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Numerical Study of Free Surface Effect on Supercavitating Flows
Son-Tung Dang,Cong-Tu Ha,Van-Tu Nguyen,Warn-Gyu Park(박원규),Dong-Hyun Kim(김동현) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11
In this paper, we focus on applying the volume of fluid (VOF) method coupled with an interface reconstruction technique to capture the free surface between liquid and gas. The governing equation is the compressible Navier-Stokes equations based on the homogeneous mixture model. A preconditioned method is applied for enhancing efficient and accurate computations over a wide range of Mach numbers. For evaluation, the present results have been compared with experiments and other numerical results. A fairly good agreement with the experimental data and other numerical results has been obtained. Finally, the simulation of natural supercavitating flows over a plate hydrofoil was conducted to show the effect of free surface on characteristic length of supercavitation.
Nguyen, Hong Nga,Son, Dong-Ju,Lee, Jae-Woong,Hwang, Dae-Youn,Kim, Young-Kyu,Cho, Jeong-Sik,Lee, Ung-Soo,Yoo, Hwan-Soo,Moon, Dong-Cheul,Oh, Ki-Wan,Hong, Jin-Tae The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.10
Mutation in the presenilin 2 (PS2mt) is known to be one of factors involved in the development of Alzheimer's disease (AD). It was recently revealed that an abnormality of lipid metabolism is a phenomenon occurring in AD. Therefore, the aim of this study was to investigate the potential relationship between the mutation of PS2 and alterations of the lipid profile within the brain. The results showed there increases in the levels of cholesterol, low density lipoprotein and triglyceride, but a decrease in the level of high density lipoprotein in brain tissues expressing mutant PS2. These findings indicated that PS2mt is involved in the abnormalities of the lipid profile, which could cause or result in the development of AD.
Targeted doxorubicin nanotherapy strongly suppressing growth of multidrug resistant tumor in mice
Nguyen, Dai Hai,Lee, Jung Seok,Bae, Jin Woo,Choi, Jong Hoon,Lee, Yunki,Son, Joo Young,Park, Ki Dong Elsevier 2015 International journal of pharmaceutics Vol.495 No.1
<P><B>Abstract</B></P> <P>The rational design of nanomedicine to treat multidrug resistant (MDR) tumors <I>in vivo</I> is described in the study. We prepared multifunctionalized Pluronic micelles that are already well-established to be responsive to low pH and redox in order to systemically deliver doxorubicin (DOX) to MDR tumors. Folic acids (FAs) were introduced on the micelle surface as tumor-targeting molecules. In vitro, the DOX-loaded micelles exerted high cytotoxicity in the DOX-resistant cells by bypassing MDR efflux. Cellular uptake studies clearly demonstrated that FA-conjugated DOX micelles (FA/DOX micelles) were efficiently internalized and accumulated in the MDR cells. In vivo studies indicated significant efficacy of FA/DOX micelles for MDR tumors in mice, and that the volume of tumors was 3 times smaller in this group than that of tumors in the free DOX group, and 8 times smaller than the tumors in the saline group. To the best of our knowledge, this methodology has been recognized to have significantly high efficacy, compared to previously reported DOX nanoparticle formulations. This superior anti-tumor efficacy of FA/DOX micelles in MDR tumor-bearing mice can be attributed to FA-targeted and -mediated endocytosis, inhibition of MDR effect, and subsequent DOX release triggered by dual stimuli (low pH and redox) inside the tumor. Given the promise of the multifunctional micelle mediated delivery on inhibition of MDR tumor growth, FA/DOX micelle platform is a much sought after goal for cancer chemotherapy, especially for cancers resistant to anticancer drugs.</P> <P><B>Graphical abstract</B></P> <P>Folic acid (FA) and doxorubicin (DOX)-conjugated micelles (FA/DOX micelles) that are responsive to pH and redox show superior anti-tumor efficacy in multidrug resistant (MDR) tumor-bearing mice because of FA-targeted and -mediated endocytosis, inhibition of MDR efflux, and subsequent DOX release triggered by dual stimuli (low pH and redox) inside the tumor. The volume of tumors was 8 times smaller in the micelle group than the tumors in the saline group.</P> <P>[DISPLAY OMISSION]</P>
뉴엔타이(Nguyen Huy Tai),박종석(Jong Seok Park),안태인(Tae In Ahn),이정현(Jeong Hyun Lee),명동주(Dong Ju Myoung),조영열(Young Yeol Cho),손정익(Jung Eek Son) 한국원예학회 2010 원예과학기술지 Vol.28 No.1
An accurate moisture control with precise estimation of transpiration of plants is required for low capacity and small size of growing substrate in soilless culture. In this study, a relationship among cumulative transpiration, radiation, vapor pressure deficit, and a relationship between cumulative irrigation and drainage with growth stage were analyzed for development of an optimum irrigation system. Paprika (Capsicum annuum L., cv. Cupura) plants were grown with a plant density of 4.05 plants/㎡. For obtaining leaf area index (LAI), leaves were sampled every month. The LAI increased from 2.39 to 3.51 for 4 months, reflecting growth stage. Cumulative transpiration was calculated by subtracting the sum of cumulative drainage and an increase in slab weight from cumulative irrigation. Transpiration rate was changed responding proportionally to irradiation. By detailed analysis of transpiration and radiation, cumulative transpiration was regressed well with radiation integral by 2nd-order linear equations in different growth stages, while those with cumulative vapor pressure deficit was regressed by 1st-order linear equations. With increase of LAI, the slopes of cumulative irrigation and drainage curves and the difference between two slopes increased from 0.312 to 0.611, from 0.154 to 0.358, and from 0.158 to 0.253, respectively. In this study, we estimated cumulative transpiration of paprika with several environmental factors according to the plant growth stage and expect this data will contribute to making accurate irrigation strategy based on environmental and growing conditions.
Hong Nga Nguyen,Dong Ju Son,Jae Woong Lee,Dae Youn Hwang,Young Kyu Kim,Jeong Sik Cho,이웅수,유환수,Dong Cheul Moon,오기완,홍진태 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.10
Mutation in the presenilin 2 (PS2mt) is known to be one of factors involved in the development of Alzheimer’s disease (AD). It was recently revealed that an abnormality of lipid metabolism is a phenomenon occurring in AD. Therefore, the aim of this study was to investigate the potential relationship between the mutation of PS2 and alterations of the lipid profile within the brain. The results showed there increases in the levels of cholesterol, low density lipoprotein and triglyceride, but a decrease in the level of high density lipoprotein in brain tissues expressing mutant PS2. These findings indicated that PS2mt is involved in the abnormalities of the lipid profile, which could cause or result in the development of AD.