Erratum to: Intracellular Substrates of a Heme-Containing Ascorbate Oxidase in Pleurotus ostreatus

Seung-Rock Lee,Woo-Jeong Joo,Yong-Un Baek,Youn-Kyong Lee,Seong-Woon Yu,Yeon-Ran Kim,Kee-Oh Chay,Seung-Hyun Cho,Sa-Ouk Kang 한국미생물학회 2009 The journal of microbiology Vol.47 No.6

In the online version of the article the name of the second corresponding author is misspelled. The correct spelling is Sa-Ouk Kang. The online version of the original article can be found under doi: 10.1007/s12275-008-0307-8

중독한 추체로 증상을 보인 cyclosporine에 의한 뇌증 1예

강정현,곽승근,신현영,김성은,이정호,이정찬,곽상혁,윤환중,조덕연,김삼용,김제,송창준 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

The use of cyclosporine(CsA), a potent immunosuppressive agent, is associated with numerous side effects. Neurotoxicity was earlier less well known, but with growing experience central nervous system side effects are now reported up to 40% of patients. Among various CsA-induced neurotoxicities, tremor is most common and posterior leukoencephalopathy is well characterized. An encephalopathy presenting with pyramidal weakness, however, seems to be rare and poorly documented. We report here a case of encephalopathy presenting with multiple generalized seizures followed by fluctuating quadriparesis developed a few days after starting CsA and resolved spontaneously after withdrawal of the drug . A 48-year-old woman with aplastic anemia was placed upon immmunosuppressive treatment consisting of antithymocyte globulin(ATG), CsA, and methylprednisolone. Two days after starting the therapy, she developed a generalized seizure. The next day she developed 2 more episodes of seizure and the therapy was stopped. Computed tomogram of the brain was normal. Six days after starting therapy, she developed mild motor weakness and paresthesia of both lower extremities, which progressed to a definite quariparesis confining her to a bed in 3 days. Magnetic resonance imaging(MRI) of the brain revealed asymmetric, bilateral high-signal abnormalites in the subcortical white matter of fronto-temporal areas. After reaching to a maximum with some fluactuation(14 days after starting the therapy) the motor weakness started to be resolved. She was discharged with a almost complete resolution of the weakness 45 days after starting the therapy. Five months later she did well and brain MRI was negative.

마라톤후 발생한 열사병 1례

강보승,이정훈,송형곤,송근정,정연권 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Heat stroke, a medical emergency, occurs when the body's thermal regulation is upset and unable to dissipate adequate amounts of heat with a rise in body temperature. It is characterized by hyperpyrexia, with a core temperature of 40˚C or more. hot dry skin, and central nervous system disturbance and usually results in rhabdomyolysis and multiorgan failure. Our case, a 43-year-old healthy male, was caused by a marathon, half course, on a sunny day in late summer. He suddenly fell down on the road and was delivered to a nearby hospital, where a seizure developed. He was transfered to our hospital and then displayed Central Nervous System disturbance, hot dry skin, acute liver failure, rhabdomyolysis, anurlc acute renal failure, and disseminated intravasculular coagulopathy. He was treated with general supportive care and hemofiltration. Despite the aggressive management, he died of shock on the fifth day after admission.

흰쥐 경동맥 손상 모형에서 체외 방사선조사에 의한 신내막 과증식억제 : Intercellular Adhesion Molecule-1과 Vascular cell Adhesion Molecule-1의 역할 The Possible Role of Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1

강동헌,승기배,장기육,임상현,정해억,임효영,김연실,채장성,김재형,홍순조,최규보 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.9

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

Headed Reinforcement를 사용한 철근콘크리트 깊은 보의 전단거동

강경훈,이우진,김수봉,서수연,윤승조,김성수 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

Generally, headed reinforcement offers several advantages over straight bar or hooked bar anchorages to develop reinforcement in concrete members. The purpose of this study is to investigate the shear behaviors of reinforced concrete deep beam with headed reinforcement. Five deep beam specimens are designed to study the anchorage capacity of headed reinforcement as well as the contribution of H-bar and V-bar to the shear. Two anchorage types, standard 90-degree anchorage and headed reinforcement, are considered in design. From the tests, it is shown that In the test results, headed reinforcement is able to replace standard 90-degree anchorage as the anchorage method. The evaluation on the contribution of H-bar and V-bar in current design code for deep beam shows that the former is overestimated 75% and the latter is overestimated 17%.

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

간호대학생의 노인개념 및 노인환자에 대한 간호인식분석 연구

정연강,이승진 중앙대학교 의과대학 의과학연구소 1986 中央醫大誌 Vol.11 No.2

The purpose of this study was to analyse the old people concept and nursing perception toward elderly patients in order to contribute the improvement of geriatric nursing. This study was to investigate the old people concept of baccalaureate nursing students and to investigate any possible correlation between nursing perception and following variables: respondents' growth place during junior and senior high school, experience with relatives or acquaintances over 60 years old, nursing experience of elderly patients, educational experience of the elderly health & geriatric nursing, and sibling numbers. The subjects for tile elderly were 149 nursing students at C and H university locating in Seoul. Data was collected from 3th of Sep. to 8th of Oct. 1984 using 0ld People Concept questionnaire and Nursing Perception by OPQ. The data were analysed by T-test and Pearson Correlation. The results which were obtained are as follows; 1. There was not a significant difference between nursing perception toward elderly patients and the experience with relatives or acquaintances over 60 years old. (p>0.05) 2. There was not a significant difference between nursing perception toward elderly patients and clinical experiences of geriatric patients. (p>0.05) 3. There was a significant difference between nursing perception toward elderly patients and educational experiences of the elderly health and geriatric nursing. (p<0.05) 4. There was not a significant difference between nursing perception toward elderly patients and sibling numbers. (p>0.05) 5. There was a significant difference between nursing perception toward patients and the degree of old people concept. (p<0.05)

관학연계 주간보호센터 사업 운영 프로그램 개발 : 동작구민을 대상으로

한승의,김경희,정연강,전인희 중앙대학교 간호과학연구소 2001 중앙간호논문집 Vol.5 No.2

The purpose of this study was to sere as a basis for the development of more successful programs for the elderly who used adult day care center, by examining the Activities of Daily Living, Instrumental Activities of Daily Living and dementia symptom of elderly people who wed in Dongjak-gu in Seoul. Data for this present study were collected from 260 people via questionnares randomly distributed to over 65-year-old elderly people who lived in Dongjak-gu in Seoul from March to June, 2001. The findings of this study were as below: 1. For general characteristics, the women outnumbered the men, as the former group accounted for 63.8% of the subjects and 36.2% were male. By age, the largest age group was 71 to 75, which accounted for 43.2%. By disease, 87.3% suffered from disease, and most of them had mode than one disease. 2. For Activities of Daily Living, washing and dressing mean scored the highest with 2.96, and bathing stored the least with 2.87. 3. Concerning Instrumental Activities of Daily Living, what's in want of the greatest help was going shopping(4.5%), followed by cooking(4.5%) and laundering(4.5%) in the order named. 4. As a result of making a primary dementia screening test, 68 people(26.2%) were suspected to have dementia, and those people need to take dementia diagnosis test to fond out dementia prevalence.

Epithelioid 세포가 많은 Antioimmunoblastic lymphadenopathy 형의 T-세포 임파종. 면역 조직학적 검색을 실시한 증례 보고

백승호,강상균,김창진,강현욱,오도연 순천향대학교 1992 논문집 Vol.14 No.4

A peripheral T-cell lymphoma with a high content of epithelioid cells-an entity that reveals morphologic and clinical characteristics resembling those seen in angio-immunoblastic lymphadenopathy(AILD)-was separated from lymhoepithelioid cell lymphoma(Lennert' slymphoma, or LeL). It was considered a variant of the AILD type of peripheral T-cell lymphoma. AILD-PTCLep and LeL share so much similarities, clinically and morphologically, that they can't be differentiated each other. We experienced a case of AILD-PTCLep confirmed by a panel of immunohistochemistry and reviewed the differential points between the LeL.