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( Han Wook Chung ),( Yu Jin Ko ),( Sang Wook Lee ),( Hyun Woong Lee ),( Hyung Joon Kim ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background/Aims: Quantitative HBsAg (qHBsAg) titers are emerging as useful tools for measuring viral load and predicting predicting virologic response (VR). This study aimed to determine whether serial monitoring of HBsAg levels could predict virologic response to entecavir(ETV) & clevudine(CLV) therapy in treatment-naive patients with CHB Methods: A total of 157 treatment-naive patients with CHB, who visited Chung-Ang University Hospital between January 2007 and December 2008, were enrolled in this study (100 males). 97 patients(69 males, mean age 48) were treated with ETV for average 53 months, and 60 patients (31 males, mean age 43) were treated with CLV for 26months average. HBsAg levels were measured at baseline, week 12, 24, and 48. All patients were assessed for virological response (HBV DNA<140 copies/mL). Serum HBV DNA was quantified using the real time PCR assay (Artus HBV LC PCR Kit, Roche Diagnostics, lower limit of quantification, 140 copies/mL). Results: In 97 ETV-treated patients, the rates of virological response were 56.7% (55/97) at 48months and 60 CLV-treated patients, 30% (18/60) at 24 months, respectively. Mean reduction of baseline HBV DNA was -5.3, and -4.9 log10 copies/mL. In 55 VR patients treated with ETV, 43(78.1%) patients showed early decline of HBsAg titer and 31(56.3%) patients had lower baseline HBsAg levels (< 3.7 log IU/mL). In 18 VR patients treated with CLV, 9(50%) patients showed early decline of HBsAg titer and 11(61.1%) patients had also lower baseline HBsAg levels (< 3.7 log IU/mL) . Conclusions: Early decline of HBsAg was useful for predicting VR, and baseline HBsAg could be indicative as well in CHB patients treated with ETV than patients treated with CLV.
Ko, Sung-Hun,Lee, Su-Won,Lee, Seong-Ryong,Naya, Chemmangot V.,won, Chung-Yuen The Korean Institute of Power Electronics 2009 JOURNAL OF POWER ELECTRONICS Vol.9 No.4
Voltage-controlled voltage source inverter (VCVSI) based distributed generation systems (DGS) using renewable energy sources (RES) is becoming increasingly popular as grid support systems in both remote isolated grids as well as end of rural distribution lines. In VCVSI based DGS for load voltage stabilization, the power angle between the VCVSI output voltage and the grid is an important design parameter because it affects not only the power flow and the power factor of the grid but also the capacity of the grid, the sizing of the decoupling inductor and the VCVSI. In this paper, the steady state modeling and analysis in terms of power flow and power demand of the each component in the system at the different values of maximum power angle is presented. System design considerations are examined for various load and grid conditions. Experimental results conducted on a I KVA VCVSI based DGS prove the analysis and simulation results.
Air Pollution Is Associated With Ischemic Stroke via Cardiogenic Embolism
Chung, Jong-Won,Bang, Oh Young,Ahn, Kangmo,Park, Sang-Soon,Park, Tai Hwan,Kim, Jae Guk,Ko, Youngchai,Lee, SooJoo,Lee, Kyung Bok,Lee, Jun,Kang, Kyusik,Park, Jong-Moo,Cho, Yong-Jin,Hong, Keun-Sik,Nah, H Ovid Technologies Wolters Kluwer -American Heart A 2017 Stroke Vol.48 No.1
<P>Conclusions-Our findings suggest that the short-term exposure to air pollutants is associated with cardioembolic stroke, and greater care should be taken for those susceptible to cerebral embolism during peak pollution periods. Public and environmental health policies to reduce air pollution could help slow down global increasing trends of cardioembolic stroke.</P>
Chung, Young C,Baek, Jeong Y,Kim, Sang R,Ko, Hyuk W,Bok, Eugene,Shin, Won-Ho,Won, So-Yoon,Jin, Byung K Nature Publishing Group 2017 Experimental and molecular medicine Vol.49 No.3
<P>The effects of capsaicin (CAP), a transient receptor potential vanilloid subtype 1 (TRPV1) agonist, were determined on nigrostriatal dopamine (DA) neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease (PD). The results showed that TRPV1 activation by CAP rescued nigrostriatal DA neurons, enhanced striatal DA functions and improved behavioral recovery in MPTP-treated mice. CAP neuroprotection was associated with reduced expression of proinflammatory cytokines (tumor necrosis factor-α and interleukin-1β) and reactive oxygen species/reactive nitrogen species from activated microglia-derived NADPH oxidase, inducible nitric oxide synthase or reactive astrocyte-derived myeloidperoxidase. These beneficial effects of CAP were reversed by treatment with the TRPV1 antagonists capsazepine and iodo-resiniferatoxin, indicating TRPV1 involvement. This study demonstrates that TRPV1 activation by CAP protects nigrostriatal DA neurons via inhibition of glial activation-mediated oxidative stress and neuroinflammation in the MPTP mouse model of PD. These results suggest that CAP and its analogs may be beneficial therapeutic agents for the treatment of PD and other neurodegenerative disorders that are associated with neuroinflammation and glial activation-derived oxidative damage.</P>
Synthesis, Characterization, and Applications of Organic-Inorganic Hybrid Mesoporous Silica
Chung, Jin-Sung,Kim, Dong-Jun,Ahn, Wha-Seung,Ko, Joung-Ho,Cheong, Won-Jo 한국화학공학회 2004 Korean Journal of Chemical Engineering Vol.21 No.1
Organic-inorganic hybrid mesoporous materials composed of homogeneously distributed ethane group in a silica framework were prepared by using 1, 2 bis (trimethoxysilyl) ethane (BTEM) as a precursor and alkyltrime-thylammonium-chloride or-bromide surfactant as a structure directing agent with or without the presence of a swelling agent, mesitylene. Characterization of the materials was performed by XRD, TEM/SEM, ^(29)Si-/^(13)C-solid state NMR, and N_(2)-adsorption. Testing of the hybrid materials as a reversed phase HPLC column stationary phase after C 18 surface-functionalization demonstrated a promising result, which closely approaches the performance of a commercial product. Mn-salen complex tethering on the hybrid material produced a catalyst with somewhat enhanced performance in liquid phase etherification with tert-butyl hydroperoxide as oxidant.
A Novel MPPT Control of photovoltaic system using FLC algorithm
Sung-Jun Kang,Jae-Sub Ko,Jung-Sik Choi,Mi-Geum Jang,Ju-Hui Mun,Jin-Gook Lee,Dong-Hwa Chung 제어로봇시스템학회 2011 제어로봇시스템학회 국제학술대회 논문집 Vol.2011 No.10
This paper proposes a novel maximum power point tracking (MPPT) using a fuzzy logic control (FLC) algorithm for robust in environment changing. The power available at the output of photovoltaic (PV) cell keeps changing with radiation and temperature because solar cell exhibits a nonlinear current-voltage characteristic. So its maximum power point (MPP) of PV cells varies with radiation and temperature. MPPT methods are used in PV systems to make full utilization of PV array output power which depends on radiation and temperature. Conventional MPPT controller such as constant voltage (CV), perturbation and observation (PO) and incremental conductance (IC) are researched. But these controllers have the problem that is failure to MPP with environment changing. The proposed FLC controller is based the fuzzy control algorithm and able to robust control with environment changing. Also the PV systems applied FLC controller is modeled by PSIM and the response characteristics of FLC method according to the environment variation is analyzed through comparison with performance of conventional methods. The validity of this controller is proved through response results.