http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Woo, Jong-Min,Park, So Jung,Kang, Ho Il,Kim, Byoung Guk,Shim, Sun Bo,Jee, Seung Wan,Lee, Su Hae,Sin, Ji Soon,Bae, Chang Joon,Jang, Mee Kyung,Cho, Chunghee,Hwang, Dae Youn,Kim, Chuel Kyu D.A. Spandidos 2010 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.25 No.5
<P>Tau is a neuronal phosphoprotein responsible for the formation of the neurofibrillary tangles in Alzheimer's disease. To characterize the changes in global gene expression in the brain of transgenic mice that overexpress human Tau23 protein in response to the increase of Tau23 phosphorylation, total RNA extracted from the hippocampus of 12-month-old transgenic and wild-type mice was converted to cDNA, labeled with biotin and hybridized to oligonucleotide microarrays. The microarray results were confirmed by real-time RT-PCR and Western blotting method. It was determined that 43 genes were up-regulated and 8 genes were down-regulated by Tau23 in transgenic mice compared to controls, based on the arbitrary difference in the 2-fold change. Among the up-regulated transcripts, those encoding for transporter and oxidoreductase were dramatically over-represented, followed by those related to regulatory molecule, cytoskeletal protein, signaling molecule, and extracellular matrix protein. Genes encoding for transcription factor, regulatory molecule, miscellaneous function, and chaperone were significantly reduced in the down-regulated group. The major genes in the up-regulated categories included Ecrg4, Folr1, Defb11, Aqp1 and Soctdc1. The major genes in the down-regulated categories were Ncor1, Gpm6a, and Hspd1. These results indicate that the microarray analysis identifies several gene functional groups and individual genes that respond to a sustained increase in Tau23 phosphorylation levels in the brain of transgenic mice. In addition, the results suggest the microarray test is a useful tool for increased understanding of the role of Tau23 protein in regulating neurodegenerative disorders.</P>
Min Sun Kim,Jun Seo Goo,Ji Eun Kim,So Hee Nam,Sun Il Choi,Hye Ryun Lee,In Sik Hwang,Sun Bo Shim,Seung Wan Jee,Su Hae Lee,Chang Joon Bae,Jung Sik Cho,Jun Yong Cho,Dae Youn Hwang 한국실험동물학회 2011 Laboratory Animal Research Vol.27 No.1
Exercise training is highly correlated with the reduced glucose-stimulated insulin secretion (GSIS), although it enhanced insulin sensitivity, glucose uptake and glucose transporter expression to reduce severity of diabetic symptoms. This study investigated the impact of short-term swimming exercise on insulin regulation in the Goto-Kakizaki (GK) rat as a non-obese model of non-insulin-dependent diabetes mellitus. Wistar (W/S) and GK rats were trained 2 hours daily with the swimming exercise for 4 weeks, and then the changes in the metabolism of insulin and glucose were assessed. Body weight was markedly decreased in the exercised GK rats compare to their non-exercised counterpart, while W/S rats did not show any exercise-related changes. Glucose concentration was not changed by exercise, although impaired glucose tolerance was improved in GK rats 120 min after glucose injection. However, insulin concentration was decreased by swimming exercise as in the decrease of GSIS after running exercise. To identify the other cause for exercise-induced insulin down-regulation, the changes in the levels of key factors involved in insulin production (C-peptide) and clearance (insulin-degrading enzyme; IDE) were measured in W/S and GK rats. The C-peptide level was maintained while IDE expression increased markedly. Therefore, these results showed that insulin down-regulation induced by short-term swimming exercise likely attributes to enhanced insulin clearance via IDE over-expression than by altered insulin production.
김호정,윤미옥,이수정,최현철,김지영,김인화,심창구,강신정 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.2
A method that describes the determination of the in vitro release of ketoprofen from gels was suggested. The experimental system of the method consists of a Franz diffusion cell, which contains a pH 7.4 phosphate buffer as a receptor medium, and a 70 μm mesh woven nylon membrane as a diffusion barrier. Under the given condition of the system, the diffusion of ketoprofen across the membrane was rapid enough that the apparent release profile of ketoprofen obtained from the present method could represent the release of the drug from gel preparations. The release of ketoprofen in the present method was reproducible, and the rate increased in proportion to the concentration of ketoprofen in the gel. These suggest that the present method is applicable to the quality evaluation of gel preparations containing ketoprofen.
이양민,이병문,임장수,김창민,강동우,심현숙,이재기 동아대학교 정보기술연구소 2003 情報技術硏究所論文誌 Vol.11 No.1
Cases that apply mobile technology in own company's business processing in various industry area are increasing. In this paper, we propose a Mobile Portal constructin method accepting that flowing these age. Analyze instance that is applying mobile service in another industry to achieve Mobile Portal service and we chose core technology with this result. As focus of research, we implemented interaction interface between web page and database, conversion skill between wire and wireless contents, communicatin method between web page and contents conversion server, and application technology on Mobile service target Business and implemented Mobile service that applicable.
Elastomers and Composites : Research Papers ; Improving Light Stability of Natural Rubber Latex Foam
( Chang Su Shim ),( Jeong Seok Oh ),( Chang Kook Hong ) 한국고무학회 2015 엘라스토머 및 콤포지트 Vol.50 No.2
In this study, natural rubber latex foam was prepared in order to replace commercialized polyurethane foams as a car seat material. Physical properties of the latex foam were investigated and the light stability was improved. The latex foam was mixed in an aqueous solution state, and the degree of foaming and the accelerator ratios were appropriately controlled. Tensile properties, hysteresis and dynamic mechanical properties of the latex foam were measured to compare with those of polyurethane foams. UV light absorbers and radical scavengers were added for improving light stability of the latex foam. Xenon lamp test was conducted to investigate the effects of the reagents on light stability. Our results revealed that the prepared latex foam including a light absorber with an antioxidant showed excellent light stable performances.
Ecopathological Analysis of Apple stem grooving virus-K Harboring Talaromyces flavus
Shim Hye-Kyung,Hwang Kyu-Hyon,Shim Chang-Ki,Hong Seung-Beom,Son Su-Wan,Kim Dong-Giun,Choi Yong-Mun,Chung Young-Jae,Kim Dae-Hyun,Jee Hyeong-Jin,Lee Suk-Chan The Korean Society of Plant Pathology 2006 Plant Pathology Journal Vol.22 No.3
Pear black necrotic leaf spot (PBNLS) on pear trees (Pyrus pyrifolia) is caused by a Korean isolate of Apple stem grooving virus (ASGV-K). Yellow spots were detected in Phaseolus vulgaris (kidney bean) and Chenopodium quinoa which were grown near the diseased pears in year 2000 through 2003. The ASGV-K, the causative agent of PBNLS, was detected from the symptoms of the diseased kidney bean plant and C. quinoa. ASGV-harboring fungi were also isolated from symptomatic plants and from soils surrounding the infected plants. The ASGV-harboring fungus was identified and characterized as Talaromyces flavus. Ecopathological studies showed that the number of ASGV-harboring fungi on the pear leaves was not correlated with differences in temperature or severity of symptoms. Additionally, there was no difference in fungus frequency among the orchard locations or different host plants. Although the frequency of fungi isolated from the soil was not affected by changes in temperature or location, the fungi occurred at higher densities in the rhizosphere than in the plants themselves.
Investigation into the Efficacy of Val-SN-38, a Valine-Ester Prodrug of the Anti-Cancer Agent SN-38
( Chang Koo Shim ),( Won Sik Shim ),( Min Koo Choi ),( Su Geun Yang ),( Eun Young Kwak ) 한국응용약물학회 2012 Biomolecules & Therapeutics(구 응용약물학회지) Vol.20 No.3
We recently reported that Val-SN-38, a novel valine ester prodrug of SN-38, had greatly improved the intracellular accumulation of SN-38 in MCF-7 cell line, probably through enhanced uptake via amino acid transporters. In the present study, the effi cacy of Val-SN-38 was further investigated both in vitro and in vivo. It was found that the in vitro cytotoxic effect of Val-SN-38 was similar to that of SN-38. Moreover, Val-SN-38 exhibited an equal potency to that of SN-38 in survival experiments in vivo. Because these results seemed to be contrary to the previous fi nding, further investigation was performed to fi nd out the underlying cause of the contradiction. As only the lactone form is known to have cytotoxic activity, the proportion of lactone in Val-SN-38 and SN-38 was determined, but no differences were found. However, it turned out that Val-SN-38 had poor stability compared with SN-38, which resulted in a decrease in benefi cial effi cacy for Val-SN-38. Overall, the present study showed that a valine-added prodrug approach could be advantageous provided that the stability of the compound can be ensured. We believe this is a noteworthy study that unravels the discrepancy between intracellular accumulation and effi cacy of valine-added prodrug.
Chang Joon Bae,Min Sun Kim,Su Youn Yim,Dae Youn Hwang,Cheul Kyu Kim,Byoung Guk Kim,Sun Bo Shim,Seung Wan Jee,Su Hae Lee,Ji Soon Sin,Byoung Chun Lee,Jong Min Woo,Mee Kyung Jang,Kab Ryong Chae 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.1
Allergic disease such as atopic dermatitis, asthma and rhinitis is an immune disease characterized by the skin inflammation and the abnormal expression of cytokines including interleukin. It has been reported that the immune response is differently changed according to a kind of a chemical allergens or an inbred mouse strain. However, in preview studies, there have been no trials to elucidate an allergic response in the chronic diseases model. Thus, the aim of this study was to investigate whether a phthalic anhydride (PA) as chemical allergen would impact on the immonological factors of several disease model such as TG2576 (Alzheimer’s disease model) or NOD (type I diabetes disease model). To accomplish this, the 15% (w/v) PA solution was repeatedly spread on the ear’s dorsum of three types of animals including BALB/c, TG2576 and NOD mice and the ear thickness of them was measured by vernier calipers for 12 days. After treatment, the immune response-related factors were detected in the lymph node of three kinds of mice, respectively. The ear thickness indicating degree of skin inflammation was significantly increased in the TG2576 and NOD mice compared with BALB/c mice. Also, interleukin-4 in auricular lymph node was significantly changed in the disease model mice. These findings suggest that the PA solution as chemical allergen can induce the difference on skin inflammation and interleukin-4 expression as the allergic-related immunological factors among the BALB/c, TG2576, NOD mice.