여성 요도증후군에서 Terazocin의 효과에 대한 연구

우승효,신관희,한광희,정원일,이형래,이상철,김용태,김원재 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.2

연구목적: 여성 요도증후군을 보이는 환자에서 교감신경차단제인 terazocin을 복용한 후 치료 효과에 대한 각 증상의 변화와 부작용을 알아보고자 하였다. 대상 및 방법: 1997년부터 1999년까지 충북대학교병원 비뇨기과에 내원한 35명의 여성 중 요검사 및 요배양 검사, 그리고 다른 이학적 검사에서 이상이 없는 요도증후군 환자를 대상으로 간질성방광염 증상점수(ICSS)를 terazocin (3mg/day for 3 months) 투여 전후에 조사하였고, 치료 후 3개월과 1년에 Likert scale 점수를 조사하였다. 결과: ICSS는 비치료군은 18.3±5.9점, 치료군은 16.5±6.8점으로 두군간의 차이는 없는 것으로 나타났다(p=0.52). 치료군은 치료 후 3개월에 시행한 ICSS가 9.9±7.8점으로 치료 전에 비해 현격히 증상이 호전되는 것으로 나타났다(p=0.0001). 특히 3개월에 시행한 Likert scale에서는 주간 및 야간빈뇨, 절박뇨, 배뇨통의 횟수 및 강도, 그리고 전체적인 증상정도에서 40-70% 가량 호전된 것으로 밝혀졌으며 이는 1년 후에도 증상의 호전이 지속되는 것으로 나타났다. 비치료군에서의 1년 후 Likert scale은 6명 중 2명이 전체적인 증상의 호전이 있는 것으로 나타났다. 결론: Terazocin은 환자의 약 70%가량에서 증상의 호전을 가져왔고, 비치료군에서도 환자의 33%가 저절로 증상이 좋아진 것으로 보아 Terazocin은 여성 요도증후군에서 분명히 효과가 있으나 증상이 심할 경우 보조적인 치료로 이용되는 것이 바람직할 것으로 사료된다. Purpose: We performed to assess the effects and complications of terazocin in women with chronic female urethral syndrome. Materials and Methods : Thirty-five women with chronic female urethral syndrome were studied from March 1997 to August 1999. The subjects exhibited normal findings without the pyuria and bacteriuria in urinalysis and urine culture and were invested the interstitial symptom score(ICSS). 29 subjects of them took a terazocin 1-4 mg/day for 3 months. They were reevaluated for the ICSS and Likert scale after 3 months and for Likert scale after 1 year. Results: The ICSS before treatment were showed 18.3±5.9 in the untreated patient group and 16.5±6.8 in the treated patient group, and no statistically difference between both patient groups(p=0.52). In the treated patient group, the ICSS after treatment were showed 9.9±7.8, significant difference between before and after treatment(p=0.0001). The Likert scale was showed at 3 months after treatment that frequency, nocturia, urgency, pain frequency, pain intensity, daily activities, and overall symptoms were improved in 65.5%, 55.2%, 24.1%, 41.4%, 41.4%, 70%, 70%, and 70% of 29 subjects, each other. Overall symptom score assessed at 1 year were showed that 3 subjects was aggravated. In untreated patient group, 2 of 6 was improved in overall symptom score. Conclusion: Terazocin was effective above 70% in the treated group, and symptoms were improved spontaneously in a third of the untreated group. So, we thought that terazocin would be useful as supportive treatment in period of severe symptoms.

양방향성 형상기억합금을 이용한 초소형 공작물 클램핑 장치 개념설계

신우철,박형욱,노승국,박종권 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

In this paper, a micro workpiece clamping device, which is possible to be applied in micro machine-tools, based on a shape memory alloy is introduced. Especially, the train procedure to transform a commercial one-way shape memory alloy into a two-way shape memory alloy is described. Also, it is experimentally verified that through the train procedure, the applied shape memory alloy ring exhibits two-way shape memory behavior of 220㎛ deformation. In addition, a conceptual design and a basic configuration of the work-piece clamping device using the two-way type shape memory alloy are suggested.

형상기억합금 기반 공구 클램핑장치의 자동 공구교환 시스템 개발

신우철,노승국,김병섭,박종권 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

This study developed an auto tool change system of the SMA-based tool clamping device for applications of micro-machine tools. This paper first introduces clamping/unclamping mechanisms of the auto tool change system and its basic configuration. In addition, it shows experimental results of times needed for clamping/unclamping operations of a prototype of the auto tool change system. The average values were estimated to 7.2(s) and 2.6(s) respectively. These results confirm that the auto tool change system is feasible.

Clozapine으로 인한 야뇨증에서 Oxybutynin Hydrochloride 사용 3례

지익성,박철범,이선우,왕성근,신석철 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

Clozapine은 치료 저항성 정신분열병의 치료에 있어서의 우수한 효과에도 불구하고, 야뇨증과 같은 환자를 곤란하게 하는 부작용을 유발한다. 야뇨증은 발견 즉시 처리되야 할 부작용 중의 하나이다. 저자들은 oxybutynin hydrochloride가 일일 용량 5∼10mg의 소량으로, 별다른 부작용 없이 빠르게 항 야뇨증 효과가 나타남을 알 수 있었고, clozapine으로 인한 야뇨증 치료의 대안으로 만족할 만한 것이었다. 중심단어:Oxybutinin hydrochloride·Clozapine·야뇨증·정신분열병증. Nocturnal enuresis has been recognized as an adverse effect of clozapine treatment. We re-ported 3 chronic schizophrenic patients who had showed nocturnal enuresis following clozapine treatment. Oxybutynin hydrochloride on clozapine-induced enuresis was very effective in 3 patients. The dose in our patients was 5 to 10mg/day. This medication was well tolerated. It is suggested that oxybutynin hydrochloride is a effective therapeutic option in clozapine-induced nocturnal enuresis. KEY WORDS:Oxbutynin hydrochloride ·Clozapine·Nocturnal enuresis·Schizophrenia.

알코올 사용 장애 환자의 스트레스와 대처 양식 및 부적응에 관한 연구

박민철,오상우,이귀행,노승호,백영석,이상열,김재현 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2

Background: This study was explored the influences of perceived stress, coping style on maladaptation of patients with alcohol use disorders. Methods: To investigate these objects, 66 patients with alcohol use disorders were completed scales for the perceived stress, coping style, dysfunctional attitude, alcohol expectancy, self-efficacy, social support, state-trait anxiety, quantity of alcohol use, problems of alcohol use and BDI. The data were analyzed by t-test, correlation and multiple regression analysis. Results: First, the results showed the significant difference between long term group and short term group on the problem-related alcohol use and trait anxiety. Second, the results showed the significant difference between severe problem related alcohol use group and mild problem related alcohol use group on cognitive coping, negative expectancy, quantity of alcohol use. Third, among each variables of patients with alcohol use disorders, quantity of alcohol use had significantly high correlation with quantity of alcohol by family, quantity of alcohol by friends, perceived stress, negative expectancy. Problems of alcohol use had significantly high correlation with negative expectancy, cognitive coping, percieved stress, social support and self efficacy. Finally, vulnerability-stress model predicted 26.1% of variances of quantity of alcohol use, 48.9% of variances of problems of alcohol use and 13.9% variances of depression. Conclusions: The results of the study indicated the superiority of vulnerability stress model to predict quantity of alcohol use, problems of alcohol use and depression.

딜티아젬 함유 코아 펠렛으로부터 약물의 용출에 미치는 폴록사머 함량의 영향

이승우,감성훈,홍지웅,최기송,박은석,지상철 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4

In order to evaluate the effect of poloxamer 407 content on the dissolution profiles of pellets, diltiazem HCl (DTL) core pellets were prepared with poloxamer 407 (50∼90% w/w, with lactose as filler) using an extruder and a spheronizer. Any possible interaction between the drug and excipients was evaluated using DSC, IR and TLC. Dissolution tests were performed using USP basket method. In addition, scanning electron micrograph was performed to examine the surface roughness and cross sections. The release of DTL from the core pellets was decreased with increasing poloxamer 407 content. Cracks appeared on the surface of the core pellets with increasing the poloxamer 407 content, which may play a role on the retardation of the release of DTL from core pellets. There was no any significant interaction between the drug and excipients employed to prepare the core pellets.

복합 관동맥병변에서의 Rotational Atherectomy : 초기결과

김진우,박성욱,홍명기,이상곤,이일수,이철환,최기준,강덕현,송재관,김재중,박승정 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.9

당뇨병성 다발성 신경병증에 대한 Thioctic acid의 유효성 및 안정성에 관한 연구

박철영,김영설,오승준,우정택,김성운,양인명,김진우,최영길 대한당뇨병학회 2001 임상당뇨병 Vol.2 No.1

연구배경: 당뇨병성 신경병증은 당뇨병 환자에서 흔히 나타나는 합병증으로서 임상 증상은 가볍거나 없을 수도 있지만 많은 경우에 통증, 작열감, 이감각증이나 무감각증 등의 증상을 동반하지만, 이에 대한 명확한 기전이나 뚜렷한 치료방법이 없었다. 최근에 신경세포내 산화성 스트레스의 증가로 신경세포의 손상이 발생된다는 기전이 주목을 받으면서, 당뇨병성 신경병증 환자에게 항산화제인 thiotic acid를 사용하여 좋은 효과를 관찰한 논문들이 발표되었다. 이에 저자들은 한국의 당뇨병성 다발성 신경병증 환자에서 thiotic acid를 경구 투여 후에 신경병증에 의한 효과 및 안정성을 평가하였다. 방법: 모든 대상 환자에게 Thioctic acid 600㎎ 을 1일 1회 아침 식전 30분에 8주간 투여하여 당뇨병성 다발성 신경병증에 대한 TSS의 개선여부에 대한 임상적 유효성 및 이상반응, 내약성, 실험실적 지표의 변화를 통한 안정성을 관찰하였다. 결과: 치료시작 전에 관찰한 환자가 호소하는 증상은 통증이 가장 많았으며 무감각, 작열감, 이상감각 순의 빈도를 보였다. 통증, 작열감, 이감각증, 무감각증의 평균 TSS는 1차 방문시 5.8± 1.8, 2차방문시는 4.4±1.7, 3차 방문시는 3.1±1.1로 사용기판에 따라 통계학적으로 유의한 증상의 호전이 있었다. 또한 TSS의 개선 뿐만 아니라 통증, 작열감, 이감각증 및 무감각증 각각의 증상도 치료전과 치료 4주 후 및 치료 8주 후를 비교했을 때 통계학적으로 유의한 증상의 호전이 있었다. TSS가 1차 방문 시와 비교했을 때 3차 방문시에 30% 이상 개선되었을 때(1차 방문시에 TSS 4인 환자는 2점 이상 개선되었을때) 임상적으로 의미가 있는 반응으로 간주하고 계산한 반응률은 71.3%였다. 결론: 당뇨병성 다발성 신경병중 환자에 대해 항 산화제인 thioctic acid 600㎎ 경구 투여요법은 당뇨병성 신경병증의 증상완화에 유용하며, 안전한 것으로 사료된다. Background: The study was peformed to evaluate the efficacy and safety of oral treatment with the antioxidant α-lipoic acid (Thioctcid??) in diabetic patients with peripheral polyneuropathy. Methods: Thioctacid?? 600㎎ was orally administered once a day for 8 weeks in 61 diabetic patients with peripheral polyneuropathy. Neuropathic symptom(pain, burning, paresthesia, and numbness) were scored before, and of 4 and 8 weeks after treatment. In addition, neuropathy by the physician and patients at the end of treatment. The primary endpoint was the response role after 8 weeks treatment, defined as an improvement in the total symptom score of at least more than 30%. Results: Efficacy was evaluated among forty-four patients who had completely the study according to the protocol and safety was evaluated among all of 61 patients who had taken the study medication. The response rate after 8 weeks was 77.3%. The total symptom score was significantly decreased of 4-week, and further decreased of 8-week. All the individual scores for neuropathic symptom were also significantly reduced of 4-week and further decreased at 8-week. Conclusion: These finding indicate that oral treatment with thioctacid?? at a dose of 600㎎/day for 8 weeks will improve peripheral polyneuropathy in diabetic patients, without causing any serious adverse events.

포도당과 이소프로테레놀에 의한 시상하부의 소마토스타틴 분비가 갑상선자극호르몬방출호르몬에 의한 갑상선자극호르몬에 미치는 효과

박철영,양인명,오승준,김덕윤,우정택,김성운,김진우,김영설,최영길 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5

겉보기 열용량법을 이용한 합금의 레이저 융용풀에서의 열 및 유동해석

김우승,심복철,임익태 漢陽大學校 工學技術硏究所 1997 工學技術論文集 Vol.6 No.1

An apparent capacity method is employed to solve numerically transient and steady state laser melting emblem of alloy. Momentum equations are solved in the liquid and mushy zones by using the SOLA-VOF algorithm. Using a laser with a top-hat profile, a wide range of studies are performed for steel. The streamline plots show the existence of rotating cell in the molten pool. It is found that the shapes of pool, the distributions of surface velocity and surface temperature are quite different from the case without convection effect in the mushy zone.