강원도지역에서 발생한 발진열과 쯔쯔가무시병

민창홍,장우현,강재승,조수익,최문기,조민기,윤창순,김윤원 대한감염학회 1988 감염 Vol.20 No.2

In Korea, there has been an increasing concern on rickettsiosis as one of most prevailing acute febrile illness, since murine typhus and scrub typhus had not been reported for 2 decades until 1986 and thereafter a few studies were reported on these diseases. A microimmunofluorescence test was used to study antibodies to R. typhi and R. tsutsugamushi in urban and rural inhabitants students, and patiants suspected of leptospirosis or rickettsiosis from 1986 to 1987 in Kangwon-do Korea. 43% of inhabitatnts and 17% of students reacted to R. typhi. Only one inhabitant among inhabitants and students reacted to R. tsutsugamushi. Among 169 patients, 43(25%) reacted to R. typhi, 38(22%) to R. tsutsugamushi and 25(15%) to Leptospira interrogans. Sexual rate(male; female) in murine typhus was 1.7:1, that in scrub typhus was 1:2.2 and that in leptospirosis was 1.5;1. The age ditribution of patients with murine typhus was generally even over 20 years old. But 71% of patients with scrub typhus were over 40 years old. Scrub typhus was most prevailing in female over 40 years old. Murine typhus was relatively more prevailing in Choonchun city than rural area as compared with scrub typhus and leptospirosis. Most of scrub typhus occurred in rural area. Most of each disease occurred between September and November (murine typhus; 93%, scrub typhus; 95%, leptospirosis; 84%) with a peak in October. Scrub typhus considerably occurred not only October(58%) but also November(28%). All patients with scrub typhus were immediately diagnosed by antibody when they visited hospital. 53% of patients with murine typhus were diagnosed when they visited hospital within 7 days after onset of illness, and others were done by second sera obtained 8 days after. The patients in whom IgM was seronegative but antibodies of other class were seropsitive by 20 days after onset of illness, were 14% in murine typhus and 26% in scrub typhus. At least those patients were considered to be infected second. Murine typhus and scrub typhus were suggested to be endemic diseases in Kangwon-do as antibodies of inhabitants and characteristics of patients' sera were considered. By serologic finding of patients with scrub typhus in Kangwon-do, Gilliam was 59'% of etiologic strain of scrub typhus, Karp was 41q% and Kato was none. Most scrub typhus occurred in person to be related to agriculture, but murine typhus was not related to job and occurred more in small city than rural area. Rash was scarcely detected in murine typhus and scrub typhus, and eschar was in 50% of scrub typhus only. Serum transaminase elevated in many patients with scrub typhus and murine typhus. Leukocytosis and abnormal finding in chest X-ray were showed in some patients with scrub typhus but were scarcely in murine typhus.

속박 (束縛) 과 침수 (浸水) 로 유도된 흰쥐의 스트레스성 급성 (急性) 위점막병변 (胃粘膜病變) 발생에 있어서 위산분비의 (胃酸分泌) 역할

민영일(Young Il Min),박충기(Choong Kee Park),장린(Rin Chang),김병호(Byung Ho Kim),장영운(Young Woon Chang),이정일(Jung Il Lee),박승준(Seung Joon Park),정주호(Joo Ho chung),정지창(Jee Chang Jung) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.1

N/A The possible roles of gastric acid secretion in the pathogenesis of stress ulcers induced by restraint with water-immersion for 7 hours in pylorus-ligated rats were investigated. Control rats with pylorus-ligation only did not show any gastric mucosa} lesion, and their mean gastric acid output was 449.2 ± 36.1 umol/rat. In contrast, the stressed rats, group II, showed multiple, punctate and hemorrhagic erosions in gastric mucosa, and mean gastric acid output was decreased to the level of 253.7 ± 27.3 umol/rat. Subcutaneous administration of histamine(40 mg/kg every 2.5 h for a total three times) to stressed rats augmented the lesion with severe multiple, linear and hemorrhagic erosions and mean acid output increased significantly (328.1 ± 31.5 umol/, p<0.005) compared with group II. Pretreatment with rantidine(20 mg/kg) or prostaglandin E2 (30 ug/kg) before exposure to stress reduced gastric lesion formation slightly with no significance. In ranitidine pretreated rats, mean gastric acid output was decreased significantly (120.1 ± 15.3 umol/rat, p<0.005) compared with group II. However, in prostaglandin pretreated rats, mean gastric acid output showed no significant changes. Therefore, it is suggested that increased gastric acid secretion seems to be an aggravating or a permissive factor rather than a major factor in the pathogenesis of stress-induced gastric mucosal lesions.

마우스 각종 장기의 Xanthine Dehydrogenase-Xanthine Oxidase 활성도에 미치는 산소 농도의 영향

장승훈,한기정,권년수,이희성 중앙대학교 의과대학 의과학연구소 1993 中央醫大誌 Vol.18 No.2

Xanthine oxidase (XO) derved from xanthine dehydrogenase (XD) during ischemia plays important roles in tissue damage by generating superoxide radicals. In the present study, we examined in vivo regulations of XD-XO activities of various organs by environmental oxygen tension. Mice were exposed to 100% oxygen for 3, 10, or 30 h, or 7% oxygen (73% nitrogen) for 4h. XD-XO activities of liver, kidney, lung and brain were measured. The enzyme activities in both liver and kidney were markedly increased by the treatment with 100% oxygen. In the liver the enhanced activity was sustained until 30 h, while the elevated renal activity was found only in the mouse treated for 10 h. XD-XO activities were decreased in lung and brain by the treatment with 100% oxygen. When mice were exposed to 7% oxygen, XD-XO activity was markedly decreased in lung and brain, while the activites in liver and kidney were not significantly changed. These results indicate that XD-XO can be regulated by the environmental oxygen tension, and the regulation is organ-specific.

의과대학 인성교육 모델개발을 위한 예비연구

송창훈,임성철,박종,이승일,도남용,박상기,박상화 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

징병 신체검사에서 나타난 청소년기 추간반탈출증의 유병률과 임상적 특징 : A Study Based on Examinations for Conscription

홍창기,박철기,박형천,윤승환 대한척추신경외과학회 2004 Neurospine Vol.1 No.1

Objective: The authors analyzed the large series of intervertebral disc herniation in adolescence to evaluate the prevalence, clinical characteristics, and possible risk factors on the basis of the data from the examinations for conscription. Material and Methods: Of 77685 nineteen-old-males who were given an examination for conscription at Regional Military Manpower Administration of Seoul in 2002, 382 patients exempted from conscription due to intervertebral disc herniation were analyzed. The diagnosis were made from the medical certificate, medical record, magnetic resonance imaging(MRI)(or computed tomography(CT)) which examinee presented and confirmed with the aid of reexamination of CT. Radiological char cteristics and severity of intervertebral disc herniation as well as structural abnormalities of vertebral columns were carefully evaluated with CT scan and MRI scan. Possible risk factors like overweight, structural abnormality of vertebral column, trauma were analyzed statistically using one-sample T-test and chi - square test on the assumption that P value less than 0.05 was considered statistically significant. Result: Prevalence of intervertebral disc herniation in adolescence aged nineteen years and younger were 0.5%. L4-5 level was the most frequently affected site followed by L5-S1. Of all 382 patients of intervertebral disc herniation, 29% were considered serious with reference to radiological evidence of root compression or siginificant discogenic spinal stenosis. Limbus fracture was found in 6.8% of patients. Overweight was the significant risk factor of the disease(p=0.0). However, neither structural abnormality of vertebral column nor trauma showed any relation to pathogenesis of intervertebral disc herniation. Conclusion: In adolescence aged nineteen years and younger, the prevalence of intervertebral disc herniation was 0.5% and accompanying limbus fracture was more frequent when compared with adult. Overweight was the only significant risk factor of the disease.

조선대학교 의과대학의 유급제도 개선을 위한 예비조사

박종,박상기,박상학,도남용,송창훈,이승일,임성철 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

조선대학교 의과대학 의학과 학사편입학제도의 전향적 검토

임성철,박상기,도남용,박상학,이승일,송창훈,박종 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

곰팡이에서 분리한 Helicobacter pylori 항균물질의 분리 및 구조규명

남궁준,연승우,백남수,김태한,김영호,김창진,김기원 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-

Helicobacter pylori is a Gram-negative bacterium which causes chronic gastritis and is associated with gastric ulcer, duodenal ulcer and gastric carcinoma. In the process of screening of antibacterial activities against H. pylori from soil microorgani는, fungus No. 60686 was isolated. After fementaion of No. 60686, the antibacterial compound was isolated, purified and followed by extraction of mycelium with orgainic solvents, acetone and ethyl acetate, through silica gel chromatography, LH-20 gel chromatography and HPLC. As a result of the structural analyses of the compound by IR, ^1H- and ^13C-NMR, FAB/Mass spectrophotomer, the compound having the antimicrobial activity was idenfitied as chaetoglobosin A (C_32H_36N_2O_5), a cytochalasan derivative. The antimicrobial activity of chaetoglobosin A was tested against Gram-positive and negative bacteria by paper disk method. Among the test strains of 9 Gram-positive bacteria and 18 Gram-negative bacteria containing 4 H. pylori strains, the growth of 4 H. pylori strains and 3 S. aureus strains (SG 511, 285 and 503) was only inhibited by chaetoglobosin A. Also it was shown that its growth inhibition against H. pylori strains was stronger than that against S. aureus strains at the treatment of the same concentration. Therefore it was concluded that chaetoglobosin A has a specific growth inhibition against H. pylori of the tested bacteria.

경동맥 스텐스의 조기결과

심원흠,홍범기,최동훈,김선호,김동익,김승민,이도연,장병철 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.1

조선대학교 의과대학 유급제도 개선을 위한 예비조사

박종,박상기,박상학,도남용,송창훈,이승일,임성철 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

This is a pilot study to improve the flunk system, a self-reported questionnaire survey was done by 58 professors among a total of 94 professors at Chosun University Medical School in December 1997. The results were as follows : 1. In regard to the student's residence, 69% of professors answered that the current system was appropriate. For a proper method of flunking. 46.6% of the professors agreed to the introduction of retesting by the Academic Affairs Department and 44.8% of the professors agreed to the evaluation of academic achievement of each subject. 2. Sixty-seven point two percents of professors agreed to the changing of time of flunk. 43.1% felt at the end of course, 24.1% felt at midterm, and 25.9% felt that the current system. 3. In regard to flunking, 34.5% of professors thought the current system-if a student receives an F grade in to be one subject, he/she was flunked-was sufficient, but 65.6% of the professors felt needed there improvement. The method of improvement was considered was losing more than two credits-fail(32.8%), and losing more than four credits-fail(10.3%). 4. Eighty-four point five percent of the professors agreed to the necessity of flunking by grade point average(GPA) and 77.6% of the professors answered that the students who must re-register should take all designated subjects. 5. Seventy-two point four percent of the professors opposed summer or winter courses for students who flunk and 51.7% of the professors opposed the necessity of a management system for students. In conclusion, the professors in Chosun University Medical College recognized the necessity of improving the flunk system, especially, the time, method and record keeping. So a concrete follow-up study needed to improve the flunk system.