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RISS 인기검색어
- 검색키워드
- 저자 : Su-Nyeong Jang (검색결과 16 건)
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Park Su Hyun,Lee Kang Nyeong,Lee Oh Young,Choi Myung Gyu,Kim Jie-Hyun,Sung In-Kyung,Jang Jae Young,Park Kyung Sik,Chun Hoon Jai,Kim Eun Young,Lee Jun Kyu,Jang Jin Seok,Kim Gwang Ha,Hong Su Jin,Lee Yon 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2
Background/Aims: Efficacy of proton pump inhibitors is limited in patients with nonerosive reflux disease (NERD). The aim of this study was to comparatively evaluate the efficacy and safety of esomeprazole with sodium bicarbonate and esomeprazole alone. Methods: This was a multicenter, randomized, double-blind, active-controlled, noninferiority comparative study. A total of 379 patients with NERD were randomly allocated to receive either EsoduoⓇ (esomeprazole 20 mg with sodium bicarbonate 800 mg) or NexiumⓇ (esomeprazole 20 mg) once daily for 4 weeks from January 2019 to December 2019. The patients had a history of heartburn for at least 2 days in the week before randomization as well as in the last 3 months and no esophageal mucosal breaks on endoscopy. The primary endpoint was a complete cure of heartburn at week 4. The secondary and exploratory endpoints as well as the safety profiles were compared in the groups at weeks 2 and 4. Results: A total of 355 patients completed the study (180 in the EsoduoⓇ group and 175 in the NexiumⓇ group). The proportions of patients without heartburn in the entire 4th week of treatment were not different between the two groups (33.33% in the EsoduoⓇ group and 35% in the NexiumⓇ group, p=0.737). There were no significant differences in most of the secondary and exploratory endpoints as well as the safety profiles. Conclusions: EsoduoⓇ is as effective and safe as NexiumⓇ for managing typical symptoms in patients with NERD (ClinicalTrial.gov identifier: NCT03928470).
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Inactivation of Foot-and-Mouth Disease Virus by Citric Acid and Sodium Carbonate with Deicers
Hong, Jang-Kwan,Lee, Kwang-Nyeong,You, Su-Hwa,Kim, Su-Mi,Tark, Dongseob,Lee, Hyang-Sim,Ko, Young-Joon,Seo, Min-Goo,Park, Jong-Hyeon,Kim, Byounghan American Society for Microbiology 2015 Applied and environmental microbiology Vol.81 No.21
<P>Three out of five outbreaks of foot-and-mouth disease (FMD) since 2010 in the Republic of Korea have occurred in the winter. At the freezing temperatures, it was impossible to spray disinfectant on the surfaces of vehicles, roads, and farm premises because the disinfectant would be frozen shortly after discharge and the surfaces of the roads or machines would become slippery in cold weather. In this study, we added chemical deicers (ethylene glycol, propylene glycol, sodium chloride, calcium chloride, ethyl alcohol, and commercial windshield washer fluid) to keep disinfectants (0.2% citric acid and 4% sodium carbonate) from freezing, and we tested their virucidal efficacies under simulated cold temperatures in a tube. The 0.2% citric acid could reduce the virus titer 4 logs at −20°C with all the deicers. On the other hand, 4% sodium carbonate showed little virucidal activity at −20°C within 30 min, although it resisted being frozen with the function of the deicers. In conclusion, for the winter season, we may recommend the use of citric acid (>0.2%) diluted in 30% ethyl alcohol or 25% sodium chloride solvent, depending on its purpose.</P>
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Inhibitory Potential of Bilobetin Against CYP2J2 Activities in Human Liver Microsomes
Zhexue Wu,Su-Nyeong Jang,박소영,Nguyen Minh Phuc,Kwang-Hyeon Liu 사단법인 한국질량분석학회 2020 Mass spectrometry letters Vol.11 No.4
Cytochrome P450 2J2 (CYP2J2) is a member of the cytochrome P450 superfamily, and is known to be arachidonic acid epoxygenase that mediates the formation of four bioactive regioisomers of epoxyeicosatrienoic acids (EETs). CYP2J2 is also involved in the metabolism of drugs such as albendazole, astemizole, danazol, ebastine, and terfenadine. CYP2J2 is highly expressed in the heart and cancer tissues. In this study, the inhibitory potential of ten natural products against CYP2J2 activity was evaluated using human liver microsomes and tandem mass spectrometry. Among them, bilobetin, which is a kind of biflavo- noid, exhibits a strong inhibitory effect against the CYP2J2-mediated astemizole O-demethylation (IC 50 = 0.73 µM) and terfena- dine hydroxylation (IC 50 = 0.89 µM). This result suggests that bilobetin can be used as strong CYP2J2 inhibitor in drug metabolism study.
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박소영,전지현,Su-Nyeong Jang,Im-Sook Song,유광현 사단법인 한국질량분석학회 2021 Mass spectrometry letters Vol.12 No.2
Previous in vitro studies have demonstrated that ginsenoside Rc inhibits UGT1A9, but there are no available data to indicate that ginsenoside Rc inhibits UGT1A9 in vivo. The effect of single and repeated intravenous injection of ginsenoside Rc was evaluated on the pharmacokinetics of mycophenolic acid. After injection of ginsenoside Rc (5 mg/kg for one day or 3 mg/kg for five days), 2-mg mycophenolic acid was intravenously injected, and the pharmacokinetics of mycophenolic acid and mycophenolic acid-β-glucuronide were determined. Concentrations of mycophenolic acid and its metabolite from rat plasma were analyzed using a liquid chromatography-triple quadrupole mass spectrometry. Single or repeated pretreatment with ginse- noside Rc had no significant effects on the pharmacokinetics of mycophenolic acid (P > 0.05): The mean difference in maximum plasma concentration (C max ) and area under the concentration-time curve (AUC inf ) were within 0.83- and 0.62-fold, respectively, compared with those in the absence of the ginsenoside Rc. These results indicate that ginsenoside Rc has a negligible effect on the disposition of mycophenolic acid in vivo despite in vitro findings indicating that ginsenoside Rc is a selective UGT1A9 inhibitor. As a result, ginsenoside Rc has little possibility of interacting with drugs that are metabolized by UGT1A9, including mycophenolic acid.
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Si Jun Kim,Jang Jae Lee,Young Seok Lee,Chul Hee Cho,In Ho Seong,Han Sol Choi,Jin Ho Lee,Won Nyeong Jeong,Ha Jeong Choi,Ye Bin You,Min Su Choi,Shin Jae You 한국진공학회 2021 한국진공학회 학술발표회초록집 Vol.2021 No.2
This presentation presented analysis of the electron heating mechanism in capacitively coupled plasma based on particle-in-cell Monte Carlo collision (PIC-MCC) simulation. As discharge current decreases, abrupt reduction of low energy electron population in electron energy probability function(EEPF) were observed, while the gradual decrease of high energy electrons. This change of the EEPF shape was analyzed in terms of power absorption and electric filed. It is believed that this research elucidates the understanding of the electron heating mechanism at low discharge current
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