Wind tunnel tests on flow fields of full-scale railway wind barriers

Su, Yang,Xiang, Huoyue,Fang, Chen,Wang, Lei,Li, Yongle Techno-Press 2017 Wind and Structures, An International Journal (WAS Vol.24 No.2

The present study provides a deeper understanding of the flow fields of a full-scale railway wind barriers by means of a wind tunnel test. First, the drag forces of the three wind barriers were measured using a force sensor, and the drag force coefficients were compared with a similar scale model. On this basis, the mean wind velocity and turbulence upwind and downwind of the wind barriers were measured. The effects of pore size and opening forms of the wind barrier were discussed. The results show that the test of the scaled wind barrier model may be unsafe, and it is suitable to adopt the full-scale wind barrier model. The pore size and the opening forms of wind barriers have a slight influence on the flow fields upwind of the wind barrier but have some influences on the flow fields and power spectra downwind of the wind barrier. The smaller pore size generates a lower turbulence density and value of the power spectrum near the wind barrier, and the porous wind barriers clearly provide better shelter than the bar-type wind barriers.

Wind tunnel tests on flow fields of full-scale railway wind barriers

Yang Su,Huoyue Xiang,Chen Fang,Lei Wang,Yongle Li 한국풍공학회 2017 Wind and Structures, An International Journal (WAS Vol.24 No.2

The present study provides a deeper understanding of the flow fields of a full-scale railway wind barriers by means of a wind tunnel test. First, the drag forces of the three wind barriers were measured using a force sensor, and the drag force coefficients were compared with a similar scale model. On this basis, the mean wind velocity and turbulence upwind and downwind of the wind barriers were measured. The effects of pore size and opening forms of the wind barrier were discussed. The results show that the test of the scaled wind barrier model may be unsafe, and it is suitable to adopt the full-scale wind barrier model. The pore size and the opening forms of wind barriers have a slight influence on the flow fields upwind of the wind barrier but have some influences on the flow fields and power spectra downwind of the wind barrier. The smaller pore size generates a lower turbulence density and value of the power spectrum near the wind barrier, and the porous wind barriers clearly provide better shelter than the bar-type wind barriers.

Qualitative and quantitative analysis of the saponins in Panax notoginseng leaves using ultra-performance liquid chromatography coupled with time-of-flight tandem mass spectrometry and high performance liquid chromatography coupled with UV detector

Liu, Fang,Ma, Ni,He, Chengwei,Hu, Yuanjia,Li, Peng,Chen, Meiwan,Su, Huanxing,Wan, Jian-Bo The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.2

Background: Panax notoginseng leaves (PNL) exhibit extensive activities, but few analytical methods have been established to exclusively determine the dammarane triterpene saponins in PNL. Methods: Ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC/Q-TOF MS) and HPLC-UV methods were developed for the qualitative and quantitative analysis of ginsenosides in PNL, respectively. Results: Extraction conditions, including solvents and extraction methods, were optimized, which showed that ginsenosides Rc and Rb3, the main components of PNL, are transformed to notoginsenosides Fe and Fd, respectively, in the presence of water, by removing a glucose residue from position C-3 via possible enzymatic hydrolysis. A total of 57 saponins were identified in the methanolic extract of PNL by UPLC/Q-TOF MS. Among them, 19 components were unambiguously characterized by their reference substances. Additionally, seven saponins of PNL-ginsenosides Rb1, Rc, Rb2, and Rb3, and notoginsenosides Fc, Fe, and Fd-were quantified using the HPLC-UV method after extraction with methanol. The separation of analytes, particularly the separation of notoginsenoside Fc and ginsenoside Rc, was achieved on a Zorbax ODS C8 column at a temperature of $35^{\circ}C$. This developed HPLC-UV method provides an adequate linearity ($r^2$ > 0.999), repeatability (relative standard deviation, RSD < 2.98%), and inter- and intraday variations (RSD < 4.40%) with recovery (98.7-106.1%) of seven saponins concerned. This validated method was also conducted to determine seven components in 10 batches of PNL. Conclusion: These findings are beneficial to the quality control of PNL and its relevant products.

Development and Evaluation of Simultaneous Quantification of Naringin, Prunin, Naringenin, and Limonin in Citrus Juice

Hui Ni,Su Fang Zhang,Qiu Feng Gao,Yang Hu,Ze Dong Jiang,Feng Chen 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.4

Quantification of limonin, naringin, prunin, and naringenin is an important approach for monitoring of debittering processes of citrus products. Naringin and limonin have different polarity and solubility values, causing difficulty in simultaneous extraction and quantification. A procedure combining HPLC and solid-phase extraction was developed to simultaneously quantify these analytes in citrus juice. Analytes exhibited calibration curves of good linearity along with low limit of detection and limit of quantification values. Naringin, prunin, naringenin, and limonin exhibited respective recovery values of 92.2-100.6, 92.0-97.3, 98.1-102.2, and 102.4-103.9%, respectively. Relative standard deviations were lower than 5%. For analysis of naringin, prunin, naringenin, and limonin in citrus juices, the simultaneous method displayed analytical results identical to traditional respective quantification methods. The simultaneous method is highly effective for monitoring naringin, prunin, naringenin, and limonin levels in citrus juice.

The Effects of Tai Chi Intervention on Healthy Elderly by Means of Neuroimaging and EEG: A Systematic Review

Pan, Zhujun,Su, Xiwen,Fang, Qun,Hou, Lijuan,Lee, Younghan,Chen, Chih C.,Lamberth, John,Kim, Mi-Lyang Frontiers Media S.A. 2018 FRONTIERS IN AGING NEUROSCIENCE Vol.10 No.-

<P>Aging is a process associated with a decline in cognitive and motor functions, which can be attributed to neurological changes in the brain. Tai Chi, a multimodal mind-body exercise, can be practiced by people across all ages. Previous research identified effects of Tai Chi practice on delaying cognitive and motor degeneration. Benefits in behavioral performance included improved fine and gross motor skills, postural control, muscle strength, and so forth. Neural plasticity remained in the aging brain implies that Tai Chi-associated benefits may not be limited to the behavioral level. Instead, neurological changes in the human brain play a significant role in corresponding to the behavioral improvement. However, previous studies mainly focused on the effects of behavioral performance, leaving neurological changes largely unknown. This systematic review summarized extant studies that used brain imaging techniques and EEG to examine the effects of Tai Chi on older adults. Eleven articles were eligible for the final review. Three neuroimaging techniques including fMRI (<I>N</I> = 6), EEG (<I>N</I> = 4), and MRI (<I>N</I> = 1), were employed for different study interests. Significant changes were reported on subjects' cortical thickness, functional connectivity and homogeneity of the brain, and executive network neural function after Tai Chi intervention. The findings suggested that Tai Chi intervention give rise to beneficial neurological changes in the human brain. Future research should develop valid and convincing study design by applying neuroimaging techniques to detect effects of Tai Chi intervention on the central nervous system of older adults. By integrating neuroimaging techniques into randomized controlled trials involved with Tai Chi intervention, researchers can extend the current research focus from behavioral domain to neurological level.</P>

Validation of the Chinese Version of Penn Alcohol Craving Scale for Patients With Alcohol Use Disorder

Yu-Yu Ko,Su-Chen Fang,Wei-Chien Huang,Ming-Chyi Huang,Hu-Ming Chang 대한신경정신의학회 2024 PSYCHIATRY INVESTIGATION Vol.21 No.2

Objective The Penn Alcohol Craving Scale (PACS) is a five-item, single-dimension questionnaire that is used to measure a patient’s alcohol craving. We sought to develop the Chinese version of the PACS (PACS-C) and assess its reliability and validity.Methods A total of 160 Taiwanese patients with alcohol use disorder were enrolled in this study. The internal consistency and concurrent validity of the PASC-C with the visual analogue scale (VAS) for craving, the Yale–Brown Obsessive Compulsive Scale for heavy drinking (YBOCS-hd), and the Severity of Alcohol Dependence Questionnaire (SADQ) were assessed. The test–retest reliability of the PASC-C was evaluated 1 day after the baseline measurements. Confirmatory factor analysis (CFA) was performed to examine the psychometric properties of the PACS-C.Results The PACS-C exhibited good internal consistency (Cronbach’s α=0.95) and test–retest reliability (r=0.97). This scale showed high correlations with the VAS (r=0.81) and YBOCS-hd (r=0.81 and 0.79 for the obsession and compulsion subscales, respectively), and moderate correlation with the SADQ-C (r=0.47). Furthermore, CFA results revealed that the PACS-C had good fit indices under various models.Conclusion The PACS-C appears to be a reliable and valid tool for assessing alcohol craving in patients with alcohol use disorder in Taiwan.

Ginsenoside Rg1 alleviates A deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice

Han Zhang,Yong Su,Zhenghao Sun,Ming Chen,Yuli Han,Yan Li,Xianan Dong,Shixin Ding,Zhirui Fang,Weiping Li,Weizu Li 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.6

Background: Ginsenoside Rg1 (Rg1), an active ingredient in ginseng, may be a potential agent for thetreatment of Alzheimer’s disease (AD). However, the protective effect of Rg1 on neurodegeneration in ADand its mechanism of action are still incompletely understood. Methods: Wild type (WT) and APP/PS1 AD mice, from 6 to 9 months old, were used in the experiment. The open field test (OFT) and Morris water maze (MWM) were used to detect behavioral changes. Neuronal damage was assessed by hematoxylin and eosin (H&E) and Nissl staining. Immunofluorescence,western blotting, and quantitative real-time polymerase chain reaction (q-PCR) were used toexamine postsynaptic density 95 (PSD95) expression, amyloid beta (Ab) deposition, Tau and phosphorylatedTau (p-Tau) expression, reactive oxygen species (ROS) production, and NAPDH oxidase 2(NOX2) expression. Results: Rg1 treatment for 12 weeks significantly ameliorated cognitive impairments and neuronaldamage and decreased the p-Tau level, amyloid precursor protein (APP) expression, and Ab generation inAPP/PS1 mice. Meanwhile, Rg1 treatment significantly decreased the ROS level and NOX2 expression inthe hippocampus and cortex of APP/PS1 mice. Conclusions: Rg1 alleviates cognitive impairments, neuronal damage, and reduce Ab deposition byinhibiting NOX2 activation in APP/PS1 mice.

Identification and Characterization of MADS-box Genes Involved in Floral Organ Development in Chinese Chestnut (Castanea mollissima Blume)

Yang Liu,Guosong Chen,Yuerong Gao,Kefeng Fang,Qing Zhang,Qingqin Cao,Ling Qin,Yu Xing,Shuchai Su 한국원예학회 2021 원예과학기술지 Vol.39 No.4

Chinese chestnut (Castanea mollissima) is a woody plant species with important economic and ecological value and is widely cultivated for nut production. Due to its unique flowering structure, the identification of genes related to flower development is extremely important in Chinese chestnut, and MADS-box genes are directly involved in floral organ morphogenesis. In this study, we report a MADS-box gene family in Chinese chestnut. According to their gene structure and phylogenetic trees, 53 CmMADS proteins were identified and clustered into five groups in Chinese chestnut. The MIKC<SUP>C</SUP> group was further divided into 12 subgroups, and the BS subgroup was not found in Chinese chestnut. The classification and motif composition of Chinese chestnut MADS proteins were also analyzed. Additionally, we evaluated the expression of all the MADS-box genes in floral organs by quantitative real-time PCR. Overall, most of the type II genes had higher expression levels in the floral organs compared with leaves and cotyledons. These results provide valuable information for future studies of the regulation of MADS-box genes in Chinese chestnut during flower development.

Association between PCR-RFLP Polymorphisms of Five Gene Loci and Milk Traits in Chinese Holstein

Zhang, R.F.,Chen, H.,Lei, C.Z.,Fang, X.T.,Zhang, Y.D.,Hu, S.R.,Su, L.H. Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.2

The objective of this study was to assess the association of polymorphisms in ${\kappa}$-cn, ${\beta}$-lg, ${\beta}$-lg 5′ flanking region, CSN1S2, and IGFBP-3 genes with milk production traits and mastitis-related traits in Chinese Holstein. Traits analyzed were 305 day standard milk yield, protein percentage, fat percentage, the ratio of fat percentage and protein percentage, pre-somatic cell count, somatic cell count, and somatic cell score, respectively. CSN1S2 locus was uninformative because only one genotype BB was found in Chinese Holstein. Allele frequencies of A and B in IGFBP-3 gene were 0.5738 and 0.4262 in Chinese Holstein population, which was different from reported Qinchuan cattle population. The genotypes of animals at IGFBP-3 locus significantly affected 305 day standard milk yield, protein percentage, and somatic cell score. The ${\beta}$-lg genotypes had a significant effect on protein percentage and the ratio of fat percentage and protein percentage. Polymorphism in ${\beta}$-lg 5′ flanking region was associated with 305 day standard milk yield, protein percentage, fat percentage, pre-somatic cell count, and somatic cell count. No significant associations of the polymorphism in ${\kappa}$-cn gene were observed for any trait.

Clinical Neuropathological Analysis of 10 Cases of Cerebral Amyloid Angiopathy-Related Cerebral Lobar Hemorrhage

Li, Xiao-Qiu,Su, Dong-Feng,Chen, Hui-Sheng,Fang, Qu The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.46 No.4

Objective : The clinical and pathological characteristics of 10 cases of cerebral amyloid angiopathy (CAA)-related cerebral lobar hemorrhage (CLH) that was diagnosed at autopsy were investigated to facilitate the diagnosis of this condition. Methods : The clinical characteristics of 10 cases of CAA-related CLH were retrospectively reviewed, and a neuropathological examination was performed on autopsy samples. Results : The 10 cases included two with a single lobar hemorrhage and eight with multifocal lobar hemorrhages. In all of the cases, the hemorrhage bled into the subarachnoid space. Pathological examinations of the 10 cases revealed microaneurysms in two, double barrel-like changes in four, multifocal arteriolar clusters in five, obliterative onion skin-like intimal changes in four, fibrinoid necrosis of the vessels in seven, neurofibrillary tangles in eight, and senile plaques in five cases. Conclusion : CAA-related CLHs were located primarily in the parietal, temporal, and occipital lobes. These hemorrhages normally consisted of multiple repeated CLHs that frequently bled into the subarachnoid space. CAA-associated microvascular lesions may be the pathological factor underlying CLH.