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RISS 인기검색어
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- 저자 : Sun Der Sheng (검색결과 25 건)
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Der Sheng Sun,이현용,임현우,원혜성,고윤호 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.4
Background/Aims: The purpose of the study is to investigate the associations between sarcopenia and health-related quality of life in elderly men and women in Korea. Methods: In a cross-sectional study using data from 2008 to 2011 Korean National Health and Nutrition Examination Survey, 4,937 adults aged 60 years and older who underwent a dual-energy X-ray absorptiometry scan were included in the study. Sarcopenia is defined as an appendicular skeletal muscle index of two standard deviations or more below the mean for young, healthy reference populations. The health-related quality of life was measured using the EuroQol-5 dimension questionnaire. Results: The overall prevalence of sarcopenia was 6.6% in these Korean people over the age of 60 years: 11.1% for men and 3.2% for women. Sarcopenic men tended to have lower income, lower physical activity, lower body mass index, and smaller waist circumference compared with nonsarcopenic men. Sarcopenic women tended to have higher body mass index and larger waist circumference compared with nonsarcopenic women. Sarcopenic men showed higher impairments in mobility, self-care, usual activities, and pain/discomfort compared with nonsarcopenic men. Women with sarcopenia also showed higher impairments in mobility, self-care, usual activities, and anxiety/depression compared with nonsarcopenic women. Sarcopenia showed an association with impairments in selfcare for men, and with impairments in self-care, usual activities, and anxiety/ depression for women, after adjusting for other confounding factors. Conclusions: There is a significant association between sarcopenia and impaired health-related quality of life in this elderly Korean population, and these results differ between men and women.
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Der Sheng Sun,Hye Sung Won,Soon Auck Hong,Ji Hyung Hong,Heejoon Jo,Heejin Lee,Okran Kim,Myung Ah Lee,Yoon Ho Ko 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.2
Background/Aims: Hyaluronic acid (HA) regulates cell adhesion, migration and proliferation in various cancers. The clinical implications of HA in resected head and neck squamous cell carcinoma have not been elucidated. We investigated the clinical significance and prognostic value of the expression of tumoral and stromal HA and its related proteins in oropharyngeal and oral cavity cancer. Methods: Resected tissues from oropharyngeal or oral cavity cancer patients undergoing surgery were analysed in tissue microarrays divided into stroma and cancer panels. The expression levels of HA, HA synthases and hyaluronidases were also assessed by immunohistochemistry. Results: A total of 160 resected oropharyngeal or oral cavity cancer tissues were analysed. Stromal HA expression was observed more frequently in human papilloma virus (HPV)-negative tumors, but other clinicopathological characteristics did not differ. In patients with HPV-negative oral cavity cancers, high stromal HA expression was associated with significantly shorter recurrence-free survival and overall survival compared with low stromal HA expression. The expression of HA in both tumors and stroma was significantly correlated with poorer outcomes than other combinations in patients with HPV-negative oral cavity cancers. However, these prognostic roles of HA were not observed in patients with HPV-negative oropharyngeal cancers. In the HPV-stratified multivariate analysis, high stromal HA expression remained an independent indicator of poor prognosis in terms of recurrence-free survival. Conclusions: High stromal HA and expression of HA in both tumors and stroma were correlated with poor prognosis in HPV-negative oral cavity cancer, but not in HPV-negative oropharyngeal cancers.
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Der Sheng Sun,Yoon Ho Ko,Jong Youl Jin,In Sook Woo,Suk Young Park,Yun Ae Eom,Jin Hyoung Kang,Hoon Kyo Kim 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.3
Background/Aims: We compared the efficacy of the granisetron transdermal system (GTS) with that of ondansetron for controlling chemotherapy-induced nausea and vomiting (CINV) in patients treated with highly emetogenic chemotherapy (HEC). Methods: We randomized a total of 389 patients to groups treated by GTS and ondansetron before HEC. The primary endpoint was the percentage of patients achieving complete response (CR; no retching/vomiting/rescue medication) of CINV from the time of chemotherapy initiation to 24 hours after the last administration of chemotherapy (prespecified non-inferiority margin of 15%). Quality of life (QoL) was also assessed using the Functional Living Index-Emesis (FLIE). Results: The per protocol analysis included 152 (47.80%) and 166 patients (52.20%) in the GTS and ondansetron groups, respectively. In the full analysis set, the most common diagnosis, regimen, and period of chemotherapy were lung cancer (149 patients, 40.27%), cisplatin-based regimen (297 patients, 80.27%), and 1 day chemotherapy (221 patients, 59.73%). The CR rates were 86.84% and 90.36% in the GTS and ondansetron groups, respectively; the treatment difference was −3.52% (95% confidence interval, −10.52 to 3.48) and met the primary endpoint, indicating that GTS was not inferior to ondansetron. Patient satisfaction, assessed on the FLIE, showed significantly higher scores in the GTS group compared to the ondansetron group (mean ± standard deviation, 1,547.38 ± 306.00 and 1,494.07 ± 312.05 mm, respectively; p = 0.0449). Conclusions: GTS provided effective, safe, and well-tolerated control of CINV and improved the QoL in HEC.
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손덕승 ( Der Sheng Sun ),장재혁 ( Jae Hyuck Chang ),남관우 ( Kwan Woo Nam ),권정현 ( Jung Hyun Kwon ),서정필 ( Jung Pil Suh ),박호성 ( Ho Sung Park ),백창렬 ( Chang Nyol Paik ),박재명 ( Jae Myung Park ),조유경 ( Yu Kyung Cho ) 대한소화기기능성질환·운동학회 2007 Journal of Neurogastroenterology and Motility (JNM Vol.13 No.1
Achalasia is characterized by esophageal nonperistaltic contraction and incomplete relaxation of the lower esophageal sphincter with swallowing, as can be seen on esophageal manometry. Since the low esophageal sphincter in gastroesophageal reflux disease (GERD) is hypotensive or inappropriately relaxed, achalasia has been considered quite distinct from GERD. The food in the low esophagus of a patient with achalasia can ferment and cause inflammation. GERD should be differentiated from retention esophagitis. We recently experienced a 32-year-old male patient who complained of chest pain. He was previously diagnosed with a variant of angina pectoris, but his symptoms did not improve with calcium channel blocker or nitrate. He was diagnosed with reflux esophagitis on esophagogastroduodenoscopy and 24 hour esophageal pH monitoring, and also with achalasia on the esophageal manometry. After esophageal balloon dilatation for treating the achalasia, his symptoms were much improved. (Kor J Neuro-gastroenterol Motil 2007;13:72-75)
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