http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Somasundaram Saravanamoorthy,정일민,Vanaraj Ramkumar,Baskar Ramaganthan,MAYAKRISHNAN GOPIRAMAN 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.60 No.-
Highly efficient and cost-effective NiO-based carbon nanocomposite (NiO/CNP) was prepared for the transfer hydrogenation of aromatic aldehydes and reduction of nitrophenols. Uniform dispersion of NiO nanoparticles, surface area of NiO/CNP (67 m2 g−1), chemical state and content of Ni in NiO/CNP (+2, 5.1 wt%) were confirmed. High rate constant (kapp) values of 4.2 × 10−2 s−1 and 3.06 × 10−2 s−1 were calculated for the NiO/CNP–catalyzed reduction of nitrophenols. The NiO/CNP demonstrated an excellent catalytic activity towards the transfer hydrogenation reactions under very mild reaction conditions. Chemoselectivity, heterogeneity, stability, reusability and scale reaction of the NiO/CNP system were tested.
Sivachandiran Somasundaram,Jaehoon Jeong,Ganesh Irisappan,김태완,홍순호 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.1
To produce malic acid from non-oxidative pathway route in Escherichia coli using two key enzymes and synthetic scaffold complex. E. coli was engineered to produce malic acid from glucose by co-localization of two key enzymes phosphoenolpyruvate carboxylase (Ppc) and malate dehydrogenase (MdhA) with synthetic scaffold complex. Scaffold plasmid has produced the maximum concentration of 3.51 g/L malic acid from 10 g/L glucose in 48 h of culture. pH 5.5 and temperature 30°C were optimum for malic acid production without any engineering of competing metabolic pathways. E. coli mutant strains and different concentrations of glucose also tested. When 50 g/L glucose was used as substrate, 20.4 g/L of malic acid was produced.
Sivaraman Somasundaram,전수지,박상혁 한국고분자학회 2016 Macromolecular Research Vol.24 No.3
Utilization of small-molecule based organic photovoltaic (OPV) devices has received strong attention due to their easy preparation, purification, and batch-to-batch resemblance in properties. In this work, a series of simple benzothiadiazole and triphenylamine-containing molecules were synthesized, and their application to organic photovoltaic devices was investigated. The absorption spectra demonstrated that the absorption wavelength of the small molecules could be tuned dramatically by extension of molecular structure from donor-acceptor-acceptor (D-A-A’) to A’-A-D-D-A-A’ sequences. Due to the intramolecular energy transfer from the acceptor to donor and vice versa in D-A-A’ structures in prepared molecules, the maximum emission wavelengths were red-shifted gradually with the increase of chain length. Bulk heterojunction (BHJ) type solar cell devices were fabricated by using the small molecules as donors and (6,6)-phenyl C61-butyric acid methyl ester (PC61BM) as acceptor (2:1), gave maximal open circuit voltage of the photovoltaic cells of 0.59 V and the power conversion efficiencies of the devices were measured 0.83% under AM 1.5G irradiation (100 mWcm-2).
B. Somasundaram,K.T. Anand,D. Kirubakaran,P. Ganeshan,Sathish Kannan,A.H. Seikh,A. Ghosh 한양대학교 청정에너지연구소 2023 Journal of Ceramic Processing Research Vol.24 No.4
Metal-based composites, such as those used in the aerospace and automotive industries, are becoming increasingly popular dueto their intrinsic advantages like higher strength-to-weight ratios and less wear rates. An aluminium 7475 alloy based on MMCwas tested using the Taguchi design of the experiment. The major goal is to use the Taguchi method to anticipate the bestparameters for castings with the highest tensile strength and hardness. Good quality castings can only be made with precisecontrol of the process parameters. Stir casting was employed to make test samples with varying reinforcement weightpercentages, stirring speeds, and processing temperatures. Analytical variance and orthogonal arrays were used to explore theinfluence of process factors on the desired attributes. The Taguchi method was used to identify the best settings for maximizingthe mechanical characteristics of composites. The fundamental objective of this investigation is to find how various parameterscan be altered to produce defect-free castings with the necessary tensile strength and hardness for certain applications. TheTaguchi optimization method was demonstrated by conducting a test at the optimal level of processing parameters.
( Sivachandiran Somasundaram ),( Murali Kannan Maruthamuthu ),( Irisappan Ganesh ),( Gyeong Tae Eom ),( Soon Ho Hong ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.9
Gamma-aminobutyric acid is a precursor of nylon-4, which is a promising heat-resistant biopolymer. GABA can be produced from the decarboxylation of glutamate by glutamate decarboxylase. In this study, a synthetic scaffold complex strategy was employed involving the Neurospora crassa glutamate decarboxylase (GadB) and Escherichia coli GABA antiporter (GadC) to improve GABA production. To construct the complex, the SH3 domain was attached to the N. crassa GadB, and the SH3 ligand was attached to the N-terminus, middle, and C-terminus of E. coli GadC. In the C-terminus model, 5.8 g/l of GABA concentration was obtained from 10 g/l glutamate. When a competing pathway engineered strain was used, the final GABA concentration was further increased to 5.94 g/l, which corresponds to 97.5% of GABA yield. With the introduction of the scaffold complex, the GABA productivity increased by 2.9 folds during the initial culture period.
( Sivakumar Lingappa ),( Muthugounder Subramanian Shivakumar ),( Thamilarasan Manivasagam ),( Somasundaram Thirugnanasambandan Somasundaram ),( Palaniappan Seedevi ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.6
Epalrestat (EPS) is a brain penetrant aldose reductase inhibitor, an approved drug currently used for the treatment of diabetic neuropathy. At near-plasma concentration, EPS induces glutathione biosynthesis, which in turn reduces oxidative stress in the neuronal cells. In this study, we found that EPS reduces neurodegeneration by inhibiting reactive oxygen species (ROS)-induced oxidative injury, mitochondrial membrane damage, apoptosis and tauopathy. EPS treatment up to 50 μM did not show any toxic effect on SH-SY5Y cell line (neuroblastoma cells). However, we observed toxic effect at a concentration of 100 μM and above. At 50 μM concentration, EPS showed better antioxidant activity against H<sub>2</sub>O<sub>2</sub> (100 μM)-induced cytotoxicity, ROS formation and mitochondrial membrane damage in retinoic acid-differentiated SH-SY5Y cell line. Furthermore, our study revealed that 50 μM of EPS concentration reduced the glycogen synthase kinase-3 β (GSK3-β) expression and total tau protein level in H<sub>2</sub>O<sub>2</sub> (100 μM)-treated cells. Findings from this study confirms the therapeutic efficacy of EPS on regulating Alzheimer's disease (AD) by regulating GSK3- β and total tau proteins phosphorylation, which helped to restore the cellular viability. This process could also reduce toxic fibrillary tangle formation and disease progression of AD. Therefore, it is our view that an optimal concentration of EPS therapy could decrease AD pathology by reducing tau phosphorylation through regulating the expression level of GSK3-β.
Subramanian, Palanisamy,Ravichandran, Anjali,Manoharan, Vinosha,Muthukaruppan, Reka,Somasundaram, Selvakumar,Pandi, Boomi,Krishnan, Anand,Marimuthu, Prabhu Narayanasamy,Somasundaram, Selliah Swamy Nat Elsevier 2019 Process biochemistry Vol.86 No.-
<P><B>Abstract</B></P> <P>In the past few years, green synthesized silver nanoparticles (AgNPs) are one of predominantly used materials in therapeutics and clinical practices. In this study, AgNPs were synthesized from aqueous extract of <I>Oldenlandia umbellata</I> and investigated their pharmaceutical properties. UV–vis spectroscopy of <I>O. umbellata</I> mediated silver nanoparticles (AgNPs@OUa) showed a peak at 423 nm. Fourier transform infrared spectroscopy and phytochemical screening explained the contribution of biomolecules in AgNPs@OUa synthesis. Field emission scanning electron microscope and high-resolution transmission electron microscope examination revealed that small monodispersed spherical nanoparticles had an average size of 22.7 nm. Antioxidant assays were used to examine antioxidant properties of AgNPs@OUa in comparison with <SMALL>L-</SMALL>ascorbic acid (Vitamin C) as a standard antioxidant. AgNPs@OUa showed dose-dependent antioxidant activities. Antibacterial activities of AgNPs@OUa exhibited the highest zone of inhibition against <I>Streptococcus mutans</I> and <I>Escherichia coli</I> were 16.03 ± 0.35 mm and 19.76 ± 0.25 mm, respectively, at concentration of 1.0 mg L<SUP>−1</SUP>. Biocompatibility of AgNPs@OUa against human lung fibroblast (WI-38) cell line was also tested. Even though, the cells treated with the uppermost concentration (100 μg/mL) of AgNPs@OUa, it enhances the cell viability (∼90%), suggesting that AgNPs@OUa had no toxicity with excellent biocompatibility.</P> <P><B>Highlights</B></P> <P> <UL> <LI> First report on the bio synthesis of AgNPs using <I>O. umbellata</I> aqueous extract. </LI> <LI> The AgNPs@OUa were characterized by spectral and microscopy analysis. </LI> <LI> AgNPs@OUa were act as a significant antioxidant and antibacterial activities. </LI> <LI> AgNPs@OUa showed excellent biocompatibility against WI-38 cell lines. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>