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자가면역 췌장염의 동반증상 없이 발생한 IgG4 연관 경화성 담관염
천송욱 ( Song Wook Chun ),최자성 ( Ja Sung Choi ),강버들 ( Beo Deul Kang ),김유진 ( Yu Jin Kim ),한기준 ( Ki Jun Han ),조현근 ( Hyeon Geun Cho ),오화은 ( Hwa Eun Oh1 ),조재희 ( Jae Hee Cho ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.1
IgG4-related systemic diseases are characterized by a diffuse or mass forming inflammatory reaction rich in lymphocytes and IgG4-positive plasma cells (lymphoplasmacytic infiltration), fibrosclerosis of variable organs and obliterative phlebitis. They usually involve various organs including the pancreas, bile duct, gallbladder, salivary gland, retroperitoneum, kidney, lung, and prostate. However, most of them are accompanied by autoimmune pancreatitis, and good response to steroid treatment is one of the hallmarks of this disease. We report a case of an 67-year-old man with IgG4 associated sclerosing cholangitis, who was diagnosed by endoscopic retrograde cholangiopancreatography and successfully treated with steroid therapy. (Korean J Gastroenterol 2013; 62:69-74)
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Yum, Woo Sung,Jeong, Yeonung,Song, Heamin,Oh, Jae Eun Elsevier 2018 Construction and Building Materials Vol.185 No.-
<P><B>Abstract</B></P> <P>This study explored the possibility of using limestone fines (LF) as a supplementary material in activated slag binder systems using two types of activators (i.e., 10 wt% of Ca(OH)<SUB>2</SUB> or 10 wt% of Ba(OH)<SUB>2</SUB>) and investigated the interactions of the activators with LF in each binder system through strength testing, powder X-ray diffraction, thermogravimetry, and mercury intrusion porosimetry. Using these binders, concrete brick samples containing LF were also made and examined for possible industrial applications. Although the influences of the LF addition on the strength, dissolution degree of the slag, reaction products, and pore-size distribution depended on the type and dosage of the activator, the addition was generally advantageous for all these aspects in both types of activations. The concrete brick made of 20 wt% LF using the Ba(OH)<SUB>2</SUB> activation fulfilled the Korean standard requirements of strength and water absorption for concrete bricks, and it also satisfied the criteria of the leaching test for possible toxic elements.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Limestone fines (LF) was studied as a supplementary material in activated slags. </LI> <LI> Main activators for slag were Ca(OH)<SUB>2</SUB> or Ba(OH)<SUB>2</SUB>. </LI> <LI> At early ages, the use of LF significantly improved strength in both activations. </LI> <LI> The use of LF significantly changed reaction products of Ba(OH)<SUB>2</SUB> activation. </LI> <LI> However, the use LF did not alter reaction products of Ca(OH)<SUB>2</SUB> activation. </LI> </UL> </P>
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만성 콩팥병 환자에서 추정 사구체 여과율에 따른 25-Hydroxyvitamin D의 특성
고정희 ( Jung Hee Koh ),곽임수 ( Ihm Soo Kwak ),송상헌 ( Sang Heon Song ),이수봉 ( Soo Bong Lee ),이하린 ( Harin Rhee ),성은영 ( Eun Young Seong ),박창준 ( Chang Jun Park ),김태균 ( Tae Kyun Kim ),오상보 ( Sang Bo Oh ) 대한내과학회 2012 대한내과학회지 Vol.83 No.6
Background/Aims: Accumulating data suggest that vitamin D deficiency is prevalent in patients with chronic kidney disease (CKD). However, comprehensive data are lacking for Koreans. The aim of this study was to survey vitamin D deficiency among patients with CKD in Korea and to identify the relationships among various factors. Methods: We conducted a retrospective cohort study of 444 patients who were divided into four subgroups by estimated glomerular filtration rate (eGFR) for comparisons of mean 25-hydroxyvitamin D [25(OH)D] level and other parameters. In addition, non-dialyzed patients were categorized into four groups based on 25(OH)D levels (<10, 10-19, 20-29, and ≥ 30 ng/mL), and risk factors for severe vitamin D deficiency (<10 ng/mL) were investigated. Results: Of patients with an eGFR ≥ 60 mL/min/1.73 m2, 43% (34/79) showed severe 25(OH)D deficiency, and the mean 25(OH)D level was 11.7±5.3 ng/mL. In CKD3 group, 53.2% (41/77) showed severe 25(OH)D deficiency, with a mean level of 11.3±7.2 ng/mL. In CKD4 group, 53.3% (49/92) had severe 25(OH)D deficiency, with a mean level of 11.0±6.2 ng/mL. Approximately 71% (139/196) of patients in CKD5 group showed severe deficiency, and the mean level was 9.2±5.9 ng/mL. Severe 25(OH)D deficiency was affected by winter season, renal function, diabetes, and low-density lipoprotein cholesterol. The serum parathyroid hormone level was inversely correlated with the 25(OH)D level, such that 25(OH)D < 20 ng/mL were associated with a steep increase in parathyroid hormone. Conclusions: Vitamin D deficiency is highly prevalent in the Korean population. Few patients met a sufficient 25(OH)D concentration, even in the early stages of CKD. Our data suggest that 25(OH)D level of 20 ng/mL is a threshold for a rapid increase in parathyroid hormone levels. (Korean J Med 2012;83:740-751)
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Song, Jyewon,Oh, Sung Jin,Kang, Wook Ho,Hyung, Woo Jin,Choi, Seung Ho,Noh, Sung Hoon Lippincott Williams Wilkins, Inc. 2009 Annals of surgery Vol.249 No.6
OBJECTIVE:: To evaluate the technical feasibility, effectiveness, and safety of robot-assisted gastrectomy (RAG) with lymphadenectomy, using the da Vinci system through analyses of our initial series of 100 consecutive patients. SUMMARY BACKGROUND DATA:: The application of robotic surgery was proven to be one of the best cutting-edge technologies for successful minimally invasive surgery by providing solutions to the many drawbacks of laparoscopic surgery, yet few reports have studied robotic surgery in gastric cancer. METHODS:: A review of a prospectively designed database at our institute from July 2005 to October 2007 revealed a series of 100 consecutive RAG patients with a preoperative diagnosis of early gastric cancer. Clinicopathologic characteristics and surgical outcomes were analyzed. RESULTS:: All operations were performed successfully without open or laparoscopic conversion. There were 33 total gastrectomies and 67 subtotal gastrectomies with D1+&bgr; or extended lymphadenectomy (D2). The mean total operation time and console time were 231 and 150 minutes, respectively. There were 13 postoperative morbidities and 1 postoperative mortality. The first flatus was noted on postoperative day 2.9, soft diet was started on postoperative day 4.2, and the mean postoperative hospital stay was 7.8 days. Although all patients were diagnosed as early gastric cancer preoperatively, the final pathology report revealed that 19 patients exhibited a depth deeper than T2. The mean number of retrieved lymph nodes was 36.7 (range, 11–83). None of the specimens showed microscopic tumor involvement in the resection line. CONCLUSIONS:: This study demonstrated that RAG with lymphadenectomy can be applied safely and effectively for patients with gastric cancer.
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Oh, Sung Jin,Hyung, Woo Jin,Li, Chen,Song, Jyewon,Rha, Sun Young,Chung, Hyun Cheol,Choi, Seung Ho,Noh, Sung Hoon Blackwell Publishing Asia 2009 Journal of gastroenterology and hepatology Vol.24 No.3
<P>Abstract</P><P>Background and Aim: </P><P>The prevalence of being overweight has risen remarkably in Korea. This study sought to clarify the relationship between being overweight and surgical outcomes in gastric cancer patients.</P><P>Methods: </P><P>A total of 410 patients who underwent curative total gastrectomies with D2 dissection from January 2000 to December 2003 were retrospectively studied from a prospectively designed database. The patients were assigned to two groups based upon their body mass index (BMI): non-overweight, BMI < 25 kg/m<SUP>2</SUP>; overweight, BMI ≥ 25 kg/m<SUP>2</SUP>. Perioperative surgical outcomes, postoperative morbidity, mortality, recurrence, and prognosis were analyzed.</P><P>Results: </P><P>The overweight group had longer operation time and more postoperative complications than the non-overweight group. The two groups were similar in terms of transfusion volumes, postoperative bowel movement, time to initiation of a soft diet, and postoperative hospital stay. Patterns of recurrence and cumulative survival rates were similar for each group. Multivariate analysis showed that being overweight was not a risk factor for recurrence or poor prognosis.</P><P>Conclusion: </P><P>Although being overweight was associated with increased operation time and higher risk of complications in gastric cancer patients undergoing curative total gastrectomy, it had no effect on recurrence or long-term survival.</P>
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Influence of ship emissions on ozone concentrations around coastal areas during summer season
Song, Sang-Keun,Shon, Zang-Ho,Kim, Yoo-Keun,Kang, Yoon-Hee,Oh, In-Bo,Jung, Chang-Hoon Elsevier 2010 Atmospheric environment Vol.44 No.5
<P><B>Abstract</B></P><P>The influence of ship emissions on ozone (O<SUB>3</SUB>) concentrations in a coastal area (CA) including Busan port, Korea was examined based on a numerical modeling approach during a high O<SUB>3</SUB> episode. The analysis was performed by two sets of simulation scenarios: (1) with ship emissions (e.g., TOTAL case) and (2) without ship emissions (e.g., BASE case). A process analysis (PA) (the integrated processes rate (IPR) and integrated reaction rate (IRR) analyses) was used to evaluate the relative contributions of individual physical and chemical processes in O<SUB>3</SUB> production in and around the CA (e.g., sites of Dong Sam (DS) and Dae Yeon (DY)). The model study suggested the possibility that pollutant gases emitted from the ships traversing Busan port can exert a direct impact on the O<SUB>3</SUB> concentration levels in the CA. Largest impacts of ship emissions on the O<SUB>3</SUB> concentrations were predicted at the coast (up to 15 ppb) and at inland locations (about 5 ppb) due to both the photochemical production of pollutant gases emitted from the ships and meteorological conditions. From the PA, the photochemical production of O<SUB>3</SUB> (P(O<SUB>3</SUB>)) due to ship emissions in the CA was found to increase by a mean of 1.5 ppb h<SUP>−1</SUP> (especially by ≥10 ppb h<SUP>−1</SUP> at the DS site) during the day.</P>
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Oh, Jung-Min,Kim, Su-Hyeong,Lee, Yun-Il,Seo, Miran,Kim, So-Young,Song, Yong-Sang,Kim, Woo-Ho,Juhnn, Yong-Sung Oxford University Press 2009 Carcinogenesis Vol.30 No.1
<P>Human papillomavirus (HPV) is the major cause of uterine cervical cancer, but the role of the HPV E5 in carcinogenesis is not clearly understood. Prostaglandins are known to contribute to carcinogenesis of cervical cancer, and we therefore investigated the effect of HPV16 E5 on the expression of prostaglandin E2 (PGE2) receptors and underlying mechanisms. Stable expression of the E5 induced expression of the EP4 subtype of PGE2 receptors in C33A cervical cancer cells, and transfection of E5 small interfering RNA (siRNA) decreased it. EP4 protein expression was increased in human cervical cancer tissues, and EP4 mediated E5-induced increase in anchorage-independent colony formation and vascular endothelial growth factor expression. E5 induced cyclooxygenase-2 (COX-2) expression, and COX-2 increased PGE2 secretion and EP4 expression. The induction of EP4 by PGE2 and E5 was inhibited by an EP4 antagonist, inhibitors of cyclic adenosine monophosphate-dependent protein kinase or phosphatidylinositol 3-kinase, and a cyclic adenosine monophosphate response element (CRE) decoy. E5 increased the luciferase expression controlled by a variant CRE of the EP4 promoter, and it also increased the binding of cyclic adenosine monophosphate response element binding protein (CREB) to oligonucleotides containing this CRE. We conclude that the HPV16 E5 protein induces EP4 receptor protein in cervical cancer cells and that this induction involves epidermal growth factor receptor, COX-2, PGE2, EP2 and EP4, protein kinase A, CREB and CRE.</P>
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Oh, Yeo Kyoung,Lee, Hyun Jung,Jeong, Mi-Hee,Rhee, Marie,Mo, Ji-Won,Song, Eun Hyeon,Lim, Joong-Yeon,Choi, Kyung-Hee,Jo, Inho,Park, Sang Ick,Gao, Bin,Kwon, Yongil,Kim, Won-Ho American Association for Cancer Research 2008 Molecular cancer research Vol.6 No.7
<P>Taxol (paclitaxel) is a potent anticancer drug that has been found to be effective against several tumor types, including cervical cancer. However, the exact mechanism underlying the antitumor effects of paclitaxel is poorly understood. Here, paclitaxel induced the apoptosis of cervical cancer HeLa cells and correlated with the enhanced activation of caspase-3 and TAp73, which was strongly inhibited by TAp73beta small interfering RNA (siRNA). In wild-type activating transcription factor 3 (ATF3)-overexpressed cells, paclitaxel enhanced apoptosis through increased alpha and beta isoform expression of TAp73; however, these events were attenuated in cells containing inactive COOH-terminal-deleted ATF3 [ATF3(DeltaC)] or ATF3 siRNA. In contrast, paclitaxel-induced ATF3 expression did not change in TAp73beta-overexpressed or TAp73beta siRNA-cotransfected cells. Furthermore, paclitaxel-induced ATF3 translocated into the nucleus where TAp73beta is expressed, but not in ATF3(DeltaC) or TAp73beta siRNA-transfected cells. As confirmed by the GST pull-down assay, ATF3 bound to the DNA-binding domain of p73, resulting in the activation of p21 or Bax transcription, a downstream target of p73. Overexpression of ATF3 prolonged the half-life of TAp73beta by inhibiting its ubiquitination and thereby enhancing its transactivation and proapoptotic activities. Additionally, ATF3 induced by paclitaxel potentiated the stability of TAp73beta, not its transcriptional level. Chromatin immunoprecipitation analyses show that TAp73beta and ATF3 are recruited directly to the p21 and Bax promoter. Collectively, these results reveal that overexpression of ATF3 potentiates paclitaxel-induced apoptosis of HeLa cells, at least in part, by enhancing TAp73beta's stability and its transcriptional activity. The investigation shows that ATF3 may function as a tumor-inhibiting factor through direct regulatory effects on TAp73beta, suggesting a functional link between ATF3 and TAp73beta.</P>
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