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Choi Soohwan,Ro Sun Kyun,Moon Seok Whan 대한심장혈관흉부외과학회 2024 Journal of Chest Surgery (J Chest Surg) Vol.57 No.2
Background: Early non-small cell lung cancer (NSCLC) that abuts adjacent structures requires careful evaluation due to its potential impact on postoperative outcomes and prognosis. We examined stage I NSCLC with invasion into adjacent structures, focusing on the prognostic implications after curative surgical resection. Methods: We retrospectively analyzed the records of 796 patients who underwent curative surgical resection for pathologic stage IA/IB NSCLC (i.e., visceral pleural invasion only) at a single center from 2008 to 2017. Patients were classified based on tumor abutment and then reclassified by the presence of visceral pleural invasion. Clinical characteristics, pathological features, and survival rates were compared. Results: The study included 181 patients with abutting NSCLC (22.7% of all participants) and 615 with non-abutting tumors (77.3%). Those with tumor abutment exhibited higher rates of non-adenocarcinoma (26.5% vs. 9.9%, p<0.01) and visceral/lymphatic/vascular invasion (30.4%/33.1%/12.7% vs. 8.5%/22.4%/5.7%, respectively; p<0.01) compared to those without abutment. Multivariable analysis identified lymphatic invasion and male sex as risk factors for overall survival (OS) and disease-free survival (DFS) in stage I NSCLC measuring 3 cm or smaller. Age, smoking history, vascular invasion, and recurrence emerged as risk factors for OS, whereas the presence of non-pure ground-glass opacity was a risk factor for DFS. Conclusion: NSCLC lesions 3 cm or smaller that abut adjacent structures present higher rates of various risk factors than non-abutting lesions, necessitating evaluation of tumor invasion into adjacent structures and lymph node metastasis. In isolation, however, the presence of tumor abutment without visceral pleural invasion does not constitute a risk factor.
Soohwan Choi,Hyung Suk Kim,Kyueng-Whan Min,Yung-Kyun Noh,Jeong-Yeon Lee,Ji-Yong Moon,Un Suk Jung,Mi Jung Kwon,Dong-Hoon Kim,Byoung Kwan Son,Jung Soo Pyo,Sun Kyun Ro 대한의학회 2024 Journal of Korean medical science Vol.39 No.2
Background: Tumor spread through air spaces (STAS) is a recently discovered risk factor for lung adenocarcinoma (LUAD). The aim of this study was to investigate specific genetic alterations and anticancer immune responses related to STAS. By using a machine learning algorithm and drug screening in lung cancer cell lines, we analyzed the effect of Janus kinase 2 (JAK2) on the survival of patients with LUAD and possible drug candidates. Methods: This study included 566 patients with LUAD corresponding to clinicopathological and genetic data. For analyses of LUAD, we applied gene set enrichment analysis (GSEA), in silico cytometry, pathway network analysis, in vitro drug screening, and gradient boosting machine (GBM) analysis. Results: The patients with STAS had a shorter survival time than those without STAS (P < 0.001). We detected gene set-related downregulation of JAK2 associated with STAS using GSEA. Low JAK2 expression was related to poor prognosis and a low CD8+ T-cell fraction. In GBM, JAK2 showed improved survival prediction performance when it was added to other parameters (T stage, N stage, lymphovascular invasion, pleural invasion, tumor size). In drug screening, mirin, CCT007093, dihydroretenone, and ABT737 suppressed the growth of lung cancer cell lines with low JAK2 expression. Conclusion: In LUAD, low JAK2 expression linked to the presence of STAS might serve as an unfavorable prognostic factor. A relationship between JAK2 and CD8+ T cells suggests that STAS is indirectly related to the anticancer immune response. These results may contribute to the design of future experimental research and drug development programs for LUAD with STAS. Background: Tumor spread through air spaces (STAS) is a recently discovered risk factor for lung adenocarcinoma (LUAD). The aim of this study was to investigate specific genetic alterations and anticancer immune responses related to STAS. By using a machine learning algorithm and drug screening in lung cancer cell lines, we analyzed the effect of Janus kinase 2 (JAK2) on the survival of patients with LUAD and possible drug candidates. Methods: This study included 566 patients with LUAD corresponding to clinicopathological and genetic data. For analyses of LUAD, we applied gene set enrichment analysis (GSEA), in silico cytometry, pathway network analysis, in vitro drug screening, and gradient boosting machine (GBM) analysis. Results: The patients with STAS had a shorter survival time than those without STAS (P < 0.001). We detected gene set-related downregulation of JAK2 associated with STAS using GSEA. Low JAK2 expression was related to poor prognosis and a low CD8+ T-cell fraction. In GBM, JAK2 showed improved survival prediction performance when it was added to other parameters (T stage, N stage, lymphovascular invasion, pleural invasion, tumor size). In drug screening, mirin, CCT007093, dihydroretenone, and ABT737 suppressed the growth of lung cancer cell lines with low JAK2 expression. Conclusion: In LUAD, low JAK2 expression linked to the presence of STAS might serve as an unfavorable prognostic factor. A relationship between JAK2 and CD8+ T cells suggests that STAS is indirectly related to the anticancer immune response. These results may contribute to the design of future experimental research and drug development programs for LUAD with STAS.
The Effectiveness of Visualization System for Virtual Reality Learning
Soohwan Kim,Kil Hong Joo,Seonkwan Han,JinTak Choi 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.12
In this study, we developed a visualization tool that shows learners’ interactive activities graphically during virtual reality (VR) education. Current VR system only shows learning content. However, we need to recognize learners’ interaction and information exchanges for increasing effectiveness of learning; also we need to show it effectively. Therefore, we developed visualization tool for VR learning based on web 2.0, and this tool helps teachers and students to monitor and percept the interaction activities among students, and thus it facilitates their interaction and learning in VR education environment. For experiments, 68 students participated in VR learning. The result shows that the interaction and the perception of effectiveness of learning are significant differences between VR system and web 2.0 VR system. Furthermore, for verify availability of usage, TAM (Technology acceptance model) analysis about the system is supported. This result will be basic material for constructing of future VR learning environment.
Lim, Soohwan,Park, Jeongmoo,Lee, Nayoung,Jeong, Jinkil,Toh, Shigeo,Watanabe, Asuka,Kim, Junghyun,Kang, Hyojin,Kim, Dong Hwan,Kawakami, Naoto,Choi, Giltsu American Society of Plant Biologists 2013 The Plant cell Vol.25 No.12
<P>The <I>Arabidopsis aba2</I>, <I>abi3</I>, <I>della pentuple</I>, and <I>som</I> mutant seeds germinate even at high temperature. This work shows that ABI3, ABI5, and DELLA target to the <I>SOM</I> promoter and mediate high-temperature signaling to activate the expression of <I>SOM</I> in imbibed seeds.</P>
최천운(Cheonwoon Choi),황수환(Soohwan Hwang),문경연(Kyungyon Moon) 경희대학교 인류사회재건연구원 2018 OUGHTOPIA Vol.33 No.2
본 논문은 국제사회의 주거권 논의 현황과 특징을 분석함으로써 북한지역 주민들을 대상으로 하는 주거환경 개선사업이 인도적지원의 대상이 될 수 있는지에 대해 고찰하는 데 목적이 있다. 분석 결과 주거권은 인간의 기본적 권리를 구성하며 이를 충족시키지 못하는 환경에서는 인도적 차원에서 적절한 조치가 필요함을 알 수 있었다. 하지만 지난 20년간 진행된 대북지원은 식량 및 보건, 의료지원만을 인도적 지원 대상 품목에 포함시켜 왔다. 이러한 가운데 북핵 문제로 불거진 UN의 대북제재는 인도적 지원만을 예외로 두고 있고, 향후 북미 정상회담을 통해 북핵문제가 해결된다고 하더라도 UN의 제재가 완전히 해제되는 데에는 상당한 시일이 걸릴 수도 있다. 또한 향후 대북지원은 과거와 같이 식량 및 보건, 의료지원에 국한될 가능성이 크고 이는 열악한 주거환경에 놓인 북한주민들의 주거인권에 대한 고통은 여전히 계속될 것임을 의미한다. 결과적으로 본 논문은 국제사회의 주거권 논의에 근거할 경우, 북한지역 주민들을 대상으로 한 주거환경 개선사업이 인도적 지원의 구성요소를 충족시키므로 향후 지속가능한 남북교류협력사업을 위해 인도적 지원사업의 범위에 북한지역 주거환경 개선사업을 포함시키는 방안을 주장한다. This study seeks to make a case that HABITAT operation to North Korea can be considered as humanitarian assistance under the UN’s sanction. The Korean government has decided to provide humanitarian aid to North Korea despite UN’s restrictive actions against North Korea. Although conditional, the two Koreas are considering to pursue a few economic cooperation projects. While the UN and the international community are participating in the implementation of UN Security Council resolutions to sanction North Korea, South Korea needs to consider the sustainability of humanitarian aid to North Korea. This study analyzes international human rights discourse on housing rights, the condition of North Korean housing environment, the history of North-South exchange and cooperative activities in order to seek the possibility of incorporating the HABIT operations to North Korea into humanitarian assistance. Under the UN sanctions against North Korea, it seems that HABITAT or housing related operations from humanitarian assistance to North Korea are not allowed. Considering the right to housing in international human rights discourse, however, this paper argues that HABIT or housing related operations should be allowed as humanitarian assistance.