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김태균,양희주,김규로,선양래 慶熙大學校 大學院 1995 高凰論集 Vol.16 No.-
In this paper, the pole placement design theory is applied to position control system of DC servo motor. The DC servo motor is modelled by second order linear time invariant system. We assume that All state variables are measurable and are available for feedback. If the system considered is completely state controllable, then poles of the close-loop system may be placed at any desired locations by means of state feedback through an appropriate state feedback gain matrix K. This design method called the pole placement. Proposed pole placement design has superior performance in unit step response. The pole placement design theory is very useful to drive the position control system of DC servo motor.
Molecular and functional characterization of a PEX14 cDNA from rice
Lee, Jung-Ro,Lee, Kyun-Oh,Park, Jin-Ho,Yoo, Ji-Young,Kang, Jae-Sook,Jeon, Hye-Sook,Kim, Sun-Young,Lee, Young-Mi,Kim, Sun-Tae,Lim, Chae-Oh,Bahk, Jeong-Dong,Cho, Moo-Je,Lee, Sang-Yeol Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-
In contrast to the translocation mechanisms determined in yeasts and mammalian cells, there is little information on the functions of plant peroxisomal proteins or their genomic structures. To understand the role that PEX14 plays in diverse plant peroxisomal functions and how peroxisomal translocation is mediated in plant cells, we cloned a 1827 bp cDNA encoding the peroxisomal membrane protein OsPex14p from a rice leaf cDNA library. The 54kDa OsPex14p, which has a theoretical pI value of 6.06, contains a highly conserved N-terminal domain and a short putative transmembrane domain. The OsPEX14 gene in the rice genome exists as a single-copy gene, consists of eleven exons interrupted by ten introns, and spans about 5kb of chromosome 5. The 5′-flanking region contains putative cis-acting light-responsive elements, and the transcription initiation site maps 114bp upstream of the translation start codon. OsPEX14 mRNA is highly expresssed in leaf tissues and is induced by exposure to several stresses. Heterologous expression of OsPex14p suppresses the defect in targeting of peroxisomal matrix proteins in a pex14 null mutant of Saccharomyces cerevisiae.
Lee, Jung Ro,Jang, Ho Hee,Park, Jin Ho,Jung, Ji Hyun,Lee, Seung Sik,Park, Soo Kwon,Chi, Yong Hun,Moon, Jeong Chan,Lee, Young Mee,Kim, Sun Young,Kim, Jae-Yean,Yun, Dae-Jin,Cho, Moo Je,Lee, Kyun Oh,Lee, Blackwell Publishing Ltd 2006 The Plant journal Vol.47 No.3
<P>Summary</P><P>Using the rice <I>PEX14</I> cDNA as a bait in a yeast two-hybrid assay, two splice variants of the type I peroxisomal targeting signal (PTS1) receptor, <I>Os</I>Pex5pL and <I>Os</I>Pex5pS, were cloned from a pathogen-treated rice leaf cDNA library. The proteins were produced from a single gene by alternative splicing, which generated a full-length variant, <I>OsPEX5L</I>, and a variant that lacked exon 7, <I>OsPEX5S</I>. <I>Os</I>Pex5pL contained 11 copies of the pentapeptide motif WXXXF/Y in its N-terminus, and seven tetratricopeptide repeats in its C-terminus. Expression of <I>OsPEX5L</I> and <I>OsPEX5S</I> predominantly occurred in leaf tissues, and was induced by various stresses, such as exposure to the pathogen <I>Magnaporthe grisea</I>, and treatment with fungal elicitor, methyl viologen, NaCl or hydrogen peroxide. The Arabidopsis T-DNA insertional <I>pex5</I> mutant, <I>Atpex5</I>, which does not germinate in the absence of sucrose and was resistant to indole-3-butyric acid (IBA), was perfectly rescued by over-expression of <I>Os</I>Pex5pL, but not by <I>Os</I>Pex5pS. Using transient expression of <I>Os</I>Pex5pL and <I>Os</I>Pex5pS in the <I>Atpex5</I> mutant, we show that <I>Os</I>Pex5pL translocates both PTS1- and PTS2-containing proteins into the peroxisome by interacting with <I>Os</I>Pex7p, whereas <I>Os</I>Pex5pS is involved only in PTS1-dependent import in Arabidopsis.</P>
Choi Soohwan,Ro Sun Kyun,Moon Seok Whan 대한심장혈관흉부외과학회 2024 Journal of Chest Surgery (J Chest Surg) Vol.57 No.2
Background: Early non-small cell lung cancer (NSCLC) that abuts adjacent structures requires careful evaluation due to its potential impact on postoperative outcomes and prognosis. We examined stage I NSCLC with invasion into adjacent structures, focusing on the prognostic implications after curative surgical resection. Methods: We retrospectively analyzed the records of 796 patients who underwent curative surgical resection for pathologic stage IA/IB NSCLC (i.e., visceral pleural invasion only) at a single center from 2008 to 2017. Patients were classified based on tumor abutment and then reclassified by the presence of visceral pleural invasion. Clinical characteristics, pathological features, and survival rates were compared. Results: The study included 181 patients with abutting NSCLC (22.7% of all participants) and 615 with non-abutting tumors (77.3%). Those with tumor abutment exhibited higher rates of non-adenocarcinoma (26.5% vs. 9.9%, p<0.01) and visceral/lymphatic/vascular invasion (30.4%/33.1%/12.7% vs. 8.5%/22.4%/5.7%, respectively; p<0.01) compared to those without abutment. Multivariable analysis identified lymphatic invasion and male sex as risk factors for overall survival (OS) and disease-free survival (DFS) in stage I NSCLC measuring 3 cm or smaller. Age, smoking history, vascular invasion, and recurrence emerged as risk factors for OS, whereas the presence of non-pure ground-glass opacity was a risk factor for DFS. Conclusion: NSCLC lesions 3 cm or smaller that abut adjacent structures present higher rates of various risk factors than non-abutting lesions, necessitating evaluation of tumor invasion into adjacent structures and lymph node metastasis. In isolation, however, the presence of tumor abutment without visceral pleural invasion does not constitute a risk factor.
남승혁 ( Seung Hyuk Nam ),노선균 ( Sun Kyun Ro ),정진환 ( Jin Hwan Cheong ),박기철 ( Ki Chul Park ),이철범 ( Chul Burm Lee ) 대한외상학회 2013 大韓外傷學會誌 Vol.26 No.4
Rupture of the esophagus after blunt trauma is a rare event. But any type of esophageal rupture has the high morbidity and mortality rate. In these situations, the sign and symptom of the esophageal rupture is subtle and nonspecific; therefore, the physicians are usually not suspicious. Delaying in diagnosis prevents proper treatment (surgical or non-surgical) before significant complications occurred. We report a case of a cervical esophageal perforation with primary repair and drainage after blunt trauma.
Soohwan Choi,Hyung Suk Kim,Kyueng-Whan Min,Yung-Kyun Noh,Jeong-Yeon Lee,Ji-Yong Moon,Un Suk Jung,Mi Jung Kwon,Dong-Hoon Kim,Byoung Kwan Son,Jung Soo Pyo,Sun Kyun Ro 대한의학회 2024 Journal of Korean medical science Vol.39 No.2
Background: Tumor spread through air spaces (STAS) is a recently discovered risk factor for lung adenocarcinoma (LUAD). The aim of this study was to investigate specific genetic alterations and anticancer immune responses related to STAS. By using a machine learning algorithm and drug screening in lung cancer cell lines, we analyzed the effect of Janus kinase 2 (JAK2) on the survival of patients with LUAD and possible drug candidates. Methods: This study included 566 patients with LUAD corresponding to clinicopathological and genetic data. For analyses of LUAD, we applied gene set enrichment analysis (GSEA), in silico cytometry, pathway network analysis, in vitro drug screening, and gradient boosting machine (GBM) analysis. Results: The patients with STAS had a shorter survival time than those without STAS (P < 0.001). We detected gene set-related downregulation of JAK2 associated with STAS using GSEA. Low JAK2 expression was related to poor prognosis and a low CD8+ T-cell fraction. In GBM, JAK2 showed improved survival prediction performance when it was added to other parameters (T stage, N stage, lymphovascular invasion, pleural invasion, tumor size). In drug screening, mirin, CCT007093, dihydroretenone, and ABT737 suppressed the growth of lung cancer cell lines with low JAK2 expression. Conclusion: In LUAD, low JAK2 expression linked to the presence of STAS might serve as an unfavorable prognostic factor. A relationship between JAK2 and CD8+ T cells suggests that STAS is indirectly related to the anticancer immune response. These results may contribute to the design of future experimental research and drug development programs for LUAD with STAS. Background: Tumor spread through air spaces (STAS) is a recently discovered risk factor for lung adenocarcinoma (LUAD). The aim of this study was to investigate specific genetic alterations and anticancer immune responses related to STAS. By using a machine learning algorithm and drug screening in lung cancer cell lines, we analyzed the effect of Janus kinase 2 (JAK2) on the survival of patients with LUAD and possible drug candidates. Methods: This study included 566 patients with LUAD corresponding to clinicopathological and genetic data. For analyses of LUAD, we applied gene set enrichment analysis (GSEA), in silico cytometry, pathway network analysis, in vitro drug screening, and gradient boosting machine (GBM) analysis. Results: The patients with STAS had a shorter survival time than those without STAS (P < 0.001). We detected gene set-related downregulation of JAK2 associated with STAS using GSEA. Low JAK2 expression was related to poor prognosis and a low CD8+ T-cell fraction. In GBM, JAK2 showed improved survival prediction performance when it was added to other parameters (T stage, N stage, lymphovascular invasion, pleural invasion, tumor size). In drug screening, mirin, CCT007093, dihydroretenone, and ABT737 suppressed the growth of lung cancer cell lines with low JAK2 expression. Conclusion: In LUAD, low JAK2 expression linked to the presence of STAS might serve as an unfavorable prognostic factor. A relationship between JAK2 and CD8+ T cells suggests that STAS is indirectly related to the anticancer immune response. These results may contribute to the design of future experimental research and drug development programs for LUAD with STAS.
MicroRNA signature for HER2-positive breast and gastric cancer.
Kang, Han Sung,Kim, Joseph,Jang, Sang-Geun,Kwon, Sun Young,Park, Young Soo,Green, Jeffrey E,Kim, Hark Kyun,Ro, Jungsil Potamitis Press 2014 Anticancer research Vol.34 No.7
<P>The molecular mechanism for aggressive clinical behaviour related to v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2) amplification is not fully-understood. In particular, little is known about microRNAs in the human epidermal growth factor receptor 2 (HER2) signaling network.</P>