Value of Bone Scintigraphy and Single Photon Emission Computed Tomography (SPECT) in Lumbar Facet Disease and Prediction of Short-term Outcome of Ultrasound Guided Medial Branch Block with Bone SPECT

( Won Uk Koh ),( Sung Hoon Kim ),( Bo Young Hwang ),( Woo Jong Choi ),( Jun Gul Song ),( Jeong Hun Suh ),( Jeong Gill Leem ),( Jin Woo Shin ) 대한통증학회 2011 The Korean Journal of Pain Vol.24 No.2

Background: Facet joint disease plays a major role in axial low-back pain. Few diagnostic tests and imaging methods for identifying this condition exist. Single photon emission computed tomography (SPECT) is reported that it has a high sensitivity and specificity in diagnosing facet disease. We prospectively evaluated the use of bone scintigraphy with SPECT for the identification of patients with low back pain who would benefit from medial branch block. Methods: SPECT was performed on 33 patients clinically suspected of facet joint disease. After SPECT, an ultrasound guided medial branch block was performed on all patients. On 28 SPECT-positive patients, medial branch block was performed based on the SPECT findings. On 5 negative patients, medial branch block was performed based on clinical findings. For one month, we evaluated the patients using the visual analogue scale (VAS) and Oswestry disability index. SigmaStat and paired t-tests were used to analyze patient data and compare results. Results: Of the 33 patients, the ones who showed more than 50% reduction in VAS score were assigned ``responders``. SPECT positive patients showed a better response to medial branch blocks than negative patients, but no changes in the Oswestry disability index were seen. Conclusions: SPECT is a sensitive tool for the identification of facet joint disease and predicting the response to medial branch block. (Korean J Pain 2011; 24: 81-86)

Clinical characteristics and outcome of pulmonary carcinoid tumors

( Bo Ra Lee ),( Sang Won Um ),( Kyeong Man Jeon ),( Won Jung Koh ),( Gee Young Suh ),( Man Pyo Chung ),( Ho Joong Kim ),( O Jung Kwon ),( Jhin Gook Kim ),( Young Mog Shim ) 대한내과학회 2009 대한내과학회 추계학술발표논문집 Vol.2009 No.-

A Case of Portal Vein Thrombosis by Protein C and S Deficiency Completely Recanalized by Anticoagulation Therapy

Bo Kyoung Choi,Soo Hyun Yang,Kang Hum Suh,Jin Ah Hwang,Moon Hyung Lee,Won keun Si,Ji Ho Kim 전남대학교 의과학연구소 2011 전남의대학술지 Vol.47 No.3

Portal vein thrombosis (PVT) is a rare form of venous thrombosis that affects the hepatic portal vein flow, which can lead to portal hypertension. Treatment of PVT includes anticoagulants,thrombolysis, insertion of shunts, bypass surgery, and liver transplantation. Single anticoagulation therapy is not regarded as a curative treatment but can be associated with a reduction in new thrombotic episodes. We experienced a case of acute total occlusion of PVT provoked by protein C and S deficiency syndrome. PVT was completely recanalized with oral anticoagulant therapy following low molecular weight heparin therapy.

Prevention of Acute/Severe Hypoglycemia-Induced Neuron Death by Lactate Administration

Won, Seok Joon,Jang, Bong Geom,Yoo, Byung Hoon,Sohn, Min,Lee, Min Woo,Choi, Bo Young,Kim, Jin Hee,Song, Hong Ki,Suh, Sang Won SAGE Publications 2012 Journal of cerebral blood flow and metabolism Vol.32 No.6

<P> Hypoglycemia-induced cerebral neuropathy can occur in patients with diabetes who attempt tight control of blood glucose and may lead to cognitive dysfunction. Accumulating evidence from animal models suggests that hypoglycemia-induced neuronal death is not a simple result of glucose deprivation, but is instead the end result of a multifactorial process. In particular, the excessive activation of poly (ADP-ribose) polymerase-1 (PARP-1) consumes cytosolic nicotinamide adenine dinucleotide (NAD<SUP>+</SUP>), resulting in energy failure. In this study, we investigate whether lactate administration in the absence of cytosolic NAD<SUP>+</SUP> affords neuroprotection against hypoglycemia-induced neuronal death. Intraperitoneal injection of sodium L-lactate corrected arterial blood pH and blood lactate concentration after hypoglycemia. Lactate administered without glucose was not sufficient to promote electroencephalogram recovery from an isoelectric state during hypoglycemia. However, supplementation of glucose with lactate reduced neuronal death by ∼80% in the hippocampus. Hypoglycemia-induced superoxide production and microglia activation was also substantially reduced by administration of lactate. Taken together, these results suggest an intriguing possibility: that increasing brain lactate following hypoglycemia offsets the decrease in NAD<SUP>+</SUP> due to overactivation of PARP-1 by acting as an alternative energy substrate that can effectively bypass glycolysis and be fed directly to the citric acid cycle to maintain cellular ATP levels. </P>

Effect of Nifedipine on Coronary and Portal Flow During Vasopressin Infusion

Bo Yang Suh,Hong Jin Kim,Hee Won Ham,Sung Hoon Kim,Koing Bo Kwun Korean Society of Critical Care Medicine 1986 Acute and Critical Care Vol.1 No.1

Vasopressin(Pitressin), when used to control gastrointestinal bleeding, has been shown to significantly reduce coronary flow. Our purpose was to determine if Nifedipine could be used to counteract Vasopressin's coronary effect. Six mongrel dogs, weighing approximately 25 kg, underwent laparotomy and left thoracotomy under Pentobarbital anesthesia. Electromagnetic flowmeter probes were used to measure blood flow in the circumflex coronary artery(CCF), the superior mesenteric artery(SVAF) and portal vein(PVFP). Portal venous pressure(PP), femoral arterial and Swan-Ganz catheters were inserted. After baseline control psrameters were recorded, Pitressin was administered at a continuous rate of 0. 04 U/kg/min. When all parameters stabilized., Nifedipine was infused at 0,3μg kg/min. Under Pitressin infusion PVP, PP, SMAF, CCF and cardiac output decreased by an average of 43.4, 73.1, 56.8, 54.8 and 59.1% respectively. When Nifedipine was added to Pitressin infusion, CCF and cardiac output increased significantly, averaging 105 and, 83.5% of control, respectively; SMAF also increased moderately to an average of 76% of control value. However, both PVF and PP remained lower than control by average of 59. 7 and 78.1% respectively. These data indicate that with Pitressin and. Nifedipine infusion PVP and PP were reduced significantly while CCF and cardiac output were preserved

Prevention of Traumatic Brain Injury-Induced Neuron Death by Intranasal Delivery of Nicotinamide Adenine Dinucleotide

Won, Seok Joon,Choi, Bo Young,Yoo, Byung Hoon,Sohn, Min,Ying, Weihai,Swanson, Raymond A.,Suh, Sang Won Mary Ann Liebert, Inc. Publishers 2012 Journal of Neurotrauma Vol. No.

<P>Traumatic brain injury (TBI) is one of the most devastating injuries experienced by military personnel, as well as the general population, and can result in acute and chronic complications such as cognitive impairments. Since there are currently no effective tools for the treatment of TBI, it is of great importance to determine the mechanisms of neuronal death that characterize this insult. Several studies have indicated that TBI-induced neuronal death arises in part due to excessive activation of poly(ADP-ribose) polymerase-1 (PARP-1), which results in nicotinamide adenine dinucleotide (NAD?) depletion and subsequent energy failure. In this study, we investigated whether intranasal administration of NAD? could reduce neuronal death after TBI. Rats were subjected to a weight-drop TBI model that induces cortical and hippocampal neuronal death. The intranasal administration of NAD? (20?mg/kg) immediately after TBI protected neurons in CA1, CA3, and dentate gyrus of the hippocampus, but not in the cortex. In addition, delayed microglial activation normally seen after TBI was reduced by NAD? treatment at 7 days after insult. Neuronal superoxide production and PARP-1 accumulation after TBI were not inhibited by NAD? treatment, indicating that reactive oxygen species (ROS) production and PARP-1 activation are events that occur upstream of NAD? depletion. This study suggests that intranasal delivery of NAD? represents a novel, inexpensive, and non-toxic intervention for preventing TBI-induced neuronal death.</P>

대구 · 경북지역 대장직장암 환자의 식사관련 위험인자의 분석 (Ⅰ) : 대장직장암 환자의 일상생활 패턴 및 식행동 특성

서수원(Suh Soo-Won),구보경(Koo Bo-Kyung),전수한(Jeon Su-Han),이혜성(Lee Hye-Sung) 韓國營養學會 2005 Journal of Nutrition and Health Vol.38 No.2

Clinical Features and Treatment Outcomes of Langerhans Cell Histiocytosis: A Nationwide Survey From Korea Histiocytosis Working Party

Kim, Bo Eun,Koh, Kyung-Nam,Suh, Jin Kyung,Im, Ho Joon,Song, Joon Sup,Lee, Ji Won,Kang, Hyoung Jin,Park, Kyung Duck,Shin, Hee Young,Choi, Hyoung Soo,Lee, Soo Hyun,Yoo, Keon Hee,Sung, Ki Woong,Koo, Hong by Lippincott Williams Wilkins. 2014 Journal of pediatric hematology/oncology Vol.36 No.2

A nationwide survey was conducted to clarify the clinical features and outcomes of Korean children with Langerhans cell histiocytosis (LCH). Korea Histiocytosis Working Party analyzed the data of 603 patients who were diagnosed with LCH between 1986 and 2010 from 28 institutions in Korea. Median age at diagnosis was 65 months (range, 0 to 276 mo). Bone was the most frequently affected organ (79.6%) followed by skin (19.2%). Initially, 419 patients (69.5%) had single-system involvement (SS), 85 (14.1%) with multisystem (MS) disease without risk organ involvement (MS-RO), and 99 (16.4%) multisystem disease with risk organ involvement (MS-RO). The 5-year overall survival (OS) rates in the SS, MS-RO, and MS-RO groups were 99.8%, 98.4%, and 77.0%, respectively (P<0.001), and the 5-year reactivation rates were 17.9%, 33.5%, and 34.3%, respectively (P<0.001). The OS rate was lower in patients with RO involvement (P=0.025) and lack of response to initial treatment (P=0.001). MS involvement (P=0.036) was an independent risk factor for reactivation. Permanent consequences were documented in 99 patients (16.4%). Reactivation of disease, MS involvement, and age at diagnosis ≤2 years were associated with higher incidence of permanent consequences. This study emphasized that further efforts are required to improve survival of MS-RO patients and reduce reactivation in younger patients with MS involvement.

전염성 질병 관련 요인이 소비자의 외식소비생활에 미치는 영향에 관한 연구 : 코로나 19를 중심으로

서보원(Bo Won Suh) 융합관광콘텐츠학회 2021 융합관광콘텐츠연구 (JCTC) Vol.7 No.2

목적 본 연구에서는 전염성 질병이 국내 소비자들의 외식소비활동에 어떠한 영향을 미치는지 코로나 19(COVID-19)를 중심으로 조사하고, 나아가 전염병 유행 시 올바른 외식활동에 대한 방안을 제시하고자 한다. 방법 분석에는 SPSS 21.0이 사용되었으며, 전염성 질병 및 외식활동과 관련한 요인을 추출하기 위해 요인 분석이 실시되었고, 요인분석 결과에 따라 추출된 변수들 사이의 유의적인 영향관계를 설명하기 위하여 선형회귀분석이 실시되었다. 결과 분석결과 전염병 확산시의 외식활동 의도에 영향을 미치는 요인으로는 ‘전염병에 대한 인식’, ‘외식활동에 대한 태도’, ‘외식활동에 대한 준거집단 의견’ 그리고 ‘생활방역 준수’의 4가지 요인이 있는 것으로 나타났으며, 이중 ‘생활방역 준수’는 소비자의 외식활동 의도에 긍정적인 영향을, ‘전염병에 대한 인식’, ‘외식활동에 대한 태도’ 요인은 외식활동 의도에 부정적인 영향을 미치는 것으로 나타났으며, ‘외식활동에 대한 준거집단 의견’은 외식활동 의도에 유의한 영향을 미치지 않는 것으로 나타났다. 결론 본 연구는 코로나 19(COVID-19)를 중심으로 전염성 질병이 소비자들의 외식소비활동에 어떠한 영향을 미치는지 조사하여 전염성 질병과 소비자들의 외식활동과의 관계를 알아보았고, 이를 통해 전염성 질병과 외식소비생활 관련 연구의 이론적 토대를 마련하였으며, 팬데믹 하에서 관련 산업 종사자들의 마케팅 전략 수립에 도움이 되는 방안을 제시하였다. Purpose This study designed to identify how infectious diseases affected the eating-out behavior of consumers, and to propose right way for proper eating-out behavior during the pandemic. Methods SPSS 21.0 was used to analyze the data, and a factor analysis was conducted to extract factors from items related to infectious diseases and consumers’ eating-out behavior. Following the factor analysis results, a linear regression analysis was performed to explain the significant influence relationship between the extracted variables. Results Result indicated that there are four factors that affect the intention of eating-out: awareness of infectious diseases, attitude of eating-out behavior, the reference group’s opinion of eating-out behavior, and compliance with living prevention and hygiene. The data analysis showed that compliance with living prevention and hygiene positively effects on consumers intention to eating-out, while awareness of infectious diseases and attitude of eating-out behavior negatively effect on the intention to eating-out. The reference group’s opinion of eating-out behavior did not show a significant impact on consumers’ intention of eating-out. Conclusion This study identified how infectious diseases affect consumers’ eating-out behavior, laid the theoretical foundation for related researches, and suggested ways to help related industry workers establish marketing strategies under the pandemic.

Administration of Zinc plus Cyclo-(His-Pro) Increases Hippocampal Neurogenesis in Rats during the Early Phase of Streptozotocin-Induced Diabetes

Choi, Bo Young,Kim, In Yeol,Kim, Jin Hee,Lee, Bo Eun,Lee, Song Hee,Kho, A Ra,Sohn, Min,Suh, Sang Won MDPI AG 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.1

<P>The effects of zinc supplementation on hippocampal neurogenesis in diabetes mellitus have not been studied. Herein, we investigated the effects of zinc plus cyclo-(His-Pro) (ZC) on neurogenesis occurring in the subgranular zone of dentate gyrus after streptozotocin (STZ)-induced diabetes. ZC (27 mg/kg) was administered by gavage once daily for one or six weeks from the third day after the STZ injection, and histological evaluation was performed at 10 (early phase) or 45 (late phase) days after STZ injection. We found that the proliferation of progenitor cells in STZ-induced diabetic rats showed an increase in the early phase. Additionally, ZC treatment remarkably increased the number of neural progenitor cells (NPCs) and immature neurons in the early phase of STZ-induced diabetic rats. Furthermore, ZC treatment showed increased survival rate of newly generated cells but no difference in the level of neurogenesis in the late phase of STZ-induced diabetic rats. The present study demonstrates that zinc supplementation by ZC increases both NPCs proliferation and neuroblast production at the early phase of diabetes. Thus, this study suggests that zinc supplemented with a histidine/proline complex may have beneficial effects on neurogenesis in patients experiencing the early phase of Type 1 diabetes.</P>