Plenary Session 2 : PS-2-1 ; Outcomes of hepatitis B virus recurrence after liver transplantation: a multicenter analysis in Korea

( Hee Yeon Kim ),( Jong Young Choi ),( Dong Goo Kim ),( Myoung Soo Kim ),( Soon Il Kim ),( Shin Hwang ),( Sung Gyu Lee ),( Kwang Woong Lee ),( Kyung Suk Suh ),( Young Seok Han ),( Dong Lak Choi ),( Se 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: The outcome of hepatitis B virus (HBV) infection after liver transplantation (LT) was improved by hepatitis B immunoglobulin (HBIG) and nucles(t)ide analogue (NUA). However, HBV recurrence after LT is critical because the recurrence is occasionally accompanied by a progressive destruction of graft and poor survival. The aims of this study were to investigate the significance HBV recurrence and identity factors associated with HBV recurrence. Methods: From October 1999 to February 2011, a total of 2684 consecutive LT recipients who underwent HBV-associated LT were retrospectively enrolled from 7 transplantation centers in Korea. Results: Prophylaxis regimens were HBIG monotherapy (67.7%) or a combination of HBIG with NUA (22.3%). The recurrence rate of HBV was 6.1% (164 recipients) during mean follow-up duration of 10.9 years. The median time from transplantation to recurrence was 2.1 years (0.1-7.9 years). Of the 1,071 patients with hepatocellular carcinoma (HCC) prior to LT, 155 patients (14.5%) had HCC recurrence after transplantation, and 48 patients (31.0%) had HBV recurrence. Of the 48 patients with recurrence of both HBV and HCC, 25 patients (52.1%) experienced HBV recurrence after HCC recurrence. In the multivariate analysis, pretransplant HCC, pretransplant HBV DNA above 5.5 log copies/mL was independent clinical factors influencing HBV recurrence after LT. The mortality rate among the recipients with HBV recurrence was 34.1% (56 recipients). Mean overall survival was 6.4 years in the HBV-recurrence group and 9.9 years in the HBV-nonrecurrence group (p<0.001). HBV recurrence was not an independent prognostic factor for overall survival. HCC recurrence was the most important factor for overall survival. Conclusions: The overall outcome of LT in HBV-related liver disease was excellent with the current prophylaxis regimen Choon Hyuck David Kwon,8 Suk-Koo Lee8 Pretransplant HBV DNA and HCC were important factors for HBV recurrence. HBV recurrence after LT did not significantly influence on the overall survival without combining of HCC recurrence.

분절 광배근 유리피판의 유용성

이훈범,김석원,정윤규,박윤규 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.5

Since the first report by Tansini in 1896, the latissimus dorsi muscle free flap has been widely used for various types of soft tissue defect due to reliable anatomy with a sufficient diameter of neurovascular pedicle and a sizable muscle. However, for relatively small soft tissue defect, latissimus dorsi free flap offers several distinct disadvantages of donor site including loss of the posterior axillary fold and flattening of the posterolateral chest wall, weakness of upper arm strength in extension, adduction and internal rotation. We treated three patients having various types of soft tissue defect using segmental latissimus dorsi muscular free flap depending on its descending branch of thoracodorsal neurovascular pedicles. There were no serious complications during 18 months of mean follow-up. We concluded that this method has some advantages such as no weakness of strength of the upper arm including walking on crutches, preserving the posterior axillary fold, preventing winging of the scapula and increased chance of using a flow-through technique. Here we present our cases of reconstruction of soft tissue defect using segmental latissimus dorsi free flap with a review of the literature.

DSP TMS320F240을 이용한 선형 동기 모터 드라이버 개발

이재헌,김상우,이석규,이달해 영남대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.28 No.2

This paper proposes a DSP240 based controller for brushless linear motor to enhance its performance and reliability. The designed controller is mainly composed of position, speed and current controller, which are carried out by the high-speed digital signal processor(DSP). This system is implemented by using 16-bit DSP(TMS320F240), a high-integrated logic device(EPM7128), and IPM(Intelligent Power Module) for compact and powerful system design. The experimental results show the effective performance of the proposed controller for the brushless linear synchronous motor.

Cone beam형 전산화단층촬영에 의한 흡수선량

이의태,김규태,최용석,황의환 대한구강악안면방사선학회 2007 Imaging Science in Dentistry Vol.37 No.2

Purpose : To measure the absorbed doses of cone beam computed tomography (CBCT), which is recently being more frequently used, and to compare them with those of panoramic radiography. Materials and Methods : To measure the absorbed doses of CBCT (PSR-9000N, Asahi Roentgen Ind. Co., Japan), we placed TLD chips on the skin regions above the parotid and thyroid glands, and on the dorsum of tongue in a dental head phantom. We used two image acquisition modes of the Dental and Panoramic modes of CBCT, which differed in the field of view. Also, panoramic radiographs (Auto IIIN, Asahi Roentgen Ind. Co., Japan) were taken to compare with the absorbed doses of CBCT. Result : In the Dental mode of CBCT, the absorbed doses of the parotid gland, dorsum of tongue, and thyroid gland were 3.53, 3.13, and 0.36 mGy, respectively. In the Panoramic mode of CBCT, they were 9.57, 9.15, and 0.85 mGy, respectively. The panoramic mode showed higher absorbed doses than those of the Dental mode. In the panoramic radiography, the absorbed doses of the parotid gland, dorsum of tongue, and thyroid gland were 1.21, 1.19, and 0.16 mGy, respectively. And they were about 1/3 of the Dental mode and 1/9 of the Panoramic mode of CBCT. Conclusion : Absorbed doses of CBCT are higher than those of panoramic radiography, and dependent upon the field of view.

쌍자엽식물의 자엽에 있어서 α-Amylase활성에 관한 식물생장물질의 연구 : Ⅰ. 녹두 자엽에서 α-Amylase 활성에 대한 식물 생장 조절체의 효과 Ⅰ. Effects of Plant Growth Regulator on α-Amylase Acticity in the Cotyledons of Mung Bean(Phaseolus radiatus L.)

李相淑,曺圭燦,權五溶 충남대학교 자연과학연구소 1992 忠南科學硏究誌 Vol.19 No.1

The effects of plant growth regulators on α-amylase activities in the embryonic axis-attached and detached cotyledons of mung bean (Phaseolus radiatus L.) have been investigated. α-Amylase activities in the attached cotyledons of developing mung bean have been markedly increased for 3 days after the imbibition and then gradually decreased. The changes of α-amylase activity have accorded with changes on the band density of α-amylase isozymes in the attached and detached cotyledons. Two bands of isozyme have appeared on day 3 in the attached cotyledons, but on day 4 in the detached cotyledons. When the 10^-6 M solutions of GA_3 and kinetin have been exogenously supplied in the detached cotyledons for 3 days, α-amylase activities have occurred with about 1.5-fold in GA_3 and 1.25-fold in kinetin rather than the control. α-Amylase activities have been increased with 1.8-fold in the detached cotyledons treated with the 10^-3 M and 10^-4 M solutions of IAA. In contrast with the treatment of IAA, α-amylase activities have been increased with 3.5-fold in the detached cotyledons treated with the 10^-5 M and 10^-6 M solutions of 2, 4-dichlorophenoxyacetic acid belonged to synthetic auxin. Consequently, it has been indicated that the embryonic axis in the cotyledons of mung bean has been directly influence on α-amylase activity, and the α-amylase activity of the detached cotyledons treated with a 10^-6 M solution of 2, 4-dichlorophenoxyacetic acid has developed much increased effect. For this reason, it has been suggested that auxin from the embryonic axis has been probably induced α-amylase in the attached cotyledons during germination of mung bean.

정상 관동맥을 가진 심장 점액종 환자에서 발생한 급성 심근 경색증 1예

이정민,이현승,전은정,윤호중,정욱성,오용석,김철민,김재형,최규보,홍순조,이교영,심상인 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.9

세침 흡입 생검으로 진단된 간의 혈관근지방종 1 예

이경아,유은실,민영일,김해련,심기남,정훈용,양석균,홍원선,박의련,이문규 대한소화기학회 1999 대한소화기학회지 Vol.33 No.6

Hepatic angiomyolipoma is a rare benign tumor of the liver composed of blood vessel, smooth muscle cells, fat and myelocomponent. The preoperative diagnosed of the lesion is important because of its therapeutic implications. Radiologic findings are not specific because the composed elements are variable in proportion and distribution. Thus, the findings at computed tomography, ultrasono graphy and magnetic resonance imaging may be only suggestive and its definitive diagnosed requires histologic confirmation. We experienced a case of hepatic angiomyolipoma in patient with chronic hepatitis diagnosed preoperatively by fine-needle aspiraton biopsy under ultrasound guidance. To our knowledge, this is the first case of hepatic angiomyolipoma diagnosed preoperatively in Korea. We report it with review of literatures.

방사선조사가 Porphyromonas gingivalis에 미치는 영향

이창환,김규태,최용석,황의환 대한구강악안면방사선학회 2008 Imaging Science in Dentistry Vol.38 No.1

Purpose : The aim of this study was to observe a direct effect of irradiation on the periodontopathic Porphyromonas gingivalis (P. gingivalis). Materials and Methods : P. gingivalis 2561 was exposed to irradiation with a single absorbed dose of 10, 20, 30, and 40 Gy. Changes in viability and antibiotic sensitivity, morphology, transcription, and protein profile of the bacterium after irradiation were examined by pour plating method, disc diffusion method, transmission electron microscopy, RT-PCR, and immunoblot, respectively. Results : Viability of irradiated P. gingivalis drastically reduced as irradiation dose was increased. Irradiated P. gingivalis was found to have become more sensitive to antibiotics as radiation dose was increased. With observation under the transmission electron microscope, the number of morphologically abnormal cells was increased with increasing of irradiation dose. In RT-PCR, decrease in the expression of fimA and sod was observed in irradiated P. gingivalis. In immunoblot, change of profile in irradiated P. gingivalis was found in a number of proteins including 43-kDa fimbrillin. Conclusion : These results suggest that irradiation may affect the cell integrity of P. gingivalis, which is manifested by the change in cell morphology and antibiotic sensitivity, affecting viability of the bacterium.

전분/펙틴/몬모릴로나이트 나노복합 필름의 특성 및 산소 투과도 연구

서석훈,서길수,유성구,신용섭,정세환,김성철,배광수,이태진,장상희,신부영 한국공업화학회 2003 공업화학 Vol.14 No.8

Na^(+)-MMT로부터 제조한 생분해성 전분/펙틴/몬모릴로나이트 나노복합재료의 기계적 특성, 열적 특성, 그리고 산소 투과성을 연구하였다. XRD와 TEM의 결과로부터 고분자의 삽입으로 인하여 실리케이트 층간 간격이 증가하였으며, 또한 삽입형 전분/펙틴/몬모릴로나이트 나노복합재료임을 확인하였다. 합성된 전분/펙틴/몬모릴로나이트 나노복합재료의 경우 적은 양의 MMT로부터 기계적 특성과 열적 안정성이 우수함을 보였다. 그리고 전분/펙틴/몬모릴로나이트 나노복합재료의 산소 투과성은 고분자 매트릭스에 분산되어 있는 몬모릴로나이트에 의하여 현저히 저하됨을 보여주었다. Mechanical property. thermal property. and oxygen permeability of biodegradable Pectin/Starch-montmorillonite nanocomposite, prepared with Na-MMT, have been studied X-ray diffraction and TEM experiments on polymer/silicate composite samples demonstrated that the intercalation of polymer chains leads to increase in the spacing between silicate layers. In addition, it were found that the intercalated Starch/Pectin/monotmorillonite nanocomposite were prepared. It was found that the addition of only a small amount of clay was enough to improve the thermal stability- and mechanical property of Starch/Pectin/montmorillonite nanocomposite. Oxygen permeability of Starch/Pectin/montmorillonite composite was generally lower than that of pectin/starch.

천연골재 및 재생골재콘크리트의 Na₂SO₄침식에 의한 화학저항성에 관한 실험적 연구

김규용,이정율,박유신,강석표,김무한 忠南大學校 産業技術硏究所 1998 산업기술연구논문집 Vol.13 No.1

Now a day, the more Proportion of concrete used in practice is exposed to serious chemical attack Chemical reactions that involve formation of expansive products in hardened concrete can lead to certain harmful effects. In this study, it is to compare and investigate the chemical resistance of natural and recycled aggregate concrete by attacked Na₂SO₄according to W/C ratio. The result of this study is that the chemical resistance of recycled aggregate concrete is lower than natural aggregate concrete. But it is developed the chemical resistance by decreasing the W/C ratio.