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송영기 ( Young Kee Shong ) 대한갑상선학회 2009 International Journal of Thyroidology Vol.2 No.1
18F-fluorodeoxyglucose positron-Emission Tomography (FDG-PET) is very useful for the follow up of differentiated thyroid carcinoma. FDG-PET could determinate the recurrent or metastatic foci of thyroid cancer in 70∼90% of patients with elevated thyrogobulin level during thyroid hormone withdrawal, especially whose I-131 whole body scan were negative. However, currently neck ultrasonography (USG) is the primary choice to detect recurrent disease in neck because FDG-PET is rather expensive and available only in limited center. FDG-PET could be recommended in patients with negative USG result or for detecting distant metastasis in patients with local recurrence. The number of patients with incidentally found FDG uptake in thyroid gland after FDG-PET or PET/CT was increased. Diagnostic procedures such as USG and cytological examination or pathological examination including hemithyroidectomy were essential for these patients due to the high risk of malignancy. FDG-PET did not have any advantage for the preoperative evaluation comparing other diagnostic modalities. It could be selectively used in the high risk patients.
Graves 병 환자에서 갑상선 아전절제술 후 갑상선자극항체와 갑상선자극홀몬 결합억제 면역글로불린의 변화
송영기(Young Kee Shong),이병두(Byoung Doo Rhee),조보연(Bo Youn Cho),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min),오승근(Seung Keun Oh) 대한내과학회 1989 대한내과학회지 Vol.37 No.1
N/A The authors measured changes in thyroid stimulating antibody (TSAb) and thyrotropin binding inhibitor immunoglobulin (TBII) in 15 patients with Graves' disease treated with subtotal thyroidectomy. Before surgery all 15 had detectable TBII actvities, and 11 had TSAb activities. During the 12 month postoperative follow-up, TBII disappeared in 7 out of 15, and TSAb disappeared in 6 out of 11. Twelve months after surgery, 10 patients with negative TSAb (including 4 patients whose TSAb activities were negative before surgery) remained in remission, Of 5 patients whose TSAb remained persistently positivie during the 12 month observation period, one remained in remission, two experienced relapse, and two became hypothyroid. In the persistently positive TSAb and TBII group, their activities did not change after surgery. There was no difference in clinical and laboratory findings save for the higher TSAb and TBII activity preoperatively between the persistently positive group and disappearing group. In summary, after subtotal thyroidectomy, TSAb and TBII disappeared in some of the patients. Disappearance of TSAb is associated with remission but persistence of TSAb has no prognostic implication. The production sites of thyrotropin reccptor antibody are thought to be intrathyroidal, but in some patients extrathyroidal production might contribute significantly, due to the pattern of postoperative changes in thyrotropin receptor antibody activities.
송영기(Young Kee Shong),박경수(Kyong Soo Park),조보연(Bo Youn Cho),고창순(Chang Soon Koh),오승근(Seung Keun Oh),박성희(Seong Hoe Park),김용일(Yong Il Kim) 대한내과학회 1986 대한내과학회지 Vol.30 No.6
N/A Five cases of differentiated carcinoma of thyroid associated with brain metastasis are reported. All of the patients had distant metastatic diseases or massive invasion of the surrounding tissue at the initial diagnosis. Metastatic lesions in the brain were not detected by conventional radioiodine whole body scan but by computerized axial tomography. TSH suppression, external radiotherapy, and radioactive iodine were tried but no consistently satisfactory effects were achieved. The prognosis of the patients with brain metastasis was poor, four patient diedat two to four months after detection of brain metastasis and only one patient is alive two months after detection, at the time of writing this paper.
백서 고환 간질 세포에서 TSH 와 TSH 수용체 항체에 대한 cAMP 와 Testosterone 의 반응
송영기(Young Kee Shong),조보연(Bo Youn Cho),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min),이문호(Mun Ho Lee) 대한내과학회 1988 대한내과학회지 Vol.35 No.3
N/A To investigate the physiological role of TSH receptor in testes and the effect of various TSH receptor antibodies (TRAb), we measured cAMP production ad testosterone release in enzymatically dispersed rat testicular interstitial cells under the stimulation of TSH and TRAb, and compared the results with in those of tests done in FRTL-5 cells. TSH increased cAMP production and testosterone release in a dose-dependent manner similar to hCG. TSAb which stimulated thyroid adenylate cyclase (AC) were able to stimulate teaticular interstitial cell AC in 8 out of 30 patients (277p) and testosterone release in 12 out of 30(40%) patients with Graves' disease. Blocking type TRAb inhibited TSH-induced cAMP production and testosterone release in a dose-dependent manner but had no effect on basal cAMP production and testosterne release, These findings suggest that TSH receptors in testes might have a somewhat dissimilar nature from that in the thyroid and that testicular TSH receptor might be involved in testosterone production.
외래환자에서 선별검사로서의 갑상선자극호르몬 측정이 지니는 임상적 의의
송영기,문대혁,김기수,김홍규 대한내분비학회 1995 Endocrinology and metabolism Vol.10 No.3
The objective of this study is to determine the clinical significance of thyrotropin(TSH) measurement as a screening test in ambulatory patients. One hundred and nintynine patients with abnormal TSH levels detected at routine examinations were studied. The patients were examined and histories about the recent medications and nonthyroidal illness were taken. Additional thyroid tests were done including measuments of total T_3, free T_4, antithyroid autoantibodies, thyroid scan and radioiodine uptake. Of the total 199 patients, 107(54.7%) had thyroid diseases. 49 out of 101 patients with subnormal TSH had thyroid diseases, and the remainder had supressed TSH due to medications, associated nonthyroidal illness, and normal variations. 58 out of 99 patients with elevated TSH had thyroid diseases. Of those 47 patients whose TSH level was below 0.05 mIU/L, functional sensitivity of TSH assay in our laboratory, 37 had thyroid diseases. Of those 19 patients whose TSH level was above 7.0mIU/L, two times of upper normal limit, all had thyroid iseases. Simultaneous measurement of free T_4 disclosed 50(25.1%) out of total 199 patients with abnormal TSH levels had abnormal free T_4 values which is regarded as evidence of clinical thyroid dysfunction. In summary, a single measurement of TSH level alone seems to have high sensitivity but low specificity. Simultaneous measurement of free T_4 can reasonably compensate the low specificity of TSH measurement. In case of ambulatory patients without significant nonthyroidal illness, TSH values below functional sensitivity or above twice upper normal limit may predict thyroid disease and dysfunction with reasonable specificity(J Kor Soc Endocrinol 10: 191-199, 1995).
한국인 갑상선결절 환자에서 산발성 갑상선 수질암의 선별조사로서 일상적 칼시토닌 측정의 임상적 의의
송영기,조보연,박혜영,최철수 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.1
Background : It is not easy to diagnose sporadic medullary thyroid carcinoma(MTC) before surgery and this might lead the patient reoperation and/or lowered chance of definite cure. Methods : The prevalence of sporadic MTC in Korean was studied in patients with thyroid nodules. A prospective study of 1048 consecutive patients with thyroid nodules was performed. In all patients, measurements of basal serum calcitonin, thyroid hormones, TSH, anti-thyroglobulin antibody and anti-thyroperoxidase antibody were undertaken along with technetium-99m thyroid scintigraphy and fine needle aspiration cytology. In patients with elevated basal calcitonin levels, calcium stimulated calcitonin level was determined. Results: Two patient had markedly elevated calcitonin levels(over 3,200 pg/mL and 1,763 pg/ mL) and another one slightly elevated calcitoni#n(71.9 pg/mL). Fine needle aspiration cytology was suggestive of MTC in one and nodular hyperplasia in the other two. They underwent surgery and histological examination revealed MTC in those two with markedly elevated calcitonin levels. The patient with slightly elevated calcitonin, who was on the maintenance hemodialysis due to chronic renal failure, had nodular hyperplasia. Conclusion: MTC was found in 0.19% of patients with thyroid nodules, which was not different with the previously reported prevalence in Europe. Routine measurements of serum calcitonin might be of value to detect sporadic MTC; however, the cost-effectiveness of routine measurement of serum calcitonin is not clear, considering the relatively low prevalence of MTC in Koreans(J Kor Soc Endocrinol 11:11-17, 1996).