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RISS 인기검색어
- 검색키워드
- 저자 : Suman Poudel (검색결과 3 건)
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Mingyue Jiang,Suman Poudel,Kyung Song 대한약학회 2023 Archives of Pharmacal Research Vol.46 No.8
Natural compounds known as phytochemicals have served as valuable resources for the development of new anti-cancer drugs and treatment of malignancies. Among these phytochemicals, baicalein is an emerging anti-tumor flavonoid obtained from Scutellaria baicaleinsis (Lamiaceae), but its underlying mechanisms of action and molecular targets have not yet been completely elucidated. Here, we identified new mechanisms for the anti-tumor activities of baicalein, providing evidence that hyaluronan-mediated motility receptor (HMMR) and androgen receptor (AR) are new molecular targets of baicalein in human cancer cells. We observed that HMMR, known to be highly associated with poor prognosis in a wide range of human cancers, was substantially downregulated by baicalein at mRNA and protein levels. Reporter assays further revealed that the suppression of HMMR by baicalein might occur through a transcriptional regulatory mechanism with the participation of Egr-1, E2F3α, and serum response factor (SRF). We also found that baicalein significantly inhibits androgenic responses in hormone-responsive prostate cancer cells, indicating that this might be attributed to the downregulation of AR promoter activity by baicalein. Additionally, baicalein markedly induced the expression of tumor suppressive miR-30C, which might be partly involved in baicalein-mediated autophagy and anti-cancer effects. Overall, our study sheds light on new diverse mechanisms of the anti-cancer effects exhibited by baicalein, implying that baicalein could be a potential therapeutic agent against human cancers and function as an inhibitor of HMMR and AR.
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Clay Therapy in Wound Healing: A Brief Review of the Literature
Ovincy Cene,Babel Shrinit,Baral Suman,Poudel Shasi,Jain Surbhi 대한창상학회 2024 Journal of Wound Management and Research Vol.20 No.1
Clay is ubiquitous, and its hydrous phyllosilicate properties have promoted its use as a traditional wound healing agent in many cultures. Various types of natural clay have been utilized for skin diseases and wound treatments. Therefore, we aimed to study natural and synthetic clay minerals and summarize their applicability in medical settings. A review of prospective studies published since 2008 examining the properties of different forms of natural clay minerals and their therapeutic benefits in wound care was conducted. Studies were obtained using the databases of Google Scholar, PubMed, Web of Science, and HINARI (Health Inter-Network Access to Research Initiative) and searching related journals. The primary outcomes were assessed qualitatively and were categorized by the type of natural clay used. The included papers studied five available types of clay: Chamliyal clay, French green clay, Oregon Mineral Technologies blue clay, Kisameet clay, and various synthetic clays. The studies found how these forms of clay together demonstrate anti-inflammatory and antibacterial properties while promoting fibroblast regeneration and circulation while remaining biocompatible. Clay-based materials may be a potential alternative for conventional dressings for wound healing in resource-limited settings. This review opens doors to expanding clay-based therapies for wound healing.
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