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김영숙,김애정,김선여,김순경 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.1
This study was conducted to investigate the effect of mulberry leaves on lipid metabolism in adult females. The subjects(n=13) intake 1.8g mulberry leaves powdered per day with the common diet. To conduct this study, anthropometric measurements, daily nutrients intake, and serum lipids(total-cholesterol, HDL-cholesterol, triglycerides, LDL-cholesterol) were measured 3 times(before, after 2week and 4week during the experimental periods). The results are as follows: Serum LDL-cholesterol contents were significantly(P<0.05) decreased with treatment of mulberry leaves powder. And serum total-cholesterol and triglycerides were decreased, but did not show significant differences.
한방 다이어트 식품 HBM(Healthy Body Maker)의 체중감소 및 혈청 콜레스테롤 저하 효과
박재상,김애정,김선여 동아시아식생활학회 2001 동아시아식생활학회지 Vol.11 No.4
This study was performed to investigate the effects of HBM(Healthy Body Maker) on the weight loss and serum cholesterol level of rats. Twenty male Sprague-Dawley rats weighing 200±5g were grouped into 2. Rats were raised for 6 weeks with diet containing 0% and 5% of HBM. 1. There were no clinical signs for all the experimental period(6 weeks) in 0% and 5% groups. 2. At 3 and 6 weeks, body weight of 5% HBM group was significantly lower than that of control group. respectively (p<0.05, p<0.01). 3. At 4 weeks, the level of MCHC of 5% HBM group was significantly higher than that of control group(p<0.01). And at 6 weeks the level of RBC and Hct of 5% HBM group were significantly higher than those of control group(p<0.05). 4. At 6 weeks, the level of serum cholesterol of 5% HBM group was significantly lower than that of control group. 5. Absolute liver weight of 5% HBM group was significantly lower than that of control group(p<0.05). 6. Minor subaceous sickness of liver cell in the control group appeared but no symptom of liver cell in 5% HBM group, It is concluded that HBM was a safe and effective diet food which aided in inducing weight loss in rat without any observed harmful clinical side effects.
황금(黃芩)의 4-VO로 유발한 흰쥐뇌허혈에 대한 신경방어효과
李秉哲,林康鉉,金榮玉,金善礪,安德均,朴虎君,金護哲 대한본초학회 1999 大韓本草學會誌 Vol.14 No.2
Scutellariae Radix(SR), the root of Scutellaria baicalensis G_EORGI, whose property, flavour and channel tropism is bitter in flavour, cold in property(寒), acting on the lung, gallbladder, stomach and large intestine channels(歸?,?,?,大??), has the effects of clearing away heat and dampness(淸熱??), purging fire, detoxicating(?火解?), stopping bleeding(止血) and preventing miscarriage(安?). This drug is one of the popular drugs in traditional Korean medicine, which has been used to antipyretic, antibacterial, antitoxic and antihypersensitive effects. So this study was planned to check the neuroprotective effect of SR on the global ischemia induced by 4-vessel occlusion in Wister rats. and SR extract was lyophilized after extraction with 70% methanol. We induced 4-vessel occlusion for 10 minutes and reperfused again. The number of CA1 pyramidal neurons were counted after 7 days of reperfusion under the cresyl violet staining. The result obtained that in 4-VO ischemia, SR showed significantly neuroprotective effects(1,000 and 500 ㎎/㎏ of SR extracts, p<0.05) compared with control group. Each neuroprotective ratio was about 27.4 %, 23.2 % respectively. Consequently, Scutellariae Radix has neuroprotective effects on the global ischemia induced by 4-vessel occlusion in Wistar rats.
Protective effects of a novel herbal decoction on focal cerebral ischemia in a rodent model
Kim, Myung-Gyou,Choi, Jae-Hwan,Lim, Jong-Pil,Kim, Dae-Keun,Shin, Tae-Yong,Boo, Yungmin,Kim, Sun-Yeou,Kim, Hocheol,Ha, Eunyoung,Park, Hun-Kuk,Kim, Jeongseon,Lim, Ha-Sup,Kim, Ee-Hwa,Kim, Jeung-Beum,Leem Informa UK (TaylorFrancis) 2007 Neurological research Vol.29 No.suppl1
사염화탄소에 의하여 유발된 흰쥐의 간 독성에 미치는 비테인의 효과
김선여(Sun Yeou Kim),김홍표(Hong Pyo Kim),이미경(Mi Kyeong Lee),변순정(Soon Jeong Byun),김승희(Seung Hee Kim),문애리(A Ree Moon),한형미(Hyung Mi Han),허훈(Hoon Huh),김영중(Young Choong Kim) 대한약학회 1993 약학회지 Vol.37 No.5
Effects of betaine, a major component of Lycii Fructus, on carbon tetrachloride intoxicated rats were evaluated. Histological studies showed that betaine had improved the typical necrosis around centrilobular area in liver tissue due to the carbon tetrachloride intoxication. Betaine, whether it was administrated simultaneously or prior to carbon tetrachloride, prevented or retarded the elevation of liver-weight/body-weight ratio due to the carbon tetrachloride intoxication. Betaine also significantly elevated the reduced activities of some enzymes, cytochrome P-450, 7-ethoxycoumarin-O-deethylase and glutathione-S-transferase, involved in xenobiotic metabolism due to carbon tetrachloride intoxication. These results demonstrate a possible hepato-protective role of betaine against fatty liver that could be easily induced by carbon tetrachloride in rat.
일차 배양한 흰쥐의 간세포에서 사염화탄소로 인한 독성에 미치는 비테인의 효과
김선여(Sun Yeou Kim),김홍표(Hong Pyo Kim),이미경(Mi Kyeong Lee),김승희(Seung Hee Kim),문애리(A Ree Moon),한형미(Hyung Mi Han),허훈(Hoon Huh),김영중(Young Choong Kim) 대한약학회 1993 약학회지 Vol.37 No.5
Betaine, a major component of Lycii Fructus, was evaluated for its anti-hepatotoxic activity on carbon tetrachloride-induced hepatotoxicity in primary cultured rat hepatocytes. Betaine was found to attenuate carbon tetrachloride-induced hepatotoxicity both morphologically and biochemically. Typical hepatocyte necrosis due to carbon tetrachloride seemed to be reduced by 50 to 500mcM of betaine under microscopical observation. The value of glutamic pyruvic transaminase released from the hepatocytes into the medium significantly decreased as betaine concentration increased. Betaine also significantly elevated the reduced activities of some enzymes, cytochrome P-450, 7-ethoxycoumarin-O-deethylase and glutathione-S-transferase, involved in xenobiotic metabolism due to carbon tetrachloride-induced hepatotoxicity. These results demonstrate a possible hepato-protective role of betaine against fatty liver that could be easily induced by carbon tetrachloride.
뽕잎추출물이 콜레스테롤 투여 흰쥐의 혈청지질에 미치는 영향
김선여(Sun-Yeou Kim),이완주(Won-Chu Lee),김현복(Hyun-Bok Kim),김애정(Ae-Jung Kim),김순경(Soon-Kyung Kim) 한국식품영양과학회 1999 한국식품영양과학회지 Vol.27 No.6
뽕잎이 고지혈증에 미치는 영향을 알아보기 위하여 고지혈증이 유도된 흰쥐의 뽕잎추출물을 경구투여한 후 혈청학ㆍ조직학적인 검사를 행하였고, 부가적으로 뽕잎이 인체의 지질대사에 미치는 영향을 조사하였다. 뽕잎추출물을 흰쥐의 각각 0.1g/㎏ of body weight과 1g/㎏ of body weight의 농도로 투여함으로써 총 콜레스테롤과 중성지질 함량을 유의성있게 감소시켰고 또한 총 콜레스테롤 중의 HDL-콜레스테롤이 차지하는 비와 lipase의 활성을 증가시켰다. 이러한 혈청학적인 결과는 조직학적인 검사를 통하여 확인할 수 있었고 인체실험에서도 동물실험에서와 같은 경향을 나타냈고 특히 뽕잎파우더의 투여로 중성지질이 유의적으로 감소하였다. This study was conducted to investigate the effect of mulberry leaves on lipid metabolism in cholesterol-induced hypercholesterolemia rats. The mulberry treatment group showed decreases of serum lipid concentration compared with hyperlipidemic group. Also, Mulberry leaves inhibited the activity of HMG-Co A reductase, increased lipase activity. In histopathological examination, abdominal aorta showed no critical lesions with mulberry leaves treatment. These results suggest that hypolipidemic effects of mulberry leaves on rats were the inhibition of cholesterol synthesis and acceleration of cholesterol catabolism in the liver. For human, serum triglyceride contents were more significantly decreased with treatment of mulberry leaves powder.
Nocatriones A and B, Photoprotective Tetracenediones from a Marine-Derived <i>Nocardiopsis</i> sp.
Kim, Min Cheol,Hwang, Eunson,Kim, Taejung,Ham, Jungyeob,Kim, Sun Yeou,Kwon, Hak Cheol American Chemical Society and American Society of 2014 Journal of natural products Vol.77 No.10
<P>Two new tetracenedione derivatives, nocatriones A (<B>1</B>) and B (<B>2</B>), were discovered from the culture broth of a marine actinomycete, <I>Nocardiopsis</I> sp. KMF-002, which was isolated from the tissue of an unidentified dark purple marine sponge. The structures of <B>1</B> and <B>2</B>, which are tetracenediones containing α-pyrone substituents, were determined to be 3,8,10,11-tetrahydroxy-2-(4-hydroxy-2-oxo-2<I>H</I>-pyran-6-yl)-1-methyltetracene-5,12-dione (<B>1</B>) and 3,8,10,12-tetrahydroxy-2-(4-hydroxy-2-oxo-2<I>H</I>-pyran-6-yl)-1-methyltetracene-6,11-dione (<B>2</B>). Ultraviolet B (UVB)-irradiated cells treated with 10 μM nocatrione A (<B>1</B>) significantly decreased the level of MMP-1, a protein that degrades collagen and other extracelluar matrix components that comprise dermal tissue, when compared to untreated cells. These results support that nocatriones A (<B>1</B>) and B (<B>2</B>) may show antiphotoaging activity in UVB-irradiated models.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2014/jnprdf.2014.77.issue-10/np5006086/production/images/medium/np-2014-006086_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np5006086'>ACS Electronic Supporting Info</A></P>
( Sun Yeou Kim ),( Ji Ho Park ),( Ye Ji Hong ),( Seul A Kim ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.4
In this study, we found that Forsythiae fructus (FF) and one of its main compounds, arctigenin, signifi cantly inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Arctigenin also suppressed the expression of inducible nitric oxide synthase and cyclooxygenase-2, and inhibited the activation of extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38. Moreover, it also reduced levels of proinfl ammatory cytokines, interleukin 1β, tumor necrosis factor α and prostaglandin E2, and inhibited neuronal death in LPS-treated organotypic hippocampal cultures. Therefore, we suggest that arctigenin may confer a neuroprotective effect via the inhibition of neuroinfl ammation.