Measurement of Neutron Total Cross Section and Resonance Parameters of Natural Hafnium at Pohang Neutron Facility

A. K.M.M.H. Meaze,Guinyun Kim,Dongchul Son,Hengsik Kang,Hossain Ahmed,In Soo Ko,Jong Hwa Chang,Kun Joong Yoo,Moo-Hyun Cho,Tae-Ik Ro,Won Namkung,Won-Chung Chung,Young Seok Lee,Young-Ae Kim 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.2

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숙지황 분말을 첨가한 국수의 품질 특성 및 항산화성

민아영(A Young Min),손아영(Ah Young Son),김현정(Hyun Jeong Kim),신숙경(Suk Kyung Shin),김미리(Mee Ree Kim) 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.3

본 연구는 숙지황 분말을 이용한 기능성 면류를 제조하기 위해서 숙지황 분말을 밀가루에 0, 2.5, 5, 7.5% 첨가하여 제조한 국수의 품질 특성 및 항산화성을 조사하였다. 숙지황분말 첨가가 증가함에 따라 국수의 중량, 부피, 함수율은 감소하였고 탁도는 증가하였다. 색도는 숙지황 분말의 첨가량이 증가할수록 L값과 b값은 감소하고 a값은 증가하는 경향을 나타내었다. 수분 함량은 숙지황 분말의 첨가량이 증가할 수록 감소하였다. 숙지황 분말 첨가량이 증가할수록 국수의 경도는 증가하였고, 탄력성, 응집성, 검성 및 씹힘성은 감소하였다. 숙지황 분말의 첨가 농도가 증가함에 따라 아밀로그래프상의 호화개시 온도는 증가하였고, 최고 점도와 최종점도는 감소하였다. 숙지황 분말 첨가 농도가 높아질수록 polyphenol 함량은 증가하였고, DPPH radical 소거능에서 IC50값이 감소하였으므로 숙지황 분말 첨가량이 증가할수록 항산화능이 높아지는 것을 알 수 있었다. 관능검사 결과 숙지황 분말 2.5% 첨가 국수가 전체적인 기호도 및 구입의사에서 가장 높게 평가되었다. 이상의 결과로 볼 때 숙지황 분말을 첨가한 기능성 국수의 개발이 가능하였고 기능성을 고려하였을 때는 숙지황 분말 7.5% 첨가가 가장 그 항산화 활성이 우수하였다. 하지만 제품 개발 특성상 관능적 특성을 크게 고려하였을 때, 숙지황 분말을 2.5% 첨가하여 국수를 제조하는 것이 가장 적합한 것으로 사료된다. The purpose of this study was to evaluate the quality characteristics and antioxidant activities of noodles added with Rehmanniae Radix Preparata powder (RP). Wheat flour noodles were prepared with four levels of RP (0, 2.5, 5, and 7.5%). Moisture absorption of RP added noodles was somewhat greater than that of control. The turbidity of RP noodles decreased according to addition of RP. Hunter L (lightness) and b (yellowness) values of RP added noodles decreased according to addition of RP amount. Textural properties (measured by a texture analyzer), hardness, and springiness of RP noodles up to 5% were not significantly different from those of control. Antioxidant activity of RP added noodles increased according to addition of RP: IC50 values of DPPH radical scavenging activity for raw noodles was 3.77 mg/g, whereas values of raw noodles with RP 2.5 and 7.5% were 3.69 mg/g and 2.47 mg/g, respectively. Polyphenol content increased according to addition of RP. Amylogram showed that RP addition increased initial gelatinization temperature, decreased breakdown, and reduced setback and consistency, which indicates protection against retrogradation. The sensory preference test revealed that cooked noodles with added 2.5% RP showed the highest scores for color, odor, taste, and overall preference. It is suggested that RP up to 2.5% could be substituted for wheat flour to improve noodle quality.

Hairy Root Cultures of Taxus cuspidata for Enhanced Production of Paclitaxel

Jung A Kim,백광현,Young Mi Son,Sung Ho Son,Heungsop Shin 한국응용생명화학회 2009 Journal of Applied Biological Chemistry (J. Appl. Vol.52 No.2

Hairy root cultures were established by transforming seedlings of Taxus cuspidata Sieb. Et Zucc (Korean yew) using Agrobacterium rhizogenes. Initially, 107 lines of hairy roots were induced by infection with 3 strains of Agrobacterium (R1000, A4, and 15384), however, only three lines generated from the R1000 strain were stably grown on hormone-free media over 10 months of successive cultures. These lines were designated as RC11104, RC11105 and RC11106. The hairy root line RC 11106 was selected for further experiments for taxol production based on its growth properties. Upon methyl jasmonate treatment, the RC11106 line accumulated 52.5 mg/L of taxol over 2 weeks of incubation at a 20-L culture scale.

간호실무에서 신봉이론(Espoused theories)에 대한 탐색적 연구

서문자,김혜숙,이은희,박영숙,조경숙,강현숙,임난영,김주현,이소우,조복희,이명하,지성애,하양숙,손영희,권성복,김희진,추진아 성인간호학회 2001 성인간호학회지 Vol.13 No.1

As a nursing practice involves nurses' actions in a specific context of health care, this study has focused on exploring the espoused theories in nursing practice within the action science perspectives, Espoused theories are the belief, principles, and rationale expressed by the practitioner as guiding her/his actions in a situation of practice. The data were analysed qualitatively and 25 elements of espoused theories of nursing action were identified and clustered into 6 categories. The 25 elements of espoused theories are as follows: The clinical nurse worked in wholistic and individual nursing, focussed on the patient's needed, comfort and supportive nursing (5 theories of nursing goal) ; excellent skills, knowledge based, assessment and data collection, explaining, educating or a scientific basis(6 theories of nursing intervention): advocacy, value oriented, treatment, account- ability and commitment(4 theories of nursing ethics) ; human respect. partnership, trust(3 theories of patient-nurse relationship) : knowledgable, accumulated clinical experiences and personally lived experiences. positive perspectives(4 theories of nurse), role of intervention. rewarding peer relationship(3 theories of situations) The above mentioned espoused theories are similar to that of nursing textbooks which students learned through basic nursing education and almost the same as the Acts ofa Nurse in Korean. However, we are doubtful whether nurses actually do as they think. Therefore. it is recommended to review the theories-in-use in order to and any discrepancies between the espoused theories and the reality of nursing actions

Naïve BALB/c Mice에서 유래한 비장세포와 복강 대식세포에서 송화가루 추출물(Pinus densiflora Pollen Extract)의 면역 증강 효과

김준영(Jun Young Kim),김산(San Kim),김세정(Se Jeong Kim),장세현(Se hyeon Jang),윤성란(Sung Ran Yoon),류정아(Jung A Ryu),박정민(Jeong Min Park),손조은(Joe Eun Son),정성근(Sung Keun Jung) 한국식품영양과학회 2024 한국식품영양과학회지 Vol.53 No.6

본 연구에서 PDE가 RAW264.7 대식세포에 이어 BALB/c 마우스로부터 유래한 복강 대식세포에서 NO 생성을 증가시켰으며, DEX에 의해 억제된 비장세포 증식능과 사이토카인 생성도 회복시킴으로써 전임상 모델 수준에서도 면역증강 효능이 있음을 확인하였다. 따라서 본 연구 결과는 PDE가 면역증강 기능성 식품 소재가 될 수 있는 근거를 제공한다. 향후 PDE의 지표성분의 동정 및 정량화 등 추가 연구가 진행된다면, PDE를 건강기능식품으로 개발하는 데 좋은 정보가 될 것으로 생각된다. COVID-19, SARS, and MERS were declared pandemic and are all infectious diseases caused by a virus. The innate immune system is important for preventing such infectious diseases. Therefore, this study examined the effects of Pinus densiflora pollen extract (PDE) on improving innate immunity. Pinus densiflora pollen is a natural micronutrient reservoir rich in various amino acids, vitamins, minerals, enzymes, and flavonoids required by the body. This study used splenocytes and peritoneal macrophages derived from BALB/c mice. PDE enhanced nitric oxide production in peritoneal macrophages. PDE alleviated dexamethasone (DEX)-induced reduction of splenocyte proliferation in concanavalin A (Con A)-stimulated splenocytes. PDE alleviated the DEX-induced reduction of interleukin-6, interleukin-1β, and tumor necrosis factor-α production in Con A-stimulated splenocytes. These results indicate that PDE can be a health-functional food material that improves immunity.

Hairy Root Cultures of Taxus cuspidata for Enhanced Production of Paclitaxel

Kim, Jung-A,Baek, Kwang-Hyun,Son, Young-Mi,Son, Sung-Ho,Shin, Heung-Sop The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.2

Hairy root cultures were established by transforming seedlings of Taxus cuspidata Sieb. Et Zucc (Korean yew) using Agrobacterium rhizogenes. Initially, 107 lines of hairy roots were induced by infection with 3 strains of Agrobacterium (R1000, A4, and 15384), however, only three lines generated from the R1000 strain were stably grown on hormone-free media over 10 months of successive cultures. These lines were designated as RC11104, RC11105 and RC11106. The hairy root line RC 11106 was selected for further experiments for taxol production based on its growth properties. Upon methyl jasmonate treatment, the RC11106 line accumulated 52.5 mg/L of taxol over 2 weeks of incubation at a 20-L culture scale.

Matrix Metalloproteinase-8 Plays a Pivotal Role in Neuroinflammation by Modulating TNF-α Activation

Lee, Eun-Jung,Han, Jeong Eun,Woo, Moon-Sook,Shin, Jin A.,Park, Eun-Mi,Kang, Jihee Lee,Moon, Pyong Gon,Baek, Moon-Chang,Son, Woo-Sung,Ko, Young Tag,Choi, Ji Woong,Kim, Hee-Sun The American Association of Immunologists, Inc. 2014 JOURNAL OF IMMUNOLOGY Vol.193 No.5

<P>Matrix metalloproteinases (MMPs) play important roles in normal brain development and synaptic plasticity, although aberrant expression of MMPs leads to brain damage, including blood–brain barrier disruption, inflammation, demyelination, and neuronal cell death. In this article, we report that MMP-8 is upregulated in LPS-stimulated BV2 microglial cells and primary cultured microglia, and treatment of MMP-8 inhibitor (M8I) or MMP-8 short hairpin RNA suppresses proinflammatory molecules, particularly TNF-α secretion. Subsequent experiments showed that MMP-8 exhibits TNF-α–converting enzyme (TACE) activity by cleaving the prodomain of TNF-α (A<SUP>74</SUP>/Q<SUP>75</SUP>, A<SUP>76</SUP>/V<SUP>77</SUP> residues) and, furthermore, that M8I inhibits TACE activity more efficiently than TAPI-0, a general TACE inhibitor. Biochemical analysis of the underlying anti-inflammatory mechanisms of M8I revealed that it inhibits MAPK phosphorylation, NF-κB/AP-1 activity, and reactive oxygen species production. Further support for the proinflammatory role of microglial MMP-8 was obtained from an in vivo animal model of neuroinflammatory disorder. MMP-8 is upregulated in septic conditions, particularly in microglia. Administration of M8I or MMP-8 short hairpin RNA significantly inhibits microglial activation and expression/secretion of TNF-α in brain tissue, serum, and cerebrospinal fluid of LPS-induced septic mice. These results demonstrate that MMP-8 critically mediates microglial activation by modulating TNF-α activity, which may explain neuroinflammation in septic mouse brain.</P>

TGF- <i>β</i> and Hypoxia/Reoxygenation Promote Radioresistance of A549 Lung Cancer Cells through Activation of Nrf2 and EGFR

Lee, Sae-lo-oom,Ryu, Hwani,Son, A-rang,Seo, Bitna,Kim, Jooyoung,Jung, Seung-Youn,Song, Jie-Young,Hwang, Sang-Gu,Ahn, Jiyeon Hindawi Publishing Corporation 2016 Oxidative medicine and cellular longevity Vol.2016 No.-

<P>Although many studies have examined the roles of hypoxia and transforming growth factor- (TGF-) <I>β</I> separately in the tumor microenvironment, the effects of simultaneous treatment with hypoxia/reoxygenation and TGF-<I>β</I> on tumor malignancy are unclear. Here, we investigated the effects of redox signaling and oncogenes on cell proliferation and radioresistance in A549 human lung cancer cells in the presence of TGF-<I>β</I> under hypoxia/reoxygenation conditions. Combined treatment with TGF-<I>β</I> and hypoxia activated epidermal growth factor receptor (EGFR) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a redox-sensitive transcription factor. Interestingly, Nrf2 knockdown suppressed the effects of combined treatment on EGFR phosphorylation. In addition, blockade of EGFR signaling also suppressed induction of Nrf2 following combined treatment with hypoxia and TGF-<I>β</I>, indicating that the combined treatment induced positive crosstalk between Nrf2 and EGFR. TGF-<I>β</I> and hypoxia/reoxygenation increased the accumulation of reactive oxygen species (ROS), while treatment with N-acetyl-<SMALL>L</SMALL>-cysteine abolished the activation of Nrf2 and EGFR. Treatment with TGF-<I>β</I> under hypoxic conditions increased the proliferation of A549 cells compared with that after vehicle treatment. Moreover, cells treated with the combined treatment exhibited resistance to ionizing radiation (IR), and knockdown of Nrf2 increased IR-induced cell death under these conditions. Thus, taken together, our findings suggested that TGF-<I>β</I> and hypoxia/reoxygenation promoted tumor progression and radioresistance of A549 cells through ROS-mediated activation of Nrf2 and EGFR.</P>

성별에 따른 청소년의 스트레스와 자아개념의 관계

송광민,차영아,남상인 순천향대학교 인문과학연구소 2008 순천향 인문과학논총 Vol.21 No.-

This study aims to examine the relationship between the stress and the self-concept of the adolescents according to the gender. This study used the data of Korea Youth Panel Survey (KYPS) Performed by Korea Institute for Youth Development. Prior to the study, factor analysis was performed in order to examine how the dimension of the stress and self-concept could be structured. As a result of factor analysis, the stress could be divided into four dimensions of the stress from parent, study, friends and appearance/material, while the self-concept was divided into four dimension of natural self, self-torment self, deviated self and leading self. Among four factors of self concept, self-torment self was proved to have the closest relationship with stress. And there was no big difference in this result when compared between both genders. As a result of gender comparison for multi-variable regression analysis with self concept as dependent variable, the friend stress was the most influential factor in case of male students while appearance/material stress was the most influential factor in case of female students.

간호대학생이 지각하는 임상실습지도자의 교수효율성과 임상실습만족도의 관계

황현아,김희진,김예지,이규희,이영롱,박성희,손수빈 이화여자대학교 간호과학대학 2012 이화간호학회지 Vol.- No.46

Purpose: The purpose of this study was to investigate the relationship between teaching effectiveness and clinical practice satisfaction among nursing students. Method: The subjects of this study were 107 junior and senior nursing students in E university. Data were collected using self-reported questionnaire including general and practicum related characteristics, teaching effectiveness of clinical instructors and clinical practice satisfaction from September 12 to September 21, 2011. Collected data were analyzed by SPSS 19 program using t-test, ANOVA with Scheffe test, and Pearson`s correlation coefficients. Result: The mean score of teaching effectiveness was 3.35(±.51), and mean of clinical practice satisfaction was 3.19±.47. There were significant differences of teaching effectiveness of clinical instrutor by satisfaction of overall clinical practicum(F=8.332, p<.001), satisfaction of practice hour(F=3.230, p=.044), and satisfaction of major(F=9.883, p<.001). There were significant differences of clinical practice satisfaction by grade(t=2.274, p=.025), motive of choosing nursing science as a major(F=3.329, p=.007), satisfaction of overall clinical practicum(F=17.437, p<.001), satisfaction of practice hours(F=9.925, p<.001), and satisfaction of nursing major(F=12.748, p<.001). Relationship between teaching effectiveness of clinical instructor and clinical practice satisfaction showed positive correlation(r=.704, p<.001). Conclusion: In this study, teaching effectiveness of clinical instructor was related with clinical practice satisfaction. Therefore, we should consider improving teaching effectiveness of clinical instructor to improve clinical practice satisfaction.