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6-shogaol suppresses oxidative damage in L6 muscle cells
Hur Jinyoung,Lee Yeonmi,Lee Chang Jun,Park Ho-Young,Choi Sang Yoon 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.5
Ginger (Zingiber Officinale Roscoe) has been known reduce muscle pain after exercise, and 6-shogaol {(E)-1-(4- Hydroxy-3-methoxyphenyl)dec-4-en-3-one)} is the major essential oil contained in ginger. In this study, the protective effect of 6-shogaol on L6 muscle cells against oxidative damage was measured. 6-shagol inhibited the damage of L6 cell induced by H2O2, and allowed the increase in mRNA and protein expression levels of intracellular HO-1 and NRF2. 6-shogaol also reduced the production of intracellular ROS. These results suggested that 6-shagol effectively inhibits oxidative damage of skeletal muscle cell.
Gliotoxin ameliorates TNBS-induced colitis through regulation of NF-kB, and up-regulation of HO-1
김상욱 ( Kim Sang Ug ),( Jay Min Oh ),( Yeon Hwa Kim ),( Jung Moo Hur ),( Kyo Sang Yoo ),( Yong Sung Kim ),( Joo Jin Yeom ),( Tae Hyeon Kim ),( Suck Chei Choi ),( Chang Duk Jun ),( Yong Ho Nah ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<Background & aims> During inflammation in colon, cells of the gut mucosa produce or express various inflammatory mediators, including IL-8, TNF-a and IL-1b, and intercellular adhesion molecule 1 (ICAM-1). These cytokines and chemokines have recently been
Kim, Se-Jin,Ho Hur, Joon,Park, Channy,Kim, Hyung-Jin,Oh, Gi-Su,Lee, Joon No,Yoo, Su-Jin,Choe, Seong-Kyu,So, Hong-Seob,Lim, David J,Moon, Sung K,Park, Raekil Nature Publishing Group 2015 Experimental and molecular medicine Vol.47 No.2
<P>Bucillamine is used for the treatment of rheumatoid arthritis. This study investigated the protective effects of bucillamine against cisplatin-induced damage in auditory cells, the organ of Corti from postnatal rats (P2) and adult Balb/C mice. Cisplatin increases the catalytic activity of caspase-3 and caspase-8 proteases and the production of free radicals, which were significantly suppressed by pretreatment with bucillamine. Bucillamine induces the intranuclear translocation of Nrf2 and thereby increases the expression of γ-glutamylcysteine synthetase (γ-GCS) and glutathione synthetase (GSS), which further induces intracellular antioxidant glutathione (GSH), heme oxygenase 1 (HO-1) and superoxide dismutase 2 (SOD2). However, knockdown studies of HO-1 and SOD2 suggest that the protective effect of bucillamine against cisplatin is independent of the enzymatic activity of HO-1 and SOD. Furthermore, pretreatment with bucillamine protects sensory hair cells on organ of Corti explants from cisplatin-induced cytotoxicity concomitantly with inhibition of caspase-3 activation. The auditory-brainstem-evoked response of cisplatin-injected mice shows marked increases in hearing threshold shifts, which was markedly suppressed by pretreatment with bucillamine <I>in vivo</I>. Taken together, bucillamine protects sensory hair cells from cisplatin through a scavenging effect on itself, as well as the induction of intracellular GSH.</P>
( Sung Joon Park ),( Jin Hur ),( Won Ho Son ) 한국체육학회 2015 국제스포츠과학 학술대회 Vol.2015 No.1
Purpose: Whether a professional sport game can succeed is determined by what factors it has to attract various sports consumers to the arena. A sport or a game that fails to attract sports consumers will eventually be forgotten by the audiences. In other words, how to attract sports consumers determines whether or not a professional sport game will succeed. As personal and social interests in various professional sports increase, however, the behavior of sports consumers is also diversifying. The increasingly fierce competition and the nearly saturated sports market mean that retaining consumers is of primary importance. In order to ensure continuous survival and growth of professional soccer, it is crucial to conduct a marketing campaign, based on the characteristics and behavior of consumers, that enhances consumers` after purchases to soccer by appealing to their needs, desires, and values. Professional soccer teams and leagues must focus their efforts on creating strategy designed to attract as many consumers to the stadiums as possible. The analysis of servicescape of professional soccer will enhance customers` positive feelings and satisfaction, thereby solidifying continuous relationship between the audience and professional soccer and increasing the number of consumers returning to stadiums. This study was conducted in order to identify and verify the correlations between servicescape of professional soccer, customers` feelings and satisfaction, and after purchases to the sport. Method: 307 samples were collected through random sampling from the audiences of the four teams that competed at 2014 Professional soccer. Those unqualified for the study were excluded from the collected samples. The remaining effective samples were given explorative factor analysis, reliability analysis, and correlation analysis using SPSSWIN Ver. 18.0. Then a confirmative factor analysis was run using AMOS 18.0. Result: The overall findings were: χ2 = 415.041; GFI = .902; AGFI = .911; RMR = .043; NFI = .917; and TLI = .924, meaning the samples suited the purpose of the study. The findings of the structural equation model analysis were: χ2 = 418.214; GFI = .911; AGFI = .901; NFI = .921; and TLI = .932 Based on these findings and procedure, the following findings were obtained. Conclusion: First, servicescape had significant influence on affect. Second, servicescape had significant influence on customer satisfaction. Third, affect had significant influence on customer satisfaction and after purchases. Fourth, customer satisfaction had significant influence after purchases.
In-hospital mortality in patients with STEMI admitted during off hours
( Sung-Soo Kim ),( Myung Ho Jeong ),( Jeong Gwan Cho ),( Young Keun Ahn ),( Jong Hyun Kim ),( Shung Chull Chae ),( Young Jo Kim ),( Seung Ho Hur ),( In Whan Seong ),( Taek Jong Hong ),( Dong-hoon Choi 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Conflicting results exist on the outcome of off hours PCI in ST elevation myocardial infarction (STEMI). However, there were only a few studies that have focused on the clinical characteristics and outcomes of off hours PCI in STEMI. So, we studied the clinical characteristics and hospital mortality in STEMI patients treated with primary PCI during regular hours (weekdays 9:00 AM to 6:00 PM) versus off hours Weekdays 6:01 PM to 8:59 AM, weekends, and holidays) in Korea Acute Myocardial Infarction Registry. We analyzed in hospital and one year mortality among 5,665 consecutive ST segment elevation myocardial infarction patients treated with primary PCI between November 2005 to January 2008. Total 2,848 (50.2%) patients were treated during off hours. Baseline finding were similar, although regular hours patients were older. Median symptom to balloon time (304 min, IQR 175 to 750 vs. 270 min, IQR 145 to 551, p=0.001) were longer for regular hours primary PCI. Median door to balloon time (71min, IQR: 48 to 132 vs. 59 min, IQR 39 to 110 min, p=0.001) were longer for off hours pPCI. Also, Cardiac enzyme such as Max CK-MB (212.1±299.3 vs 194.7±303.4, p=0.031) and max TnI (72.6±239.5 vs. 58.9±94.4, p=0.013) were increased in off hours pPCI. However, unadjusted in hospital (6.0% off hours vs. 6.0% regular hours, p=0.946) and one year cardiac mortality (11.3% off hours vs. 11.7% regular hours, p=0.661) were comparable. In multivariate analysis, off hours primary PCI did not predict an adverse outcome. In conclusion, when primary PCI was performed within an appropriate reperfusion strategy, the clinical effectiveness of either off hours or regular hours pPCI is comparable.
Hur, Beong-Ik,Choi, Byung-Kwan,Sung, Soon-Ki,Cho, Won-Ho,Cha, Seung-Heon,Choi, Chang-Hwa The Korean Neurosurgical Society 2010 Journal of Korean neurosurgical society Vol.47 No.2
Objective : The secondary verification of Leksell Gamma Knife treatment planning system (LGP) (which is the primary verification system) is extremely important in order to minimize the risk of treatment errors. Although prior methods have been developed to verify maximum dose and treatment time, none have studied maximum dose coordinates and treatment volume. Methods : We simulated the skull shape as an ellipsoid with its center at the junction between the mammillary bodies and the brain stem. The radiation depths of the beamlets emitted from 201 collimators were calculated based on the relationship between this ellipsoid and a single beamlet expressed as a straight line. A computer program was coded to execute the algorithm. A database system was adopted to log the doses for $31{\times}31{\times}31$ or 29,791 matrix points allowing for future queries to be made of the matrix of interest. Results : When we compared the parameters in seven patients, all parameters showed good correlation. The number of matrix points with a dose higher than 30% of the maximal dose was within ${\pm}\;2%$ of LGP. The 50% dose volume, which is generally the target volume, differs maximally by 4.2%. The difference of the maximal dose ranges from 0.7% to 7%. Conclusion : Based on the results, the variable ellipsoid modeling technique or variable ellipsoid modeling technique (VEMT) can be a useful and independent tool to verify the important parameters of LGP and make up for LGP.
Hur, Sang-sun,Choi, Suk-won,Lee, Dong-ryul,Park, Jong-hwan,Chung, Tae-ho Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P>This study was conducted to determine if topical application of<I> Moringa oleifera</I> extracts and its bioconversion product fermented by<I> Rhizopus oligosporus</I> has therapeutic properties enhancement for treatment of atopic dermatitis.<I> Rhizopus oligosporus</I> (KCCM 11232P) was used to ferment<I> Moringa</I> leaves' extracts in this study. Comparison of organic acids and flavonols in<I> Moringa</I> simple extracts and their fermented product by HPLC analysis revealed that concentration of organic acids and flavonols of bioconversion product was lower than that of hot water extracts. The fermentation process is used as a nutrient for isolation of each component by microorganisms and growth of microorganisms. The results demonstrated that MF extracts effectively reduced clinical features based on macrography, scratching count, and severity scores, as well as model's serum IgE level, including histopathological analyses.</P>