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Pei Feng,Jiye Jia,Shuping Peng,Yang Shuai,Hao Pan,Xinna Bai,CIJUN SHUAI 한국생체재료학회 2022 생체재료학회지 Vol.26 No.1
Background: The reinforcement effect of fiber-reinforced polymer composites is usually limited because of the poor interfacial interaction between fiber and polymer, though fiber reinforcement is regarded as an effective method to enhance the mechanical properties of polymer. Methods: In this study, nano-SiO2 particles grafted by 3-Glycidoxypropyltrimethoxysilane (KH560) were introduced onto the surface of 3-Aminopropyltriethoxysilane (KH550) modified carbon fiber (CF) by a self-assembly strategy to improve the interfacial bonding between CF and biopolymer poly (lactic acid) (PLLA). Results: The results indicated that PLLA chains preferred to anchor at the surface of nano-SiO2 particles and then formed high order crystalline structures. Subsequently, PLLA spherulites could epitaxially grow on the surface of functionalized CF, forming a transcrystalline structure at the CF/PLLA interface. Meanwhile, the nano-SiO2 particles were fixed in the transcrystalline structure, which induced a stronger mechanical locking effect between CF and PLLA matrix. The results of tensile experiments indicated that the PLLA/CF-SiO2 scaffold with a ratio of CF to SiO2 of 9:3 possessed the optimal strength and modulus of 10.11 MPa and 1.18 GPa, respectively. In addition, in vitro tests including cell adhesion and fluorescence indicated that the scaffold had no toxicity and could provide a suitable microenvironment for the growth and proliferation of cell. Conclusion: In short, the PLLA/CF-SiO2 scaffold with good mechanical properties and cytocompatibility had great potential in the application of bone tissue engineering.
Zou Jin-feng,Li Shuai-shuai,Xu Yuan,Dan Han-cheng,Zhao Lian-heng 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.2
Seepage force is simplified as seepage volumetric force in the stress field along the radial direction. Out-of-plane stress and seepage force are incorporated, and the theoretical solutions for stress, displacement, and plastic radius of a circular opening for the elastic-brittle-plastic and elastic-plastic rock mass are proposed based on the Mohr–Coulomb (MC) and generalized Hoek-Brown (HB) failure criteria. The presented solution and Wang’s solution (2012) are compared, and the corrected version of the proposed method is validated. Numerical examples of the proposed method based on the MC and generalized HB failure criteria reveal that the distributions of stress and displacement in the surrounding rock of the tunnel are significantly influenced by seepage force and out-ofplane stress. Displacement and plastic radius when seepage force and out-of-plane stress are considered are larger than those when the seepage force is not considered; the regulations of stress, however, run opposite. The results of displacement and plastic radius based on the generalized HB failure criterion are larger than those based on the MC failure criterion.
Nrf2 Overexpression Predicts Prognosis and 5-FU Resistance in Gastric Cancer
Hu, Xiu-Feng,Yao, Jun,Gao, She-Gan,Wang, Xin-Shuai,Peng, Xiu-Qing,Yang, Yan-Tong,Feng, Xiao-Shan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9
Objective: NF-E2-related factor 2 (Nrf2) is activated in several human malignancies. However, the role of Nrf2 in gastric cancer (GC) remains incompletely understood. In this study, we therefore analyzed associations of Nrf2 expression status with clinical features and chemotherapeutic resistance in GC. Materials and Methods: A total of 186 samples from GC patients who underwent gastrectomy were used for prognostic assessment. A further 142 samples from GC cases who received first-line combination chemotherapy were applied for investigation of chemoresistance. The Nrf2 expression was evaluated by immunohistochemistry in GC samples, and its relationship with clinicopathological parameters and chemotherapy sensitivity was analyzed. The effect of Nrf2 gene silencing on chemotherapy resistance was also examined by cell viability assay in vivo. Results: Of the 186 patients with GC, 104/186 (55.9%) showed high expression for Nrf2. The overexpression of Nrf2 was an independent predictor of overall survival [OS, hazard ratio (HR) 3.9; P=0.011] and disease-free survival (DFS, HR 4.3; P=0.002). The gene silencing of Nrf2 reduced resistance to cell death induced by 5-FU in GC cell lines. Conclusion: Our data show that Nrf2 is an independent prognostic factor in GC. Furthermore, Nrf2 confers resistance to chemotherapeutic drug 5-FU in GC cells. Taken together, Nrf2 is a potential prognostic marker and predictive for 5-FU resistance in GC.
Friction and Wear of Self-mated SiC and Si3N4 in Green Water-based Lubricant
Shuai Yan,Bin Lin,Feng Liu,Fugang Yan 한국정밀공학회 2012 International Journal of Precision Engineering and Vol. No.
Hydrostatic/hybrid bearings have been used in many engineering applications. In order to address the disadvantages of lubricating oil such as pollution and resource consumption, researchers are trying to use water to replace oil in these bearings. To eliminate the corrosivity of water and increase its viscosity, additives were added in water and this new lubricant is called “green water-based lubricant”. Ceramics are considered to be very suitable tribo-pair materials in water. In order to select the best material in the green water-based lubricant and explore the effect of the additives, this paper carried out friction and wear experiments of self-mated SiC and self-mated Si3N4 in this new lubricant on a ring-toring tribometer. The results show that self-mated SiC possesses better running-in property, higher load-carrying capacity,lower friction coefficient, lower wear rate and smoother surface topography. The results show that the self-mated SiC and green water-based lubricant is a promising combination to replace the metal/oil system in hydrostatic/hybrid bearings.
Feng Gang,Lin Jian,Yang Shuai,Zhang Boxuan,Wang Jiangang,Yang Jia,Xu Zhongfeng,Lei Yongping 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.11
Pressure resistance welding is usually used to seal the connection between the cladding tube and the end plug made of zirconium alloy. The seal welded joint has a direct effect on the service performance of the fuel rod cladding structure. In this paper, the pressure resistance welded joints of zirconium alloy tube-plug structure were obtained by thermal-mechanical simulation experiments. The microstructure and microhardness of the joints were both analyzed. The effect of processing parameters on the microstructure was studied in detail. The results showed that there was no β-Zr phase observed in the joint, and no obvious element segregation. There were different types of Widmanst¨atten structure in the thermo-mechanically affected zone (TMAZ) and heat affected zone (HAZ) of the cladding tube and the end plug joint because of the low cooling rate. Some part of the grains in the joint grew up due to overheating. Its size was about 2.8 times that of the base metal grains. Due to the high dislocation density and texture evolution, the microhardnesses of TMAZ and HAZ were both significantly higher than that of the base metal, and the microhardness of the TMAZ was the highest. With the increasing of welding temperature, the proportion of recrystallization in TMAZ decreased, which was caused by the increasing of strain rate and dislocation annihilation
Influence of Particle Shape on the Density and Compressive Performance of Calcareous Sand
Shuai Wang,Xue-Wen Lei,Qing-Shan Meng,Jie-Li Xu,Ling-Feng Xie,Yu-Jie Li 대한토목학회 2020 KSCE Journal of Civil Engineering Vol.24 No.1
Particle shape influence the bearing capacity of calcareous sand foundations in island reef engineering. An improved Computer Image Analysis method that combined with mathematical statistics was proposed to categorize and sort different shapes of calcareous sand particles within the size range of 5 – 10 mm. Three single-shape calcareous sand specimens (granular ᅠ ᅠshape, dendritic shape, long strip shape) were obtained. A new self-developed vibration device was used measuring the maximum density of calcareous, the shape and content as the variables in the orthogonal test. On this basis, the lateral compression tests were carried out to assess the influence of particle shape on the density, compressive performance of calcareous sand. Test results showed that better discriminability was achieved by taking mean flatness (EL/B) as the quantification parameter of the particle shapes. The average flatness EL/B of specimens is approximately normally distributed in the statistical results. The shape and content of sand particles had an obvious influence on the density of calcareous sand. The compressive properties of calcareous sands with different particle shapes have obvious differences. After loaded, the particle size distribution of specimen improved, the average flatness EL/B of the granular-shaped specimens increased, while that of the dendritic-shaped and the long-strip-shaped specimens decreased, the average flatness EL/B of the specimens tended to be uniform. The relative fracture rate Br and the load value Pmax satisfied the exponential function fitting relationship. Therefore, it can be argued that particle shape should be taken into consideration when optimizing the foundation design in island reef engineering to achieve better compressive performance of the foundation.
Studies on the influence factors of wind dynamic responses on hyperbolic cooling tower shells
Jun-Feng Zhang,Qing-Shuai LIU,Yao-Jun Ge,Lin Zhao 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.72 No.5
Wind induced dynamic responses on hyperbolic cooling tower (HCT) shells are complicated functions of structure and wind properties, such as the fundamental frequency fmin, damping ratio ζ, wind velocity V, correlationship in meridian direction and so on, but comprehensions on the sensitivities of the dynamic responses to these four factors are still limited and disagree from each other. Following the dynamic calculation in time domain, features of dynamic effects were elaborated, focusing on the background and resonant components σB and σR, and their contributions to the total rms value σT. The σR is always less than σB when only the maximum σT along latitude is concerned and the contribution of σR to σT varies with responses and locations, but the σR couldn’t be neglected for structural design. Then, parameters of the above four factors were artificially adjusted respectively and their influences on the gust responses were illustrated. The relationships of σR and the former three factors were expressed by fitted equations which shows certain differences from the existing equations. Moreover, a new strategy for wind tunnel tests aiming at surface pressures and the following dynamic calculations, which demands less experiment equipment, was proposed according to the influence from meridian correlationship.