抗癌丹을 投與한 胃癌 患者 105例에 對한 臨床報告

유화승,최우진,이용연,서상훈,조정효,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

Clinical studies were carried out 105 cases of patients with stomach cancer treated by Hangamdan(抗癌丹) from January 1th 1998 to September 30th 2000. The results were summarized as follows; 1. Distribution of those attached by stomach cancer, by sex, showed that Male is more then Female, by age, showed that the number of forties, fifties, sixties are majority. 2. Distribution of diagnostic stage, in descending order; stage Ⅲ(45.1%, top), stage Ⅳ(40.2%). 3. The effects of maintenance and improvement in the symptoms with traditional oriental therapy(77.8%) and combined treatment of western and oriental therapy(92.3%) were observed. The effects of the symptoms were as follows; abdominal pain (16.3%), general body weakness(10.5%), nausea&vomiting (8.6%), diarrhea(6.7%) and etc, in orders. 4. Analysis of hematology attached by stomach cancer, maintenance and increasing of WBC(89.4%), RBC(63.6%), Hgb(62.3%), Platelet(95.6%) were observed. After taken Hangamdan, the safety of the liver and kidney were as follows; maintenance and decreasing of AST(85.3%), ALT(91.6%), BUN(84.8%), Creatinine(92.4%) were observed. 5. Analysis of IL-12 and IFN-γ attached by stomach cancer, increasing of IL-12(39.1%), IFN-γ(69.6%) were observed. 6. Analysis of QOL attached by stomach cancer, maintenance and improvement of combined treatment of western and oriental therapy(91%), traditional oriental therapy(85.2%) were observed. 7. Analysis of survival in patients with Ⅳ stage of stomach cancer, above 6 months(17.1%), 12 months(85.2%) were observed. 8. Analysis of antitumor effects, maintenance of traditional oriental therapy(81.5%) and maintenance and improvement of combined treatment of western and oriental therapy(89.7%) were observed. Analysis of tumor marker attached by stomach cancer, maintenance of CEA(85.7%) were observed. 9. Analysis of curative valuation, maintenance and improvement of traditional oriental therapy(77.7%), combined treatment of western and oriental therapy(82.1%) were observed. From the above results, it is suggested that Hangamdan has significant effects of antitumor and immune activity, also could be usefully applied for stomach cancer patients by combination with western therapy or alone.

西歐 代替醫學의 癌 治療에 關한 硏究

兪和承,李容淵,徐祥熏,崔宇鎭,曺政孝,李淵月,孫彰奎,趙鍾寬 대한한방종양학회 2000 대한한방종양학회지 Vol.6 No.1

At here, we investigated the historical background, current stage, and concrete therapies of altematives in cancer therapy. We obatined the conclusion below. 1. Alternative medicine(AM) is a unothodoxial medical physiology, medical practice or intervension that overcome the side effects. faults, limits of coventional medicine. 2. Recentely, as emerging New-age movement, collgpse of Decarte's mecanical cosmology, and emphasis on patient rights, the interest of AM is increased, and foreign & domestic use rates of AM are risen. 3. After coventional medicine in cancer therapies tha depends on poerations, radiations, and chemotherapy is bounded, Altematives in cancer therapy are rapidly developed, and the majority of users are often considered satisfactory. 4. Alternatives in cancer therapy are classified six boundaries; Diet and Nutrition, MInd-body Technique, Integrated System, Pharmacologic and Biologictreatments, Immuno Enhanced Therapy, Immuno Enthaced Therapy, Natural and herbal medicine. 5. Looking at contents of Alternatives in cancer therapy, we get to know most of them are similar to the treatment of oriental medicine in holistic method, therapy, philosophy. If we synthesize the alternative medicine's treatment mentioned above and investigate it with oriental medical viewpoint, that may help us approach the conquest of cancer and improve the rate of cure. that may help us approach the conquest of cancer and improve the rate of cure. 6. It is certain that foreign AM will be imported reversely, and we must prepare for rebuilding of Korean traditional AM systemically, investing for activity positively, making national policy for medical system.

민들레 추출액 농도에 따른 민들레 코팅쌀밥의 품질에 관한 연구

유경미,이연경,김세희,황인경,이부용,김성수,홍희도,김영찬 한국조리과학회 2005 한국식품조리과학회지 Vol.21 No.1

Washed rice was coated by spraying aqueous dandelion (Taraxacum officinale) extracts at 20, 30, 40 'Brix and dried at room temperature. The coating procedure was conducted 5 mL/min for 10min. Property changes in the dandelion coated rice and un-coated cooked rice were observed during 2 days of storage. Increasing the coating concentration was associated with lower color values (L, a value) and moisture contents. Sensory and texture properties generally decreased in the cooked rice coated with dandelion more than the control (non-coated rice). But, D-20(20 °Brix of the dandelion concentration) resulted in better textural properties and s ensnry scores for hardness and overall acceptability in cooked rice. Compared to the control, the washed rice roated with 20 °Brix for 0 and 2 days showed better quality in sensory activities, a lower gel consistency and better textural activities. It was concluded that the optimum coating ration of rice and added dandelion extract for cooking were 20 °Brix and 5% respectively, in proportion to the total weight of raw rice.

Modified 9Cr-1Mo 강의 항온변태처리에 따른 미세조직 및 경도변화

유정훈,주성욱,허성강,신기삼,이수,정연길 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-

Evolution of microstructure and its relation with hardness in the modified 9%Cr-1%Mo steel which was isothermally heat-treated has been investigated in various heat-treatment temperatures and time of duration. For microstructural and crystallographic analyses, optical microscope, scanning and transmission electron microscopes, energy dispersive spectrometer, and X-ray diffractometer were used. Vickers microhardness tester were used for the measurement of hardness. Precipitates of the complex M23C6, M(C,N) formed at grain boundaries and interiors of grains had led to the secondary hardening. Normalized specimen and all of the isothermally heat-treated ones showed no evidence of retained austenite.

실천적 문제 중심의 고등학교 가정과 교육과정 개발에 관한 연구 : 식생활 내용을 중심으로

유지연,신상옥 한국 가정과 교육 학회 1997 한국가정과교육학회지 Vol.9 No.1

The purpose of this study was to develop a Home Economics curriculum for high school students based on practical problems focusing on Food and Nutrition. This study developed practical-problem based approach to curriculum development. This curriculum provided a series of the objectives, contents, learning activities, and assessments. The objectives were divided into process objectives and content objectives. The objectives focused on three systems of action which were technical action, communicative action, and emancipatory action. The contents of this curriculum focused on three practical problems ; 1) What should I do regarding my well-being? ; 2) What should I do regarding my family's well-being? ; 3) What should I do regarding my society's well-being? The cooperative learning strategies were mainly used in this curriculum. Students were assessed through learning experiences and achievement.

사망진단서(사체검안서) 상의 선행사인으로부터 사망통계의 원사인이 선정되는 비율 : 3개 대학병원에서 교부된 사망진단서를 중심으로

박우성,박석건,정철원,김우철,탁우택,김부연,서순원,김광환,서진숙,부유경 한국의료QA학회 2004 한국의료질향상학회지 Vol.11 No.1

Background : To exatnine the problems intolved in writing practice of death certificates, we cotnpated the determination of underlying cause of death for wital statistics using recorded underlying cause of death in issued death statistics. Methods : We collected 688 rnortality certificates issue in year of 2,000 from 3 university hospitals. And we also collected vital statistics from ministry of statistics. The causes of death were coded by experienced medical record wpecialists. And causes of death determined at ministry of statistics for national vita statistics were mapped to causes of death recorded at each death certificates. The rate that underlying causes of death for vital statistics were derived from underlying causes of death recorded at issued death certificaties sere analysed. Results : 64.5% of underlying cause of death for could be derived from underlying cause of death recorded at issued death certificates, 8.6% derived from intermediate cause of death, and 3.9% derived from direct cause of death. In 23% of cases, underlying cause of death could not be derived using issued death certificates. The rate that underlying cause of death for vital statistics could be derived from underlying cause of death recorded at death certificates was different between 3 university hospitals. Ane the rate was also different between death certificates and postmortem certificates. We classified the causes of death using 21 major categories. The rate was different between diseases or conditions tha caused death too. Conclusion : When we examined the correctness of death certificate writing practice using abpve methods, cortectness of writing could not be told as satisfactory. There was difference in correctness of writing between hospotals, between death certificates and postmortem certificates, and between diseases and conditions that caused death. With this results, we suggested some strategy to improve the correctness of death certificate writing practice.

제 2형 당뇨병 환자에서 혈중 Metalliproteinase-9의 농도

김상용,김희중,주유철,최동현,배학연 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2

Purpose : Diabetic nephropathy is a serious complication of diabetes and accounts for much of its morbidity and mortality. It is well known that the overt clinical phase of diabetic nephropathy is preceded for many years by the presence of microalbuminuria. Microalbuminuria is thought to be a marker of widespread vascular damage and may underlie the propensity toward severe extrarenal vascular disease in microalbuminuric patients. Metalloproteinase-9 has a broad substrate specificity for native collagens as well as proteoglycan and elastin. One study reported that an increased plasma metalloproteinase-9 concentration precedes the development of microalbuminuria in type 2 diabetic patients. Another study reported that a high glucose concentration cause a abnormality on the activity of metalloproteinase by the mesangeal cell. The purpose of the present study was to examine whether palsma metalloproteinase-9 concentrations are altered at various complications in type 2 diabetic patients. Methods : Sixty patients with type 2 diabetes and thirty healthy control were recruited for the present study. No patient had any malignancy or history of heart disease, liver disease, collagen disease. We recorded age, duration of diabetes, and blood pressure. After an overnight fast, blood was drawn from an antecubita1 vein of measurement of glucose, metalloproteinase-9, HbA1C, and serum creatinine. To measure plasma concentration of metalloproteinase-9, a one step sandwich enzyme immunoassay using two monoclonal antibodies was used. Patients were divided into two group according to the presence or abscence of microalbuminuria. The groups were then compared with regard to clinical and laboratory characteristics and serum concentration of metalloproteinase-9. Results : The mean serum levels of metalloproteinase-9 in diabetic patients (62.32±25.83ng/㎖) were significantly higher than in healthy controls(12.92±4.97ng/㎖) (p<01). The mean serum levels of metalloproteinase-9 in diabetic patients with microalbuminuria(81.16±41.43ng/㎖) were significantly higher than in those with normoalbuminuria(31.48±7.34ng/㎖) (p<01) and much more than in healthy control(12.92±4.97ng/㎖) (p<05). Furthermore, the severity of nephropathy were closely associated with the serum metalloproteinase-9 level and the serum metalloproteinase-9 level was significantly correlated with microalbuminuria. The mean serum level of metalloproteinase-9 in diabetic patients with retinopathy(61.74±39.07ng/㎖) was significantly higher than in those with no retinopathy(34.98±9.02ng/㎖) (p<05). But, in diabetic patients with normoalbuminuria, there is no difference between the groups with retinopathy versus no retinopathy. Conclusion : In summary, a sustained increase in serum metalloproteinase-9 in patients with type 2 diabetes is associated with a high risk for the development of microalbuminuria. The results of this study suggest that the serum rnetalloproteinase-9 was a useful and noninvasive marker for the development of diabetic nephropathy. It could be also used to predict the development of diabetic complications and to assess therapeutics or the prognosis of diabetes. The usefulness of this model will be clarified by a larger scale and serial study.

요오드 식품의 섭취빈도 및 기타 갑상선질환 유발인자에 관한 연구

윤상연,이경혜,유봉옥 창원대학교 생화과학연구소 1999 생활과학연구 Vol.3 No.-

Frequency of iodine contained food intake and symptom, risk factors of thyroid disease and demographic informations were investigated form 30 patients with various thyroid disease (hypothyroidism simple goiter and thyroid adenoma) and 30 normal control subjects. All subjects were female. Iodine contained food intake was assessed using the food frequency questionnaires with portion sizes. Family history of thyroid disease, frequency of depression. nervousness and stress. experience of abortion, appetites were higher in patients group compared to normal control group. But intake of iodine contained food and food habits did not differ between two groups. In this study, therefore, personality, stress and family history of thyroid disease affected more cause of thyroid disease than the frequency of iodine contained food intake.

Apolipoprotein E 다형성에 따른 사업장 근로자의 혈중 지질농도, 영양소 섭취 및 건강관련 생활습관

박유경,조상운,강지연,백윤미,성숙희,최태인 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.5

The purpose of this study was to investigate the association among nutrient intakes and health-related lifestyles with cardiovascular disease risk assessed by blood lipid profile according to Apolipoprotein E genotypes. Middle-aged industrial male workers who had completed their annual medical examination were recruited and data of 675 subjects who finished the nutrient survey were used in the analysis. Anthropometric parameters, dietary assessment (FFQ), health-related lifestyles and blood profiles were used for statistical analyses. Apo E genotype groups were classified into the following three genotypes: Apo E2 group (including E2/E2, E2/E3, E2/E4), Apo E3 group (including E3/E3), Apo E4 group (including E3/E4, E4/E4). The frequency of Apo E2, E3, and E4 allele were 13.3%, 75.0% and 11.7% respectively. There were no significant differences in the anthropometric parameters depending on different Apo E genotypes. Also, no significant differences in the nutrient intakes were found according to the genotype groups. The nutrient intakes of all subjects were similar to or higher than the level of KDRIs (Dietary Reference Intakes For Koreans) except for intakes of calcium (67.44% of KDRIs), vitamin A (73.83% of KDRIs) and vitamin B2 (78.02% of KDRIs). Also, there were no significant differences of health-related lifestyles according to Apo E genotype groups. As for the lipid profiles, Apo E4 group had significantly higher total and LDL-cholesterol concentrations than the Apo E2 group (p < 0.05). We confirmed that plasma total and LDL-cholesterol concentrations were greatly influenced by Apo E genotypes. However, nutrient intakes and health-related lifestyles were not associated with Apo E genotypes.

抗癌丹을 投與한 大腸癌 患者 83例에 대한 臨床報告

이용연,서상훈,유화승,최우진,조정효,이연월,손창규,조종관 대한한방종양학회 2000 대한한방종양학회지 Vol.6 No.1

Climical studies were carried out 83 cases of patients with colorectal cancer treated bv Hangamdan(抗癌丹) from January lth 1998 to September 30th 2000. The results were summarized as follows; 1. Distribution of those attached by colorectal cancer, by sex, showed that Male is more then Female, by age, showed that the numbber of fifties is majorith. 2. distribution of diagnostic stage, in descending order; stage Ⅲ(53%, top), stagew Ⅵ(45.8%). 3. The effects of maintenance and improvement in the symptoms with traditional oriental therapy(83.3%) and combined treatment of westem and oriental therapy(92.1%)were boserved. The effects of the symptoms were as folows: diarrhea(37.3%),abdominal pain (25.3%), general body weakness(22.9%), nausea(20.5%) and etc. in orders. 4. Analysis of hematology attached by colorectal cancer, maintenance and increasing of WBC(89.9%), RBC(74.7%), Hgb(81.1%), Platelet(92.4%) were Observed. After taken Hangamdan, the satety of the liver and kidney were as follows; maintenance and decreasting of AST(85.9%), ALT(94.8%) , GTP(87.5%), Creatinine(90.9%) were observed. 5. of IL-12 and IFN-λ attached by colorectal cancer, increasing of IL-12(53.3%), IFN-λ(80%) were observedl. 6. Analysis of QOL attached by colorectal cancer, maintenance and improvement of combined treatment of western and oniental therapy(89.6%), traditional oriental therapy(83.3%) were observed. 7. Analysis of survival in patients with Ⅳ stage of colorectal cancer, above 7 months(18.4%), 12 months(65.8%). 8. Analysis of antitumor effects, maintenance of traditional oriental therapy(83.3%) and maintenance and improvement of combined treatment of western and oriental therapy(80.5%) were observed. Analysis of tumor marker attached by colorectal cancer, maintenance and decreasing of CEA(78.8%) were boserved 9. Analysis of curative valuation, maintenance and improvement of traditional oriental therapy(83.3%), combined treatment of westem and oriental therapy(72.7%) were observed.