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Son, Tae-Gen,Kim, So-Jung,Kim, Keun-Ho,Kim, Min-Sun,Chung, Hae-Young,Lee, Jae-Won 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7
Senescence marker protein 30 (SMP30) is identified as an important aging marker molecule and known to play multifunctional roles as an intracellular calcium regulatory protein in the signaling process. To elucidate the functional significance of SMP30, we established the stably transfected P19 cell line with SMP30 expression vector. Overexpression of SMP30 slightly suppressed the proliferation of P19 cells. However, SMP30 overexpression was cytoprotective against calcium-mediated stress such as calcium ionophore (A23187), and thapsigargin. We found that SMP30 overexpression reduced the elevated intracellular calcium levels induced by A23187, but not by thapsigargin. In addition, SMP30 transfected P19 cells were more protective to tert-butylhydroperoxide induced cytotoxicity, indicating the antioxidative properties of SMP30. Taken together, our results suggest that external calcium regulation and antioxidant properties are involved in the cytoprotective mechanism of SMP30.
Won-Keun Son,Soo-Gil Park 한국정보과학회 1999 Journal of Electrical Engineering and Information Vol.4 No.1
In this work, we measured the ability of adsorption and distribution coefficient of metallic ions. When SPEES was cured for 48 hours at 200℃ and 250℃, ion exchange capacity was reduced to 37.87% and 56.88% of initial value and lost completely within 30 hours at 300℃. For SPEES in organic solvent system, as the solvent had higher polarity, ion exchange capacity increased, but distribution coefficient decreased at the same time. Ion exchange capacity was 5.93 meq/g, similar to initial value, after 25 time repeated adsorption and desorption, and it shows that functional group has chemical resistance to the oxidation catalysis reaction of metal ion. The amount of selective adsorption of metallic ions to SPEES ion mixed metallic ions solution was the order of Ba(Ⅱ)>Mg(Ⅱ)>K(I)>Na(Ⅰ).
The Binding Properties of Metal Ions with Sulfonated Poly(Ether Ether Sulfone)
Won-Keun Son,Soo-Gil Park 한국정보과학회 1999 Journal of Electrical Engineering and Information Vol.4 No.2
we determinated bonding constants for alkali metal cation (Li, Na, K) of the ion exchange resin of sulfonated poly(ether ether sulfone)(SPEES) in tetrahydrofurane(THF) and dioxane. As the polarity of a solvent increased and the reaction temperature decreased, the bonding constant became large. As the radii of metallic ion increased, the binding constant also increased in the order of Li(Ⅰ)<Na(Ⅰ)<K(Ⅰ). In the bonding reaction between SPEES ion exchanger and alkali picrate metal, the enthalpy of reaction ranged from -3.473 ~ -4.780 kcal/mol, while entropy ranged from 1.608~4.542 cal/Kㆍmol. Therefore it was spontaneous reaction due to the negative value of Gibb's free energy. When SPEES ion exchanger and alkali metal ion bind each other, they have good ion exchange capacity because of increasing the stability of the system.
Orthosiphon stamineus Reduces Appetite and Visceral Fat in Rats
Son, Jo-Young,Park, So-Young,Kim, Jong-Yeon,Won, Kyu-Chang,Kim, Yong-Dae,Choi, Yun-Jung,Zheng, Ming-Shan,Son, Jong-Keun,Kim, Yong-Woon The Korean Society for Applied Biological Chemistr 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.2
To evaluate whether Orthosiphon stamineus (OS) reduces appetite and fat deposition, food intake and visceral fat mass following treatment with OS (450 mg/kg/day, per oral) for 2 weeks in Sprague-Dawley (SD) rats were measured. Hypothalamic neuropeptides associated with appetite regulation was also analyzed. Two weeks of OS treatment reduced food intake and visceral fat mass compared to saline-treated SD rats. OS treatment for 2 weeks elevated the expression of proopiomelanocortin (POMC) in the hypothalamus, whereas neuropeptide Y (NPY) expression was decreased, which may be associated with the elevation of plasma leptin concentration in OS-treated rats. Methanol and butanol extracts of OS increased leptin mRNA expression in 3T3-L1 cells in dose-dependent manner. Acute study showed intraperitoneal injection of various concentrations of OS increased POMC expression in the hypothalamus, whereas NPY expression decreased dose-dependently. These results suggest that OS reduces appetite, which may have resulted from the increased expression of POMC and decreased expression of NPY in the hypothalamus in association with the elevation of leptin. OS could be a medicinal food applicable for body weight control.
Genotypic characterization of fluoroquinolone-resistant Escherichia coli isolates from edible offal
Son, Se Hyun,Seo, Kwang Won,Kim, Yeong Bin,Noh, Eun Bi,Lee, Keun-Woo,Oh, Tae-Ho,Kim, Seung-Joon,Song, Jae-Chan,Kim, Tae-Wan,Lee, Young Ju The Korean Society of Veterinary Science 2020 大韓獸醫學會誌 Vol.60 No.3
Edible offal is easily contaminated by Escherichia coli (E. coli) and fluoroquinolone (FQ)-resistant E. coli is considered a serious public health problem, thus, this study investigated the genetic characteristics of FQ-resistant E. coli from edible offal. A total of 22 FQ-resistant E. coli isolates were tested. A double mutation in each gyrA and parC led the highest MIC. Four (18.2%) isolates carried plasmid-mediated quinolone resistance genes. The fimH, eaeA, escV, astA, and iucC genes were confirmed. Seventeen isolates (77.3%) were positive for plasmid replicons. The isolates showed high genetic heterogeneity based on pulsed-field gel electrophoresis patterns.
( Won Il Kim ),( Bing Tian Zhao ),( Je Hyun Lee ),( Dong Ung Lee ),( Young Shik Kim ),( Byung Sun Min ),( Jong Keun Son ),( Mi Hee Woo ) 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
A simple GC method with a FID detector was developed in order to determine to determine two main compounds (β-sitosterol and lupenone) for Adenophorac Radix. β-Sitosterol and lupenone were analyzed by the gradient thermal ramping method. Nitrogen was used as the carrier gas at 108 kPa. The flow rate of gas was 2.0Ml/min:2μL of filered sample was injected at a split ratio of 1:80. This method was fully validated with respect to linearity, precision, accuracy in an Adenophorae Radix extract. The GFC analytical method for classification analysis was performed by repeated analysis of 59 reference samples in order to differentiate between Adenophora triphylla var. japonica Hara and 14 Condonopsis lanceolata. The results indicate that the GC-FID method is suitable and reliable for the quality evaluation of Adenophorae Radix.
Speciation of M(II)-Oxalate Complex in an Electrodynamic Cell Dissolving CRUD
Won-Keun Son,Sang Yoon Park,Sion Kim,Changhyun Roh 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
During the operation of a nuclear power plant (NPP), corrosion products called CRUD (Chalk River unidentified deposit) accumulate on the surface of the primary system. The CRUD components of pressurized light water reactors or heavy water reactors, represented by (NixFe1-x)(FeyCr1-y)2O4, are composed of Fe3O4, NiFe2O4, FeCr2O4, NiCr2O4, etc. Radionuclide such as Co-60 are deposited within this CRUD, so the entire deposited material must be dissolved and removed for decontamination. Chemical decontamination has the advantage of being able to decontaminate a wide metal surface, but has the disadvantage of generating a large amount of secondary waste. Recently, chemical decontamination methods that add an electrodynamic process are being studied to overcome these shortcomings. This technology is a method of dissolving CRUD by applying an electric field in the anodic compartment of a cell separated by CEM. It is a method of accelerating CRUD dissolution by generating a large amount of hydrogen ions in the anodic compartment. Dissolved metal ions pass through the CEM (cation exchange membrane) and move to the cathodic compartment (pH > 12), where they are removed by adsorption or precipitation process. Therefore, the speciation characteristics between decontamination agent (oxalic acid) and metal ions are very important. In this study, we investigated the speciation characteristics of Fe(II), Ni(II), Co(II) - oxalate, which are important complex species in CRUD dissolution cells. The thermodynamic equilibrium constant for hydrolysis of each ion and of M(II)-oxalate were collected and speciation characteristics were analyzed using the MINEQL 5.0 program. From the speciation characteristics of M(II)-oxalate, effective radionuclide removal methods in an electrodynamic cell were considered.