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Kim, S-H,Kim, E-J,Hitomi, M,Oh, S-Y,Jin, X,Jeon, H-M,Beck, S,Jin, X,Kim, J-K,Park, C G,Chang, S-Y,Yin, J,Kim, T,Jeon, Y-j,Song, J,Lim, Y C,Lathia, J D,Nakano, I,Kim, H Macmillan Publishers Limited 2015 CELL DEATH AND DIFFERENTIATION Vol.22 No.9
Glioblastomas (GBMs) maintain their cellular heterogeneity with glioma stem cells (GSCs) producing a variety of tumor cell types. Here we interrogated the oncogenic roles of Lim domain only 2 (LMO2) in GBM and GSCs in mice and human. High expression of LMO2 was found in human patient-derived GSCs compared with the differentiated progeny cells. LMO2 is required for GSC proliferation both in vitro and in vivo, as shRNA-mediated LMO2 silencing attenuated tumor growth derived from human GSCs. Further, LMO2 is sufficient to induce stem cell characteristics (stemness) in mouse premalignant astrocytes, as forced LMO2 expression facilitated in vitro and in vivo growth of astrocytes derived from Ink4a/Arf null mice and acquisition of GSC phenotypes. A subset of mouse and human GSCs converted into vascular endothelial-like tumor cells both in vitro and in vivo, which phenotype was attenuated by LMO2 silencing and promoted by LMO2 overexpression. Mechanistically, the action of LMO2 for induction of glioma stemness is mediated by transcriptional regulation of Jagged1 resulting in activation of the Notch pathway, whereas LMO2 directly occupies the promoter regions of the VE-cadherin gene for a gain of endothelial cellular phenotype. Subsequently, selective ablation of human GSC-derived VE-cadherin-expressing cells attenuated vascular formation in mouse intracranial tumors, thereby significantly prolonging mouse survival. Clinically, LMO2 expression was elevated in GBM tissues and inversely correlated with prognosis of GBM patients. Taken together, our findings describe novel dual roles of LMO2 to induce tumorigenesis and angiogenesis, and provide potential therapeutic targets in GBMs.
A STUDY on FOREST FIRE SPREADING ALGORITHM with CALCULATED WIND DISTRIBUTION
Song,J,H,Kim,E,S,Lim,H,J,Kim,H,Kim,H,S,Lee,S,Y 한국화재소방학회 1997 한국화재소방학회 학술대회 논문집 Vol.1997 No.-
There are many parameters in prediction of forest fire spread. The variables such as fuel moisture, fuel loading, wind velocity, wind direction, relative humidity, slope, and solar aspect have important effects on fire. Particularly, wind and slope factors are considered to be the most important parameters in propagation of forest fire. Generally, slope effect cause different wind distribution in mountain area. However, this effect is disregarded in complex geometry. In this paper, wind is estimated by applying computational fluid dynamics to the forest geometry. Wind velocity data is obtained by using CFD code with Newtonian model and slope is calculated with geometrical data. These data are applied fer 2-dimentional forest fire spreading algorithm with Korean ROS(Rate Of Spread). Finally, the comparison between the simulation and the real forest fire is made. The algorithm spread of forest fire will help fire fighter to get the basic data far fire suppression and the prediction to behavior of forest fire.
Proportion And Characteristics Of Transient Nodules In A Retrospective Analysis Of Pulmonary Nodules
( Jin Yeong Yu ),( Su Young Chi ),( Hee Jung Ban ),( Yong Soo Kwon ),( In Jae Oh ),( Kyu Sik Kim ),( Yu Il Kim1 ),( Sung Chul Lim ),( Song Choi ),( Yun Hyeon Kim ),( Young Chul Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.-
가토에서 일측 요관 부분 및 완전폐색시 신장과 요관의 조직학적 변화
김상현,김용웅,육승모,한동석,노안식,임재성,김홍식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2
This study was designed to clarify histologic changes in the experimental rabbit kidney and ureter after unilateral partial or complete ureteral obstruction. A total of 20 adult white rabbits were divided into 4 subgroups in the partial obstruction followed by 2 weeks, the partial obstruction followed by 4 weeks, the complete obstruction followed by 2 weeks, and the complete obstruction followed by 4 weeks. The normal control group was consisted of 5 adult white rabbits. The kidneys and ureters for light microscopy were fixed in 10% neutral formalin, embedded in paraffin and stained with hematoxylin and eosin. Abnormal histologic fingings showed in ipsilateral kidney and ureter of all subgroups(such as dilatation of uriniferous tubule, focal necrosis and desquamation of epithelium, interstitial fibrosis, glomerular congestion, widening of Bowman's space, dilatation of ureter, epithelial cell atrophy or loss, interstitial fibrosis and interstitial inflammation). These findings were most severe in the group of the complete-obstructed ureter for 4 weeks. No significant changes showed in contralateral ureter of all subgroups. The degree of obstruction was severe and period of obstruction was long, the histological changes in ipsilateral side were severe. Despite of changes in ipsilateral side no abnormal findings showed in contralateral side. We suggest that long term experimental investigation of histologic changes in ipsilateral side and compensatory changes in contralateral side have to be studied.
김재수,임성규,김재봉,정경미 광주교육대학교 초등교육연구소 2001 初等敎育硏究 Vol.15 No.2
The purpose of this study was to develop an writing strategy with brainstorming. Concrete instructional contents for the dvelopment of writing strategy with brainstorming and the continuous application of the strategy to the whole writing's processes were developed here. And its method of application to elementary school and university were also described. The modern writing theory which reflects the importance of thinking had emphasis on the diversification of thinking ability. From this point of view, brainstorming which is adopted to a way of enhancing thinking ability was applied to students' writings. Brainstorming aims to pull out the unique idea from the consciousness of students and this study tried to develop continuous model of writing strategy through brainstorming. The advantage of continuous model could be in teaching the students interactively for whole writing processes. This study showed that brainstorming could be applied to the whole writing process, idea production - idea construction - paragraph writing, and described the results of its application at the order of method - application - consideration of instruction.
최선택,은종렬,임상우,김봉준,이헌주,구미진,최준혁 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1
Background: Cholestatic hepatitis is failure of bile to reach the duodenum with hepatocellular damage and no demonstrable obstruction of the major bile ducts. The prognosis is usually good with recovery in less than 4 weeks after withdrawal of the offending drug. However, a prolonged course lasting over 3 months is possible and, in rare cases, progression to ductopenia with development of a vanishing bile duct syndrome occurs. A differential diagnosis with other causes of Chronic liver disease is needed. Materials and Methods: From January 1991 through Jaunary 2000, 14 patients diagnosed as cholestatic hepatitis by liver biopsy were inclouded. The possible causative drug, clinical features, laboatory findings, and progression of cholestatic hepatitis were evaluated. The semiquantitative study of liver lesions was performed by two independent observers. Results: Causes of cholestatic hepatitis are 5 cases of oriental medicine, 3 cases of anti-tuberculosis medication, 1 case of ticlopidine and antibiotics and 4 cases of unknown causes. The clinical features of cholestatic hepatitis were jaundice, itching, urine color change, and general weakness. During 6 to 30 months, LFT of 5 patients showed prolonged elevation. Elevated total cholesterol ≥250 mg/dL in 6 patients, pheripheral blood eosinophilia in 5 patients, auto-antibody positive in 6 patients were observed respectively. The biopsies showed intralobular bilirubinostasis with a mixed portal inflammatory infiltration. Conclusion: In cholestatic hepatitis. durations of abnormal LFT are variable regardless of causative drugs. If cholestatic hepatitis progresses toward chronic course, viral hepatitis, primary biliary cirrhosis, and autoimmune hepatitis should be differentially diagnosed and sequential liver biopsies are needed.
신재범,이상영,김재수,박성희,임준석 韓國海洋大學校 附設 海洋科學技術硏究所 1992 硏究論文集 Vol.1 No.1
In the active sonar development, the reverberation is one of the major factors to be overcome like the clutter in the rader development. Unfortunately real reverberation data in various cases cannot be achieved so easily as real clutter data can be and there is a trend to build a simulator before a complex sonar system is developed. In the sonar simulator, the synthesized reverberation signal is necessary. In this paper we propose an algorithm to simulate the reverberation for the moving active sonar to use it in a simulator, and show some simulated results.