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Han Sungpil,Choi Hee Youn,Kim Yo Han,Choi SeungChan,Kim Seokuee,Nam Ji Yeon,Kim Bongtae,Song Geun Seog,Lim Hyeong-Seok,Bae Kyun-Seop 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.1
Background/Aims: Tegoprazan, a novel potassium-competitive acid blocker, is expected to overcome the limitations of proton pump inhibitors and effectively control nocturnal acid breakthrough. To evaluate the pharmacodynamics of tegoprazan versus dexlansoprazole regarding nocturnal acid breakthrough in healthy subjects. Methods: In a randomized, open-label, single-dose, balanced incomplete block crossover study, 24 healthy male volunteers were enrolled and randomized to receive oral tegoprazan (50, 100, or 200 mg) or dexlansoprazole (60 mg) during each of two administration periods, separated by a 7- to 10-day washout period. Blood samples were collected for pharmacokinetic parameter analysis; gastric monitoring was performed for pharmacodynamic parameter evaluation. Results: All 24 subjects completed the study. Average maximum plasma concentration, area under the plasma concentration–time curve, and mean time with gastric pH >4 and pH >6 for tegoprazan demonstrated dose-dependent incremental increases. All the tegoprazan groups reached mean pH ≥4 within 2 hours, whereas the dexlansoprazole group required 7 hours after drug administration. Based on pharmacodynamic parameters up to 12 hours after evening dosing, 50, 100, and 200 mg of tegoprazan presented a stronger acid-suppressive effect than 60 mg of dexlansoprazole. Moreover, the dexlansoprazole group presented a comparable acid-suppressive effect with the tegoprazan groups 12 hours after dosing. Conclusions: All the tegoprazan groups demonstrated a significantly faster onset of gastric pH increase and longer holding times above pH >4 and pH >6 up to 12 hours after evening dosing than the dexlansoprazole group.
Versatile Multilayer Transparent Electrodes for ITO-Free and Flexible Organic Solar Cells
Seungchan Han,Sooyeon Lim,Hoyeon Kim,Hyunsu Cho,Seunghyup Yoo IEEE 2010 IEEE journal of selected topics in quantum electro Vol.16 No.6
<P>Multilayer transparent electrodes based on a dielectric-metal-dielectric structure are explored as an effective alternative to indium tin oxide (ITO) electrodes that can lead to ITO-free or highly flexible organic photovoltaic (OPV) cells with a performance comparable to conventional cells. The role of each layer in multilayer electrodes is discussed with an emphasis on the potential role of inner dielectric layer as a buffer layer, and the optimization strategy considering the overall optical structure is provided. Experimental results showing the OPV performance under dynamic flexibility test are also provided as a function of the number of bending cycles.</P>
Strain-Controllable Magnetism in Co Decorated Pyridinic N-Doped Graphene
Seungchan Jo,Sangho Lee,Kyung-Han Yun,Yubin Hwang,Yong-Chae Chung IEEE 2014 IEEE transactions on magnetics Vol.50 No.8
<P>An external strain is suggested as an effective means to finely control the magnetic properties of a candidate medium for future spintronics devices. To demonstrate the potential of this concept, the biaxial strain effects on the magnetic moment of Co adatom on pyridinic N-doped graphene (PNG) sheet were investigated using density functional theory calculations. Under the strain from -5% to 5%, the magnetic moment of the Co adatom on PNG was increased continuously from 1.72 to 1.95 μ<SUB>B</SUB>. Also, Co adatoms are expected to be dispersed on the PNG surface without metal clustering in this range of applied strain due to its strong binding with the pyridinic nitrogen defects. From these results, it is anticipated that reliable control of magnetism in Co decorated PNG system is available by use of an external strain.</P>
한병찬(Han ByungChan),김재환(Kim JaeHwan),임승찬(Lim SeungChan),권영진(Kwan YoungJin),임남형(Lim NamHyoung),이진옥(Lee JinOk),장승엽(Jang SeungYup) 한국철도학회 2006 한국철도학회 학술발표대회논문집 Vol.- No.-
High performance fiber reinforced cement composite(mortar) shows ultra high ductile behavior in the hardened state, because of the fiber bridging properties. Therefore, a variety of experiments have being performed to access the performance of the materials recently. In this study, a flexural fatigue test was carried out to investigate flexural fatigue behavior and provide basic data for fatigue design. Based on the flexural fatigue test, the fatigue safety of the high performance fiber reinforced cement mortar specimens was estimated. For the fatigue test, 10x10x40cm specimens were designed. A static flexural load test was also performed before the fatigue test to analyze the structural behavior of the specimens. The initiation of fatigue cracks in the specimens could be detected through the history of displacement range. Fatigue limit was predicted Weibull distribution using S-N relationship, and a satisfactory result was obtained.
한병찬(Han ByungChan),김재환(Kim JaeHwan),임승찬(Lim SeungChan),권영진(Kwan YoungJin),임남형(Lim NamHyoung),이진옥(Lee JinOk),장승엽(Jang SeungYup) 한국철도학회 2006 한국철도학회 학술발표대회논문집 Vol.- No.-
The synthetic fibers such as polyvilyl-alcohol(PVA) fiber are poised as a low cost alternative for reinforcement in structural applications. It has been reported that synthetic fiber in cement composites can control restrained tensile stresses and cracks and increase toughness, resistance to impact, corrosion, fatigue and durability. High performance fiber reinforced cementitious composite(HPFRCC) shows ultra high ductile behavior in the hardened state, because of the fiber bridging properties. In this study, it was proposed a direct tensile testing machine(DTTM) to be simple and to be applied to HPFRCC, and examined the tensile properties of HPFRCC by this machine. As a results, it was confirmed that a direct tensile test of HPFRCC could be certainly carried out DTTM to be developed in this study. Also, tensile strength and yield strength of HPFRCC were similar regardless of specimens thickness. And, all specimens revealed the stable strain-hardening behavior and multiple cracking in flexible and tensile loads. But, deviation of strain at ultimate tensile strength increased with the increase of specimen thickness.
Diallyl Biphenyl-Type Neolignans Have a Pharmacophore of PPARα/γ Dual Modulators
( Yujia Han ),( Jingjing Liu ),( Sungjin Ahn ),( Seungchan An ),( Hyejin Ko ),( Jeayoung C. Shin ),( Sun Hee Jin ),( Min Won Ki ),( So Hun Lee ),( Kang Hyuk Lee ),( Song Seok Shin ),( Won Jun Choi ),( 한국응용약물학회 2020 Biomolecules & Therapeutics(구 응용약물학회지) Vol.28 No.5
Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adiponectin- secretion promoting compounds in the adipogenic differentiation model of human bone marrow mesenchymal stem cells (hBM-MSCs). In a target identification study, magnolol, honokiol, and 4-O-methylhonokiol were elucidated as PPARα and PPARγ dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPARα/γ dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.
Kojyl cinnamate esters are peroxisome proliferator-activated receptor α/γ dual agonists
Kim, Sae On,Han, Yujia,Ahn, Sungjin,An, Seungchan,Shin, Jeayoung C.,Choi, Hyunjung,Kim, Hyoung-June,Park, Nok Hyun,Kim, Yong-Jin,Jin, Sun Hee,Rho, Ho Sik,Noh, Minsoo Elsevier 2018 Bioorganic & medicinal chemistry Vol.26 No.21
<P><B>Abstract</B></P> <P>Adiponectin is an adipocytokine with insulin-sensitizing, anti-inflammatory, anti-atherosclerotic, and anti-aging properties. Compounds with the ability to promote adiponectin secretion are of interest for the development of anti-aging drugs to improve skin-aging phenotypes. In the phenotypic assay to measure adiponectin secretion during adipogenesis in human adipose tissue-derived mesenchymal stem cells (hAT-MSCs), kojyl cinnamate ester derivatives increased adiponectin secretion. A target identification study showed that the kojyl cinnamate ester derivatives competitively bound to peroxisome proliferator-activated receptor α/γ (PPARα/γ). The upregulation of adiponectin production induced by kojyl cinnamate ester derivatives was significantly correlated with PPARα and PPARγ binding activities. Kojyl cinnamate ester derivatives significantly increased the transcription of genes encoding cholesterol and fatty acid synthesizing enzymes in hAT-MSCs. Notably, the kojyl cinnamate esters upregulated the gene transcription of lipid metabolic enzymes in human epidermal keratinocytes, which are important in the integrity of skin permeability barrier. In addition, the kojyl cinnamate esters that function as PPARα/γ dual modulators inhibited ultraviolet B irradiation-induced inflammation in human epidermal keratinocytes. Therefore, kojyl cinnamate ester derivatives are a novel class of PPARα/γ dual agonists with the potential to improve skin-aging phenotypes.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>