조선대학교 의과대학 유급제도 개선을 위한 예비조사

박종,박상기,박상학,도남용,송창훈,이승일,임성철 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

This is a pilot study to improve the flunk system, a self-reported questionnaire survey was done by 58 professors among a total of 94 professors at Chosun University Medical School in December 1997. The results were as follows : 1. In regard to the student's residence, 69% of professors answered that the current system was appropriate. For a proper method of flunking. 46.6% of the professors agreed to the introduction of retesting by the Academic Affairs Department and 44.8% of the professors agreed to the evaluation of academic achievement of each subject. 2. Sixty-seven point two percents of professors agreed to the changing of time of flunk. 43.1% felt at the end of course, 24.1% felt at midterm, and 25.9% felt that the current system. 3. In regard to flunking, 34.5% of professors thought the current system-if a student receives an F grade in to be one subject, he/she was flunked-was sufficient, but 65.6% of the professors felt needed there improvement. The method of improvement was considered was losing more than two credits-fail(32.8%), and losing more than four credits-fail(10.3%). 4. Eighty-four point five percent of the professors agreed to the necessity of flunking by grade point average(GPA) and 77.6% of the professors answered that the students who must re-register should take all designated subjects. 5. Seventy-two point four percent of the professors opposed summer or winter courses for students who flunk and 51.7% of the professors opposed the necessity of a management system for students. In conclusion, the professors in Chosun University Medical College recognized the necessity of improving the flunk system, especially, the time, method and record keeping. So a concrete follow-up study needed to improve the flunk system.

축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

의과대학 인성교육 모델개발을 위한 예비연구

송창훈,임성철,박종,이승일,도남용,박상기,박상화 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

논문 : 국립공원 탐방로 내 위험 급경사지 유지관리 방안 연구

김홍균 ( Hong Gyun Kim ),김태호 ( Tae Ho Kim ),김재학 ( Jae Hak Kim ),곽재환 ( Jae Hwan Kwak ),박성욱 ( Sung Wook Park ),최수원 ( Soo Won Choi ),송영갑 ( Young Karb Song ) 대한지질공학회 2016 지질공학 Vol.26 No.1

국립공원은 주로 산악 지형 내 조성되어 있으므로 산사태에 의한 피해 가능성을 항상 내포하고 있다. 본 연구는 산사태 연구의 일환으로 국립공원 탐방로 내 위험 급경사지를 체계적으로 유지관리하기 위한 방안을 마련하는데 목적이 있다. 국립공원에 특화된 자체 체크리스트를 제작하였으며, 전국 19개 국립공원 183개소 급경사지에 대한 실태조사가 이루어졌다. 실태조사의 최종 목적은 위험 급경사지에 대한 안정화 대책을 마련하는 것으로 현장조사와 안정해석의 과정을 거친다. 일부 급경사지에서는 위험성 판단을 위해 지상라이다 등 특수 장비를 이용한 조사를 시도하였다. 중장기 정비계획을 위한 투자우선순위 공식을 개발하였으며, 현장자료를 이용한 순위 및 위험등급을 산출하였다. 최종적으로 위험 급경사지의 향후 체계적인 관리를 위해 “국립공원 급경사지 유지관리시스템”을 개발하였으며, 모든 현장자료들은 시스템 내 DB화 되었다. National parks, which are located mainly in mountainous areas, are always at risk of damage by landslides. The goal of this study is to establish a method for systematically maintaining hazardous steep slopes along trails in national parks. We produced a checklist suitable for each of the 19 national parks nationwide and investigated 183 slopes. The aim of these investigations is to recommend appropriate slope-stability countermeasures, including field investigations and stability analysis. We made preliminary investigations at specific sites, evaluating the slope hazard using specialized equipment such as terrestrial LiDAR. An investment priority formula was developed, and ranking and hazardous grades were calculated as part of a long-term maintenance plan. Finally, to systematically manage dangerous slopes and to house all the field data within one system, we developed the “Slope Maintenance System in National Parks” based on web server that can show various information for slopes.

C-reactive protein accelerates DRP1-mediated mitochondrial fission by modulating ERK1/2-YAP signaling in cardiomyocytes

( Suyeon Jin ),( Chan Joo Lee ),( Gibbeum Lim ),( Sungha Park ),( Sang-hak Lee ),( Ji Hyung Chung ),( Jaewon Oh ),( Seok-min Kang ) 생화학분자생물학회 2023 BMB Reports Vol.56 No.12

C-reactive protein (CRP) is an inflammatory marker and risk factor for atherosclerosis and cardiovascular diseases. However, the mechanism through which CRP induces myocardial damage remains unclear. This study aimed to determine how CRP damages cardiomyocytes via the change of mitochondrial dynamics and whether survivin, an anti-apoptotic protein, exerts a cardioprotective effect in this process. We treated H9c2 cardiomyocytes with CRP and found increased intracellular ROS production and shortened mitochondrial length. CRP treatment phosphorylated ERK1/2 and promoted increased expression, phosphorylation, and translocation of DRP1, a mitochondrial fission-related protein, from the cytoplasm to the mitochondria. The expression of mitophagy proteins PINK1 and PARK2 was also increased by CRP. YAP, a transcriptional regulator of PINK1 and PARK2, was also increased by CRP. Knockdown of YAP prevented CRP-induced increases in DRP1, PINK1, and PARK2. Furthermore, CRP-induced changes in the expression of DRP1 and increases in YAP, PINK1, and PARK2 were inhibited by ERK1/2 inhibition, suggesting that ERK1/2 signaling is involved in CRP-induced mitochondrial fission. We treated H9c2 cardiomyocytes with a recombinant TAT-survivin protein before CRP treatment, which reduced CRP-induced ROS accumulation and reduced mitochondrial fission. CRP-induced activation of ERK1/2 and increases in the expression and activity of YAP and its downstream mitochondrial proteins were inhibited by TAT-survivin. This study shows that mitochondrial fission occurs during CRPinduced cardiomyocyte damage and that the ERK1/2-YAP axis is involved in this process, and identifies that survivin alters these mechanisms to prevent CRP-induced mitochondrial damage. [BMB Reports 2023; 56(12): 663-668]

약물 수송 및 분자 영상기법을 위한 나노 기술적 접근

박학수,황성주,박정숙 충남대학교 약학대학 의약품개발연구소 2007 藥學論文集 Vol.22 No.-

Nanotechnology, a multidisciplinary scientific undertaking, involves creation and utilization of materials, devices or systems on the nanometer scale. The field of nanotechnology is currently undergoing explosive development on many fronts. The technology is expected to create innovations and play a critical role in various biomedical applications, not only in drug delivery, but also in molecular imaging, biomarkers and biosensors. Target-specific drug therapy and methods for early diagnosis of pathologies are the priority research areas where nanotechnology would play a vital role. This review considers different nano-technology-based drug delivery and imaging approaches, and their economic impact on pharmaceutical and biomedical industries.

대학생의 정신건강에 관한 연구 (Ⅰ) : 1994학년도 조선대학교 신입생 일부를 대상으로 1994 Chosun University Entrants

박상학,조용래 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.2

본 연구는 본교 신입생들의 정신건강의 실태를 객관적으로 파악하고, 대학생의 정신병리에 대해 어떤 인구학적 및 심리사회적 변인들이 관련이 있는 지를 탐색적으로 고찰하고자 하였다. 1994년도 조선대학교 신입생 865명을 대상으로, SCL-90-R 및 저자들을 포함해서 김학렬 등이 개발한 1994학년도 조선대학교 신입생 실태조사 설문지를 실시하였다. 연구 결과, 1) 심리적 부적응자로 잠정 분류될 수 있는 학생의 비율이 조사 대상자 전체의 5.5%였으며, 남학생이 여학생에 비해 더 높았다. 2) 심리적 부적응 비율은 단과 대학, 재수 여부 및 부모생존(결손가정) 여부에 따라서 유의한 차이를 보이지 않았다. 3) 학생들의 정신병리와 심리사회적 변인들의 관계에서는 자기지각변인이 정신병리에 대해 가장 설명력이 큰 예언변인이었으며, 부모와의 친밀도와 고교생활 간의 상호작용 효과는 강박증 및 전반적인 심리적 부적응을 제외한 거의 모든 유형의 정신병리에 대해 유의하였다. 4) 성차는 심리적 부적응 및 간이 정신진단검사의 몇가지 임상척도에 대해 유의한 직접적인 효과가 있었으며, 또한 정신병리와 심리사회적 변인의 관계에 유의한 중재변인으로 작용하였다. 결론적으로, 조선대학교 신입생들 중 심리적 부적응자로 잠정 분류될 수 있는 학생의 비율은 몇개의 다른 대학들에 비해 낮았으며, 또한 본 연구의 결과들은 대학생의 정신건강에 대한 예방적 치료적 측면에서 중요한 기초 자료를 제공하고 있다고 사료된다. Objectives : The purposes of this study are to identify the current status of the mental health of Chosun university(CU) entrants and to explore the relationship between some demographic and psychosocial variables and psychopathology. Methods : Korean version of symptom checklist-90-revision(SCL-90-R) and the questionnaire for the survey on 1994 Cu entrants' developed by Hack-Ryul Kim et al. including authors were administered to entrants(N=865) admitted to CU in 1994. Results : 1. The percentage of entrants tentatively classifiable as psychologically maladjusted was 5.5% the total subjects surveyed, and was higher in males than in females. 2. But in that percentage the differences were not statistically significant between a) colleges, b) the groups who did or didn't experience failures in a college-entrance exam, and c) the groups who do or don't have living parents, respectively. 3) Of several psychosocial variables, self-perception was the most powerful predictor variable on the psychopathology of entrants, the interaction effect of the intimacy with parents and high school life was also significant. 4) As for sex, its direct effect on psychological maladjustment and certain scales in SCL-90-R was significant and it also played a role as a significant moderator in the relationship between psychosocial variables and psychopathology. Conclusion : It is concluded that the percentage of entrants tentatively classifiable as psychologically maladjusted in CU is lower than in some other universities, and that these results provide important basic data for the mental health of university students in terms of prevention and treatment.

O₃/H₂O₂와 O₃/Catalyst 고급산화공정에서 1,4-dioxane의 제거 특성

박진도,서정호,이학성 한국환경과학회 2006 한국환경과학회지 Vol.15 No.3

갑상선결절의 임상 및 초음차소견의 진단적 가치

박거운,박철진,박일구,신지혜,정중화,배학연,김상용 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Backgrounds: Thyroid nodule have been relatively common disease and it's prevalence estimated about 4-7%. Recently, high resolution ultrasonography has made the detection of small thyroid nodule possible, Increases in the detection of thyroid nodule have created a clinical dilemma on how to properly manage such thyroid nodules. We investigated the prevalence, clinical and ultrasonographic characterristics, and optimal diagnostic approach toward detected benign and malignant thyroid nodules. Methods: A retrosepctive review was undertaken on the 372 patients who was done Ultrasonograpy guided fine needle aspiration biopsy in Chosun University Hospital, Gwang-Ju, Korea between July 2003 and Spring 2005. Devided into four group such as benign and malignant thyroid nodule on the basis of size 1.5Cm. The review consisted of thyroid function test, antithyroid antibodies, thyroid autoantibodies, thyroid ultrasonography, fine needle aspiration biopsy in each group. Results: The prevalence of thyroid nodule malignancy rate was 18.0%. The prevalence of thyroid incidentaloma malignanct rate was 17.5%. There were no significant differences in age, sex, thyroid function test and size between the benign, malignant incidentalomas and nodule. Ultrasonographic characteristics, include ultrasonography index point showed meaningful diagnostic value for the detection of malignancy in thyroid nodule, Conclusion: Thyroid cancers are fairly common finding. There are no clinical difference between benign and malignant thyroid nodule; however, ultrasonographic findings can be used to decision of optimal management strategies 배경: 최근갑상선 초음파의 빈번한 시행으로 갑상선 결절의 발견이 증가하고 있다. 이러한 갑상선 결절중 특히 갑상션우연종을 임상적으로 어떻게 접근하고 치료를해야하는지는 적지 않는 문제가 되고 있다. 본 연구에서는 갑상선 우연종 및 직경 1.5 cm 이상의 갑상션결절의 유병률, 임상적 특징, 초음파특정 및 초음파의 진단적 유용성에 대해 알아 보았다. 방법: 2003년 7윌부터 2005년 3월까지 조선 대학교병원 내과 및 일반외과및 건강검진 센터를 통해 갑상선 초음파, 경동맥 초음파 및 경부 CT등을 통해 우연히 발견된 갑상션결절을 가진 372명을 대상으로 후향적 연구를 시행하였다. 크기 1.5 cm 미만의 양성및 악성 갑상선 결절군과 크기 1.5 cm 이상의 양성 및 악성결절로 그룹을 나누고 각 군에서 나이, 성별, 갑상선 기능검사, 항갑상선 항체, 갑상선 초음파 및 미세침흡인세포검사등을 검토하였고, 모든 갑상선 결절에 Koike (6)가 제한한 초음파지표 점수(Ultrasonographie index point)를 부여하여 각 군을 비교하였다. 결과: 분석한 갑상선 결절 372예 중 악성결절의 유병율은 18.0% (67예)였다. 갑상선 우연 종의 유병율은 81.5% (303예)였다. 갑상선 우연 종에서의 악성률은 17.5% (53예)로 나왔다. 크기 1.5 cm 이상의 양성 및 악성 갑상선 결절과 양성 및 악성 갑상선 우연종에서 나이, 성별, 갑상선 기능검사, 항갑상선항체에는 의미있는 차이가 없었다. 또한 양성 및 악성우연종에서 의 갑상선 결절크기에도 의미있는 차이는 보이지 않았다. 갑상선 결절의 초음파 지표점수만이 양성 및 악성우연종과 양성 및 악성갑상선 결절의 감별에 의미있는 차이를 보였다. 갑상 선우연종과 크기 1.5 cm 이상의 갑상선 결절에 서 양성을 나타내는 초음파지표점수는 각각 3 점과 4점으로 다르게 나타났다. 양성 및 악성 갑상선우연종의 감별에서 초음파 지표점수의 민감도는 93.6%, 특이도는 52.8%, 양성예측율은 92.4%로 나왔고, 진단적 효율은 86.4% 였으며 크기 1.5 cm 이상의 양성 및 악성 갑상선 결정의 감별에서 초음파지수 민감도는 92.7%, 특이도가 42.9%, 양성 예측도 86%, 효율 82.6%를 보였다. 결론: 갑상선결절에서의 양성 및 악성의 유무는 임상적으로 판단하기 힘들지만 갑상선 결절에서의 초음파 소견 및 초음파 지표 점수를 도입하면 이에 대한 감별에 도움을 줄 수 있다. 따라서 갑상선 초음파검사시 초음파지표점수의 사용은 향후 갑상선 결절의 진단 방향을 제시하는 중요한 길잡이가 될 수 있으리라 사료된다.

섬유판에서 음향방출원의 위치표정

박익근,김용권,윤종학,노승남,서성원 한국공작기계학회 2003 한국공작기계학회 추계학술대회논문집 Vol.2003 No.-

음향방출 신호를 이용하여 목재 섬유판(fiberboards)의 위치표정의 유용성 유무를 실험적으로 검증하였다. 위치표정의 정확도를 향상하기 위해 신호처리 방법중의 하나인 웨이블릿 변환 디노이징 기법을 활용하여 저주파수인 대칭모드(굽힘파)를 활용하고, 고주파수인 비대칭 모드(팽창파)룰 제거하여 신호를 재구성함으로써 섬유판의 위치표정시 문턱값 통과방법을 사용할 때 발생하는 도달시간차를 최소화 할 수 있음을 확인하였다. 디노이징 기법을 활용한 섬유판의 위치 표정과 굽힘강도에 대한 사상총수를 기초로 하여 목재 구조물 및 문화재의 건전성을 평가 할 수 있을 것으로 기대된다.