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- 저자 : Son. Yong-Koo (검색결과 117 건)
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표재성 방광 이행상피세포암에 있어서 방광내 항암제주입요법 밀 면역요법
설종구,신보현,하용원,김윤종,노안식,손성용 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2
Intravesical chemotherapy and immunotherapy will commonly eradicate residual papillary transitional cell carcinoma or carcinoma in situ(CIS) and clearly reduce the short-term incidence and rate of tumor recurrence. So I reviewed the effects and complications of different therapeutic agents(thiotepa, mitomycin-C, epirubicin, adriamycin, bacillus Cal mette-Cue'rin(BCG)) in superficial bladder cancer confirmed with histopathology, with the literatures. Bladder cancer were recurred more commonly in multiple tumors(50.6-56.3%), high grade tumors(52.6%) rather than in single(30.9%) and low grade(31.6%). And recurrence rates according to therapeutic agents were 83.3% in mitomycin-C, 71.4% in thiotepa, 50.0% in epirubicin, 46.6% in adriamycin and 32.6% in BCG. But incidence of complications were highest in BCG(50.5%). So sufficient preventive manuevers should be needed before intravesical theraphy, especially in BCG immunotherapy.
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요로조영상에서 요관폐색 및 음영결손을 보인 환자에서의 요관경검사
염규영,하용원,노안식,손성용,김진겸,설종구 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2
Purpose: To evaluate the clinical value of ureteroscopy for the ureteral filling defect or obstruction on the excretory or retrograde pyelogram(RGP). Materials and Methods: The 72 patients with filling defect or intrinsic obstruction ureteral lesion on the excretory urogram or RGP underwent ureteroscopy to examine and treat the lesions. We used the 9.5Fr. or 11.5Fr. rigid ureteroscope with 5Fr. working channel. Results: The results were as follows; I. Among the 72 patients, 39 were male and 33were female. The mean age of patient was 45.7 years. 2. Ureteroscopy was successfully performed in 70 cases(97%) out of 72. In 2 cases, the advance of ureteroscope was failed. 3. Among 70 successful cases, ureteroscopy revealed 45 radiolucent stones, 9 ureteral stricture, 2 ureteral TCC. I metastatic tumor, 3 blood clot, each case of ureteral polyp, epithelial hyperplasia and Von-Brunn's nest. In 7 cases, no causative lesions were identified. 4. 41 out of 45 radiolucent stones were successfully removed by ureteroscopic procedure and 9 ureteral strictures were dilated. 6 cases of ureteral mass were successfully biopsied for pathological diagnosis. 5. 23 cases of post-operative or fever were treated conservatively and 10 cases of mucosal tearing and 1 case of ureteral perforation were treated with double-J stent indwelling. Conclusions: The ureteroscopy is effective modality to evaluate and treat in the ureteral filling defect or obstruction on the excretory urogram.
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Platelet-Rich Plasma (PRP)가 토끼 척골의 분절 결손의 치료로 이식된 동종 장관골의 골유합에 미치는 효과
송주현,정진영,강용구,이한용,손문익,서상일 대한골절학회 2003 대한골절학회지 Vol.16 No.3
목적: 골종양 환자나 외상, 골수염, 인공관절 치환술 등의 환자 등의 환자 치료에 많이 사용하는 장관골의 동종 이식에 대한 PRP (Platelet-Rich Plasma)의 효과를 토끼를 이용한 실험으로 알아보고자 하였다. 대상 및 방법: 20마리의 토끼를 대상으로 각각에 일련번호를 붙이고, 각 토끼의 양측 척골에 약 2㎝ 길이의 골편을 얻어 장관골 결손을 만들고 동시에 동종 장관골을 얻어, 홀수 토끼의 척골 골편을 짝수 토끼의 골결손 분위에 이식하고, 반대로 짝수 토끼의 척골 골편을 홀수 토끼의 골결손 분위에 이식하였다. 그 후 각 토끼의 좌측 척골 이식 부위에는 아무런 처치를 하지 않고 대조군으로 삼고, 우측 척골 이식부에는 PRP 0.7cc를 처치하여 실험군으로 삼았다. 술 후 0, 4, 8, 12주에 골이식부에 대한 방사선 촬영을 통하여 골유합 성적을 평가 비교하였다. 결과: 실험군의 척골 분절 결손부에서는 대조군에서보다 동종 분절골 이식부의 골유합이 방사선학적으로 향상된 것을 관찰 할 수 있었다. 결론: 동종 장관골 분절 이식시 PRP를 병용하여 사용할 경우 더욱 효과적인 신생조직 형성을 유도할 수 있으며, 임상에도 유용하게 적용할 수 있으리라 사료된다. Purpose: The purpose of this study was to evaluate the effect of Platelet-Rich Plasma(PRP) on the healing of the allograft for the treatment of the segmental bone defect of the ulna in Rabbits. Materials and Methods: About 2 ㎝-sized segmental bone defects were created on both ulna of twenty rabbits. The rabbits were divided into two groups, even and odd number groups after numbering them from 1 to 20. The segmental bone from the odd numbered animal was transplanted to the even numbered animal, and the even numbered to the odd numbered. The left side of the ulna was grafted with a segmental allograft only. The right side of the ulna was grafted with a segmental allograft and 0.7cc of PRP. Radiographs obtained at 0, 4, 8, and 12 weeks postoperatively were graded for radiologic union. Result: The use of the combination of PRP and segmental allograft demonstrated improved healing on radiographic study compared with that demonstrated after use of allograft alone. Conclusion: The results of the study suggests that the use of the combination of PRP and segmental allograft can be considered as an alternative method to manage the segmental defect of the long bone.
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RF CMOS Power Amplifiers for Mobile Terminals
Son, Ki-Yong,Koo, Bon-Hoon,Lee, Yu-Mi,Lee, Hong-Tak,Hong, Song-Cheol The Institute of Electronics and Information Engin 2009 Journal of semiconductor technology and science Vol.9 No.4
Recent progress in development of CMOS power amplifiers for mobile terminals is reviewed, focusing first on switching mode power amplifiers, which are used for transmitters with constant envelope modulation and polar transmitters. Then, various transmission line transformers are evaluated. Finally, linear power amplifiers, and linearization techniques, are discussed. Although CMOS devices are less linear than other devices, additional functions can be easily integrated with CMOS power amplifiersin the same IC. Therefore, CMOS power amplifiers are expected to have potential applications after various linearity and efficiency enhancement techniques are used.
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Son, Hyeong-Hoon,Min, Sung-Hun,Yeon, Ji-Yeong,Kim, Jin-Woo,Park, Soo-Yong,Lee, Yong-Hee,Jeong, Pil-Soo,Koo, Deog-Bon The Korean Society of Animal Reproduction 2013 Reproductive & developmental biology Vol.37 No.4
Cathepsin B is abundantly expressed peptidase of the papain family in the lysosomes, and closely related to the cell degradation system such as apoptosis, necrosis and autophagy. Abnormal degradation of organelles often occurs due to release of cathepsin B into the cytoplasm. Many studies have been reported that relationship between cathepsin B and intracellular mechanisms in various cell types, but porcine embryos has not yet been reported. Therefore, this study evaluated the effect of cathepsin B inhibitor (E-64) on preimplantation developmental competence and quality of porcine embryos focusing on apoptosis and oxidative stress. The expression of cathepsin B mRNA in porcine embryos was gradually decreased in inverse proportion to E-64 concentration by using real-time RT-PCR. When putative zygotes were cultured with E-64 for 24 h, the rates of early cleavage and blastocyst development were decreased by increasing E-64 concentration. However, the rate of blastocyst development in $5{\mu}M$ treated group was similar to the control. On the other hand, both the index of apoptotic and reactive oxygen species (ROS) of blastocysts were significantly decreased in the $5{\mu}M$ E-64 treated group compared with control. We also examined the mRNA expression levels of apoptosis related genes in the blastocysts derived from $5{\mu}M$ E-64 treated and non-treated groups. Expression of the pro-apoptotic Bax gene was shown to be decreased in the E-64 treated blastocyst group, whereas expression of the anti-apoptotic Bcl-xL gene was increased. Taken together, these results suggest that proper inhibition of cathepsin B at early development stage embryos improves the quality of blastocysts, which may be related to not only the apoptosis reduction but also the oxidative stress reduction in porcine embryos.
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Survey-Based Analysis of the Clinical Treatment Status of Irritable Bowel Syndrome in Korea
Koo Hoon Sup,Son Hui Chang,이홍섭,Goong Hyeon Jeong,김주석,김기배,Kwon Yong Hwan,김재학,신현덕,Shin Ji Eun,지삼룡 대한의학회 2023 Journal of Korean medical science Vol.38 No.16
Background: The quality-of-life of patients with irritable bowel syndrome is low; incorrect diagnosis/treatment causes economic burden and inappropriate consumption of medical resources. This survey-based study aimed to analyze the current status of irritable bowel syndrome treatment to examine differences in doctors’ perceptions of the disease, and treatment patterns. Methods: From October 2019 to February 2020, the irritable bowel syndrome and Intestinal Function Research Study Group of the Korean Society of Neurogastroenterology and Motility conducted a survey on doctors working in primary, secondary, and tertiary healthcare institutions. The questionnaire included 37 items and was completed anonymously using the NAVER platform (a web-based platform), e-mails, and written forms. Results: A total of 272 doctors responded; respondents reported using the Rome IV diagnostic criteria (amended in 2016) for diagnosing and treating irritable bowel syndrome. Several differences were noted between the primary, secondary, and tertiary physicians’ groups. The rate of colonoscopy was high in tertiary healthcare institutions. During a colonoscopy, the necessity of random biopsy was higher among physicians who worked at tertiary institutions. ‘The patient did not adhere to the diet’ as a reason for ineffectiveness using low-fermentable oligo-, di-, and mono-saccharides, and polyols diet treatment was higher among physicians in primary/secondary institutions, and ‘There are individual differences in terms of effectiveness’ was higher among physicians in tertiary institutions. In irritable bowel syndrome constipation predominant subtype, the use of serotonin type 3 receptor antagonist (ramosetron) and probiotics was higher in primary/secondary institutions, while serotonin type 4 receptor agonist was used more in tertiary institutions. In irritable bowel syndrome diarrhea predominant subtype, the use of antispasmodics was higher in primary/secondary institutions, while the use of serotonin type 3 receptor antagonist (ramosetron) was higher in tertiary institutions. Conclusion: Notable differences were observed between physicians in primary/secondary and tertiary institiutions regarding the rate of colonoscopy, necessity of random biopsy, the reason for the ineffectiveness of low-fermentable oligo-, di-, and mono-saccharides, and polyols diet, and use of drug therapy in irritable bowel syndrome. In South Korea, irritable bowel syndrome is diagnosed and treated according to the Rome IV diagnostic criteria, revised in 2016.
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Son, Yong,Yeo, Junyeob,Moon, Hanul,Lim, Tae Woo,Hong, Sukjoon,Nam, Koo Hyun,Yoo, Seunghyup,Grigoropoulos, Costas P.,Yang, Dong‐,Yol,Ko, Seung Hwan WILEY‐VCH Verlag 2011 ADVANCED MATERIALS Vol.23 No.28
<P><B>A digital, direct nanoscale metal patterning method</B> is developed using femtosecond laser digital processing of metal nanoparticles for nanoscale electronics fabrication without using conventional vacuum deposition or a photolithography mask. This method is expected to be a potential alternative to the conventional electron beam lithography method for arbitrary nanoscale direct patterning in single‐step, low‐temperature, and non‐vacuum environments.</P>
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