유방의 섬유낭종성 질환에서 보이는 아형의 빈도에 대한 연구

은약수,김의한,강상균 순천향대학교 1993 논문집 Vol.16 No.2

To understand the incident rate about the subtype of fibrocystic disease, we collected 116 breast cases requested from Jan. 1991 to June 1992, and reviewed, The results were as follows: 1. The fibrocystic disease was observed in 52.5%(61 of 116 cases). 2. The peak incidence was in the third decade and it did not reveal before the age of 20 and after the age of 50. 3. In fibrocystic disease, epithelial hyperplasia relative to breast cancer was observed in 33%(19 of 61 cases)and the epithelial hyperplasia was more significant in the young age group. 4. Among the 61 cases of fibrocystic disease, the most frequent type was fibrosis (88.5%), and followed by microcyst(32.8%), ductal hyperplasia(24.6%), lobular hyperplasia(11.5%), apocrine metaplasia(9.8%) and macrocyst and sclerosing adenosis(1.6%) in order.

후두부 발작성 간질파와 동반된 양성 소아기 간질의 임상적 연구

유영수,이상도,김지언,임정근,박영춘 대한신경과학회 1996 대한신경과학회지 Vol.14 No.4

복합재료 하니콤 샌드위치 구조의 열응력 해석

은성수,이수용 한국항공대학교 1998 論文集 Vol.36 No.-

온도하중이 작용할 때 복합재료 하니콤 샌드위치 쉘 구조물의 거동을 파악하기 위해서 3차원 응축쉘 이론 그리고 일차전단 변형이론에 입각한 유한요소 해석이 수행되었다. 본 연구에서는 하니콤을 탄성보강재로 가정하여 온도가 증가함에 따라 하니콤과 적층쉘 사이에서 발생하는 분리현상을 규명하였다. 이러한 파손현상은 적층각도와 적층쉘 두께이 따라 다르게 나타났다. 준등방성 그리고 직교이방성 보다도 angle-ply 적층순서에서 파손이 많이 발생하였고 또한 적층쉘의 두께가 증가함에 따라 파손현상이 많이 발생하였다. Finite element analysis based on 3-D degenerated shell theory and first shear deformation theory was peformed to investigate the behavior of composite and honeycomb sandwich shell structures under thermal loading. In this study, the honeycomb was regarded as an elastic foundation and delamination phenomenon occurring between the laminated shell and the honeycomb was examined as temperature increases. The results shows that the delamination depends on lay-up angle and thickness in the composite shell. A lot of failure was occurred for angle-ply stacking sequence rather than for quasi-isotropic and cross-ply stacking sequences and a lot of failure was occurred as the thickness of the composite shell increases.

폐기물 성상과 매립방식에 따른 침출수 특성

성낙창,김은호,문추연,김정권,장성호,김수생,박출재 동아대학교 환경문제연구소 1996 硏究報告 Vol.19 No.1

In this study, we can be obtained the following conclusions about the characteristics of leachate with waste compositions and landfill methods. pH shows a tendency to increase in E. landfill, because NH₃ is created by anaerobic degradation and dissolved in leachate. The concentrations of BOD and COD become different, In case of E. landfill, food of combustible is H. & S. landfill and then SS is high in concentration. According to passed time, T-N is high in concentration, but T-P shows a similar tendency. Heavy metals of leachate is lower than threshold concentrations. If leachate is treated biologically, microbes are not inibitory.

100m 달리기시 최고 속도 구간과 감속 구간의 동작 비교 연구

은선덕,정철수,배성제 한국운동역학회 1996 한국운동역학회지 Vol.6 No.1

본 연구의 목적은 100m 달리기에서 최고 속도 구간과 감속 구간에서의 동작을 비교하여 감속의 원인을 규명하는 데 있다. 두 구간에 대한 주요 운동학적 변인인 신체 중심의 속도와 변위, 보속과 보폭, 상체의 전경각, 관절각, 각속도를 분석하여 다음과 같은 결론은 얻었다. 감속 구간에서의 지면 접촉 기간 동안과 체공 기간 동안의 신체 중심의 수평 속도는 최고 속도 구간에 비해 느린 것으로 나타났다. 보속은 최고 속도 구간에 비해 느린 것으로 나타났고, 지지 시간은 긴 것으로 나타났으며, 체공 시간은 차이가 나타나지 않았다. 보폭은 최고 속도 구간에 비해 짧은 것으로 나타났고, 착지시 신체 중심과 발끝의 수평 거리는 최고 속도 구간에 비해 긴 것으로 나타났다. 또한 상체의 전경각은 착지시에만 차이가 있었으며 최고 속도 구간에 비해 작고, 무릎 관절각은 착지시와 이지시에 있어서 최고 속도 구간에 비해 작았다. 그리고 고관절각은 반대발의 이지시와 착지시, 그리고 최소값에 있어서 최고 속도 구간에 비해 크고, 운동 범위에 있어서는 작은 것으로 나타났다. 또한 무릎 관절 각속도는 최고 속도 구간과의 비교에서 차이가 나타나지 않았다. The study was conducted to make a comparative analysis of running motion and to examine the difference in the deceleration phase(80∼90m) and the Max-speed phase(30∼40m) during the 100-meter Sprint. In this study, data was analyzed with variables including velocity and displacement of center of gravity, stride frequency, stride length, foward angle of upper body, joint angle, angular velocity in the deceleration phase and the max-speed phase. The conclusions of the study were as follows ; 1. Horizontal velocity of the center of gravity in the deceleration phase was found to be slower than that in the max-speed phase in the supporting period and non-supporting period. 2. Stride frequency in the deceleration phase was found to be slower than that in the max-speed phase, and supporting time n the deceleration phase was longer than that in the max-speed phase, also there was no difference between each phase in nonsupporting time. 3. Stride length in the deceleration phase was to be found shorter than that in the max-speed phase. 4. Horizontal distance between the center of gravity and toe in the deceleration phase was to be found longer than that in the max-speed phase. 5. Forward angle of upper body at the moment of touch down in the deceleration phase was found to be smaller than that in the max-speed phase. 6. Knee angle at the moment of touch down and take off in the deceleration phase were found to be smaller than in the max-speed phase. 7. Hip angle at the moment of touch down and take off of the other foot, and minimum hip angle in the deceleration phase were found to be larger than that in the max-speed phase, and range of, motion in the deceleration phase was smaller than that in the max-speed phase. 8. Knee angular velocity at the moment of touch down of the other foot toward flection in the deceleration phase was found to be larger than that in the max-speed phase.

좌측 상하악 구치 후방부에 발생한 다형성 선종의 치험례

우길상,이은진,김상규,김진수,변기정 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.2

Pleomorphic adenoma is a circumscribed tumor characterized microscopically by its pleomorphic or mixed appearance, and its clearly recognizable epithelial tissue intermingled with areas of mucoid, myxoid, or chondroid appearance. Plemorphic adenoma, the most common tumor of the salivary glands, is now generally accepted as epithelial and benign adenoma. The palate is the most common site for minor salivary gland tumor. We experienced a case of pleomorphic adenoma occuring in the left retromolar pad area of unusual location. It is unusually large size so that the patient cannot close his mouth. The tumor occupied his mouth fully so that he has much difficulty in closing his mouth and breathing his breath. The lesion was treated with complete excision and reconstruced with buccal fat pedicle flap immediately on the operation under general anesthesia. Histopathological finding indicated pleomorphic adenoma on the left retromolar pad area.

화해를 입은 콘크리트 기둥의 잔존강도 및 보수ㆍ보강 효과

이창은,이차돈,신영수,홍성걸 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

Experiments were performed for the real sized 13 reinforced concrete columns of 350×350×3360㎜ with normal and high strength concrete in order to observe the fire-damaged residual strength of these columns. Columns were heated according to the ISO heating curve. Main experimental parameters were: magnitude of axial load, heating time, cover thickness, and eccentricity. Effects of these parameters were experimentally quantified. Although significant reduction in residual strength was observed for the columns exposed to longer heating time, little effects on the residual strength by cover thickness and magnitude of axial load were observed. Repairing did not lead to the improvement of residual strength. Strengthening by wrapping the GFRP sheets, however, recovered the fire-damaged column strength up to 97% of axial strength of the prototype undamaged column.

결핵의 진단법으로서 중합효소 연쇄반응 검사의 가치

서상철,은상진,김한길,송경은,서장수,최성만,이원길,김재식,김중명 慶北大學校 醫科大學 1994 慶北醫大誌 Vol.35 No.1

목적 : 결핵균 동정을 위한 중합효소 연쇄반응을 임상병리검사로서 적용하기 위한 기초 실험으로 분석학적 예민도와 특이도를 알아보고 검토된 조건에 의한 중합효소 연쇄반응을 실제 임상 가검물에 적용하기 위함이다. 재료 및 방법 : Ziehl-Neelsen염색 양성인 객담, 뢰벤스타인-젠센(Loewenstein-Jensen) 배지에서 분리된 결핵균 및 M. tuberculosis H37Rv를 비롯한 항산균 표준균주 11주와 비항산균 10주를 사용하여 2가지 DNA의 분리법, 3set 프라이머, 3종류 중합효소, 2가지 미량 원심시험관 및 Easy-Cycler^R(Ericomp사, 미국)와 수조형으로 검사를 시행하여 DNA 증폭 산물을 비교하였다. 또한 이미 지일-닐슨 염색법에 의한 선별검사에서 음성을 나타낸 객담 53예, 소변 101예, 삼출액 128예, 뇌척수액 54예 등 총 370예의 임상가검물을 대상으로 하여 위에서 검토된 중합효소 연쇄반응 조건으로 검사한 성적과 지일-닐슨 염색법, 배양법 성적과 비교하였다. 결과 : DNA분리방법 2가지와 3가지 중합효소는 분석학적 예민도와 5fg로 나타나 차이를 발견할 수 없었으며, 프라이머 P1, P2쌍은 예민도가 5fg, 프라이머 INS1, INS2쌍과 프라이머 Pt3, Pt6쌍의 예민도는 0.5fg이었다. Easy-Cycler^R가 수조형에 비해 높고, 미량 원심시험관은 Robbins사 제품이 Sarstedt사 제품에 비해 높은 분석학적 예민도를 나타냈다. 프라이머 P1, P2쌍과 프라이머 INS1, INS2와 Pt3, Pt6 2쌍의 프라이머의 특이도에 있어서는 항산균 표준균주 중 M. tuberculosis H37Rv, M. tuberculosis ATCC 27294, M. bovis ATCC 29312의 3주에서 특이 증폭 띠를 관찰할 수 있었다. 그러나 비결핵성 항산균 8주에는 특이 증폭 띠를 나타내지 않았다. 또 비항산균 10주에도 특이 증폭 띠가 관찰되지 않았다. 따라서 Robbins사의 미량 원심시험관과 proteinase-K법에 의한 DNA분리방법에 Easy-Cycler^R를 사용하여 프라이머 INS1, INS2쌍으로 일차 중합효소 연쇄반응을 시행한 후 프라이머 Pt3, Pt6쌍으로 이차중합효소 연쇄반응을 시행하는 방법을 370예의 임상가검물에 시행하였고 지일-닐슨 염색법과 결핵균배양검사도 동시에 시행한 결과 중합효소 연쇄반응 양성은 106예(28.6%), 배양 양성은 27예(7.3%) 및 염색 양성은 18예(4.9%)였으며, 결핵환자는 141명(38.1%)였다. 370예의 임상 가검물로 시행한 중합효소 연쇄반응의 진단학적 예민도와 특이도, 양성결과 예측치 및 음성결과 예측치는 68.8%, 96.1%, 91.5% 및 83.3%로 각각 나타났다. 결론 : 결핵균 동정을 위한 중합효소 연쇄반응은 배양검사에 비해 신속하며, 분석학적인 예민도와 특이도가 뛰어나므로 결핵 진단을 위한 임상병리검사로서 유용하다고 사료됨. In this study, We investigated the optimal conditions of polymerase chain reaction(PCR) assay for the rapid identification of Mycobacterium tuberculosis in clinical specimens as routine laboratory test. So we have compared two DNA isolation methods, 3 polymerases, 2 set of primer, 2 kinds of thermocycler and 2 microtubes. We evaluated two DNA isolation methods, bead-beating method and proteinase-K method, the latter was more sensitive than the former. In comparision of two sets of primers, P1 and P2 primers detecting 123-base pair fragment of IS6110 made from Biosnthesis(U. S. A.) and INS1 and INS2 primers detecting 245-base pair fragment of IS986 showed equally sensitive results ie. 5fg. Specificity of primers were tested and INS1 and INS2 primers gave 245-base pair product from M. tuberculosis H37Rv, M. tuberculosis ATCC 27294 and Mycobacterium bovis ATCC 29312 but not from 8 nontuberculous mycobacterial strains such as M. kansasii ATCC 12478, M. terrae ATCC 15755, M. intracellurae ATCC 13950, M. avium ATCC 25281, M. gordonae ATCC 14470, M. fortuitum ATCC 6841, M. smegmatis ATCC 19420, M. scrofulaceum ATCC 19981. Coagulase-positive staphylococcus, coagulase-negative staphylococcus, streptococcus, Esccherichia coli, Serra-tia marcescens, Klebsiella pneumoniae, Enlerobacter aerogenes, Enterobacter cloacae, Acinetobacter calcoaceticus, Pseudomonas aerugonosa showed no 245-base pair amplification product. PCR by the P1 and P2 primers showed 123-base pair amplification product from M. tuberculosis H37Rv, M. tuberculosis ATCC 27294 and Mycobacterium bovis ATCC 29312 but not from 8 nontuberculous mycobacterial strains such as M. kansasii ATCC 12478, M. terrae ATCC 15755, M. intracellularae ATCC 13950, M. avium ATCC 25281, M. gordonae ATCC 14470, M. fortuitum ATCC 6841, M. smegmatis ATCC 19420, M. scrofulaceum ATCC 19981. Coagulase-postive staphylococcus, coagulase-negative staphylococcus, streptococcus, Escherichia coli, Serratia marcescens, Klebsiella pneumoniae, Enlerobacter aerogenes, Enterobacter cloacae, Acinelobacler calcoaceticus, Pseudomonas aeruginosa showed no 123-base pair amplification product. In comparision of polymerase, Taq DNA polymerase^R(Promega Co., U. S. A.) was more cost effective than Ampli Tag^R(Perkin-Elmer Cetus, U. S. A.), but these two were equally sensitive and specific in the detection of M. tuberculosis-specific DNA. Tac polymerase (Korea'Biotech, Korea) showed many nonspecific bands. In comparision of thermocycler, Easy-Cycler^R(Ericomp, U. S. A.) was more sensitive than water-bath type and in that of microtubes Robbin's were more sensitive than Sarstedt's PCR results were compared with results of culture for M. tuberculosis and Ziehl-Neelsen stain in 370 clinical specimens that were negative by initial Ziehl-Neelsen stain. There were 27 specimens(7.3%) that were positive for M. tuberculosis by culture, 18(4.9%) specimens that were positive by Ziehl-Neelsen stain, and 106 specimens(28.6%) that were positive for PCR and 141 cases that were positive for tuberculosis. Overall sensitivity, specificity, positive predictive value and negative predictive value were 68.8, 96.1, 91.5 and 83.3% respectively, for PCR; 19.1, 100, 100, and 66.8%, respectively for culture; and 12.8, 100, 100, and 59.0% respectively for Ziehl-Neelsen stain.

비만 여성을 대상으로 한 해조류 추출물의 국부처치와 운동 병행을 통한 지방분해 효과의 임상적 검정

서태수,이인숙,변재철,김규호,박승한,김유영,김상국,김현정,김상기,신동철,성미영,박종석,김종기,박언휘 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.3

This study was carried out to test the body fat breakdown during topical seaweed extract treatment and in combination with the aerobic exercise. Of 20 female obesity subjects, ten treated a cream types of seaweed extract(control group) and ten treated a placebo cream(placebo group). Topical treatment of each sample was designed for 4 weeks, and treated with 2 times a day about 10ml on the abdomen and the thigh, respectively. All subjects were participated aerobic dance half hour a day and four times a week. After 4 weeks of topical treatment and exercise, they were measured body fat, skinfold thickness, body circumference. Then venous blood samples were taken and analyzed blood cells, serum enzymes, and serum lipids. There were reduction of body weight, % of body fat, antebrachium, brachium, chest, waist, thigh circumference and abdomen thickness between pre and post treatment in both group. Especially, body weight and % of body fat significantly reduced in the subjects treating the seaweed extract than those treating the placebo. There were significant decrement in total cholesterol and LDL whereas increment in HDL and TBIL in the control group, but no significant difference in the placebo group. In conclusion, there were 7.6% of body fat reduction during 4 weeks of aerobic exercise and 21% of body fat reducement in combination of topical seaweed treatment and exercise, respectively. These results suggest that the topical treatment of seaweed extract should be very effective for fat breakdown. Especially, the body fat breakdown maximized in the combination with the topical seaweed extracts treatment and the aerobic exercise.

반코마이신 내성 장구균 감염에 대한 quinupristin-dalfopristin 치료 경험

추은주,최상호,조영환,정선미,김백남,김남중,김미나,김양수,우준희,류지소 대한화학요법학회 2002 대한화학요법학회지 Vol.20 No.1

VRE 감염이 중환자에서 급속히 증가하고 있으나 이에 대한 확실한 치료제가 없어 새로운 항생제에 대한 활발한 연구가 있는데 그 중 하나가 quinupristin/dalfopristin이고, 저자들은 중증 환자들의 VRE 감염에 대해 quinupristin/dalfopristin를 투여하여 치료한 임상적 경험을 하였기에 문헌고찰과 함께 보고하는 바이다. Vancomycin-resistant enterococci (VRE) was first recognized in 1992 in Korea. VRE infection have been increasingly reported in immunosuppressed patients over the past decade and have become one of major nosocomial pathogens. Clinicians carings for patients with VRE infections face severe constraints in the selection of treatment. Quinupristin/dalfopristin is active in vitro againt vancomycin-resistant E. faecium (VREF), with a MIC_(90) of 1.0㎍/mL. We studied the clinical efficacy and safety of this agent in the treatment of VREF infection. Patients were included if they had signs and symptoms of active infection including bacteremia, intra-abdominal infection, and wound infection. A total of 13 patients with VREF infection were enrolled. A favorable clinical response (cure or improvement) occured in 10 of 11 evaluable patients. The only adverse events related to quinupristin/dalfopristin were arthralgia and myalgia, which occurred in 2 of 13 patients. These results suggest that quinupristin/dalfopristin is effective and safe as treatment for VREF infections in critically ill patients with serious underlying conditions.