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정신분열병과 기분장애의 Cavum Septi Pellucidi에 관한 자기공명영상 연구
신상은,강민희,김철응,이정섭,배재남 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4
연구목적: 뇌자기공명촬영술을 이용하여 정신분열병 환자와 기분장애 환자, 대조군의 Cavum Septi Pellucidi를 측정하여 정신분열병과 기분장애에서 생물학적인 원인 중 하나인 신경 발달학적 가설을 알아보는데 있다. 방법: 34명의 정신분열병 환자와 18명의 기분장애 환자, 22명의 대조군에게 자기공명촬영술을 시행하여 CSP의 출현 빈도 및 CSP의 크기에 따른 출현빈도를 비교분석하여 다음과 같은 결과를 얻었다. 결과: CSP의 출현 빈도는 정신분열병 환자에서 61%, 기분 장애환자에서 61%, 대조군에서 41%로 나타났다. T1 강조 축상 영상에서 가장 크게 보이는 단면에서 가로로 가장 긴 부분의 길이가 3mm 이상으로 정의한 큰 CSP의 출현빈도는 정신분혈병환자에서 24%, 기분 장애 환자에서 11%, 대조군에서 5%였고 정신분열병, 기분장애, 대조군의 순으로 높은 빈도를 보였으나 통계적인 유의성은 없었다. 결론: 정신분열병, 기분장애, 대조군의 순으로 큰 CSP의 빈도가 높은 경향성은 확인할수 있었으나 통계적으로 유의한 차이는 아니었다. 그러나 본 연구는 여러 가지 제한점이 있었기 때문에 신경발달학적 가설을 알아보기 위해서는 향후 환자수를 확대하고 보다 정교하게 고안된 연구가 필요하다. Objectives: This study was designed to verify neuro-developmental hypothesis of schizo-phrenia and mood disorder. Methods: We performed Brain Magnetic Resonance Imaging study in 34 schizophrenic patients, 18 mood disorder patients and 22 controls and compared the incidence and the size of carum septi pellucidi(CSP). Results: The incidences of CSP in schizophrenia, mood disorder and controls were 61%,61%, and 41%, respectively. The incidences of large CSP, defined as largest diameter larger than 3mm in T1-weighted image, were 24% in schizophrenic patients, 11% in mood disorder patients, and 5% in controls. But they didn't show statistically significant differences. Conclusion:We could find the tendency that the incidence of CSP was high as following order ; schizophrenia, mood disorder, controls. But it was not statistically significant difference. To verify neuro-developmental hypothesis, we need larger pool of patients and better study design.
Expression of Human $\beta$-defensin 2 mRNA by Lipopolysaccharide in Human Corneal Epithelial Cells
Bae, Eon-Hee,Park, Keon-Wuk,Kim, Jong-Wook,Jang, Byeong-Churl,Lim, Ki-Jo,Jung, Tae-Young,Kwon, Young-Kyu,Shin, Sang-Woo,Kim, Sang-Pyo,Park, Jong-Hyun,Kwon, Taeg-Kyu,Baek, Won-Ki,Suh, Min-Ho The Korean Society for Microbiology 2004 Journal of Bacteriology and Virology Vol.34 No.1
Recently the transcriptional up-regulation of human $\beta$-defensin 2 (HBD-2) by lipopolysaccharide (LPS) was found to be associated with NF-${\kappa}B$ binding site. Although the general mechanisms of NF-${\kappa}B$ activation by LPS stimulation are well understood, less is known about the signal transduction pathway leading to LPS-induced NF-${\kappa}B$ activation in human corneal epithelial (HCE) cells. The aim of this study was to investigate the intracellular signals involved in LPS-induced HBD-2 mRNA expression in HCE cells. Pretreatments of inhibitors for NF-${\kappa}B$, protein tyrosine kinase, p38 mitogen activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK) attenuated the LPS-induced NF-${\kappa}B$ DNA binding activity and HBD-2 mRNA expression. Furthermore, pretreatments with inhibitors for protein kinase C (PKC), phosphatidylcholine-phospholipase C, phosphatidylinositol-phospholipase C, or phosphatidate phosphohydrolase prevented LPS-induced HBD-2 mRNA expression and HBD-2 promoter-driven luciferase activity. However, the increased expression of HBD-2 mRNA and the increased DNA binding activity of NF-${\kappa}B$ induced by LPS were not changed by the blockage of extracellular signal-regulated kinase (ERK) and of addition of antioxidants. Forskolin, a protein kinase A (PKA) agonist did not induce HBD-2 mRNA expression. These data demonstrate that LPS-induced HBD-2 mRNA expression via NF-${\kappa}B$ is, at least in part, dependent on PKC, p38 MAPK, JNK, and protein tyrosine kinase status, but appears to be independent on PKA, ERK and ROS in HCE cells. Taken together, there may be more than one signaling pathways that lead to LPS-induced up-regulation of HBD-2 mRNA expression in HCE cells.
Jang, Byeong-Churl,Lim, Ki-Jo,Choi, In-Hak,Suh, Min-Ho,Park, Jong-Gu,Mun, Kyo-Chul,Bae, Jae-Hoon,Shin, Dong-Hoon,Suh, Seong-Il D.A. Spandidos 2007 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.19 No.5
<P>The immunosuppressive effect of triptolide has been associated with suppression of T-cell activation. However, the immunosuppressive effects of triptolide on innate immunity in the epithelial barrier remain to be elucidated. Human beta-defensin (HBD)-2 is an inducible antimicrobial peptide and plays an important role in the innate immunity. We have previously demonstrated that IL-1beta induced HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK), or phosphatidylinositol-3-kinase (PI3K). In this study, we investigated effects of triptolide on IL-1beta-induced HBD-2 mRNA expression in A549 cells. Triptolide inhibited IL-1beta-induced HBD-2 mRNA expression in a dose-dependent manner. Addition of triptolide did not suppress activation of p38 MAPK, JNK, or PI3K in response to IL-1beta. Triptolide inhibited IL-1beta-induced MAPK phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK, explaining the little effect of triptolide on IL-1beta-induced phosphorylation of these kinases. Although triptolide partially suppressed IL-1beta-mediated degradation of IkappaB-alpha and nuclear translocation of p65 NF-kappaB, triptolide potently inhibited NF-kappaB promoter-driven luciferase activity in A549 cells. These results collectively suggest that the inhibitory effect of triptolide on IL-1beta-induced HBD-2 mRNA expression in A549 cells seems to be at least in part mediated through nuclear inhibition of NF-kappaB transcriptional activity, but not inhibition of p38 MAPK, JNK, or PI3K. This inhibition may explain the ability of triptolide to diminish innate immune response.</P>
Expression of Human β-defensin 2 mRNA by Lipopolysaccharide in Human Corneal Epithelial Cells
Eon-Hee Bae,Keon-Wuk Park,Jong-Wook Kim,Byeong-Churl Jang,Ki-Jo Lim,Tae-Young Jung,Young-Kyu Kwon,Sang-Woo Shin,Sang-Pyo Kim,Jong-Hyun Park,Taeg Kyu Kwon,Won-Ki Baek,Min-Ho Suh,Seong-Il Suh 대한미생물학회 2004 Journal of Bacteriology and Virology Vol.34 No.1
Clinical Characteristics of Pediatric Bipolar Disorder by Subtype in a Korean Inpatient Sample
Subin Park,Soo-Churl Cho,Ohyang Kwon,Jeong-Hoon Bae,Jae-Won Kim,Min-Sup Shin,Hee-Jeong Yoo,Bung-Nyun Kim 대한소아청소년정신의학회 2015 소아청소년정신의학 Vol.26 No.4
Objectives:We compared the clinical presentations of manic and depressive episodes and the treatment response among children and adolescents with bipolar disorder (BD) types I and II and BD not otherwise specified (NOS). Methods:The sample consisted of 66 patients, aged between 6 and 18 years, who were admitted for BD to a 20-bed child and adolescent psychiatric ward in a university hospital located in Seoul, Korea. Results:Patients with BD type I were more likely to have lower intelligence quotients and exhibit violent behaviors during manic episodes than patients with BD type II or BD NOS and to show better treatment responses during manic episodes than patients with BD NOS. Patients with BD NOS were more likely to have an irritable mood rather than a euphoric mood during the manic phase than patients with BD type I or II and to exhibit violent behaviors during the depressive phase and chronic course than patients with BD type II. Conclusion:Pediatric BD patients are heterogeneous with respect to their clinical characteristics. Implications for the usefulness of the current diagnostic subtype categories should be investigated in future studies.
TC-1 세포주를 이용한 동물모델에서 As4O6에 의한 혈관폐쇄 효과
남궁정 ( Jeong Namkung ),배수미 ( Su Mi Bae ),문란영 ( Lan Ying Wen ),오은경 ( Eun Kyeong Oh ),신재은 ( Jea Eun Shin ),김용욱 ( Yong Wook Kim ),김태응 ( Tae Eung Kim ),박태철 ( Tai Churl Park ),안웅식 ( Woong Shick Ahn ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.2
목적: As2O3는 다양한 고형암에서 혈관손상을 통하여 항종양 효과를 유도하는 것으로 알려져 있다. 본 연구에서는 자궁경부암동물 모델에서 새로운 비소 화합물인 As4O6와 As2O3를 비교하여 종양 내 혈관폐쇄 현상을 확인하고자 하였다. 연구 방법: HPV 16-E6/E7 유전자를 가지고 있는 TC-1 종양세포를 이용한 자궁경부암 동물모델에서 종양의 부피가 200~250 ㎣에 이르면 PBS, As2O3 and As4O6를 복강 내 투여하였다. 비소 화합물을 주사한 후 종양의 크기는 2~3일 간격으로 측정하고, 종양내혈관 폐쇄현상은 Evans blue 추출법과 Hoechst 33342 염색법 등 2가지 방법을 이용하여 측정하였다. 또한 헤마토실린-에오신 염색을 통하여 조직학적 변화를 관찰하였다. 결과: As2O3와 As4O6 주사 후, 종양 성장은 대조군에 비해 효과적으로 지연되었으며, As4O6 처리군이 가장 우수한 항종양 효과를 나타내었다. 또한 비소화합물의 투여는 종양내의 거대한 세포괴사와 혈관폐쇄 현상을 유도하였다. 결론: TC-1 세포주를 이식한 고형암 동물모델에서 As4O6의 처치는 혈관폐쇄 효과에 의한 항종양 효과를 나타내었다. Objective: Arsenic trioxide (As2O3) is known to have potent anti-vascular activity and significantly suppress solid tumor growth. The present study was conducted to investigate the vascular shutdown effects of a novel arsenic compound, tetraasrsenic oxide (As4O6), in comparison with As2O3 using cervical cancer animal model. Methods: Mice tumor challenge model was used C57BL/6 mice transplanted with TC-1 cells. After the growth of tumors was reached up 200~250 ㎣, mice were divided into 3 groups randomly for control and treatment of either As2O3 or As4O6. As2O3 and As4O6 was treated by i.p. injection. The tumor size was caliperated in twice for weeks and anti-vascular effect were assessed by Evans blue extraction assay and Hoechst 33342 staining. In tumor tissue, histopathological feaure was obserevd by hematoxylin and eosin (H&E) staining. Results: In mice treated with either As2O3 and As4O6 (i.p.), both of As2O3 and As4O6 was significantly suppressed the tumor growth compared with control group. Moreover, effect of As4O6 is more pronounced. These tumor growth inhibition is led to the massive necrosis and vacular shutdown in tumor tissue. Conclusion: This study suggests that As4O6 may have potential anticancer activity via vascular shutdown in C57BL/6 mice transplanted with TC-1 cells.
주의력결핍 과잉행동장애 아동에서 α-2A 아드레날린 수용체 유전자의 MspI 유전자 다형성에 따른 메칠페니데이트 치료 전후 뇌관류 비교
박수빈(Subin Park),배정훈(Jeong-Hoon Bae),김재원(Jae-Won Kim),양영희(Young-Hui Yang),오승민(Seungmin Oh),홍순범(Soon-Beom Hong),박민현(Min-Heyon Park),김붕년(Boong-Nyun Kim),신민섭(Min-Sup Shin),유희정(Hee-Jeong Yoo),조수철(Soo-Churl 대한소아청소년정신의학회 2013 소아청소년정신의학 Vol.24 No.1
Objectives:Dysregulation of the central noradrenergic system may be involved in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). The aim of this study was to examine the differences in pre- and post-treatment cerebral perfusion according to the MspI polymorphisms of the alpha-2A-adrenergic receptor gene (ADRA2A) in children with ADHD. Methods:Thirty seven drug-naive ADHD children (8.9+1.8 years old, M=32, F=5) were genotyped. Baseline single-photon emission computed tomography (SPECT) and clinical assessments were performed for ADHD children. After treatment with methylphenidate for eight weeks, SPECT and clinical assessment were repeated. Results:No differences in baseline clinical assessments or cerebral perfusion were observed according to the MspI genotype. However, after treatment, ADHD children with the G/G genotype at the MspI polymorphism showed hyperperfusion in the right cerebellar declive (p=.001, uncorrected) and hypoperfusion in the left lentiform nucleus and left cingulate gyrus (p<.001 and p=.001, uncorrected), compared to children without the G/G genotype. Conclusion:Although the results of this study should be interpreted cautiously, they suggest a possible role of the MspI polymorphisms of the ADRA2A gene in methylphenidate-induced changes in cerebral perfusion.