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Safety evaluation of cricket(Gryllus bimaculatus) extract in Sprague-Dawley rats
( Somin Lee ),( Kyu Sup Ahn ),( Hyeon Yeol Ryu ),( Hye Jin Kim ),( Jin Kyu Lee ),( Myung-haing Cho ),( Mi Young Ahn ),( Kyung Seuk Song ) 한국잠사학회 2016 International Journal of Industrial Entomology Vol.32 No.1
Recently, research investment in the improvement of food safety as a food source and specializing of nutritional source of edible insects is being actively conducted. Cricket especially has been attracting considerable interest in entomophagy; however, research on the safety assessment of cricket is limited. This study investigated the effects of cricket ethanol extract when orally administrated in Sprague-Dawley rats. Here, we performed a 4 wk repeated oral dose toxicity test in Sprague-Dawley rats following the Organization for Economic Cooperation and Development test guidelines 407 under Good Laboratory Practice regulation. Rats were randomly allocated 4 groups: vehicle control, 250, 500, 1,000 mg/kg test groups and administrated based on body weight for 28 d. The animals were observed for mortalities and clinical signs, body weight changes, food and water consumption. At the end of treatment period, blood and urine were collected and analyzed. Subsequently, the animals were sacrificed and subjected to gross pathological examination and organ weight measurement. The organs were preserved for histopathological examination. The results showed that there were no systemic toxicological effects related with the cricket ethanol extract in the 4 wk oral repeated dose toxicity study. It is considered that NOAEL of cricket ethanol extract is greater than 1,000 mg/kg/d and there was no target organ detected.
Safety evaluation of cricket(Gryllus bimaculatus) extract in Sprague-Dawley rats
Lee, Somin,Ahn, Kyu Sup,Ryu, Hyeon Yeol,Kim, Hye Jin,Lee, Jin Kyu,Cho, Myung-Haing,Ahn, Mi Young,Song, Kyung Seuk Korean Society of Sericultural Science 2016 International Journal of Industrial Entomology Vol.32 No.1
Recently, research investment in the improvement of food safety as a food source and specializing of nutritional source of edible insects is being actively conducted. Cricket especially has been attracting considerable interest in entomophagy; however, research on the safety assessment of cricket is limited. This study investigated the effects of cricket ethanol extract when orally administrated in Sprague-Dawley rats. Here, we performed a 4 wk repeated oral dose toxicity test in Sprague-Dawley rats following the Organization for Economic Cooperation and Development test guidelines 407 under Good Laboratory Practice regulation. Rats were randomly allocated 4 groups: vehicle control, 250, 500, 1,000 mg/kg test groups and administrated based on body weight for 28 d. The animals were observed for mortalities and clinical signs, body weight changes, food and water consumption. At the end of treatment period, blood and urine were collected and analyzed. Subsequently, the animals were sacrificed and subjected to gross pathological examination and organ weight measurement. The organs were preserved for histopathological examination. The results showed that there were no systemic toxicological effects related with the cricket ethanol extract in the 4 wk oral repeated dose toxicity study. It is considered that NOAEL of cricket ethanol extract is greater than 1,000 mg/kg/d and there was no target organ detected.
Microfluidics in nanoparticle drug delivery; From synthesis to pre-clinical screening
Ahn, Jungho,Ko, Jihoon,Lee, Somin,Yu, James,Kim, YongTae,Jeon, Noo Li Elsevier 2018 Advanced drug delivery reviews Vol.128 No.-
<P><B>Abstract</B></P> <P>Microfluidic technologies employ nano and microscale fabrication techniques to develop highly controllable and reproducible fluidic microenvironments. Utilizing microfluidics, lead compounds can be produced with the controlled physicochemical properties, characterized in a high-throughput fashion, and evaluated in <I>in vitro</I> biomimetic models of human organs; organ-on-a-chip. As a step forward from conventional <I>in vitro</I> culture methods, microfluidics shows promise in effective preclinical testing of nanoparticle-based drug delivery. This review presents a curated selection of state-of-the-art microfluidic platforms focusing on the fabrication, characterization, and assessment of nanoparticles for drug delivery applications. We also discuss the current challenges and future prospects of nanoparticle drug delivery development using microfluidics.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Oral Toxicity Study and Skin Sensitization Test of a Cricket
Hyeon Yeol Ryu,Somin Lee,Kyu Sup Ahn,Hye Jin Kim,Sang Sik Lee,Hyuk Ju Ko,Jin Kyu Lee,Myung-Haing Cho,Mi Young Ahn,Eun Mi Kim,Jeong Ho Lim,Kyung Seuk Song 한국독성학회 2016 Toxicological Research Vol.32 No.2
Crickets have been attracting considerable interest in the field of nutrition and toxicology due to the global exhaustion of food resulting from a growing population. The cricket is normally eaten in several countries after roasting, similar to the grasshopper; however, safety evaluation data on cricket powder is limited. Here, we performed general toxicity studies of cricket powder including a single, 2-week repeated dose range evaluation test, a 13-week repeated oral dose toxicity test in Sprague-Dawley rats, a single oral dose toxicity test in Beagle dogs, and a skin sensitization test in guinea pigs following the Organization for Economic Cooperation and Development test guidelines 406 and 408 in addition to Good Laboratory Practice. To investigate the NOAEL and target organs of cricket powder, Sprague-Dawley rats were allocated to 4 groups: vehicle control, 1,250 mg/kg, 2,500 mg/kg, 5,000 mg/kg dose test groups and cricket powder was administered over 13 weeks after single dose and dose range finding studies in rats based on the results of the single oral administration toxicity study in rats and Beagle dogs. The results of the study showed that the NOAEL of cricket powder was over 5,000 mg/kg for both sexes of rats without adverse effects in a 13-week repeated oral toxicity study and there was no skin hypersensitivity reaction. Therefore, our results reveal that crickets can be widely used as a new substitute food or nutrient resource.
Oral Toxicity Study and Skin Sensitization Test of a Cricket
Ryu, Hyeon Yeol,Lee, Somin,Ahn, Kyu Sup,Kim, Hye Jin,Lee, Sang Sik,Ko, Hyuk Ju,Lee, Jin Kyu,Cho, Myung-Haing,Ahn, Mi Young,Kim, Eun Mi,Lim, Jeong Ho,Song, Kyung Seuk Korean Society of ToxicologyKorea Environmental Mu 2016 Toxicological Research Vol.32 No.2
Crickets have been attracting considerable interest in the field of nutrition and toxicology due to the global exhaustion of food resulting from a growing population. The cricket is normally eaten in several countries after roasting, similar to the grasshopper; however, safety evaluation data on cricket powder is limited. Here, we performed general toxicity studies of cricket powder including a single, 2-week repeated dose range evaluation test, a 13-week repeated oral dose toxicity test in Sprague-Dawley rats, a single oral dose toxicity test in Beagle dogs, and a skin sensitization test in guinea pigs following the Organization for Economic Cooperation and Development test guidelines 406 and 408 in addition to Good Laboratory Practice. To investigate the NOAEL and target organs of cricket powder, Sprague-Dawley rats were allocated to 4 groups: vehicle control, 1,250 mg/kg, 2,500 mg/kg, 5,000 mg/kg dose test groups and cricket powder was administered over 13 weeks after single dose and dose range finding studies in rats based on the results of the single oral administration toxicity study in rats and Beagle dogs. The results of the study showed that the NOAEL of cricket powder was over 5,000 mg/kg for both sexes of rats without adverse effects in a 13-week repeated oral toxicity study and there was no skin hypersensitivity reaction. Therefore, our results reveal that crickets can be widely used as a new substitute food or nutrient resource.