shoulder joint range of motion, and a Box and Block Test(BBT) was performed to measure the shoulder movement. The evaluation was conducted twice in total: the pre- and post-intervention evaluation within the two groups and the pre- and post-intervention evaluation between the groups. Results In the evaluation before and after the intervention in each group, both groups showed a statistically significant increase in shoulder joint range of motion and shoulder groping ability. In the pre- and post-intervention evaluation between groups, the experimental group showed a statistically significant difference in shoulder flexion(p<.01), shoulder abduction(p<.05) and shoulder gross motor(p<.001) compared to the control group. Therefore, it is judged that the rotator cuff muscle strengthening exercise of the paralyzed shoulder of stroke patients can be applied to improve the shoulder joint range of motion and the ability to move the shoulder.

현토단(玄兎丹)의 RAW 264.7 대식 세포에서의 항염증 효과에 관한 연구

김마룡 ( Ma-ryong Kim ),강옥화 ( Ok-hua Kang ),공룡 ( Ryong Kong ),서윤수 ( Yun-soo Seo ),주전 ( Tian Zhou ),김상아 ( Sang-a Kim ),김은수 ( Eun-su Kim ),신민아 ( Min-a Sin ),이영섭 ( Young-seob Lee ),권동렬 ( Dong-yeul Kwon ) 대한본초학회 2017 大韓本草學會誌 Vol.32 No.2

Objectives : This study aimed to investigate the unknown mechanisms behind the anti- inflammatory activity of Hyeonto-dan (HT) 70% ethanol extract on LPS-stimulated RAW 264.7 cells. Methods : Cells were treated with Hyeonto-dan 1 h prior to addition of 200 ng/mL of LPS. Cell viability was measured by the MTS assay. Nitric oxide levels were determined by the Griess assay. PGE2 were measured using EIA kit. Proinflammatory cytokine production was measured by the enzyme-linked immunosorbent assay (ELISA). The expression of COX-2, iNOS, and MAPKs was investigated by Western blot, qRT-PCR. NF-κB/p65 localization and interaction of the TLR-4 receptor with LPS was examined by immunofluorescence assays. Results : Hyeonto-dan had no cytotoxicity at the measured concentration. Hyeonto-dan inhibited NO production and pro-inflammatory cytokines such as IL-6, TNF-α, and PGE2 as well as the protein and mRNA expression of iNOS and COX-2. Moreover, Hyeonto-dan inhibited the interaction between LPS and TLR-4 in murine macrophages. It suppressed phosphorylation of extracellular signal-regulated kinase (ERK 1/2), c-jun N-terminal kinase (JNK 1/2) and p38. Finally, it inhibited translocation of NF-κB in response to competitive LPS. Conclusions : Based on the results of this study, Hyeonto-dan inhibited the binding of TLR-4 receptor to LPS and inhibited the phosphorylation of extracellular signaling pathway MAPKs. These inhibitory effects are thought that the amount of NF-κB delivered to the nucleus was decreased and the inflammatory reaction was prevented by decreasing the production of LPS-induced PGE2,NO, IL-6 and TNF-α

부활을 위한 정원디자인 - 중국 우한시 국제정원박람회 창의화원 -

( Shin Sang-sup ),( Ha Myoung-jong ),( Jeong Ryong ),( Shin Hyun-sil ),( Ma Yi-chu ) 한국전통조경학회(구 한국정원학회) 2018 Journal of Korean Institute of Traditional Landsca Vol.16 No.-

본 작품은 중국 호북성 우한시에 위치하는 ‘2016 국제원림박람회장의 창의화원 테마정원 계획부지에 1,400m2 규모로 조성되었다. ‘부활을 위한 정원디자인‘이라는 주제를 설정하여 평평한 대상지 북측에 좌측능선과 우측능선을 1.5m 마운딩하여 풍수적 좌청룡과 우백호 기세를 반영했다. 작품명 ‘A Garden Design for Revival’은 자연재생과 인간성 회복을 위한 생태정원 조성을 의미한다. 자연에 대한 인간의 겸손, 소박한 구조물 및 친환경적인 조경요소, 해학이 있는 공간, 생태적 고리가 이어지는 유기적 공간조성을 목표로 ‘현실 속 낙원’을 구축코자 하였다. 첫째, 토지이용은 한국의 농촌경관에 부합되는 앞마당, 뒤뜰, 텃밭, 그리고 연못과 정자, 장독대, 돌탑, 담장 등의 시설요소를 도입했다. 좌청룡 공간은 대나무를 식재하여 부지를 위요하였고, 우백호 공간은 대나무와 돌담, 목책으로 비보개념을 대입하였다. 둘째, 마당 및 초당(草堂)은 풍수적 명당(明堂)의 형국을 고려하였으며, 뒤뜰의 신선한 공기가 따뜻하고 건조한 앞마당 쪽으로 순환하는 통기의 구조를 취하도록 하였다. 가족의 안위와 행복을 염원하는 한국적 당산목과 상징동물, 그리고 어머니의 공간을 대입하였는데, 정화수(井華水)를 떠놓고 자녀들의 안녕을 기원하며 먹거리를 위하여 장독을 채우고 관리하며, 가족들의 식사를 마련하는 개념을 반영했다. 화계와 굴뚝으로 이루어진 뒤뜰과 초당은 한국의 전통 가옥방식을 채택하여 방문자들의 쉼터 구실을 겸하도록 하였으며, 대청마루, 툇마루, 방문의 4쪽 들문, 후면벽면 토담처리, 뒤뜰과 앞마당으로 이어지는 통풍구조, 굴뚝에서 나는 연기, 뒷마당의 닭장, 모이를 줍는 닭, 장독대, 대나무 숲 등 한국적 조경요소들을 도입하였다. 셋째, 아버지의 뜰은 식구들의 식량을 위해 일하고, 땅을 경작하며 미래의 안녕을 기원하는 공간개념을 연계시켜 구성했는데, 자연을 사랑하며 자연의 일부분임을 반영한다. 생태마당은 아버지의 일터이자 마음이 서린 공간으로 실용적 가치를 고려하였는데, 생물과 먹거리, 인간이 공존하는 비오톱 뜰을 조성하는 것을 목표로 삼았다. 후원권역은 주동선 체계에서 생태연못과 계류를 조성하고 초정과 폭포수, 섶다리 등을 도입하여 한국성을 반영하였으며 풍수적 가치가 담긴 대숲 뒷동산이 채택되었다. 한편, 담과 나무울타리, 목재담장, 돌탑, 목탑 등의 조경요소를 소생물권 요소기능과 연계하였다. 돌담 상부는 보행통로로 구축하여 전망 데크 역할을 겸하도록 하였고, 목재담장 및 목탑 등은 시간이 흐르면서 자원의 순환 내지 재생산의 기지가 되도록 하였으며, 돌탑과 목탑 등은 관람자들을 위한 참여 공간으로 소원을 비는 상징 시설물이 되도록 구성했다. The title of this work 'A Garden for Revival' means the creation of an ecological garden for natural regeneration and humanity restoration. The theme covers human humility for nature, simple structures, eco-friendly landscape elements, and relaxed spaces with humor. We tried to build a 'paradise in a space' with the aim of creating an organic space in which ecological rings are well connected. First, For the land use plan for the ecological garden, we introduced a space including a front yard, a back yard, a kitchen garden, a pond, a pavilion, Buddhist monasteries, and a stone tower; which are harmonized with the rural landscape of Korea. On the north of site, a mounding is constructed with the height of 1.5m at the ridge-line of left and right side, being named as Left Blue Dragon & Right White Tiger. Bamboo is planted in the Left Blue Dragon district and it makes surrounding the site. In the Right White Tiger district, bamboo is partly planted and an area of the rest is constructed a stone wall & a log wall to supplement a Genius Loci. Second, A Cottage & Madang locate in the Genius Loci. A moist-cold air of backyard circulates to dry-warm front yard through the opened cottage doors. It makes desirable ventilation. A space of traditional Korean mother is composed of caring for her family’s safety and happiness. Mother prays for her family in front of the water bowl called Junghansu(井華水) in early morning. She fills and manages crocks with Korean fermented food, and also prepares every meal for her family. A backyard with Flower Steps & Smokestack and the cottage are suitable for visitor’s shelter. Korean traditional landscape elements are introduced such as main floor, Toenmaru, pull-up opened 4doors, back earthen wall, ventilation system backyard to front yard, smoke from smokestack, chicken coop in backyard, the chicken pecking in the yard, planter crocks, bamboo grove, and so on. Third, Farther works everyday for his family`s food. He cultivates a land and prays well-being of future. He loves the nature, and knows himself that he is a part of the nature. Eco-yard is father`s workspace and his mind is filled. The goal is that all Eco-yard makes a biotope and creates a yard with coexistence of human beings and biology. Landscape elements such as Stone wall, branches fence, log wall, stone pagoda, log pagoda, etc are a function of biotope living-based of an organism. A top of stone wall is path and plays role as an observatory deck. As time passes, a log wall and a log pagoda will decay, and then they will be food of larva and fertilizer of plants. They will be the base of resource circulation or reproduction. A stone pagoda and a log pagoda play role as the space of visitor`s participation.

솟는 고드름의 형성 원리

변희룡(Hi-Ryong Byun),윤마병(Ma-Byong Yoon),심재면(Jae-Myun Shim),김가빈(Gabyn Kim),권상훈(Sang-Hoon Kwon),권희내(Hui-nae Kwon),김진아(Jin-Ah Kim) 한국기상학회 2016 대기 Vol.26 No.1