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Mixed connective tissue disease diagnosed by high serum level of anti-U1 RNP antibody
( Sang Hwa Han ),( Kang Hoon Lee ),( Joon Hee Kim ),( Myeong Hyeon Yang ),( Min Soo Jang ),( Kee Suck Suh ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Mixed connective tissue disease (MCTD) is a disorder characterized by the overlap of features of systemic lupus erythematosus, scleroderma, and dermatomyositis. Laboratory findings of MCTD show distinctively high titer of anti-U1 RNP antibody, high titer of anti nuclear antibody (ANA), and elevation of creatine phosphokinase (CPK). And histopathologically, thinning and flattening of the epidermis, dermal mucin deposition, and predominantly lymphoplasmacytic infiltrate arranged along the dermal-epidermal junction, around hair follicles and eccrine glands can be seen. A 20-year-old female presented with erythematous diffuse variable sized patches and plaques on the face and erythematous to brownish discrete plaques and erosions on the both hands and feet. In laboratory test, anti-U1 RNP antibody was elevated more than 8.0 AI (ref.: < 1.0 AI), ANA was elevated more than 1:1280 and CPK was elevated by 244 U/L (ref.: 33-211 U/L). Histopathologic findings showed epidermal atrophy, pronounced dermal edema and perifollicular inflammatory cell infiltrate. On the basis of these clinical, laboratory, and histological findings, the diagnosis of MCTD was made. The patient was treated with methylprednisolone, hydroxychloroquine, and pentoxifylline, resulting in a significant improvement in skin lesions. Herein, we report a case of MCTD for whom high serum level of anti-U1 RNP antibody was used as an helpful diagnostic test.
Klotho as a potential predictor of deceased donor kidney transplantation outcomes
Suh Min Kim,Ahram Han,Sanghyun Ahn,Sang-Il Min,Seung-Kee Min,Jongwon Ha 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.98 No.6
Purpose: Klotho is an antiaging factor mainly produced by renal tubular cells. Klotho is reportedly decreased in an animal model of acute kidney injury and patients with chronic kidney disease. However, information on Klotho expression after kidney transplantation is limited. We analyzed the correlation between donor Klotho expression and clinical outcomes of kidney transplantation. Methods: Sixty patients who underwent deceased donor kidney transplantation between March 2015 and October 2017 were enrolled. Serum and tissue Klotho expression levels were measured by enzyme-linked immunosorbent assay and immunohistochemistry, respectively. Graft function was assessed by estimated glomerular filtration rate (eGFR). Results: Patients were divided into 2 groups according to donor Klotho expression in renal tissues. A greater improvement in eGFR was observed at 1 week after transplantation in patients receiving kidneys with higher Klotho expression (47.5 ± 21.9 mL/min/1.73 m2 vs. 63.9 ± 28.2 mL/min/1.73 m2, P = 0.030). Patients were also classified into 2 groups according to donor serum Klotho level. There was a tendency for a higher eGFR at 12 months after transplantation in patients receiving kidneys from donors with a higher Klotho level (51.0 ± 18.0 mL/min/1.73 m2 vs. 61.2 ± 16.5 mL/min/1.73 m2, P = 0.059). When subgrouped into patients with or without biopsy-proven acute rejection, 12-month eGFR remained higher in patients receiving kidneys from donors with higher serum Klotho. Conclusion: Our data demonstrated that donor tissue expression of Klotho correlated with early recovery of eGFR after kidney transplantation. Donor serum Klotho level tended to be associated with posttransplant 12-month eGFR. Donor Klotho expression might be a new predictor for deceased donor kidney transplantation outcome.
Endovascular Treatment of "Kissing Aneurysms" at the Anterior Communicating Artery
Suh, Sang-Jun,Kang, Dong-Gee,Ryu, Kee-Young,Cho, Jae-Hoon The Korean Neurosurgical Society 2008 Journal of Korean neurosurgical society Vol.44 No.3
Kissing aneurysms are the rare type of multiple aneurysms. They are adjacent aneurysms of different origin arteries in the same region, which require great care in diagnosis and treatment. We report a case of kissing aneurysms at the anterior communicating artery (AcomA) which were treated by endovascular coil embolization.
Case Report : Histologic and Dermoscopic Findings of Clear Cell Acanthosis in Seborrheic Keratosis
( Kee Suck Suh ),( Sang Hwa Han ),( Jong Bin Park ),( Dong Young Kang ),( Sang Tae Kim ),( Min Soo Jang ) 대한피부과학회 2012 大韓皮膚科學會誌 Vol.50 No.12
Clear cell acanthosis is a reaction pattern of the epidermis that can be observed as the chief histopathologic finding in clear cell acanthoma and as a focal change in other epidermal lesions, such as verruca vulgaris and seborrheic keratosis. Dermoscopy is a useful noninvasive tool that permits the visualization of key vascular structures that are usually not visible to the naked eye. A 63-year-old Korean man was presented with 2 year of a well-circumscribed, dome-shaped nodule on the nipple. Our patient represents patterns of both a clear cell acanthoma and a seborrheic keratosis on dermoscopic and histopathologic finding, but, notably, on dermoscopy vascular structures were more irregular linear distribution than classic clear cell acanthoma and different from dotted vessels shown in psoriasis. In this report, we describe a case of clear cell acanthosis in seborrheic keratosis for whom dermoscopy was used as a valuable diagnostic tool. (Korean J Dermatol 2012;50(12):1081∼1083)
( Sang Jun Suh ),( Hyung Joon Yim ),( Yeon Seok Seo ),( Chang Wook Kim ),( Chang Don Lee ),( Sang Hoon Park ),( Myung Seok Lee ),( Choong Kee Park ),( Hee Bok Chae ),( Moon Young Kim ),( Soon Koo Baik 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background/Aim: Many patients with lamivudine-resistant (LAM-R) chronic hepatitis B (CHB) had been treated by switching to entecavir (ETV) 1.0mg. Although rate of resistance to ETV (ETV-R) is reported high, current medical insurance system doesn`t pay-back for change from ETV to other agent in patients whose resistance to ETV was not identified. This study was aimed to stratify ETV therapy in LAM-R patients. Methods: One hundred and ten CHB patients who occurred LMV-R and received ETV 1.0mg up to 5 years were evaluated prospectively. At 12 months of switching to ETV, we divided subjects into non-detection group (HBV DNA<20 IU/mL) and detection group (HBV DNA≥20 IU/mL), which was subdivided into low viral load group (20≤HBV DNA<2,000 IU/mL) and high viral load group (2,000 IU/mL≤ HBV DNA). Virologic response rate (VR; HBV DNA<20 IU/mL) and ETV-R were evaluated as end point. Results: One hundred and ten patents were enrolled. The mean age was 45±11years, the proportion of male and HBeAgpositive patient was 71% (80/110) and 77% (85/110), respectively. The mean serum HBV DNA levels were 6.89±1.03, 3.26±1.81, 3.06±1.82, 2.49±1.53, 2.43±1.35 and 1.73±0.87 log10IU/ ml at baseline, month 12, 24, 36, 48 and 60, respectively. The VR (95% vs. 29%, P<0.001) was higher and ETV-R (10% vs. 54%, P=0.001) was lower in non-detection group than in detection group. The VR (27% vs. 29%, P=0.853) and ETV-R (45% vs. 57%, P=0.367) was not significantly different between low viral load and high viral load group. Resistance to ETV occurred at 26±10.3 months (median 24 months, 12-48 months) in detection group. Conclusion: Resistance rates were high in patients with detectable HBV DNA at 12 months of ETV therapy. Therefore, switching to or adding a potent nucleotide analogue (e.g. tenofovir) is warranted in LAM-R CHB patients whose HBV DNA is detected after 12 months of ETV therapy.
Analysis of Lethal Genes in Jeju and Ulnung Island Population of Dorsophila melanogaster
Suh, Dong-Sang,Sung, Kee-Chang 成均館大學校 1983 論文集 Vol.33 No.-
D. melanogaster의 제주도와 울릉도집단의 致死遺傳子와 半致致死遺傳子를 分析한 結果는 다음과 같았다. 1. 第2染色體와 第3染色體를 同時에 分析하였을 때 제주도집단은 56.5%였고 울릉도집단은 50%였다. 2. 第2染色體의 致死 및 半致死因子의 頻度는 제주도집단이 42.9%였고 울릉도집단은 31%였으며 第3染色體에서는 제주도집단이 15%, 그리고 울릉도집단이 10.9%였다. 3. 致死 및 半致死因子의 頻度가 第2染色體가 第3染色體보다 有意하게 높았다. 4. 同座率은 제주도집단에서 2.5%, 그리고 울릉도집단에서 6%를 나타내었다. 5. 致死遺傳子의 消失率(IQ^2)은 제주도집단에서 0.0046, 그리고 울릉도집단에서 0.0058로 推定되었다. 6. 이들의 保有機構는 平衡假說로 說明하는 것이 타당하다고 보여지나 앞으로 보다 많은 硏究가 必要하다고 본다.
Suh, Guk-Hee,Jung, Hee Yeon,Lee, Chang Uk,Oh, Byoung Hoon,Lee, Sang-Kyu,Lee, NamJin,Kim, JaeHyun,Kee, Baik Seok,Ko, Daekwan,Kim, Young-Hoon,Ju, Young-Su,Hong, InJa,Choi, Sungku S. Karger AG 2005 DEMENTIA AND GERIATRIC COGNITIVE DISORDERS Vol.21 No.1
<P><I>Objective:</I> To investigate the effect of the apolipoprotein E (ApoE) ε4 allele on the efficacy and tolerability of galantamine treatment. <I>Methods:</I> A total of 202 patients with mild to moderate Alzheimer’s disease participated in a 16-week, prospective, multi-center, randomized, double-blind galantamine trial in a Korean population. Patients were assessed at baseline and after 4, 8 and 16 weeks of randomized treatment using the 11-item cognitive subscale of the Alzheimer’s Disease Assessment Scale (ADAS-cog/11), the Clinician’s Interview-Based Impression of Change plus Caregiver Input (CIBIC-plus), the Disability Assessment for Dementia Scale (DAD), the Behavioural Pathology in Alzheimer’s Disease Rating Scale (BEHAVE-AD) and adverse events. ApoE genotypes were determined for all subjects. <I>Results:</I> Of the 202 subjects, 115 carried at least one ApoE ε4 allele and 87 did not. In both ApoE ε4 carriers and ApoE ε4 noncarriers, significant improvements were detected relative to baseline on ADAS-cog/11, CIBIC-plus, DAD and BEHAVE-AD. ApoE ε4 noncarriers showed better improvement in mean total BEHAVE-AD score and mean psychosis (delusions and hallucinations) subscale score than ApoE ε4 carriers. The incidence of weight loss was significantly higher in ApoE ε4 carriers (n = 11; 9.6%) than in ApoE ε4 noncarriers (n = 1; 1.2%) during this 16-week study, even though 92% of patients who complained of weight loss completed this 16-week trial successfully. <I>Conclusion:</I> ApoE ε4 genotype does not affect galantamine-related improvements in cognition, global rating, function and behavior. Longer prospective studies with larger patient populations are required to confirm these new findings.</P><P>Copyright © 2006 S. Karger AG, Basel</P>
Usefulness of dermoscopy for diagnosis of pigmented spindle cell nevus
( Sang Hwa Han ),( Kang Hoon Lee ),( Joon Hee Kim ),( Myeong Hyeon Yang ),( Min Soo Jang ),( Kee Suck Suh ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Pigmented spindle cell nevus (PSCN), also known as Reed nevus, is a melanocytic lesion clinically characterized by well circumscribed hyperpigmented flat macule. PSCN should be differentiated from Spitz nevus, dysplastic nevus, and malignant melanoma. Histologically, symmetrical proliferation and linear band-like arrangement of pigmented melanophages in the papillary dermis can be seen. And uniform, narrow, elongated, and spindle shaped cells were vertically oriented in the dermal-epidermal junction. A 27-year-old male presented with solitary well demarcated 4 x 5 mm sized blackish macule on the left arm. On dermoscopy, blackish homogenous pattern and partially distributed starburst pattern were found. Histopathologic findings showed symmetrical proliferation and linear band-like arrangement of pigmented melanophages in the papillary dermis. And uniform, narrow, elongated pigmented spindle cells were vertically oriented in dermal-epidermal junction. On the basis of these clinical, dermoscopic, and histological findings, the diagnosis of PSCN was made. Dermoscopy allows one to see surface and subsurface skin structures not easily detected by the naked eye. The typical dermoscopic findings of PSCN were reported as starburst, homogenous, globular, or peripheral reticular patterns. Herein, we report a case of PSCN for whom dermoscopy was used as an helpful diagnostic tool.