복수 설비보전센타의 복수정차 입지문제

宋省憲 弘益大學校 1988 弘大論叢 Vol.20 No.2

In many maintenance services the maintenance unit usually visits a number of demand points in a single tour. The multistop location problem is to find the depot location for the maintenance unit. We focus on locating p depots in a specified region where numerous demand points requiring maintenance services are scattered. We call it the multistop location problem of multiple facility maintenance centers. The method proposed here for the above problem can be uesfully applied to the situations where the service time performing maintenance operation is relatively short and the demand points are densely located in small area.

Anabaena variabilis ATCC 29413의 生長과 窒素固定活性에 미치는 環境要因의 影響

宋承達,韓東勳 慶北大學校 1992 論文集 Vol.52 No.-

Anabaena variabilis ATCC 29413, a photoautotrophic and nitrogen fixing cyanobacteria, was in vestigated on the growth, heterocyst differentiation and nitrogen fixation activities(ARA) along different media and environmental treatments. The lag phase in the growth curve with N-added Allen & Arnon(AA/8) was shorter than those with N-free AA/8 and N-added BG 11 media. The nitrogen fixation activity increased for 144hours during initial cell growth (Abs_660 =0.8) with N-free medium of AA/8 and then decreased, while the growth continued. It was assumed that the drastic decline of ARA beyond the cell growth of A_660=0.8 was caused by the accumulation of nitrate(NO_3^- -N ; 4.2ppm)in the medium. The accumulation of ammonium(NH_4+ -N) in the medium was about 0.32 ppm after 156hours of cell growth. The optimal conditions for nitrogenase activity of A. variabilis ATCC 29413 were anaerobic, 10,000 lux, 30℃ and pH 8 with the N-free minimal medium. The activity was significantly inhibited by less concentrations of ammonium(1 mM) than that of nitrate(6 mM). Phosphate and carbonate inhibited the activity by high concentrations although low concentrations stimulated the activity. The treatments of several toxic heavy metals showed strong inhibition of the nitrogenase activity in the order of Hg^++>Cd^++>Co^++>Zn^++>PB^++, and the concentrations for 50% inhibition of the maximum ARA were 0.41, 0.47, 0.51, 0.66 and 8.1ppm, respectively. The recovery of ARA and growth by the carbon sources in the dark condition was observed in the low concentration(1%) and in the order of sucrose>fructose>flucose.

송유관 요율결정 지원시스템의 개발 및 활용

송성헌,김우제,이문배 한국경영과학회 1999 經營 科學 Vol.16 No.1

Pipeline is an important transportation mode for oil products The pipeline transportation and storage rates affect the pipeline usage, and the pipeline usage also affects the transportation revenue and operating costs of the pipeline The purpose of our study is to develop a decision support system simulating pipeline transportation and storage rates for maximizing the utilization and profitability of the oil pipeline and apply it to the real situation To do this, a simulation model to help the decision maker decide the rates of the oil pipeline is first proposed Second, a simulation program is developed, which enables the user to evaluate the various scenarios of oil transportation and storage rates Finally, this program is applied to the case study of oil industry in Korea

수정진동자를 이용한 계면활성제의 특성 분석

송성훈,박진영,이행자,조홍식,장상목 동아대학교 환경문제연구소 1999 硏究報告 Vol.22 No.2

The phase transition phenomena and the phase separation phenomena of surfactants(SPES) are analyzed using QCA with resonant frequency and resonant resistance. The phase transition phenomena of SPES at 30℃ can be determined by measuring the resonant frequency and resonant resistance by lecithin coated on quartz crystal. The surfactants capacity of SPES can be analyzed by measuring the resonant frequency and resonant resistance of surfactants using QCA.

말기 신부전 환자에서 투여 경로에 따른 유전자 재조합 인 Erythropoietin(Epokine^(�))의 효과와 안정성에 대한 연구 : 제 4상 연구 A Phase 4 Single Center Study

송현용,윤향숙,강신욱,최규헌,하성규,이호영,한대석 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.2

목 적 : 국내 독자적 기술로 첫 개발된 유전자 재조합 인 에리트로포에틴(Epokineⓡ)의 투여방법에 따른 유효성과 안정성을 알아보고자 하였다. 방 법 : Epokineⓡ을 주당 100-150 U/kg, 주 2회, 12주간 피하 주사하여 목표 또는 안정된 혈색소치 유지 후 무작위로 피하 및 정맥 주사군으로 나누어 12주간 혈액투석 및 복막투석 환자13명, 28명에서 유효성, 안정성을 분석하였다. 결 과 : 양군에서 혈색소치와 헤마토크릿은 Epokineⓡ 투여 2주 후부터 증가, 혈색소치가 혈액투석 환자는 투여 전 7.3 g/dL, 투여 12주 9.5 g/dL, 24주 10.6 g/dL로, 복막투석 환자는 6.8g/dL에서 12주 10.2 g/dL, 24주 10.8 g/dL로 증가하였다. 양군에서 교정 망상적혈구수(%)는투여 1주 후부터 전 기간동안 증가하였다. 혈청 내 철분, ferritin치는 양군에서 투여 2주 후부터감소, 총 철분 결합능은 투여 2주 후부터 증가하였다. 12주째 혈액투석 환자에서 많은 Epokineⓡ용량이 필요했으나(142.2±20.5 vs 117.3±33.6 U/kg/wk, p<0.001) 24주 후 양군의 용량차이는 없었다(123.6±41.5 vs 99.2±49.3 U/kg/wk, p>0.05). 혈액투석 환자에서 피하 주사가Epokineⓡ 투여용량이 더 적었으나(97.4±15.4 vs 145.4±2.9 U/kg/wk, p<0.002) 복막투석 환자는 차이가 없었다(93.0±60.2 vs 105.4±9.7 U/kg/wk, p>0.05) 연구기간 중 9명(18.8%)에서혈압강하제 추가가 필요한 혈압상승, 근육통 동반 상기도 감염 유사증상 및 두통 등의 부작용이 있었다. 대부분 자연소실 혹은 대증요법으로 치유되었고 2명이 부작용으로 탈락하였다. 결 론 : 말기 신부전 환자의 빈혈 개선에 사용하는 Epokineⓡ의 효과는 복막투석 환자에서 더 좋았으며 투여 경로는 정맥주사보다 피하주사가 높음을 알 수 있었다. Background : We evaluated the clinical efficacy and safety of recombinant human erythropoietin(Epokine^(ⓡ)). Methods : A comparative prospective study of intravenously and subcutaneously administrated Epokine^(ⓡ) conducted 13 patients performing hemodialysis and 28 patients performing continuous ambulatory peritoneal dialysis with end-stage renal disease. Epokine^(ⓡ) was given initially at a dosage of 100 unit/kg, subcutaneously, two times a week. The patients had achieved stable or more than 10 g/dL of hemoglobin level for 12 weeks and then we randomized switching intravenously or subcutaneously administrated Epokine^(ⓡ) for another 12 weeks. Results : Hemoglobin(g/dL) and hematocrit(%) increased significantly from baseline levels beginning from 2 weeks after Epokine^(ⓡ) administration. In HD patients, hemoglobin increased significantly from 7.3 to 9.5 after 12 weeks and to 10.6 after 24 weeks. In CAPD patients, hemoglobin increased significantly from 6.8 to 10.2 after 12 weeks and then 10.8 after 24 weeks(p<0.05). Corrected reticulocyte count(%) was significantly increased from baseline levels beginning from 1 week after Epokine^(ⓡ) administration and continuously increased during study period in both group. Serum ferritin and serum iron decreased significantly and total iron binding capacity increased significantly after 2 weeks. At 12 weeks, HD patients were significantly needed more dosage of Epokine^(ⓡ) than CAPD patients(142.2±20.5 vs 117.3±33.6 U/kg/wk, p<0.001), but at 24 weeks, the dosage was not different(123.6±41.5 vs 99.2±49.3 U/kg/wk, p> 0.05). In HD patients, intravenously administrated Epokine^(ⓡ) group was more dosage than subcutaneously group(97.4±15.4 vs 145.4±2.9 U/kg/wk, p< 0.002), but CAPD patients were not different by administration method(93.0±60.2 vs 105.4±9.7 U/kg/ wk, p>0.05). The 9 cases(18.8%) were suffered from headache and flu-like syndrome, but these side effects were not severe and disappeared from conventional therapy. Conclusion : Epokine^(ⓡ) administration is safe and effective in treating anemia of ESRD patients and subcutaneously administration is significantly more effective than intravenously. (Korean J Nephrol 2002;21(2):190-198)

화자인식시스템에서의 켑스트럼 가중치

송철,정헌상,황의봉 조선대학교 에너지.자원신기술연구소 1999 에너지·자원신기술연구소 논문지 Vol.21 No.1

This study is to increase recognition rate and to reduce processing time in the speaker recognition system. For processing time reduction we used only difference between average reference pattern and speaker's input pattern without using DTW which had been mainly used in pattern matching. For increasing recognition rate existing cepstrum weights are modified. Experimental results with ten speakers showed increase by 1.75%(95.25% from 93.5%) in speaker verification and 100% in speaker identification.

분할배달을 고려한 발견적 배송경로 결정 방법

송성헌,강승우 弘益大學校 科學技術硏究所 1998 科學技術硏究論文集 Vol.9 No.2

This paper considers the Vehicle Routing and Schedule Problem with numerous features added in an attempt to model more realistic problems. These features include the following possibilities : a delivery to a customer is permitted to be made by more than one vehicle; customers have a time interval, or intervals, in which their delivery must be made(i. e. a time window); a vehicle type by a demand situation and available travel time per day. We proposed two heuristics: the first one uses a saving-insertion method and the second one uses a saving method. For comparsion, two of our route development methods are implemented on a specifically developed data set.

초등학교 수학 영재학급용 프로그램 개발에 관한 연구

송상현,김지영 인천교육대학교 과학교육연구소 2003 과학교육논총 Vol.15 No.-

본 연구는 초등학교 수학 영재학급에서 수학 영재들이 자신들의 영재성을 충분히 발휘할 수 있도록 하는 수학 영재 교육 프로그램을 개발하기 위한 방향을 제안하는 것이다. 이를 위하여 여러 선행 연구들을 분석/검토하여 프로그램의 목적, 유형, 내용, 운영 면에서 수학 영재 교육 프로그램 개발의 4가지 기본 방향을 정하였다. 이러한 개발의 기본 방향에 따라 전체 프로그램의 목적과의 일관성, 영재의 특성 고려, 프로그램의 유형, 학습 자료의 내용, 학습 자료의 성격, 교수 방법, 평가, 각 단위 수업에서의 구현 중점, 자료의 체제의 측면 등 9가지 면에서 수학 영재 학급용 교수-학습 자료 개발의 준거를 수립하였다. 그리고 이에 따라 초등학교 6학년 수학 영재학급의 교육 프로그램과 교수-학습 자료를 개발하고 현장에 적용하여 12차시의 수업을 분석해 봄으로써 앞의 10가지 자료개발 준거가 후속 자료개발에 시사하는 7가지의 중요한 시사점을 얻었다. The purpose of this study is to develop a Gifted Education Program in math-gifted class in elementary school. The literature analyzed in this study included earlier studies on math-gifted education programs and relevant teaching materials, math-gifted curriculum published in KEDI(Korea Educational Development Institute), and reports by gifted education demonstration schools. We proposed 4 guidelines to open the math-gifted education program. Based on the 4 guidelines, we established 9 criteria to develop math-gifted teaching/learning materials and proposed 7 considerations.

만적(滿積) 수송차량의 차량소요계획

宋省憲 弘益大學校 科學技術硏究所 1994 科學技術硏究論文集 Vol.4 No.-

The vehicle requirement planning in a company is very important not only for the stable procurement of vehicles in order to supply goods to its customers at right times and at right places, but also for the compilation of logistics budget. The purpose of this paper is to suggest a systematic approach to establish the requirement planning for the full load vehicles. Since the algorithm developed here is based on the historical vehicle routes information, the vehicle requirement planning that is close to reality can be prepared.

가토에서 TGF-β 길항제인 Decorin이 창상치유에 미치는 영향

송상훈,김선헌 전남대학교 치의학연구소 2001 구강과학 Vol.13 No.3

There have been many trials to decrease the scar formation followed by wound treatment, TGF-β plays a important role on wound healing in adult. Therefore the repression of TGF-β expression will be helpful to decrease scar formation. Decorin is known to competitively inhibit TGF-β expression. Decorin were subcutaneously administered in surgical wounds in rabbits to investgate the preventing effect of scar formation for clinical application. Histologic findings of wound healing progresses is similar with control and experimental group at 2week. 2.5㎍ decorin of administrated group was similar to those of control group at 4 and 8week. In wound healing process 10㎍ decorin of administrated groupsat showed that thickness of immature collagen fibers(scar) was decreased as compared with control group at 4, 8 weeks. 20㎍ decorin of administrated group showed similar histologic features to 10㎍ administrated group. The wounds of 8week experimental group(10, 20㎍) were completely recovered to the normal surrounding skin tissue including sweat gland and hair follicle. These results suggested that docorin can be of help to the prevention of local scar formation.