용융탄산염 내에서의 Stainless steel의 부식특성에 관한 연구

孫太源,金俊亨,金炳天 弘益大學校 科學技術硏究所 1997 科學技術硏究論文集 Vol.8 No.-

The effect of oxidant gas on corrosion behavior of separator material for molten carbonate fuel cell, the AISI 316L stainless steel in the molten carbonates was investigated by using the electrochemical techniques. The composition of electrolyte used in this study were 62mol% Li₂CO₃ and 38mol% K₂CO₃. The concentration of oxidant gases CO₂, O₂ were varied from 5vol% to 50vol% respectively. it had been found the increase of oxidant gas concentration proportionally enhanced the corrosion rate of AlSl 316L stainlees steel. From the result, we obtained to the relation between Ecorr, Icorr and CO₂ gas partial pressure and also O₂ gas partial pressure. Therefore it is suggested Ecorr ∝ P(o₂)??, Icorr ∝ P(o₂)?? and Ecorr ∝ P(co₂)?? , Icorr ∝ P(co₂)??.

신약의 개발과 임상시험

손동렬,권준택,김형기,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

치근단절제술을 이용한 치근단 병소의 치료에 대한 증례보고

손흥규,최형준,이성준,김성오 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.3

It has been reported that the operative treatment for the preservation of tooth having periapical lesion has shown over ninety percent of success whereas in the case where calcified canal is severe, canal is perforated, ledge is formed, tooth restored by post and core and cases where symptoms still exist after treatment, endodontic treatment may not all be the solution in attaining a successful treatment. Thus Apicoectomy would generally be used to prevent the loss of tooth having periapical lesion where treatment prognosis is poorly evaluated by endodontic treatment. In case 1 and 2, endodontic treatment was applied due to unilocular radiolucent lesion in periapical area but the symptoms somehow did not show improvement and therefore operated apicoectomy, and as in case 1, favorable results were attained but as in case 2, yet more observation has to be done. The followings are the results we have concluded: 1. In the process of endodontic treatment, absolute canal obturation has great effect on attaining successful treatment. 2. In cases where endodontic treatment is not highly recommended, for example, tooth having dental pulp and periapical lesion, favorable results can be attained by applying apicoectomy.

Cefixime 경구제제의 생물학적 동등성 연구

김형기,권준택,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

The bioequivalence of generic cefixime(Pofixim^(®), Kwangmyung Pharmaceutical Co.) capsule to the cefixime capsule(Suprax^(®), Dong-A Pharmaceutical Co.) as a reference drug. Single dose of 100 mg cefixime was administered to 20 healthy male volunteers in a balanced, randomized crossover design with a washout between the two study periods. Blood samples were collected up to 14 hours and plasma concentration of cefixime was measured by well validated reverse phase high-performance liquid chromatography. Pharmacokinetic parameters were analyzed by non-compartmental analysis and ANOVA test was used for the statistical analysis of parameters. No statistically significant formulation, period, or sequence effect was encountered. Ninety percent confidence intervals of log transformed C_(max) and AUC_(t) were comprised in the stipulated 0.80-1.25 range. These results suggest that test formulation of cefixime can be declared bioequivalent with the reference, both formulations in 100 mg capsule.

연세대학교 치과병원 소아치과에 내원한 신환에 대한 분석연구

최형준,손흥규 大韓小兒齒科學會 1991 大韓小兒齒科學會誌 Vol.18 No.1

The author analyzed a total of 4,753 out-patients of the department of Pediatric Dentistry of the dental hospital of Yonsei University from January 4,1988 to December 31,1989 for the purpose of making public oral health plan more effective and the improvement of the hospital management system for better clinical dental practice. The results are follows; 1.The out-patients under the age of 5 composed of 52.5% of the total group. 2.In view of the chief complaints,the dental diseases due to dental caries ranked the top(56.5%),and orthodonic treatment(11.0%),and traumatic injury(10.1%),others(22.4%),ranked the next. 3.As for the sex distribution,the number of the male patients(56.7%) dominated the female(44.3%)and it showed the tendency that male patients were refered from local clinic more than female. 4.The children resided in residency area of Mapo Gu,Kyungki Do,Seudaemun Gu,Eunpeung Gu,Kangsu Gu,Yangchun Gu,Youngdeung Po Gu in the descending order. 5.The number of children with the seven systemic disease was 428 out of 4,753(9.0%) and 97 among them were cerebral-palsieds. 6.Such habits as finger sucking and tongue thrusting were more common with the children under the age of 6 and bruxism,lip sucking and mouth breathing were more common with the those 6 or more years old. 7.The out-patients reached in January,July,August and the least in April.

Simvastatin 정제의 생물학적 동등성 연구

김형기,권준택,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

The bioequivalence of generic simvastatin tablet(Dongsung Pharmaceutical Co.) to the simvastatin tablet(Zocor^(®), MSD Korea Co.) as a reference drug. Single dose of 20 mg simvastatin was administered to 20 healthy male volunteers in a balanced, randomized crossover design with a washout between the two study periods. Blood samples were collected up to 12 hours and plasma concentration of simvastatin was measured by well validated LC-MS/MS. Pharmacokinetic parameters were analyzed by non-compartmental analysis and ANOVA test was used for the statistical analysis of parameters. No statistically significant formulation, period, or sequence effect was encountered. Ninety percent confidence intervals of log transformed C_(max) and AUC_(t) were comprised in the stipulated 0.80-1.25 range. These results suggest that test formulation of simvastatin is bioequivalent with the reference, both formulations in 20 mg tablet.

복합 치아종에 관한 증례보고

최형준,최병재,손흥규,양호정 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.2

The odontoma is relatively a common odontogenic tumor. It has come to mean as a growth in which both the epithelial and the mesenchymal cell exhibit complete differentiation, with the result that functional ameloblast and odontoblast form enamel and dentin. The etiology of it is unknown, but it has been suggested that local trauma or infection may lead to the production of such a lesion. Odontma is divided into 2 types. One is compound odontoma that is at least superficial anatomic simiarity to normal teeth, and the other is complex odontoma, that calcified dental tissues are simply an irregular mass bearing no morphologic similarity even to rudimentary teeth. Somtimes this malformation is not easily identified because its lacking of calcification. So, if permanant tooth is delayed to erupt, one should take a careful look the radiographic film to find that whether the cause of it is odontoma or not. In this case report, 3 patients with odontoma who visited Dept. of Pediatric Dentistry in Yonsei Dental College, were treated by means of surgical removal. The obtained results were as follows: 1. The odontoma is usually related to impacted tooth, and it is occurred neighboring to the crown of impacted tooth that have normally developed. So, in the case of missing tooth and delayed eruption, its presence should be investigated. 2. The odontoma can be seen vaguely radiographically, so, it is difficulty to make diagnosis. 3. The treatment of odontoma is a surgical removal. And, if it is completely removed, its occurrence is rare. 4. In the case of impacted tooth being associated with compound odontoma, continuous management is necessary for the eruption of impacted tooth after the surgical extraction of odontoma. 5. It resembles the ameloblastic odontoma radigraphically, and if it is the case, the treatment may vary, so the confirmation through histologic examination after removal of mass is necessary.

Aceclofenac 경구제제의 생물학적 동등성 연구

권준택,김형기,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

The bioequivalence of generic aceclofenac(Anacle^(®), Korea Pharma Co.) tablet to the aceclofenac tablet(Arital^(®), DaeWoong Pharmaceutical Co.) as a reference drug. Single dose of 100 mg aceclofenac was administered to 20 healthy male volunteers in a balanced, randomized crossover design with a washout between the two study periods. Blood samples were collected up to 12 hours and plasma concentration of aceclofenac was measured by well validated reverse phase high-performance liquid chromatography. Pharmacokinetic parameters were analyzed by non-compartmental analysis and ANOVA test was used for the statistical analysis of parameters. No statistically significant formulation, period, or sequence effect was encountered. Ninety percent confidence intervals of log transformed C_(max) and AUC_(t) were comprised in the stipulated 0.80-1.25 range. These results suggest that test formulation of aceclofenac is bioequivalent with the reference, both formulations in 100 mg tablet.

한국인에서의 CYP2C19 유전자형의 다형성

권준택,김형기,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

The S-mephenytoin 4'-hydroxylase (CYP2C19) metabolizes a number of clinically used drugs and shows a marked interethnic difference in the incidence of the poor metabolizer (PM). In the present study, we genotyped 215 healthy unrelated Koreans (64 females, aged 20-41 yr, residing in Chungcheong province) for functionally defective alleles, CYP2C19_(m1) and CYP2C19_(m2). Detection of the normal (CYP2C19_(wt)) and defective alleles was performed by polymerase chain reaction/restriction enzyme analysis. The genomic DNA was isolated from peripheral blood. The allelic frequencies of the wild-type (CYP2C19_(wt)) and CYP2C19_(m1) were 72.6% and 27.4%, and the wild-type (CYP2C19_(wt)) and CYP2C19_(m2) were 85.1% and 14.9%, respectively. For each CYP2C19_(m1) and CYP2C19_(m2), the observed numbers of three genotypes were similar to those calculated in accordance with the Hardy-Weinberg equation. The frequencies of homozygotes for CYP2C19_(m1), CYP2C19_(m2) and compound heterozygotes were 9.7%, 2.8% and 4.2%, respectively. The mutants of CYP2C19 were identified in 36 subjects (16.7%). These results suggest that frequency of mutants of CYP2C19 in Koreans resembled the Orientals rather than Caucasians.

매복 과잉치 발거시의 전후방적 위치선정

최형준,손흥규,최병재,황동환 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.3

Surgical removal of impacted mesiodens can be performed easily when exact position of mesiodens is identified. This case report is argued about methodological approach of exact antero-posterior postioning of mesiodens using conventional cross-sectional occlusal film and periapical film. The author concludes, 1. Among various methods of positioning mesiodens, exact position of mesiodens can be determined with occlusal film and periapical film. 2. On operation, exact antero-posterior position of mesiodens can be determined with comparing occlusal images of adjacent teeth and anatomic structure to real ones. 3. It is important that exact removal course of mesiodens has to be determined in addition to exact determination of one's position, and that it has to be determined in regard to position, morphological basis, direction of impacted pattern of mesiodens and adjacent anatomic structure. 4. In 2 cases presented, both are mesiodens of inverted conical type, and impacted direction are class Ⅰ and Ⅲ respectively according to classification author suggested, and surgery can be performed with ease by different approach directions.