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SHIN, JI-AE,LI, CHENGMING,CHOI, EUN-SUN,CHO, SUNG-DAE,CHO, NAM-PYO Spandidos Publications 2013 MOLECULAR MEDICINE REPORTS Vol.7 No.2
<P>microRNAs (miRs) are small endogenous non?coding RNAs and are associated with the pathogenesis of a number of types of human cancer. However, miR?127?3p in mucoepidermoid carcinoma (MEC) has not been studied. The present study aimed to analyze the importance of miR?127?3p in MC?3 human MEC cells. Analyses of the growth inhibitory effect and the associated mechanism of miR?127?3p were performed using 3?(4,5?dimethylthiazol?20yl)?(3?carboxymethoxyphenyl)?2?(4?sulphophenyl)?2H?tetrazolium assay, flow cytometry, 4'?6?diamidino?2?phenylindole staining, anchorage?independent cell transformation assay and western blot analysis. Transfection of exogenous miR?127?3p into MC?3 cells inhibited cell viability and led to G1/S cell cycle arrest. In addition, miR?127?3p also decreased neoplastic cell transformation in TPA?induced JB6 mouse epidermal and MC?3 cells. In addition, miR?127?3p decreased specificity protein 1 (Sp1) expression and increased p21 and p27 expression which are Sp1?dependent cell cycle?related proteins. However, miR?127?3p did not induce apoptosis or affect expression levels of myeloid cell leukemia?1 or survivin. miR?127?3p induced G1/S cell cycle arrest and increased p21 and p27 expression via modulation of Sp1. Therefore, miR?127?3p may be a therapeutic target for human MEC.</P>
A Study on Sales Promotion of Distribution Channels: Focused on a Company
Dae In Kim,Jae Beom Lee,Yong Jae Shin,Sung Wook Choi 한국유통과학회 2016 KODISA ICBE (International Conference on Business Vol.2016 No.-
The purpose of this research is to search methods to improve sales of B2B small and medium companies whose utilization of information system is insufficient based on their limited data resources. The analysis was done using SPSS 18.0, and the analysis results can be summarized as follows: As a result of the clustering analysis of agencies using K-means clustering, the agencies were classified into 4 clusters. Cluster 1 showed the highest central value followed by cluster 2 with KRW 5.05 billion, cluster 3 with KRW 2.22 billion, and cluster 4 with KRW 0.13 billion. Cluster 1 has 2 agencies, cluster 2, 11 agencies, cluster 3, 17 agencies, and cluster 4, 255 agencies. Through such clustering analysis, agencies of company A were classified, common features in the sales of the agencies were investigated, strong points and weak points of agencies were identified, proper sales promotion methods that the company can provide for the agencies were suggested, and higher sales of the company through the solutions could be searched.
( Sang-hyeon Won ),( Dae-lyong Ha ),( Jin-hwa Son ),( Jungsoo Lee ),( Kihyuk Shin ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Moon-bum Kim ),( Kyunghyung Seo ),( Byung-soo Kim ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Ixekizumab is a humanized IgG4 monoclonal antibody that selectively binds to the IL-17A cytokine and inhibits its interaction with the IL-17 receptor. It has emerged as an effective treatment for moderate to severe psoriasis. However, to date, there are no real-world data for the use of ixekizumab in the treatment of psoriasis in Korean patients. Objectives: To evaluate the effectiveness and safety of ixekizumab in the treatment of moderate to severe psoriasis in Korean patients. Methods: Thirty patients who were treated with ixekizumab were analyzed. All patients’ medical records, Psoriasis Area and Severity Index (PASI) score, body surface area (BSA), Physicians’ Global Assessment (PGA), and adverse events were investigated. Results: A significant reduction in mean baseline PASI score (14.1±2.6) was detected at 4 weeks of ixekizumab therapy (3.8±2.7), with a further improvement at weeks 12 and 24 (0.9±0.7 and 0.5±0.5, respectively). Our analysis showed that 100%, 87.5%, and 50% of patients achieved PASI 75, 90, and 100 responses, respectively, after 48 weeks of therapy. However, nine patients (30%) experienced a mild adverse event such as injection site reaction, urticaria, upper respiratory tract infection, and stomatitis. Conclusion: This study provides evidence for the use of ixekizumab in real-world clinical practice and confirm that it is effective and safe in treating Korean patients with moderate to severe psoriasis.
Biologic-resistant areas in Korean patients with moderate to severe psoriasis
( Sang-hyeon Won ),( Bong Seok Shin ),( Dae-lyong Ha ),( Jin-hwa Son ),( Jungsoo Lee ),( Kihyuk Shin ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Moon-bum Kim ),( Kyunghyung Seo ),( Byung-soo Kim ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Psoriasis in certain body sites such as palmoplantar, nail, scalp and intertriginous areas has been known to be difficult to treat. However, to date, there have been no studies for biologic-resistant areas in patients with moderate to severe psoriasis in Korea. Objectives: To investigate the body location of treatment-resistant psoriasis in Korean patients treated with biologic agents. Methods: We included fifty biologic-resistant patients with moderate to severe psoriasis treated for > 6 months in Pusan National University Hospitals(Busan and Yangsan) and Chosun University Hospital. All patients’ medical records, Psoriasis Area and Severity Index (PASI) score, the location of treatment-resistant psoriasis were investigated. Results: The mean age of the patients was 47.8±11 years, and 32 patients (64%) were male. The median PASI score (interquartile range) at treatment initiation was 15 (12.2-18.1), and current PASI score was 1.8 (1.4-2.8). The median PASI reduction from treatment initiation was 87.9% (81.3-92). The most common site of recalcitrant psoriasis was the anterior lower leg (56%) followed by the knee (48%), posterior lower leg (42%), scalp (38%), and back (34%). Conclusion: In real-world clinical practice, the most common sites of recalcitrant psoriasis in Korean patients treated with biologic agents are the anterior lower leg, knee, and posterior lower leg.
Study on Ginseng Protopanaxadiol and Protopanaxatriol Saponins-Induced Antinociception
Shin, Young-Hee,Kim, Seok-Chang,Han, Ji-Won,Kim, Dae-Hoon,Han, Sang-Sub,Shin, Dong-Ho,Nah, Seung-Yeol The Korean Society of Pharmacology 1997 The Korean Journal of Physiology & Pharmacology Vol.1 No.2
We studied the effects of ginseng protopanaxadiol (PD) and protopanaxatriol (PT) saponins on the analgesia using several pain tests such as writhing, formalin, and tail-flick test. Using mouse, pretreatment of PD or PT saponins (i.p.) induced inhibition of abdominal constrictions caused by 0.9% acetic acid administration(i.p.). The $AD_{50}$ was around 27 (17-43) mg/kg for PD and 13.5 (3-61) mg/kg for PT saponins in writhing test. Both PD and PT saponins also showed the inhibition of bitings and lickings of hindpaw after administration of 1% formalin. In particular, both PD and PT saponins showed analgesic effects on second phase of pain. The $AD_{50}$ was 44.5 (26-76) mg/kg for PD and 105 (55-200) mg/kg for PT saponins in second phase of formalin test. For first phase pain inhibition by PD or PT saponins, they were required higher concentrations. However, PD saponins showed weak analgesic effects in tail-flick test with high concentration. In conclusion, we found that both PD and PT saponins have the analgesic effects in writhing test and second phase of pain in formalin test. These results suggest that both PD and PT saponins inhibit neurogenic or tonic pain rather than acute pain.
Light Source Target Detection Algorithm for Vision-based UAV Recovery
Dae-Yeon Won,Min-Jea Tahk,Eun-Jung Roh,Sung-Sik Shin 한국항공우주학회 2008 International Journal of Aeronautical and Space Sc Vol.9 No.2
In the vision-based recovery phase, a terminal guidance for the blended-wing UAV requires visual information of high accuracy. This paper presents the light source target design and detection algorithm for vision-based UAV recovery. We propose a recovery target design with red and green LEDs. This frame provides the relative position between the target and the UAV. The target detection algorithm includes HSV-based segmentation, morphology, and blob processing. These techniques are employed to give efficient detection results in day and night net recovery operations. The performance of the proposed target design and detection algorithm are evaluated through ground-based experiments.